Diagnostic significance of ultrasound elastography strain ratio for benign and malignant breast lesions: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XU Feng ^1,2 , LIU Qian ² , XIN Jianyang ² , LIU Xiao ² , ZHENG Hui ² , ZHANG Aimei ² , WU Zhoushi ² ,  ZHANG Pengcheng ¹

1. Department of Thyroid and Breast, Xiangyang No.1 People’s Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, P. R. China;
2. The Forth Clinical College, Hubei University of Medicine, Shiyan, Hubei 442000, P. R. China;

Corresponding?author：

ZHANG Pengcheng, Email: jrk2017@163.com

Keywords：

breast nodule; ultrasound elastography; strain ratio; diagnosis; meta-analysis

DOI：

10.7507/1007-9424.201707086

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the significance of the ultrasound elastography (UE) strain ratio (SR) in the diagnosis of breast nodule by meta-analysis. Methods A computer-based online search was conducted in PubMed, The Cochrane Library (Issue 6, 2017), EMbase, CNKI, VIP, CBM, WanFang data databases, and so on (establishment time to June 2017), to collect the relevant diagnostic trials of the SR for breast nodules. Two reviewers independently screened literatures, extracted data, and evaluated the methodological quality of included studies. The meta-analysis was performed by using Stata 12.0 and Meta-Disc 1.4 software, and the combined indexes included sensitivity (Sen), specificity (Spe), positive likelihood ratio (LR+), negative likelihood ratio (LR–), and diagnostic odds ratio (DOR). Results A total of 26 studies were finally included. The results of meta-analysis showed that, the pooled Sen, Spe, LR+, LR–, and DOR was 0.88 (95% CI was 0.87 to 0.90), 0.85 (95% CI was 0.84 to 0.86), 6.66 (95% CI was 5.26 to 8.43), 0.14 (95% CI was 0.11 to 0.17), and 53.37 (95% CI was 34.96 to 81.49), respectively, P<0.000 1. Conclusion SR has high diagnostic accuracy in the differential diagnosis of benign and malignant breast nodules, it is worthy of widely utilized in the clinic.

Citation： XU Feng, LIU Qian, XIN Jianyang, LIU Xiao, ZHENG Hui, ZHANG Aimei, WU Zhoushi, ZHANG Pengcheng. Diagnostic significance of ultrasound elastography strain ratio for benign and malignant breast lesions: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(12): 1503-1512. doi: 10.7507/1007-9424.201707086 Copy

