Study on application value of carbon nanoparticles during operation of differentiated thyroid cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Dasheng , ZHOU Yuteng , HUANG Xueyang ,  LIN Hongguo , CAI Bingqin

Department of Vascular and Thyroid Surgery, Guangdong Provincial Hospital of Chinese Medicine（The Second Affiliated Hospital of Guangzhou University of Chinese Medicine）, Guangzhou 510120, P. R. China;

Corresponding?author：

LIN Hongguo, Email: linhongguodoctor@163.com

Keywords：

carbon nanoparticles; differentiated thyroid cancer; parathyroid; lymph node

DOI：

10.7507/1007-9424.202007020

Video：

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Objective To explore the application value of carbon nanoparticles during radical operation of differentiated thyroid cancer (DTC).Methods The DTC patients underwent total thyroidectomy plus neck lymph node (area Ⅳ) dissection from September 2017 to September 2019 in this hospital were retrospectively collected, who were divided into observation group and control group according to using carbon nanoparticles or not during the operation. The operation related informations [operation time, intraoperative blood loss, total drainage volume on day 3 after operation, postoperative hospitalization time, number of lymph nodes dissection (area Ⅳ), lymph node metastasis rate, and rate of parathyroid glands resected by mistake during operation] and blood calcium (Ca²⁺) level and parathyroid hormone (PTH) level before and after (24 h and 1 month) operation were compared between the two groups.Results A total of 134 patients with DTC were collected, including 76 patients in the observation group and 58 patients in the control group. There were no significant differences in baseline data such as gender, age, etc. between the two groups (P>0.05). Although there were no significant differences in terms of operation time, intraoperative blood loss, total drainage volume on day 3 after operation, postoperative hospitalization time, lymph node metastasis rate between the two groups (P>0.05), the numbers of lymph node dissection and metastasis (area Ⅳ) were more and rate of parathyroid glands resected by mistake during operation was lower in the observation group as compared with the control group (P<0.05). On hour 24 after operation, the levels of Ca²⁺ and PTH in the observation group were higher than those in the control group (P<0.05). On month 1 after operation, the PTH level in the observation group was still higher than that in the control group (P<0.05), but there was no significant difference in Ca²⁺ level between the two groups (P>0.05). Conclusion Carbon nanoparticles can better protect the function of parathyroid gland during radical operation of DTC and clean neck lymph nodes more thoroughly.

Citation： LIU Dasheng, ZHOU Yuteng, HUANG Xueyang, LIN Hongguo, CAI Bingqin. Study on application value of carbon nanoparticles during operation of differentiated thyroid cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(4): 457-460. doi: 10.7507/1007-9424.202007020 Copy

