Review on the application of omega-3 polyunsaturated fatty acids in patients with gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Xingxia ,  LI Ka

West China School of Nursing, Sichuan University/West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

LI Ka, Email: lika127@126.com

Keywords：

gastric cancer; omega-3 polyunsaturated fatty acids; review

DOI：

10.7507/1007-9424.202008056

Video：

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Objective To review the application of omega-3 polyunsaturated fatty acids (Ω-3PUFAs) in patients with gastric cancer.Method The related literatures about the application of Ω-3PUFAs in patients with gastric cancer were reviewed by searching domestic and international databases.Results Ω-3PUFAs didn’t only improve the perioperative immune function and inflammatory response in patients with gastric cancer, but also prevent the occurrence of gastric cancer, inhibit the proliferation and promote the apoptosis of gastric cancer cells, increase the sensitivity of chemotherapy, and reduce the occurrence of chemotherapy-related adverse events.Conclusions Ω-3PUFAsis an immunological nutrition, which can provide energy and also has functions of anti-inflammatory, anti-cancer, immunity regulation. It has been widely used in patients with gastric cancer, but the relevant mechanism needs further to be investigated.

Citation： ZHANG Xingxia, LI Ka. Review on the application of omega-3 polyunsaturated fatty acids in patients with gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(5): 678-682. doi: 10.7507/1007-9424.202008056 Copy

