Association between polymorphism of long non-coding RNA maternally expressed gene 3and risk of gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHANG Qi , AI Liang , DAI Youguo

Department of Abdominal Surgery, Yunnan Cancer Hospital, Kunming 650118, P. R. China;

Corresponding?author：

ZHANG Qi, Email: 576515981@qq.com

Keywords：

long non-coding RNA; maternally expressed gene 3; single nucleotide polymorphism; gastric cancer

DOI：

10.7507/1007-9424.201805074

Video：

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Objective To explore relationship between long non-coding RNA maternally expressed gene 3 (MEG3) polymorphisms and risk of gastric cancer. Methods One hundred and seventy-two Han patients with gastric cancer (gastric cancer group) and 224 Han individuals for physical examination (control group) in the Yunnan Cancer Hospital from March 2013 to October 2017 were selected as subjects. The rs7158663 and rs4081134 polymorphisms of the MEG3 were genotyped by using a TaqMan technique. The associations between the 2 polymorphisms and the risk of the gastric cancer and its clinical features were analyzed using the SPSS software. Results The frequencies of the AG+AA genotype and the A allele of the MEG3 rs7158663 in the gastric cancer group were significantly higher than those in the control group using the GG genotype and G allele as a reference respectively ［adjusted OR=1.71, 95%CI (1.14, 2.56), P=0.010; adjusted OR=1.58, 95%CI (1.15, 2.19), P=0.005］ after the Chi-square test and the adjustment of age and gender. The frequencies of the AG+AA genotype and the A allele of the MEG3 rs4081134 had no significant differences between the gastric cancer group and the control group (P>0.017). Moreover, the polymorphisms of the MEG3 rs7158663 and rs4081134 were not associated with the clinical features of the gastric cancer (P>0.017). Conclusion MEG3 rs7158663 AG+AA genotype might be one of susceptibility gene of gastric cancer in Chinese Han population.

Citation： ZHANG Qi, AI Liang, DAI Youguo. Association between polymorphism of long non-coding RNA maternally expressed gene 3and risk of gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(11): 1323-1326. doi: 10.7507/1007-9424.201805074 Copy