1.	徐鋒, 葛淑君, 陳郴, 等. 細針穿刺細胞學檢查診斷乳腺腫塊良惡性價值的 Meta 分析. 中國循證醫學雜志, 2017, 17(6): 644-651.
2.	Boji? T, Djordjevi? N, Karanikoli? A, et al. Assessment of axillary lymph nodes involvement in patients with breast cancer depending on the tumor size and its histological and nuclear grades. Vojnosanit Pregl, 2012, 69(5): 414-419.
3.	蔡熹, 丁炎, 劉波, 等. 常規超聲聯合超聲造影及彈性成像對糖尿病性乳腺病診斷價值的探討. 南京醫科大學學報(自然科學版), 2016, 36(4): 491-494.
4.	陳茂山, 黃云輝, 鄧萍, 等. 三維超聲對乳腺癌診斷價值的 Meta 分析. 現代腫瘤醫學, 2017, 25(10): 1619-1623.
5.	馬媛媛, 牟洋, 楊曉婧, 等. 乳腺惡性腫塊超聲造影增強特征表現與組織病理對照分析. 中華實用診斷與治療雜志, 2016, 30(3): 246-248.
6.	劉燦, 沈嚴嚴. 超聲新技術評估乳腺結節的研究進展. 中國中西醫結合影像學雜志, 2017, 15(2): 241-244.
7.	陳夏珊, 許萍, 王怡. 超聲彈性成像及新技術對乳腺腫塊的診斷價值. 中國醫學計算機成像雜志, 2013, 19(3): 288-291.
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13.	艾金偉, 李德勝, 劉羽, 等. 國內 HLA-B27 診斷強直性脊柱炎價值的 Meta 分析. 中國循證醫學雜志, 2015, 15(9): 1059-1067.
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18.	張智琳. 超聲彈性成像應變率比值對乳腺腫塊良惡性的鑒別診斷價值分析. 中國醫學工程, 2015, 23(7): 189-190.
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21.	于鵬麗, 張婕, 聞寶杰, 等. 超聲彈性應變率比值對 BI-RADS4 級乳腺腫塊良惡性診斷價值的分析. 腫瘤學雜志, 2016, 22(6): 439-442.
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23.	胡曉丹, 肖蓉, 楊昭暉. 超聲彈性成像應變率比值法與改良 5 分法在乳腺良惡性腫瘤中的診斷價值. 中國醫學影像學雜志, 2016, 24(12): 900-902.
24.	李云凌, 邵麗梅, 趙月環, 等. 乳腺占位病變準靜態超聲彈性成像診斷方法的對比研究. 醫學影像學雜志, 2016, 26(12): 2236-2239.
25.	彭曉靜, 李奧, 葉新華, 等. 應變式彈性成像與剪切波彈性成像技術鑒別診斷乳腺良惡性病灶的價值比較. 中華醫學超聲雜志(電子版), 2016, 13(12): 942-947.
26.	李明君, 肖螢. 超聲 SR 比值測量及等級評分法對乳腺占位的診斷價值. 西南國防醫藥, 2017, 27(4): 354-357.
27.	江寧珠, 姜偉, 黃翠平, 等. 超聲彈性成像聯合超聲造影診斷乳腺良惡性腫塊的價值分析. 臨床醫學工程, 2017, 24(4): 447-448.
28.	韋羽娟, 駱峰, 吳敏萍. 超聲彈性成像應變率比值法與評分法在不同年齡段女性乳腺癌診斷中的價值. 現代醫藥衛生, 2017, 33(11): 1688-1689.
29.	鄭燕, 董鳳林, 范晴敏. 超聲彈性成像在 BI-RADS 4A 類乳腺腫塊良惡性診斷中的應用. 中國超聲醫學雜志, 2017, 33(3): 206-208.
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1. 徐鋒, 葛淑君, 陳郴, 等. 細針穿刺細胞學檢查診斷乳腺腫塊良惡性價值的 Meta 分析. 中國循證醫學雜志, 2017, 17(6): 644-651.
2. Boji? T, Djordjevi? N, Karanikoli? A, et al. Assessment of axillary lymph nodes involvement in patients with breast cancer depending on the tumor size and its histological and nuclear grades. Vojnosanit Pregl, 2012, 69(5): 414-419.
3. 蔡熹, 丁炎, 劉波, 等. 常規超聲聯合超聲造影及彈性成像對糖尿病性乳腺病診斷價值的探討. 南京醫科大學學報(自然科學版), 2016, 36(4): 491-494.
4. 陳茂山, 黃云輝, 鄧萍, 等. 三維超聲對乳腺癌診斷價值的 Meta 分析. 現代腫瘤醫學, 2017, 25(10): 1619-1623.
5. 馬媛媛, 牟洋, 楊曉婧, 等. 乳腺惡性腫塊超聲造影增強特征表現與組織病理對照分析. 中華實用診斷與治療雜志, 2016, 30(3): 246-248.
6. 劉燦, 沈嚴嚴. 超聲新技術評估乳腺結節的研究進展. 中國中西醫結合影像學雜志, 2017, 15(2): 241-244.
7. 陳夏珊, 許萍, 王怡. 超聲彈性成像及新技術對乳腺腫塊的診斷價值. 中國醫學計算機成像雜志, 2013, 19(3): 288-291.
8. Ophir J, Céspedes I, Ponnekanti H, et al. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging, 1991, 13(2): 111-134.
