展望個性化治療：生物3D打印與藥物篩選和遞送_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

周暢 ^1,2 ^周 , 趙晨佳 ^1,2 ^周 , 季靜遠 ^1,2 ,  龐媛 ^1,2 ,  孫偉 ^1,2,3

1. ;
2. ;
3. ;

Corresponding?author：

龐媛, Email: pangyuan31@mail.tsinghua.edu.cn; 孫偉, Email: weisun@mail.tsinghua.edu.cn

Keywords：

DOI：

10.7507/1007-9424.202105046

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Citation： 周暢, 趙晨佳, 季靜遠, 龐媛, 孫偉. 展望個性化治療：生物3D打印與藥物篩選和遞送. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(7): 841-845. doi: 10.7507/1007-9424.202105046 Copy

1.	Mao S, Pang Y, Liu T, et al. Bioprinting of in vitro tumor models for personalized cancer treatment: a review. Biofabrication, 2020, 12(4): 042001.
2.	Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol, 2006, 7(3): 211-224.
3.	Nyga A, Cheema U, Loizidou M. 3D tumour models: novel in vitro approaches to cancer studies. J Cell Commun Signal, 2011, 5(3): 239-248.
4.	陳國寧, 舒花, 余佩, 等. 3D 打印技術在藥學領域研究中的應用. 中國藥學雜志, 2016, 51(16): 1353-1359.
5.	Wang J, Zhang Y, Aghda NH, et al. Emerging 3D printing technologies for drug delivery devices: Current status and future perspective. Adv Drug Deliv Rev, 2021, 174: 294-316.
6.	Lim SH, Kathuria H, Tan JJY, et al. 3D printed drug delivery and testing systems—a passing fad or the future? Adv Drug Deliv Rev, 2018, 132: 139-168.
7.	Nie J, Gao Q, Fu J, et al. Grafting of 3D bioprinting to in vitro drug screening: a review. Adv Healthc Mater, 2020, 9(7): e1901773.
8.	Moro M, Casanova M, Roz L. Patient-derived xenografts, a multi-faceted in vivo model enlightening research on rare liver cancer biology. Hepatobiliary Surg Nutr, 2017, 6(5): 344-346.
9.	Costa A, Sarmento B, Seabra V. An evaluation of the latest in vitro tools for drug metabolism studies. Expert Opin Drug Metab Toxicol, 2014, 10(1): 103-119.
10.	Grigoryan B, Paulsen SJ, Corbett DC, et al. Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science, 2019, 364(6439): 458-464.
11.	Horváth L, Umehara Y, Jud C, et al. Engineering an in vitro air-blood barrier by 3D bioprinting. Sci Rep, 2015, 5: 7974.
12.	Huh DD. A human breathing lung-on-a-chip. Ann Am Thorac Soc, 2015, 12 Suppl 1(Suppl 1): S42-S44.
13.	Liau B, Jackman CP, Li Y, et al. Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. Sci Rep, 2017, 7: 42290.
14.	Zhang YS, Arneri A, Bersini S, et al. Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials, 2016, 110: 45-59.
15.	Ma Z, Koo S, Finnegan MA, et al. Three-dimensional filamentous human diseased cardiac tissue model. Biomaterials, 2014, 35(5): 1367-1377.
16.	Khetani SR, Bhatia SN. Microscale culture of human liver cells for drug development. Nat Biotechnol, 2008, 26(1): 120-126.
17.	Hewitt NJ, Lechón MJ, Houston JB, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev, 2007, 39(1): 159-234.
18.	Xie F, Xiao Y, Chen M. Three-dimensional bioprinted liver tissue for transplantation: hope or hype? Hepatobiliary Surg Nutr, 2020, 9(6): 788-790.
19.	Kizawa H, Nagao E, Shimamura M, et al. Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery. Biochem Biophys Rep, 2017, 10: 186-191.
20.	Ma X, Qu X, Zhu W, et al. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A, 2016, 113(8): 2206-2211.
21.	Yang H, Sun L, Pang Y, et al. Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure. Gut, 2021, 70(3): 567-574.
