Effect of <sup>99</sup>Tc<sup>m</sup>-sc with carbon nanoparticles suspension injection on sentinel lymph node mapping in patients with colon cancer _CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Chengcong , HAN Bo , XIN Jianjun ,  YANG Cheng

Department of Gastrointestinal Surgery, Qingdao Central Hospital, Qingdao, Shandong 266000, P.R.China;

Corresponding?author：

YANG Cheng, Email: 18669710997@126.com

Keywords：

⁹⁹Tc^m sulfur colloid; carbon nanoparticles; colon cancer; sentinel lymph node

DOI：

10.7507/1007-9424.201611031

Video：

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Objective To evaluate the feasibility of sentinel lymph node (SLN) mapping after ⁹⁹Tc^m sulfur colloid (⁹⁹Tc^m-sc) and carbon nanoparticles injection in patients with colon cancer. Methods Forty patients with colon cancer underwent complete mesocolic excision between August 2015 and July 2016 at Qingdao Central Hospital were considered for prospective inclusion. Before resection, SLN mapping was performed with injection of ⁹⁹Tc^m-sc and carbon nanopar-ticles, then all dissected lymph nodes were detected by pathological examination. Results A total of 660 cases of lymph nodes were found in the 40 patients (average of 16.5 cases per patient). Of them, 88 nodes (average of 2.2 cases per patient) were identified as SLN in 36 of 40 patients, with a successful detection rate of 90.0% (36/40). The diagnostic accuracy, sensitivity, and false-negative rate were 87.5% (35/40), 96.2% (25/26), and 3.8% (1/26) respectively. Conclusion ⁹⁹Tc^m-sc and carbon nanoparticles suspension injection for mapping SLN is a feasiblely diagnostic method for predicting local lymph node metastasis in the patient with colon cancer.

Citation： LIU Chengcong, HAN Bo, XIN Jianjun, YANG Cheng. Effect of ⁹⁹Tc^m-sc with carbon nanoparticles suspension injection on sentinel lymph node mapping in patients with colon cancer . CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(6): 727-731. doi: 10.7507/1007-9424.201611031 Copy

1.	陳萬青, 鄭榮壽, 張思維, 等. 2012 年中國惡性腫瘤發病和死亡分析. 中國腫瘤, 2016, 25(1): 1-8.
2.	Kawada K, Taketo MM. Significance and mechanism of lymph node metastasis in cancer progression. Cancer Res, 2011, 71(4): 1214-1218.
3.	虞華明. 大腸癌免疫組織化學表達與臨床病理的關系. 實用醫技雜志, 2016, 23(8): 889-890.
4.	張淵智, 武子濤, 李世榮. 原發性結直腸癌 594 例的臨床病理與遺傳易感性. 世界華人消化雜志, 2004, 12(8): 1509-1813.
5.	Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell, 2010, 140(6): 845-858.
6.	陳道瑾, 周逢強, 甘毅. 結直腸癌前哨淋巴結體外標記的研究. 中華胃腸外科雜志, 2006, 9(2): 124-126.
7.	Cabanas RM. An approach for the treatment of penile carcinoma. Cancer, 1977, 39(2): 456-466.
8.	Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg, 1992, 127(4): 392-399.
9.	Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH40: a new method for axillary lymph-node dissection in breast cancer. Can J Surg, 2000, 43(3): 191-196.
10.	江國斌, 方紅燕, 蔡建明. 納米碳混懸液示蹤前哨淋巴結在甲狀腺乳頭狀癌中的應用. 中國癌癥雜志, 2010, 20(12): 938-940.
11.	Okamoto K, Sawai K, Minato H, et al. Number and anatomical extent of lymph node metastases in gastric cancer: analysis using intra-lymph node injection of activated carbon particles (CH40). Jpn J Clin Oncol, 1999, 29(2): 74-77.
12.	程科, 莊競, 李保東, 等. 納米碳淋巴示蹤劑在腹腔鏡輔助下進展期胃癌根治術中的應用及評價. 中國普外基礎與臨床雜志, 2016, 23(12): 1460-1463.
13.	Albayrak Y, Oren D, Gündo?du C, et al. Intraoperative sentinel lymph node mapping in patients with colon cancer: study of 38 cases. Turk J Gastrocnterol, 2011, 22(3): 286-292.
14.	呂順增, 李超, 趙婧, 等. 3 種染料示蹤劑對鼠肢體淋巴結示蹤顯色時間和淋巴管走行途徑的比較研究. 中國現代普通外科進展, 2012, 15(10): 767-770.
15.	Willaert W, Ceelen W. Extent of surgery in cancer of the colon: is more better? World J Gastroenterol, 2015, 21(1): 132-138.
16.	Saha S, Nora D, Wong JH, et al. Sentinel lymph node mapping in colorectal cancer–a review. Surg Clin North Am, 2000, 80(6): 1811-1819.
17.	van der Zaag ES, Bouma WH, Peters HM, et al. Implications of sentinel lymph node mapping on nodal staging and prognosis in colorectal cancer. Colorectal Dis, 2012, 14(6): 684-690.
18.	van der Pas MH, Meijer S, Hoekstra OS, et al. Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis. Lancet Oncol, 2011, 12(6): 540-550.
19.	Hao RT, Chen J, Zhao LH, et al. Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma. Eur J Surg Oncol, 2012, 38(8): 718-724.
20.	張潤, 王思洋, 汪曉東, 等. 納米碳的臨床應用研究進展. 腫瘤學雜志, 2012, 18(11): 866-869.
21.	Yan J, Xue F, Chen H, et al. A multi-center study of using carbon nanoparticles to track lymph node metastasis in T1-2 colorectal cancer. Surg Endosc, 2014, 28(12): 3315-3321.
22.	劉永安, 黎艷芳, 陶琦, 等. 直腸拖出雙吻合器保肛術治療超低位直腸癌臨床報道. 中國普通外科雜志, 2012, 21(10): 1308-1309.
23.	Lindsetmo RO, Joh YG, Delaney CP. Surgical treatment for rectal cancer: an international perspective on what the medical gastroenterologist needs to know. World J Gastroenterol, 2008, 14(21): 3281-3289.
24.	童漢興, 趙綱, 陸巍, 等. 聯合納米炭和 ^99mTc-硫膠體標記法行直腸癌前哨淋巴結活檢的研究. 中國實用外科雜志, 2009, 29(9): 733-735.
25.	童漢興, 張勇, 張思, 等. 結直腸癌前哨淋巴結活檢及前哨淋巴結微轉移檢測方法研究. 中國臨床醫學, 2010, 18(5): 591-594.