9. Chen L, He J, Liu G, et al. Diagnostic performances of shear-wave elastography for identification of malignant breast lesions: a meta-analysis. Jpn J Radiol, 2014, 32(10): 592-599.
10. Kim YS, Park JG, Kim BS, et al. Diagnostic value of elastography using acoustic radiation force impulse imaging and strain ratio for breast tumors. J Breast Cancer, 2014, 17(1): 76-82.
11. 時利英, 鄧輝勝. 超聲彈性成像在惡性腫瘤早期診斷中的價值. 實用腫瘤雜志, 2012, 27(6): 674-677.
12. 曾憲濤, 莊麗萍, 楊宗國, 等. Meta 分析系列之七: 非隨機實驗性研究、診斷性試驗及動物實驗的質量評價工具. 中國循證心血管醫學雜志, 2012, 4(6): 496-499.
13. 艾金偉, 李德勝, 劉羽, 等. 國內 HLA-B27 診斷強直性脊柱炎價值的 Meta 分析. 中國循證醫學雜志, 2015, 15(9): 1059-1067.
14. 智慧. 彈性應變率比值法在乳腺實性腫物良惡性超聲診斷中的價值初探. 中華醫學會第十次全國超聲醫學學術會議, 山東濟南, 2009.
15. 龔業瓊, 申俊玲. 超聲彈性成像比值法對乳腺良惡性腫塊的診斷價值. 西部醫學, 2012, 24(9): 1774-1776.
16. 趙亮, 柳莉莎, 李明慧. 超聲彈性應變率比值在乳腺良惡性腫瘤鑒別診斷中的應用價值. 中國全科醫學, 2012, 15(18): 2074-2076.
17. 黃健民, 華金才, 金巧芳. 超聲彈性成像應變率比值對乳腺腫塊良惡性病灶的臨床診斷價值研究. 中國現代醫學雜志, 2014, 24(10): 100-103.
18. 張智琳. 超聲彈性成像應變率比值對乳腺腫塊良惡性的鑒別診斷價值分析. 中國醫學工程, 2015, 23(7): 189-190.
19. 吳韻秋, 金梅, 何麗蘭, 等. 超聲彈性成像應變率比值法鑒別良惡性乳腺腫瘤的價值. 影像診斷與介入放射學, 2015, 24(2): 134-137.
20. 彭瑞芳, 楊韻賢, 鄭苑君. 超聲彈性成像與 BI-RADS-US 分級在乳腺良惡性腫塊中的診斷價值. 中國當代醫藥, 2016, 23(7): 124-126.
21. 于鵬麗, 張婕, 聞寶杰, 等. 超聲彈性應變率比值對 BI-RADS4 級乳腺腫塊良惡性診斷價值的分析. 腫瘤學雜志, 2016, 22(6): 439-442.
22. 隋燕妮, 雷冬梅, 王先銀, 等. 超聲彈性成像聯合 BI-RADS 分級對乳腺腫塊的定性診斷價值. 中國婦幼保健, 2016, 31(19): 4063-4065.
23. 胡曉丹, 肖蓉, 楊昭暉. 超聲彈性成像應變率比值法與改良 5 分法在乳腺良惡性腫瘤中的診斷價值. 中國醫學影像學雜志, 2016, 24(12): 900-902.
24. 李云凌, 邵麗梅, 趙月環, 等. 乳腺占位病變準靜態超聲彈性成像診斷方法的對比研究. 醫學影像學雜志, 2016, 26(12): 2236-2239.
25. 彭曉靜, 李奧, 葉新華, 等. 應變式彈性成像與剪切波彈性成像技術鑒別診斷乳腺良惡性病灶的價值比較. 中華醫學超聲雜志(電子版), 2016, 13(12): 942-947.
26. 李明君, 肖螢. 超聲 SR 比值測量及等級評分法對乳腺占位的診斷價值. 西南國防醫藥, 2017, 27(4): 354-357.
27. 江寧珠, 姜偉, 黃翠平, 等. 超聲彈性成像聯合超聲造影診斷乳腺良惡性腫塊的價值分析. 臨床醫學工程, 2017, 24(4): 447-448.
28. 韋羽娟, 駱峰, 吳敏萍. 超聲彈性成像應變率比值法與評分法在不同年齡段女性乳腺癌診斷中的價值. 現代醫藥衛生, 2017, 33(11): 1688-1689.
29. 鄭燕, 董鳳林, 范晴敏. 超聲彈性成像在 BI-RADS 4A 類乳腺腫塊良惡性診斷中的應用. 中國超聲醫學雜志, 2017, 33(3): 206-208.
30. 歐陽春榮, 黃間娣, 鐘倩萍, 等. 彈性應變率比值法、改良 5 分法聯合超聲 BI-RADS 分級對乳腺實性病變良惡性的診斷價值. 現代醫用影像學, 2017, 26(2): 230-233.
31. Zhi H, Xiao XY, Yang HY, et al. Ultrasonic elastography in breast cancer diagnosis: strain ratio vs 5-point scale. Acad Radiol, 2010, 17(10): 1227-1233.
32. Zhao QL, Ruan LT, Zhang H, et al. Diagnosis of solid breast lesions by elastography 5-point score and strain ratio method. Eur J Radiol, 2012, 81(11): 3245-3249.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Diagnostic significance of ultrasound elastography strain ratio for benign and malignant breast lesions: a meta-analysis

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