1.	Liao N, Zhuo Y, Chai YQ, et al. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron, 2013, 45: 189-194.
2.	韓婧, 康驊. 甲狀腺癌的發病現狀及影響因素. 實用預防醫學, 2018, 25(7): 894-897.
3.	Makita K, Hamamoto Y, Tsuruoka S, et al. Treatment intensity and control rates in combining external-beam radiotherapy and radioactive iodine therapy for metastatic or recurrent differentiated thyroid cancer. Int J Clin Oncol, 2020, 2(1): 1-7.
4.	姚京, 劉洋, 田文. 分化型甲狀腺癌再次手術技巧的探討. 中國普外基礎與臨床雜志, 2013, 20(9): 981-986.
5.	Liu J, Xu C, Wang R, et al. Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data. World J Surg Oncol, 2020, 18(1): 84.
6.	Yang Z, Flores J, Katz S, et al. Comparison of survival outcomes following postsurgical radioactive iodine versus external beam radiation in stage Ⅳ differentiated thyroid carcinoma. Thyroid, 2017, 27(7): 944-952.
7.	Aschebrook-Kilfoy B, Ward MH, Sabra MM, et al. Thyroid cancer incidence patterns in the United States by histologic type, 1992–2006. Thyroid, 2011, 21(2): 125-134.
8.	孫輝, 劉曉莉. 甲狀腺癌規范化診治理念更新及其意義. 中華實用外科雜志, 2015, 35(1): 72-76.
9.	Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid, 2016, 26(1): 1-133.
10.	Yu W, Xu G, Sun J, et al. Carbon nanoparticles guide contralateral central neck dissection in patients with papillary thyroid cancer. Oncol Lett, 2018, 16(1): 447-452.
11.	Wang L, Yang D, Lv JY, et al. Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis. Onco Targets Ther, 2017, 10: 1247-1260.
12.	Liu FZ, Zhu Y, Qian YC, et al. Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue. Pak J Med Sci, 2017, 33(6): 1485-1489.
13.	左倩, 王剛, 武林楓. 甲狀腺手術中甲狀旁腺辨識方法進展. 中國普外基礎與臨床雜志, 2020, 27(3): 358-362.
14.	Wang B, Su AP, Xing TF, et al. The function of carbon nanoparticles to improve lymph node dissection and identification of parathyroid glands during thyroid reoperation for carcinoma. Medicine (Baltimore), 2018, 97(32): e11778.
15.	張海艷, 陳娟. 納米炭跟蹤技術在甲狀腺切除術中對癌旁組織的保護作用分析. 中華普外科手術學雜志(電子版), 2019, 13(6): 634-636.
16.	王桂林, 俸瑞發. 納米炭在甲狀腺癌手術中對甲狀旁腺及喉返神經的保護作用. 中國腫瘤外科雜志, 2019, 11(6): 442-449.
17.	謝天皓, 哈思寧, 張景, 等. 甲狀腺乳頭狀癌中應用納米炭對甲狀旁腺識別及原位保留的價值. 中華普通外科雜志, 2020, 35(3): 246-247.
18.	Chaojie Z, Shanshan L, Zhigong Z, et al. Evaluation of the clinical value of carbon nanoparticles as lymph node tracer in differentiated thyroid carcinoma requiring reoperation. Int J Clin Oncol, 2016, 21(1): 68-74.
19.	Delgado-Oliver E, Vidal-Sicart S, Martínez D, et al. Applicability of sentinel lymph node biopsy in papillary thyroid cancer. Q J Nucl Med Mol Imaging, 2018 Jul 9. doi: 0.23736/S1824-4785.18.03097-2.
20.	江國斌, 方紅燕, 蔡建明. 納米碳混懸液示蹤前哨淋巴結在甲狀腺乳頭狀癌中的應用. 中國癌癥雜志, 2010, 20(12): 938-940.
21.	Xue S, Ren P, Wang P, et al. Short and long-term potential role of carbon nanoparticles in total thyroidectomy with central lymph node dissection. Sci Rep, 2018, 8(1): 11936.
22.	Yan S, Zhao W, Wang B, et al. Preoperative injection of carbon nanoparticles is beneficial to the patients with thyroid papillary carcinoma: From a prospective study of 102 cases. Medicine (Baltimore), 2018, 97(27): e11364.
23.	付浩, 張朝林, 唐振寧, 等. 納米碳在甲狀腺乳頭狀癌Ⅵ區淋巴結清掃術中應用的研究. 臨床耳鼻咽喉頭頸外科雜志, 2017, 31(14): 1089-1092.
24.	Haddad RI, Lydiatt WM, Ball DW, et al. Anaplastic thyroid carcinoma, version 2.2015. J Natl Compr Canc Netw, 2015, 13(9): 1140-1150.
25.	倪幫高, 費媛, 王彬, 等. 甲狀腺手術中甲狀旁腺誤切的危險因素分析. 中國普外基礎與臨床雜志, 2020, 27(2): 152-157.

