Association between polymorphisms of DNMT1 rs16999593 and susceptibility of breast cancer: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LONG Binbin ¹ , ZHANG Chao ² , WANG Lingling ³ ,  WANG Geng ¹

1. The Third Department of General Surgery, Shiyan Taihe Hospital, Shiyan, Hubei 442000, P. R. China;
2. Evidence-Based Medicine Center, Shiyan Taihe Hospital, Shiyan, Hubei 442000, P. R. China;
3. Institute of Dermatology Center, Shiyan Taihe Hospital, Shiyan, Hubei 442000, P. R. China;

Corresponding?author：

WANG Geng, Email: wg129@sina.com

Keywords：

breast cancer; DNA methyltransferase 1; gene polymorphism; meta-analysis

DOI：

10.7507/1007-9424.201711041

Video：

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Objective To systematically review the correlation between polymorphism of DNA methyltransferase 1(DNMT1) rs16999593 and the susceptibility of breast cancer. Methods Databases such as PubMed, EMbase, Web of Science, Chinese Biomedical Literature Database, CNKI, WanFang, and VIP database were searched from inception to Mar. 2017 to collect case-control studies on the correlation between DNMT1 rs16999593 C/T polymorphism and the susceptibility of breast cancer. Two reviewers independently identified the literatures according to inclusion and exclusion criterias, extracted data, and assessed the quality of the included studies. The meta-analysis was performed by using RevMan 5.3 software. Results A total of 5 studies involving 1 741 cases and 1 917 control subjects were included. The results of meta-analysis showed that, dominate model ［TT+TC vs. CC: OR=0.63, 95% CI was (0.30, 1.30), P=0.21］, homozygous model ［TT vs. CC: OR=1.01, 95% CI was (0.70, 1.47), P=0.95］, heterozygous model ［TC vs. CC: OR=0.44, 95% CI was (0.18, 1.04), P=0.06］, and additive model ［T vs. C: OR=1.29, 95% CI was (0.90, 1.86), P=0.16］ were not significantly related to breast cancer, but recessive gene model was related to breast cancer ［TT vs. TC+CC: OR=1.74, 95% CI was (1.01, 3.00), P=0.04］. Conclusion The current studies showed that, DNMT1 rs16999593 TT genotype decreases the susceptibility of breast cancer.

Citation： LONG Binbin, ZHANG Chao, WANG Lingling, WANG Geng. Association between polymorphisms of DNMT1 rs16999593 and susceptibility of breast cancer: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(6): 721-727. doi: 10.7507/1007-9424.201711041 Copy

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2.	DeSantis C, Ma J, Bryan L, et al. Breast cancer statistics, 2013. CA Cancer J Clin, 2014, 64(1): 52-62.
3.	DeSantis C, Siegel R, Bandi P, et al. Breast cancer statistics, 2011. CA Cancer J Clin, 2011, 61(6): 409-418.
4.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
5.	Giacinti L, Claudio PP, Lopez M, et al. Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist, 2006, 11(1): 1-8.
6.	Chen T, Hevi S, Gay F, et al. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet, 2007, 39(3): 391-396.
7.	Ye C, Beeghly-Fadiel A, Lu W, et al. Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk. Breast Cancer Res Treat, 2010, 121(3): 765-769.
8.	Xiang G, Zhenkun F, Shuang C, et al. Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among Chinese Han women in the Heilongjiang Province. Clin Breast Cancer, 2010, 10(5): 373-377.
9.	Sun MY, Yang XX, Xu WW, et al. Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China. Genet Mol Res, 2012, 11(4): 4330-4341.
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13.	Tao R, Chen Z, Wu P, et al. The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females. Tumour Biol, 2015, 36(12): 9849-9855.
14.	孫敏英. 雌激素合成、代謝相關基因和 DNMTs 單核苷酸多態性與中國漢族女性乳腺癌易感性的關聯研究. 廣州: 南方醫科大學, 2012.
15.	陶然. EZH2 和 DNMT1 基因多態性、蛋白表達對中國廣東地區漢族女性三陰性乳腺癌易感性的影響. 貴陽: 貴陽醫學院, 2014.
16.	郭家權, 陳純靜, 陳恩, 等. 乳腺癌與 MICA 基因多態性的相關性研究. 激光生物學報, 2015, 24(2): 170-174, 169.
17.	周鑫, 曹勇, 羅杰, 等. CD24 基因多態性與乳腺癌遺傳易感性的關系. 中南大學學報 (醫學版), 2013, 38(11): 1122-1129.
18.	Tuerxun·MAIMAITI, Hamulati·WUPUER, XIA Kun, et al. The effect of single and combined genotypes of CYP1A1, CYP1B1, NET and DAT1 on breast cancer susceptibility in a Han Chinese population. Life Sci Res, 2015, 19(6): 521-529.
19.	許曄瓊, 何幫順, 鄧齊文, 等. Fas/FasL 基因多態性與乳腺癌發生的相關性. 臨床檢驗雜志, 2013, 31(12): 941-944.
20.	邱秀娟, 成芳, 高俊. 中國人群 FGFR2 基因多態性與乳腺癌易感相關性研究的 Meta 分析. 中華腫瘤防治雜志, 2015, 22(3): 227-234.
21.	李卿, 王紅梅, 劉燕玲, 等. IL-10 (-1082A/G) 基因多態性和乳腺癌的相關性: Meta 分析. 現代生物醫學進展, 2017, 17(5): 820-825.
22.	魏曉東, 張可, 么坤, 等. MDM2 啟動子 SNP309 多態性與亞洲人群乳腺癌易感性關系的 Meta 分析. 世界科技研究與發展, 2015, 37(4): 377-380.
23.	李琳琳, 梁媛, 陳申, 等. XRCC1 Arg399Gln 位點多態性與乳腺癌易感性的 Meta 分析. 中國腫瘤, 2015, 24(3): 223-228.
24.	Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res, 2007, 67(3): 946-950.
25.	Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci, 2010, 101(1): 36-45.
26.	武興. DNMT1 基因多態性與胃癌患者預后的研究. 長春: 吉林大學, 2016.
27.	何幫順, 潘玉琴, 朱成賓. 甲基化轉移酶基因多態性與前列腺癌發病的相關性研究. 中華男科學雜志, 2014, 20(12): 1077-1081.
28.	王玲. DNA 甲基轉移酶 1 基因多態性和被動吸煙與宮頸癌的相關性研究. 蘭州: 蘭州大學, 2014.
29.	Montgomery KG, Liu MC, Eccles DM, et al. The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study. Breast Cancer Res, 2004, 6(4): R390-R394.