1.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond), 2019, 39(1): 22.
3.	衛生健康委員會. 胃癌診療規范(2018 年版). 中華消化病與影像雜志(電子版), 2019, 9(3): 118-144.
4.	Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet, 1971, 1(7710): 1143-1145.
5.	Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet, 1979, 2(8140): 433-435.
6.	Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol, 2018, 9: 345-381.
7.	Department of Health and Human Services US. Dietary Guidelines for Americans 2015–2020. Eight Edition [Internet]. Available from: http://health.gov/ietaryguidelines/2015/guidelines/.
8.	中國營養學會. 中國居民膳食指南(2016). 北京: 人民衛生出版社, 2016.
9.	Klek S. Omega-3 fatty acids in modern parenteral nutrition: A review of the current evidence. J Clin Med, 2016, 5(3): 34.
10.	Mocellin MC, Fernandes R, Chagas TR, et al. A meta-analysis of n-3 polyunsaturated fatty acids effects on circulating acute-phase protein and cytokines in gastric cancer. Clin Nutr, 2018, 37(3): 840-850.
11.	Zhao Y, Wang C. Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: A meta-analysis of randomized control trials in China. Medicine (Baltimore), 2018, 97(16): e0472.
12.	何紀恩, 李曉花. ω-3 多不飽和脂肪酸(ω-3 PUFA)對存在營養風險的胃癌患者術后炎性反應的影響. 實用癌癥雜志, 2017, 32(3): 405-407.
13.	Wu DY, Lewis ED, Pae M, et al. Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Front Immunol, 2019, 9: 3160.
14.	Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans, 2017, 45(5): 1105-1115.
15.	高俊, 王靜東, 王琦三. 含 ω-3 多不飽和脂肪酸的腸外營養對胃癌病人免疫功能影響的 Meta 分析. 腸外與腸內營養, 2015, 22(2): 107-111.
16.	Lin MT, Yeh SL, Yeh CL, et al. Parenteral N-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy. Shock, 2006, 25(1): 56-60.
17.	Gurzell EA, Teague H, Harris M, et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. J Leukoc Biol, 2013, 93(4): 463-470.
18.	Weimann A, Braga M, Carli F, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
19.	Ida S, Hiki N, Cho H, et al. Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg, 2017, 104(4): 377-383.
20.	潘敦, 陳輝, 李良慶. 添加 ω-3 魚油脂肪乳的圍術期腸外營養支持對老年胃癌患者營養狀況、免疫功能及術后并發癥的影響. 中國老年學雜志, 2016, 36(19): 4792-4794.
21.	程康文, 王貴和, 束寬山, 等. 添加 ω-3 魚油脂肪乳的腸外營養對胃癌術后患者營養、應激及肝功能的影響. 中國普外基礎與臨床雜志, 2020, 27(8): 964-969.
22.	Wei Z, Wang W, Chen J, et al. A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors. Nutr J, 2014, 13: 25.
23.	Ma CJ, Wu JM, Tsai HL, et al. Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients. Nutr J, 2015, 14: 9.
24.	Wang J, Yu JC, Kang WM, et al. Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: a randomized clinical trial. Nutrition, 2012, 28(6): 623-629.
25.	Park HW, Lee NM, Kim JH, et al. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr, 2015, 145(2): 277-283.
26.	秦龍, 李婷, 任明揚, 等. 圍手術期應用 ω-3 多不飽和脂肪酸對胃癌根治術患者術后恢復及生活質量的影響. 現代生物醫學進展, 2019, 19(2): 346-349.
27.	梁濤, 伍曉汀. ω-3 多不飽和脂肪酸對老年胃癌患者術后譫妄的預防作用. 中國普外基礎與臨床雜志, 2019, 26(2): 174-179.
28.	Lee S, Lee J, Choi IJ, et al. Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population. Sci Rep, 2018, 8(1): 3823.
29.	Kuriki K, Wakai K, Matsuo K, et al. Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects. Cancer Epidemiol Biomarkers Prev, 2007, 16(11): 2406-2415.
30.	Caro Y, Petit T, Grondin I, et al. Chemical characterization of unconventional palm oils from Hyophorbe indica and two other endemic Arecaceae species from Reunion Island. Nat Prod Res, 2020, 34(1): 93-101.
31.	Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric Cancer, 2019, 22(3): 435-445.
32.	Correia M, Michel V, Matos AA, et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. PLoS One, 2012, 7(4): e35072.
33.	Han YM, Kim KJ, Jeong M, et al. Suppressed Helicobacter pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing endogenous ω-3 polyunsaturated fatty acids. Oncotarget, 2016, 7(41): 66606-66622.
34.	馬家馳, 郭天康, 陳泉, 等. 多不飽和脂肪酸 ω-3 和 ω-6 影響胃癌新生血管的機制. 中華胃腸外科雜志, 2017, 20(1): 84-89.
35.	史浩, 郭天康. 多不飽和脂肪酸 ω-3 和 ω-6 對胃癌細胞侵襲影響的研究. 銀川: 寧夏醫科大學, 2013.
36.	鞏濤, 李勇, 郭建文, 等. ω-3 多不飽和脂肪酸對人胃癌 BGC823 細胞周期及凋亡的影響. 中國臨床營養雜志, 2006, 14(2): 77-81, 141.
37.	盛虹, 吳丹. ω-3 多不飽和脂肪酸對胃癌細胞生長的影響及其機制研究. 上海: 上海交通大學, 2012.
38.	蔣亦燕, 蔣亦雯, 樓哲豐, 等. ω-3 多不飽和脂肪酸對胃癌生長及 RHO -ROCK1 信號通路相關基因表達的影響. 中國醫師雜志, 2018, 20(11): 1641-1646.
39.	王寶貴, 張暉, 丁學偉, 等. ω-3 多不飽和脂肪酸對胃癌細胞系生長抑制作用及其機制的研究. 中華腫瘤防治雜志, 2011, 18(5): 336-338.
40.	Hosseinzadeh A, Ardebili SM. Efficacy of omega fatty acid supplementation on mRNA expression level of tumor necrosis factor alpha in patients with gastric adenocarcinoma. J Gastrointest Cancer, 2016, 47(3): 287-293.
41.	Shekari N, Javadian M, Ghasemi M, et al. Synergistic beneficial effect of docosahexaenoic acid (DHA) and docetaxel on the expression level of matrix metalloproteinase-2 (MMP-2) and microRNA-106b in gastric cancer. J Gastrointest Cancer, 2020, 51(1): 70-75.
42.	柳欣欣, 于健春. ω-3 多不飽和脂肪酸對胃癌治療作用機制研究. 北京: 中國協和醫科大學, 2010.
43.	Eltweri AM, Thomas AL, Chung WY, et al. The effect of supplementary omegaven? on the clinical outcome of patients with advanced esophagogastric adenocarcinoma receiving palliative epirubicin, oxaliplatin, and capecitabine chemotherapy: A phase Ⅱ clinical trial. Anticancer Res, 2019, 39(2): 853-861.