1. Liao N, Zhuo Y, Chai YQ, et al. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron, 2013, 45: 189-194.
2. 韓婧, 康驊. 甲狀腺癌的發病現狀及影響因素. 實用預防醫學, 2018, 25(7): 894-897.
3. Makita K, Hamamoto Y, Tsuruoka S, et al. Treatment intensity and control rates in combining external-beam radiotherapy and radioactive iodine therapy for metastatic or recurrent differentiated thyroid cancer. Int J Clin Oncol, 2020, 2(1): 1-7.
4. 姚京, 劉洋, 田文. 分化型甲狀腺癌再次手術技巧的探討. 中國普外基礎與臨床雜志, 2013, 20(9): 981-986.
5. Liu J, Xu C, Wang R, et al. Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data. World J Surg Oncol, 2020, 18(1): 84.
6. Yang Z, Flores J, Katz S, et al. Comparison of survival outcomes following postsurgical radioactive iodine versus external beam radiation in stage Ⅳ differentiated thyroid carcinoma. Thyroid, 2017, 27(7): 944-952.
7. Aschebrook-Kilfoy B, Ward MH, Sabra MM, et al. Thyroid cancer incidence patterns in the United States by histologic type, 1992–2006. Thyroid, 2011, 21(2): 125-134.
8. 孫輝, 劉曉莉. 甲狀腺癌規范化診治理念更新及其意義. 中華實用外科雜志, 2015, 35(1): 72-76.
9. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid, 2016, 26(1): 1-133.
10. Yu W, Xu G, Sun J, et al. Carbon nanoparticles guide contralateral central neck dissection in patients with papillary thyroid cancer. Oncol Lett, 2018, 16(1): 447-452.
11. Wang L, Yang D, Lv JY, et al. Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis. Onco Targets Ther, 2017, 10: 1247-1260.
12. Liu FZ, Zhu Y, Qian YC, et al. Recognition of sentinel lymph nodes in patients with papillary thyroid cancer by nano-carbon and methylene blue. Pak J Med Sci, 2017, 33(6): 1485-1489.
13. 左倩, 王剛, 武林楓. 甲狀腺手術中甲狀旁腺辨識方法進展. 中國普外基礎與臨床雜志, 2020, 27(3): 358-362.
14. Wang B, Su AP, Xing TF, et al. The function of carbon nanoparticles to improve lymph node dissection and identification of parathyroid glands during thyroid reoperation for carcinoma. Medicine (Baltimore), 2018, 97(32): e11778.
15. 張海艷, 陳娟. 納米炭跟蹤技術在甲狀腺切除術中對癌旁組織的保護作用分析. 中華普外科手術學雜志(電子版), 2019, 13(6): 634-636.
16. 王桂林, 俸瑞發. 納米炭在甲狀腺癌手術中對甲狀旁腺及喉返神經的保護作用. 中國腫瘤外科雜志, 2019, 11(6): 442-449.
17. 謝天皓, 哈思寧, 張景, 等. 甲狀腺乳頭狀癌中應用納米炭對甲狀旁腺識別及原位保留的價值. 中華普通外科雜志, 2020, 35(3): 246-247.
18. Chaojie Z, Shanshan L, Zhigong Z, et al. Evaluation of the clinical value of carbon nanoparticles as lymph node tracer in differentiated thyroid carcinoma requiring reoperation. Int J Clin Oncol, 2016, 21(1): 68-74.
19. Delgado-Oliver E, Vidal-Sicart S, Martínez D, et al. Applicability of sentinel lymph node biopsy in papillary thyroid cancer. Q J Nucl Med Mol Imaging, 2018 Jul 9. doi: 0.23736/S1824-4785.18.03097-2.
20. 江國斌, 方紅燕, 蔡建明. 納米碳混懸液示蹤前哨淋巴結在甲狀腺乳頭狀癌中的應用. 中國癌癥雜志, 2010, 20(12): 938-940.
21. Xue S, Ren P, Wang P, et al. Short and long-term potential role of carbon nanoparticles in total thyroidectomy with central lymph node dissection. Sci Rep, 2018, 8(1): 11936.
22. Yan S, Zhao W, Wang B, et al. Preoperative injection of carbon nanoparticles is beneficial to the patients with thyroid papillary carcinoma: From a prospective study of 102 cases. Medicine (Baltimore), 2018, 97(27): e11364.
23. 付浩, 張朝林, 唐振寧, 等. 納米碳在甲狀腺乳頭狀癌Ⅵ區淋巴結清掃術中應用的研究. 臨床耳鼻咽喉頭頸外科雜志, 2017, 31(14): 1089-1092.
24. Haddad RI, Lydiatt WM, Ball DW, et al. Anaplastic thyroid carcinoma, version 2.2015. J Natl Compr Canc Netw, 2015, 13(9): 1140-1150.
25. 倪幫高, 費媛, 王彬, 等. 甲狀腺手術中甲狀旁腺誤切的危險因素分析. 中國普外基礎與臨床雜志, 2020, 27(2): 152-157.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study on application value of carbon nanoparticles during operation of differentiated thyroid cancer

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