1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
2. DeSantis C, Ma J, Bryan L, et al. Breast cancer statistics, 2013. CA Cancer J Clin, 2014, 64(1): 52-62.
3. DeSantis C, Siegel R, Bandi P, et al. Breast cancer statistics, 2011. CA Cancer J Clin, 2011, 61(6): 409-418.
4. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
5. Giacinti L, Claudio PP, Lopez M, et al. Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist, 2006, 11(1): 1-8.
6. Chen T, Hevi S, Gay F, et al. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet, 2007, 39(3): 391-396.
7. Ye C, Beeghly-Fadiel A, Lu W, et al. Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk. Breast Cancer Res Treat, 2010, 121(3): 765-769.
8. Xiang G, Zhenkun F, Shuang C, et al. Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among Chinese Han women in the Heilongjiang Province. Clin Breast Cancer, 2010, 10(5): 373-377.
9. Sun MY, Yang XX, Xu WW, et al. Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China. Genet Mol Res, 2012, 11(4): 4330-4341.
10. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
11. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. 2011-03. http://www.cochrane-handbook.org/.
12. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
13. Tao R, Chen Z, Wu P, et al. The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females. Tumour Biol, 2015, 36(12): 9849-9855.
14. 孫敏英. 雌激素合成、代謝相關基因和 DNMTs 單核苷酸多態性與中國漢族女性乳腺癌易感性的關聯研究. 廣州: 南方醫科大學, 2012.
15. 陶然. EZH2 和 DNMT1 基因多態性、蛋白表達對中國廣東地區漢族女性三陰性乳腺癌易感性的影響. 貴陽: 貴陽醫學院, 2014.
16. 郭家權, 陳純靜, 陳恩, 等. 乳腺癌與 MICA 基因多態性的相關性研究. 激光生物學報, 2015, 24(2): 170-174, 169.
17. 周鑫, 曹勇, 羅杰, 等. CD24 基因多態性與乳腺癌遺傳易感性的關系. 中南大學學報 (醫學版), 2013, 38(11): 1122-1129.
18. Tuerxun·MAIMAITI, Hamulati·WUPUER, XIA Kun, et al. The effect of single and combined genotypes of CYP1A1, CYP1B1, NET and DAT1 on breast cancer susceptibility in a Han Chinese population. Life Sci Res, 2015, 19(6): 521-529.
19. 許曄瓊, 何幫順, 鄧齊文, 等. Fas/FasL 基因多態性與乳腺癌發生的相關性. 臨床檢驗雜志, 2013, 31(12): 941-944.
20. 邱秀娟, 成芳, 高俊. 中國人群 FGFR2 基因多態性與乳腺癌易感相關性研究的 Meta 分析. 中華腫瘤防治雜志, 2015, 22(3): 227-234.
21. 李卿, 王紅梅, 劉燕玲, 等. IL-10 (-1082A/G) 基因多態性和乳腺癌的相關性: Meta 分析. 現代生物醫學進展, 2017, 17(5): 820-825.
22. 魏曉東, 張可, 么坤, 等. MDM2 啟動子 SNP309 多態性與亞洲人群乳腺癌易感性關系的 Meta 分析. 世界科技研究與發展, 2015, 37(4): 377-380.
23. 李琳琳, 梁媛, 陳申, 等. XRCC1 Arg399Gln 位點多態性與乳腺癌易感性的 Meta 分析. 中國腫瘤, 2015, 24(3): 223-228.
24. Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res, 2007, 67(3): 946-950.
25. Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci, 2010, 101(1): 36-45.
26. 武興. DNMT1 基因多態性與胃癌患者預后的研究. 長春: 吉林大學, 2016.
27. 何幫順, 潘玉琴, 朱成賓. 甲基化轉移酶基因多態性與前列腺癌發病的相關性研究. 中華男科學雜志, 2014, 20(12): 1077-1081.
28. 王玲. DNA 甲基轉移酶 1 基因多態性和被動吸煙與宮頸癌的相關性研究. 蘭州: 蘭州大學, 2014.
29. Montgomery KG, Liu MC, Eccles DM, et al. The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study. Breast Cancer Res, 2004, 6(4): R390-R394.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Association between polymorphisms of DNMT1 rs16999593 and susceptibility of breast cancer: a meta-analysis

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