1.	鄭斌, 王宇. 長鏈非編碼 RNA UCA1 在消化系統腫瘤中的研究進展. 中國腫瘤, 2018, 27(3): 209-213.
2.	張川, 張新晨. 長鏈非編碼 RNA MEG3 在消化道腫瘤中的研究進展. 胃腸病學和肝病學雜志, 2017, 26(9): 1057-1060.
3.	朱棟良, 尹小平, 王芳元. 長鏈非編碼 RNA-MALAT1 對結直腸癌細胞介導的血管形成的影響. 中國普外基礎與臨床雜志, 2015, 22(1): 60-63.
4.	唐龍, 唐世磊, 劉古月, 等. 長鏈非編碼 RNA 在常見消化系統腫瘤中的研究進展. 中國普外基礎與臨床雜志, 2015, 22(8): 1014-1018.
5.	楊自國, 郭曉波, 石玉龍, 等. 胃癌轉移相關長鏈非編碼 RNA 的研究進展. 中國普外基礎與臨床雜志, 2015, 22(4): 513-516.
6.	王藝超, 李志輝, 陳文杰, 等. 甲狀腺乳頭狀癌相關長鏈非編碼 RNA 的研究進展. 中國普外基礎與臨床雜志, 2017, 24(8): 1030-1034.
7.	Li C, Liang G, Yao W, et al. Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer. Oncol Rep, 2016, 35(3): 1529-1540.
8.	Dan J, Wang J, Wang Y, et al. LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer. Biomed Pharmacother, 2018, 99: 931-938.
9.	Wei GH, Wang X. LncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway. Eur Rev Med Pharmacol Sci, 2017, 21(17): 3850-3856.
10.	Peng W, Si S, Zhang Q, et al. Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. J Exp Clin Cancer Res, 2015, 34: 79.
11.	孫倩, 劉博巽, 林夢潔, 等. 長鏈非編碼 RNAMEG3 對胃癌細胞增殖的影響. 南京醫科大學學報 (自然科學版), 2014, 34(1): 1-6.
12.	韓韜, 何曉璞, 劉靜, 等. 長鏈非編碼 RNA MEG3 抑制人胃癌 SGC-7901 細胞增殖的研究. 現代腫瘤醫學, 2015, 23(11): 1504-1508.
13.	孟菲菲, 司君利, 解祥軍, 等. 長鏈非編碼 RNAs MEG3 和 GAS5 在胃癌組織中的表達及其與預后的關系. 中國臨床研究, 2016, 29(11): 1449-1452, 1457.
14.	Xu G, Meng L, Yuan D, et al. MEG3/miR21 axis affects cell mobility by suppressing epithelial mesenchymal transition in gastric cancer. Oncol Rep, 2018, 40(1): 39-48.
15.	Sun R, Liang Y, Yuan F, et al. Functional polymorphisms in the promoter region of miR-17-92 cluster are associated with a decreased risk of colorectal cancer. Oncotarget, 2017, 8(47): 82531-82540.
16.	Yuan F, Sun R, Li L, et al. A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer. Sci Rep, 2016, 6: 30195.
17.	Cao X, Zhuang S, Hu Y, et al. Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese. Oncotarget, 2016, 7(14): 19054-19059.
18.	Zhuo ZJ, Zhang R, Zhang J, et al. Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children. Aging (Albany NY), 2018, 10(3): 481-491.
19.	Piccoli MT, Gupta SK, Viereck J, et al. Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction. Circ Res, 2017, 121(5): 575-583.
20.	Gong WJ, Peng JB, Yin JY, et al. Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer. Acta Pharmacol Sin, 2017, 38(4): 581-590.
21.	Zhang Z, Liu T, Wang K, et al. Down-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: Evidence from the GEO database. Gene, 2017, 630: 49-58.
22.	Wang P, Chen D, Ma H, et al. LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. Onco Targets Ther, 2017, 10: 5137-5149.
23.	Li R, Fang L, Pu Q, et al. MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection. Sci Signal, 2018, 11(536): pii: eaao2387.
24.	Wang Q, Li M, Shen Z, et al. The long non-coding RNA MEG3/miR-let-7c-5p axis regulates ethanol-induced hepatic steatosis and apoptosis by targeting NLRC5. Front Pharmacol, 2018, 9: 302.
25.	He JH, Han ZP, Liu JM, et al. Overexpression of long non-coding RNA MEG3 inhibits proliferation of hepatocellular carcinoma Huh7 cells via negative modulation of miRNA-664. J Cell Biochem, 2017, 118(11): 3713-3721.
26.	Wang M, Huang T, Luo G, et al. Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway. J Huazhong Univ Sci Technolog Med Sci, 2015, 35(4): 541-545.
27.	He H, Dai J, Zhuo R, et al. Study on the mechanism behind lncRNA MEG3 affecting clear cell renal cell carcinoma by regulating miR-7/RASL11B signaling. J Cell Physiol, 2018 Jul 3.