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond), 2019, 39(1): 22.
3. 衛生健康委員會. 胃癌診療規范(2018 年版). 中華消化病與影像雜志(電子版), 2019, 9(3): 118-144.
4. Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet, 1971, 1(7710): 1143-1145.
5. Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet, 1979, 2(8140): 433-435.
6. Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol, 2018, 9: 345-381.
7. Department of Health and Human Services US. Dietary Guidelines for Americans 2015–2020. Eight Edition [Internet]. Available from: http://health.gov/ietaryguidelines/2015/guidelines/.
8. 中國營養學會. 中國居民膳食指南(2016). 北京: 人民衛生出版社, 2016.
9. Klek S. Omega-3 fatty acids in modern parenteral nutrition: A review of the current evidence. J Clin Med, 2016, 5(3): 34.
10. Mocellin MC, Fernandes R, Chagas TR, et al. A meta-analysis of n-3 polyunsaturated fatty acids effects on circulating acute-phase protein and cytokines in gastric cancer. Clin Nutr, 2018, 37(3): 840-850.
11. Zhao Y, Wang C. Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: A meta-analysis of randomized control trials in China. Medicine (Baltimore), 2018, 97(16): e0472.
12. 何紀恩, 李曉花. ω-3 多不飽和脂肪酸(ω-3 PUFA)對存在營養風險的胃癌患者術后炎性反應的影響. 實用癌癥雜志, 2017, 32(3): 405-407.
13. Wu DY, Lewis ED, Pae M, et al. Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Front Immunol, 2019, 9: 3160.
14. Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans, 2017, 45(5): 1105-1115.
15. 高俊, 王靜東, 王琦三. 含 ω-3 多不飽和脂肪酸的腸外營養對胃癌病人免疫功能影響的 Meta 分析. 腸外與腸內營養, 2015, 22(2): 107-111.
16. Lin MT, Yeh SL, Yeh CL, et al. Parenteral N-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy. Shock, 2006, 25(1): 56-60.
17. Gurzell EA, Teague H, Harris M, et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. J Leukoc Biol, 2013, 93(4): 463-470.
18. Weimann A, Braga M, Carli F, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr, 2017, 36(3): 623-650.
19. Ida S, Hiki N, Cho H, et al. Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg, 2017, 104(4): 377-383.
20. 潘敦, 陳輝, 李良慶. 添加 ω-3 魚油脂肪乳的圍術期腸外營養支持對老年胃癌患者營養狀況、免疫功能及術后并發癥的影響. 中國老年學雜志, 2016, 36(19): 4792-4794.
21. 程康文, 王貴和, 束寬山, 等. 添加 ω-3 魚油脂肪乳的腸外營養對胃癌術后患者營養、應激及肝功能的影響. 中國普外基礎與臨床雜志, 2020, 27(8): 964-969.
22. Wei Z, Wang W, Chen J, et al. A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors. Nutr J, 2014, 13: 25.
23. Ma CJ, Wu JM, Tsai HL, et al. Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients. Nutr J, 2015, 14: 9.
24. Wang J, Yu JC, Kang WM, et al. Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: a randomized clinical trial. Nutrition, 2012, 28(6): 623-629.
25. Park HW, Lee NM, Kim JH, et al. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr, 2015, 145(2): 277-283.
