Progress in the study of programmed cell death in acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Jie ¹ , GAO Lei ¹ , CHEN Yafeng ¹ , HUANG Ye ¹ , LIU Huan ¹ , XU Ke ² ,  FENG Dianxu ¹

1. Department of General Surgery, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P. R. China;
2. Central Laboratory, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P. R. China;

Corresponding?author：

FENG Dianxu, Email: fdianxu@sohu.com

Keywords：

acute pancreatitis; programmed cell death; review

DOI：

10.7507/1007-9424.201904003

Video：

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Objective To understand the current progress of programmed cell death in the pathogenesis of acute pancreatitis, and to provide reference for the pathogenesis and treatment of acute pancreatitis.Method The research progress of acute pancreatitis and programmed cell death in recent years was reviewed by reading relevant literatures at home and abroad in recent years.Results Programmed cell death was defined as controlled cell death performed by intracellular procedures, including apoptosis, autophagy, programmed necrosis, and coronation. The pattern of death of pancreatic acinar cells mainly includes apoptosis and programmed necrosis. Although the pathogenesis of acute pancreatitis had not yet been fully clarified, it was known that through the study of programmed cell death, it could help us to understand the pathogenesis and pathogenesis of acute pancreatitis and provide more effective treatment methods.Conclusions Programmed cell death is very important for acute pancreatitis. The mechanism of programmed cell death in acute pancreatitis is necessary for the treatment and prevention of it.

Citation： LI Jie, GAO Lei, CHEN Yafeng, HUANG Ye, LIU Huan, XU Ke, FENG Dianxu. Progress in the study of programmed cell death in acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(11): 1350-1354. doi: 10.7507/1007-9424.201904003 Copy