1. 陳萬青, 鄭榮壽, 張思維, 等. 2012 年中國惡性腫瘤發病和死亡分析. 中國腫瘤, 2016, 25(1): 1-8.
2. Kawada K, Taketo MM. Significance and mechanism of lymph node metastasis in cancer progression. Cancer Res, 2011, 71(4): 1214-1218.
3. 虞華明. 大腸癌免疫組織化學表達與臨床病理的關系. 實用醫技雜志, 2016, 23(8): 889-890.
4. 張淵智, 武子濤, 李世榮. 原發性結直腸癌 594 例的臨床病理與遺傳易感性. 世界華人消化雜志, 2004, 12(8): 1509-1813.
5. Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell, 2010, 140(6): 845-858.
6. 陳道瑾, 周逢強, 甘毅. 結直腸癌前哨淋巴結體外標記的研究. 中華胃腸外科雜志, 2006, 9(2): 124-126.
7. Cabanas RM. An approach for the treatment of penile carcinoma. Cancer, 1977, 39(2): 456-466.
8. Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg, 1992, 127(4): 392-399.
9. Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH40: a new method for axillary lymph-node dissection in breast cancer. Can J Surg, 2000, 43(3): 191-196.
10. 江國斌, 方紅燕, 蔡建明. 納米碳混懸液示蹤前哨淋巴結在甲狀腺乳頭狀癌中的應用. 中國癌癥雜志, 2010, 20(12): 938-940.
11. Okamoto K, Sawai K, Minato H, et al. Number and anatomical extent of lymph node metastases in gastric cancer: analysis using intra-lymph node injection of activated carbon particles (CH40). Jpn J Clin Oncol, 1999, 29(2): 74-77.
12. 程科, 莊競, 李保東, 等. 納米碳淋巴示蹤劑在腹腔鏡輔助下進展期胃癌根治術中的應用及評價. 中國普外基礎與臨床雜志, 2016, 23(12): 1460-1463.
13. Albayrak Y, Oren D, Gündo?du C, et al. Intraoperative sentinel lymph node mapping in patients with colon cancer: study of 38 cases. Turk J Gastrocnterol, 2011, 22(3): 286-292.
14. 呂順增, 李超, 趙婧, 等. 3 種染料示蹤劑對鼠肢體淋巴結示蹤顯色時間和淋巴管走行途徑的比較研究. 中國現代普通外科進展, 2012, 15(10): 767-770.
15. Willaert W, Ceelen W. Extent of surgery in cancer of the colon: is more better? World J Gastroenterol, 2015, 21(1): 132-138.
16. Saha S, Nora D, Wong JH, et al. Sentinel lymph node mapping in colorectal cancer–a review. Surg Clin North Am, 2000, 80(6): 1811-1819.
17. van der Zaag ES, Bouma WH, Peters HM, et al. Implications of sentinel lymph node mapping on nodal staging and prognosis in colorectal cancer. Colorectal Dis, 2012, 14(6): 684-690.
18. van der Pas MH, Meijer S, Hoekstra OS, et al. Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis. Lancet Oncol, 2011, 12(6): 540-550.
19. Hao RT, Chen J, Zhao LH, et al. Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma. Eur J Surg Oncol, 2012, 38(8): 718-724.
20. 張潤, 王思洋, 汪曉東, 等. 納米碳的臨床應用研究進展. 腫瘤學雜志, 2012, 18(11): 866-869.
21. Yan J, Xue F, Chen H, et al. A multi-center study of using carbon nanoparticles to track lymph node metastasis in T1-2 colorectal cancer. Surg Endosc, 2014, 28(12): 3315-3321.
22. 劉永安, 黎艷芳, 陶琦, 等. 直腸拖出雙吻合器保肛術治療超低位直腸癌臨床報道. 中國普通外科雜志, 2012, 21(10): 1308-1309.
23. Lindsetmo RO, Joh YG, Delaney CP. Surgical treatment for rectal cancer: an international perspective on what the medical gastroenterologist needs to know. World J Gastroenterol, 2008, 14(21): 3281-3289.
24. 童漢興, 趙綱, 陸巍, 等. 聯合納米炭和 ^99mTc-硫膠體標記法行直腸癌前哨淋巴結活檢的研究. 中國實用外科雜志, 2009, 29(9): 733-735.
25. 童漢興, 張勇, 張思, 等. 結直腸癌前哨淋巴結活檢及前哨淋巴結微轉移檢測方法研究. 中國臨床醫學, 2010, 18(5): 591-594.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of ⁹⁹Tc^m-sc with carbon nanoparticles suspension injection on sentinel lymph node mapping in patients with colon cancer

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of 99Tcm-sc with carbon nanoparticles suspension injection on sentinel lymph node mapping in patients with colon cancer

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Effect of ⁹⁹Tc^m-sc with carbon nanoparticles suspension injection on sentinel lymph node mapping in patients with colon cancer