1. 鄭斌, 王宇. 長鏈非編碼 RNA UCA1 在消化系統腫瘤中的研究進展. 中國腫瘤, 2018, 27(3): 209-213.
2. 張川, 張新晨. 長鏈非編碼 RNA MEG3 在消化道腫瘤中的研究進展. 胃腸病學和肝病學雜志, 2017, 26(9): 1057-1060.
3. 朱棟良, 尹小平, 王芳元. 長鏈非編碼 RNA-MALAT1 對結直腸癌細胞介導的血管形成的影響. 中國普外基礎與臨床雜志, 2015, 22(1): 60-63.
4. 唐龍, 唐世磊, 劉古月, 等. 長鏈非編碼 RNA 在常見消化系統腫瘤中的研究進展. 中國普外基礎與臨床雜志, 2015, 22(8): 1014-1018.
5. 楊自國, 郭曉波, 石玉龍, 等. 胃癌轉移相關長鏈非編碼 RNA 的研究進展. 中國普外基礎與臨床雜志, 2015, 22(4): 513-516.
6. 王藝超, 李志輝, 陳文杰, 等. 甲狀腺乳頭狀癌相關長鏈非編碼 RNA 的研究進展. 中國普外基礎與臨床雜志, 2017, 24(8): 1030-1034.
7. Li C, Liang G, Yao W, et al. Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer. Oncol Rep, 2016, 35(3): 1529-1540.
8. Dan J, Wang J, Wang Y, et al. LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer. Biomed Pharmacother, 2018, 99: 931-938.
9. Wei GH, Wang X. LncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway. Eur Rev Med Pharmacol Sci, 2017, 21(17): 3850-3856.
10. Peng W, Si S, Zhang Q, et al. Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. J Exp Clin Cancer Res, 2015, 34: 79.
11. 孫倩, 劉博巽, 林夢潔, 等. 長鏈非編碼 RNAMEG3 對胃癌細胞增殖的影響. 南京醫科大學學報 (自然科學版), 2014, 34(1): 1-6.
12. 韓韜, 何曉璞, 劉靜, 等. 長鏈非編碼 RNA MEG3 抑制人胃癌 SGC-7901 細胞增殖的研究. 現代腫瘤醫學, 2015, 23(11): 1504-1508.
13. 孟菲菲, 司君利, 解祥軍, 等. 長鏈非編碼 RNAs MEG3 和 GAS5 在胃癌組織中的表達及其與預后的關系. 中國臨床研究, 2016, 29(11): 1449-1452, 1457.
14. Xu G, Meng L, Yuan D, et al. MEG3/miR21 axis affects cell mobility by suppressing epithelial mesenchymal transition in gastric cancer. Oncol Rep, 2018, 40(1): 39-48.
15. Sun R, Liang Y, Yuan F, et al. Functional polymorphisms in the promoter region of miR-17-92 cluster are associated with a decreased risk of colorectal cancer. Oncotarget, 2017, 8(47): 82531-82540.
16. Yuan F, Sun R, Li L, et al. A functional variant rs353292 in the flanking region of miR-143/145 contributes to the risk of colorectal cancer. Sci Rep, 2016, 6: 30195.
17. Cao X, Zhuang S, Hu Y, et al. Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese. Oncotarget, 2016, 7(14): 19054-19059.
18. Zhuo ZJ, Zhang R, Zhang J, et al. Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children. Aging (Albany NY), 2018, 10(3): 481-491.
19. Piccoli MT, Gupta SK, Viereck J, et al. Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction. Circ Res, 2017, 121(5): 575-583.
20. Gong WJ, Peng JB, Yin JY, et al. Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer. Acta Pharmacol Sin, 2017, 38(4): 581-590.
21. Zhang Z, Liu T, Wang K, et al. Down-regulation of long non-coding RNA MEG3 indicates an unfavorable prognosis in non-small cell lung cancer: Evidence from the GEO database. Gene, 2017, 630: 49-58.
22. Wang P, Chen D, Ma H, et al. LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. Onco Targets Ther, 2017, 10: 5137-5149.
23. Li R, Fang L, Pu Q, et al. MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection. Sci Signal, 2018, 11(536): pii: eaao2387.
24. Wang Q, Li M, Shen Z, et al. The long non-coding RNA MEG3/miR-let-7c-5p axis regulates ethanol-induced hepatic steatosis and apoptosis by targeting NLRC5. Front Pharmacol, 2018, 9: 302.
25. He JH, Han ZP, Liu JM, et al. Overexpression of long non-coding RNA MEG3 inhibits proliferation of hepatocellular carcinoma Huh7 cells via negative modulation of miRNA-664. J Cell Biochem, 2017, 118(11): 3713-3721.
26. Wang M, Huang T, Luo G, et al. Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway. J Huazhong Univ Sci Technolog Med Sci, 2015, 35(4): 541-545.
27. He H, Dai J, Zhuo R, et al. Study on the mechanism behind lncRNA MEG3 affecting clear cell renal cell carcinoma by regulating miR-7/RASL11B signaling. J Cell Physiol, 2018 Jul 3.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Association between polymorphism of long non-coding RNA maternally expressed gene 3and risk of gastric cancer

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