1.	Mole DJ, Webster SP, Uings I, et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med, 2016, 22(2): 202-209.
2.	Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
3.	Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet, 2015, 386(9988): 85-96.
4.	中華醫學會消化病學分會胰腺疾病學組, 《中華胰腺病雜志》編輯委員會, 《中華消化雜志》編輯委員會, 等. 中國急性胰腺炎診治指南(2013, 上海). 中華胰腺病雜志, 2013, 13(2): 73-78.
5.	Vege SS, Gardner TB, Chari ST, et al. Low mortality and high morbidity in severe acute pancreatitis without organ failure: a case for revising the Atlanta classification to include "moderately severe acute pancreatitis". Am J Gastroenterol, 2009, 104(3): 710-715.
6.	Man SM, Karki R, Kanneganti TD. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev, 2017, 277(1): 61-75.
7.	Heasman J, Crawford A, Goldstone K, et al. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell, 1994, 79(5): 791-803.
8.	Kerr JF. An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine. Pathology, 1969, 1(2): 83-94.
9.	Coulson A, Sulston J, Brenner S, et al. Toward a physical map of the genome of the nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A, 1986, 83(20): 7821-7825.
10.	Schulte-Hermann R, Bursch W, L?w-Baselli A, et al. Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol Toxicol, 1997, 13(4-5): 339-348.
11.	Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol, 2008, 9(3): 231-241.
12.	Baran K, Rodriguez D, Green D. The DNA damage response mediates apoptosis and tumor suppression//Wu H. Cell death. Springer: New York, 2014: 135-165.
13.	Green DR, Ferguson T, Zitvogel L, et al. Immunogenic and tolerogenic cell death. Nat Rev Immunol, 2009, 9(5): 353-363.
14.	Rock KL, Lai JJ, Kono H. Innate and adaptive immune responses to cell death. Immunol Rev, 2011, 243(1): 191-205.
15.	Srikrishna G, Freeze HH. Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia, 2009, 11(7): 615-628.
16.	He R, Wang L, Zhu J, et al. Methane-rich saline protects against concanavalin A-induced autoimmune hepatitis in mice through anti-inflammatory and anti-oxidative pathways. Biochem Biophys Res Commun, 2016, 470(1): 22-28.
17.	Chen O, Ye Z, Cao Z, et al. Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radic Biol Med, 2016, 90: 1-11.
18.	Xie Q, Fei M, Fa Z, et al. Methane-rich saline alleviates cerulein-induced acute pancreatitis by inhibiting inflammatory response, oxidative stress and pancreatic apoptosis in mice. Int Immunopharmacol, 2017, 51: 17-24.
19.	Cui H, Li S, Xu C, et al. Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. Mol Med Rep, 2017, 16(4): 5121-5128.
20.	王興鵬, 王冰嫻, 吳愷, 等. 細胞凋亡在急性壞死型胰腺炎早期腸黏膜上皮細胞死亡中的作用. 中華消化雜志, 2001, 21(5): 267-270.
21.	Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol, 2010, 22(2): 124-131.
22.	Mijaljica D, Prescott M, Devenish RJ. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy, 2011, 7(7): 673-682.
23.	Massey A, Kiffin R, Cuervo AM. Pathophysiology of chaperone-mediated autophagy. Intern J Biochemistry Cell Biology, 2004, 36(12): 2420-2434.
24.	Biczo G, Vegh ET, Shalbueva N, et al. Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology, 2018, 154(3): 689-703.
25.	劉曉. 急性胰腺炎時自噬變化的意義及干擾素γ對自噬影響的實驗研究. 上海: 第二軍醫大學, 2013.
26.	Wild P, McEwan DG, Dikic I. The LC3 interactome at a glance. J Cell Sci, 2014, 127(Pt 1): 3-9.
27.	Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ, 2005, 12(Suppl 2): 1542-1552.
28.	巴微, 逄越, 李慶偉. 程序性壞死(Necroptosis)的分子機制. 遺傳, 2014, 36(6): 519-524.
29.	Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, et al. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol, 2014, 15(2): 135-147.
30.	Pasparakis M, Vandenabeele P. Necroptosis and its role in inflammation. Nature, 2015, 517(7534): 311-320.
31.	Zhang T, Xia M, Zhan Q, et al. Sodium butyrate reduces organ injuries in mice with severe acute pancreatitis through inhibiting HMGB1 expression. Dig Dis Sci, 2015, 60(7): 1991-1999.
32.	Hilbi H, Chen Y, Thirumalai K, et al. The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages. Infect Immun, 1997, 65(12): 5165-5170.
33.	Hilbi H, Moss JE, Hersh D, et al. Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem, 1998, 273(49): 32895-32900.
34.	Chen Y, Smith MR, Thirumalai K, et al. A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J, 1996, 15(15): 3853-3860.
35.	Qiu T, Pei P, Yao X, et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis, 2018, 9(10): 946.
36.	Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol, 2009, 7(2): 99-109.
37.	Hoque R, Sohail M, Malik A, et al. TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology, 2011, 141(1): 358-369.
38.	Xia P, Pan Y, Zhang F, et al. Pioglitazone confers neuroprotection against ischemia-induced pyroptosis due to its inhibitory effects on HMGB-1/RAGE and Rac1/ROS pathway by activating PPAR-γ. Cell Physiol Biochem, 2018, 45(6): 2351-2368.
39.	Maacke H, Kessler A, Schmiegel W, et al. Overexpression of p53 protein during pancreatitis. Br J Cancer, 1997, 75(10): 1501-1504.
40.	Pan T, Zhou T, Li L, et al. Monocyte programmed death ligand-1 expression is an early marker for predicting infectious complications in acute pancreatitis. Crit Care, 2017, 21(1): 186.
41.	Chen J, Chen J, Wang X, et al. Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways. Biomed Pharmacother, 2016, 82: 1-7.
42.	Xu P, Lou XL, Chen C, et al. Effects of peroxisome proliferator-activated receptor-γ activation on apoptosis in rats with acute pancreatitis. Dig Dis Sci, 2013, 58(12): 3516-3523.
43.	Shao G, Zhou Y, Song Z, et al. The diffuse reduction in spleen density: an indicator of severe acute pancreatitis? Biosci Rep, 2017, 37(1): BSR20160418.
44.	路廣海, 張偉輝, 張迎媚, 等. 急性胰腺炎胰腺腺泡細胞脹亡和巨噬細胞激活的關系. 中華消化外科雜志, 2009, 8(4): 275-277.