26. 秦龍, 李婷, 任明揚, 等. 圍手術期應用 ω-3 多不飽和脂肪酸對胃癌根治術患者術后恢復及生活質量的影響. 現代生物醫學進展, 2019, 19(2): 346-349.
27. 梁濤, 伍曉汀. ω-3 多不飽和脂肪酸對老年胃癌患者術后譫妄的預防作用. 中國普外基礎與臨床雜志, 2019, 26(2): 174-179.
28. Lee S, Lee J, Choi IJ, et al. Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population. Sci Rep, 2018, 8(1): 3823.
29. Kuriki K, Wakai K, Matsuo K, et al. Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects. Cancer Epidemiol Biomarkers Prev, 2007, 16(11): 2406-2415.
30. Caro Y, Petit T, Grondin I, et al. Chemical characterization of unconventional palm oils from Hyophorbe indica and two other endemic Arecaceae species from Reunion Island. Nat Prod Res, 2020, 34(1): 93-101.
31. Sugano K. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric Cancer, 2019, 22(3): 435-445.
32. Correia M, Michel V, Matos AA, et al. Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. PLoS One, 2012, 7(4): e35072.
33. Han YM, Kim KJ, Jeong M, et al. Suppressed Helicobacter pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing endogenous ω-3 polyunsaturated fatty acids. Oncotarget, 2016, 7(41): 66606-66622.
34. 馬家馳, 郭天康, 陳泉, 等. 多不飽和脂肪酸 ω-3 和 ω-6 影響胃癌新生血管的機制. 中華胃腸外科雜志, 2017, 20(1): 84-89.
35. 史浩, 郭天康. 多不飽和脂肪酸 ω-3 和 ω-6 對胃癌細胞侵襲影響的研究. 銀川: 寧夏醫科大學, 2013.
36. 鞏濤, 李勇, 郭建文, 等. ω-3 多不飽和脂肪酸對人胃癌 BGC823 細胞周期及凋亡的影響. 中國臨床營養雜志, 2006, 14(2): 77-81, 141.
37. 盛虹, 吳丹. ω-3 多不飽和脂肪酸對胃癌細胞生長的影響及其機制研究. 上海: 上海交通大學, 2012.
38. 蔣亦燕, 蔣亦雯, 樓哲豐, 等. ω-3 多不飽和脂肪酸對胃癌生長及 RHO -ROCK1 信號通路相關基因表達的影響. 中國醫師雜志, 2018, 20(11): 1641-1646.
39. 王寶貴, 張暉, 丁學偉, 等. ω-3 多不飽和脂肪酸對胃癌細胞系生長抑制作用及其機制的研究. 中華腫瘤防治雜志, 2011, 18(5): 336-338.
40. Hosseinzadeh A, Ardebili SM. Efficacy of omega fatty acid supplementation on mRNA expression level of tumor necrosis factor alpha in patients with gastric adenocarcinoma. J Gastrointest Cancer, 2016, 47(3): 287-293.
41. Shekari N, Javadian M, Ghasemi M, et al. Synergistic beneficial effect of docosahexaenoic acid (DHA) and docetaxel on the expression level of matrix metalloproteinase-2 (MMP-2) and microRNA-106b in gastric cancer. J Gastrointest Cancer, 2020, 51(1): 70-75.
42. 柳欣欣, 于健春. ω-3 多不飽和脂肪酸對胃癌治療作用機制研究. 北京: 中國協和醫科大學, 2010.
43. Eltweri AM, Thomas AL, Chung WY, et al. The effect of supplementary omegaven? on the clinical outcome of patients with advanced esophagogastric adenocarcinoma receiving palliative epirubicin, oxaliplatin, and capecitabine chemotherapy: A phase Ⅱ clinical trial. Anticancer Res, 2019, 39(2): 853-861.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Review on the application of omega-3 polyunsaturated fatty acids in patients with gastric cancer

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