1. Mole DJ, Webster SP, Uings I, et al. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med, 2016, 22(2): 202-209.
2. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
3. Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet, 2015, 386(9988): 85-96.
4. 中華醫學會消化病學分會胰腺疾病學組, 《中華胰腺病雜志》編輯委員會, 《中華消化雜志》編輯委員會, 等. 中國急性胰腺炎診治指南(2013, 上海). 中華胰腺病雜志, 2013, 13(2): 73-78.
5. Vege SS, Gardner TB, Chari ST, et al. Low mortality and high morbidity in severe acute pancreatitis without organ failure: a case for revising the Atlanta classification to include "moderately severe acute pancreatitis". Am J Gastroenterol, 2009, 104(3): 710-715.
6. Man SM, Karki R, Kanneganti TD. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev, 2017, 277(1): 61-75.
7. Heasman J, Crawford A, Goldstone K, et al. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell, 1994, 79(5): 791-803.
8. Kerr JF. An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine. Pathology, 1969, 1(2): 83-94.
9. Coulson A, Sulston J, Brenner S, et al. Toward a physical map of the genome of the nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A, 1986, 83(20): 7821-7825.
10. Schulte-Hermann R, Bursch W, L?w-Baselli A, et al. Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol Toxicol, 1997, 13(4-5): 339-348.
11. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol, 2008, 9(3): 231-241.
12. Baran K, Rodriguez D, Green D. The DNA damage response mediates apoptosis and tumor suppression//Wu H. Cell death. Springer: New York, 2014: 135-165.
13. Green DR, Ferguson T, Zitvogel L, et al. Immunogenic and tolerogenic cell death. Nat Rev Immunol, 2009, 9(5): 353-363.
14. Rock KL, Lai JJ, Kono H. Innate and adaptive immune responses to cell death. Immunol Rev, 2011, 243(1): 191-205.
15. Srikrishna G, Freeze HH. Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia, 2009, 11(7): 615-628.
16. He R, Wang L, Zhu J, et al. Methane-rich saline protects against concanavalin A-induced autoimmune hepatitis in mice through anti-inflammatory and anti-oxidative pathways. Biochem Biophys Res Commun, 2016, 470(1): 22-28.
17. Chen O, Ye Z, Cao Z, et al. Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radic Biol Med, 2016, 90: 1-11.
18. Xie Q, Fei M, Fa Z, et al. Methane-rich saline alleviates cerulein-induced acute pancreatitis by inhibiting inflammatory response, oxidative stress and pancreatic apoptosis in mice. Int Immunopharmacol, 2017, 51: 17-24.
19. Cui H, Li S, Xu C, et al. Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. Mol Med Rep, 2017, 16(4): 5121-5128.
20. 王興鵬, 王冰嫻, 吳愷, 等. 細胞凋亡在急性壞死型胰腺炎早期腸黏膜上皮細胞死亡中的作用. 中華消化雜志, 2001, 21(5): 267-270.
21. Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol, 2010, 22(2): 124-131.
22. Mijaljica D, Prescott M, Devenish RJ. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy, 2011, 7(7): 673-682.
23. Massey A, Kiffin R, Cuervo AM. Pathophysiology of chaperone-mediated autophagy. Intern J Biochemistry Cell Biology, 2004, 36(12): 2420-2434.
24. Biczo G, Vegh ET, Shalbueva N, et al. Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology, 2018, 154(3): 689-703.
25. 劉曉. 急性胰腺炎時自噬變化的意義及干擾素γ對自噬影響的實驗研究. 上海: 第二軍醫大學, 2013.
26. Wild P, McEwan DG, Dikic I. The LC3 interactome at a glance. J Cell Sci, 2014, 127(Pt 1): 3-9.
27. Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ, 2005, 12(Suppl 2): 1542-1552.
28. 巴微, 逄越, 李慶偉. 程序性壞死(Necroptosis)的分子機制. 遺傳, 2014, 36(6): 519-524.
29. Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, et al. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol, 2014, 15(2): 135-147.
30. Pasparakis M, Vandenabeele P. Necroptosis and its role in inflammation. Nature, 2015, 517(7534): 311-320.
31. Zhang T, Xia M, Zhan Q, et al. Sodium butyrate reduces organ injuries in mice with severe acute pancreatitis through inhibiting HMGB1 expression. Dig Dis Sci, 2015, 60(7): 1991-1999.
32. Hilbi H, Chen Y, Thirumalai K, et al. The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages. Infect Immun, 1997, 65(12): 5165-5170.
33. Hilbi H, Moss JE, Hersh D, et al. Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J Biol Chem, 1998, 273(49): 32895-32900.
34. Chen Y, Smith MR, Thirumalai K, et al. A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J, 1996, 15(15): 3853-3860.
35. Qiu T, Pei P, Yao X, et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis, 2018, 9(10): 946.
36. Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol, 2009, 7(2): 99-109.
37. Hoque R, Sohail M, Malik A, et al. TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology, 2011, 141(1): 358-369.
38. Xia P, Pan Y, Zhang F, et al. Pioglitazone confers neuroprotection against ischemia-induced pyroptosis due to its inhibitory effects on HMGB-1/RAGE and Rac1/ROS pathway by activating PPAR-γ. Cell Physiol Biochem, 2018, 45(6): 2351-2368.
39. Maacke H, Kessler A, Schmiegel W, et al. Overexpression of p53 protein during pancreatitis. Br J Cancer, 1997, 75(10): 1501-1504.
40. Pan T, Zhou T, Li L, et al. Monocyte programmed death ligand-1 expression is an early marker for predicting infectious complications in acute pancreatitis. Crit Care, 2017, 21(1): 186.
41. Chen J, Chen J, Wang X, et al. Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways. Biomed Pharmacother, 2016, 82: 1-7.
42. Xu P, Lou XL, Chen C, et al. Effects of peroxisome proliferator-activated receptor-γ activation on apoptosis in rats with acute pancreatitis. Dig Dis Sci, 2013, 58(12): 3516-3523.
43. Shao G, Zhou Y, Song Z, et al. The diffuse reduction in spleen density: an indicator of severe acute pancreatitis? Biosci Rep, 2017, 37(1): BSR20160418.
44. 路廣海, 張偉輝, 張迎媚, 等. 急性胰腺炎胰腺腺泡細胞脹亡和巨噬細胞激活的關系. 中華消化外科雜志, 2009, 8(4): 275-277.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Progress in the study of programmed cell death in acute pancreatitis

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