22.	Bhise NS, Manoharan V, Massa S, et al. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication, 2016, 8(1): 014101.
23.	Ali M, Pr AK, Yoo JJ, et al. A photo-crosslinkable kidney ECM-derived bioink accelerates renal tissue formation. Adv Healthc Mater, 2019, 8(7): e1800992.
24.	Tr?ndle K, Rizzo L, Pichler R, et al. Scalable fabrication of renal spheroids and nephron-like tubules by bioprinting and controlled self-assembly of epithelial cells. Biofabrication, 2021 Jan 29. Online ahead of print.
25.	Jang KJ, Mehr AP, Hamilton GA, et al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb), 2013, 5(9): 1119-1129.
26.	Marino D, Colombi F, Ribero D, et al. Targeted agents: how can we improve the outcome in biliary tract cancer? Hepatobiliary Surg Nutr, 2013, 2(1): 31-33.
27.	Usón Junior PLS, Ahn D, Sonbol MB, et al. Perspectives on immunotherapy utilization for hepatobiliary cancers in the United States. Hepatobiliary Surg Nutr, 2020, 9(4): 501-504.
28.	Zhao Y, Yao R, Ouyang L, et al. Three-dimensional printing of Hela cells for cervical tumor model in vitro. Biofabrication, 2014, 6(3): 035001.
29.	Zhou XW, Liu C, Zhao XR, et al. A 3D bioprinting liver tumor model for drug screening. World J Pharm Pharm Sci, 2016, 5(4): 196-213.
30.	Yang Y, Du T, Zhang J, et al. A 3D-engineered conformal implant releases DNA nanocomplexs for eradicating the postsurgery residual glioblastoma. Adv Sci (Weinh), 2017, 4(8): 1600491.
31.	Mao S, He J, Zhao Y, et al. Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing. Biofabrication, 2020, 12(4): 045014.
32.	王曉麗, 常民. 一種靶向—穿膜肽的設計、合成及活性研究. 蘭州: 蘭州大學, 2017.
33.	Rosenholm JM, Zhang J, Linden M, et al. Mesoporous silica nanoparticles in tissue engineering—a perspective. Nanomedicine (Lond), 2016, 11(4): 391-402.
34.	何冬林, 韓福國, 王釗, 等. 基于熔融沉積成型的 3D 打印在藥物制劑中的研究進展. 藥學學報, 2016, 51(11): 1659-1665.
35.	Beck RCR, Chaves PS, Goyanes A, et al. 3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems. Int J Pharm, 2017, 528(1-2): 268-279.
36.	Yu DG, Shen XX, Branford-White C, et al. Novel oral fast-disintegrating drug delivery devices with predefined inner structure fabricated by three-dimensional printing. J Pharm Pharmacol, 2009, 61(3): 323-329.
37.	Scoutaris N, Ross SA, Douroumis D. 3D printed “Starmix” drug loaded dosage forms for paediatric applications. Pharm Res, 2018, 35(2): 34.
38.	Goyanes A, Det-Amornrat U, Wang J, et al. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. J Control Release, 2016, 234: 41-48.
39.	Muwaffak Z, Goyanes A, Clark V, et al. Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings. Int J Pharm, 2017, 527(1-2): 161-170.
40.	Lim SH, Ng JY, Kang L. Three-dimensional printing of a microneedle array on personalized curved surfaces for dual-pronged treatment of trigger finger. Biofabrication, 2017, 9(1): 015010.
41.	Sun Y, Ruan X, Li H, et al. Fabrication of non-dissolving analgesic suppositories using 3D printed moulds. Int J Pharm, 2016, 513(1-2): 717-724.
42.	Fu J, Yu X, Jin Y. 3D printing of vaginal rings with personalized shapes for controlled release of progesterone. Int J Pharm, 2018, 539(1-2): 75-82.
43.	Zhao C, Wang Z, Hua C, et al. Design, modeling and 3D printing of a personalized cervix tissue implant with protein release function. Biomed Mater, 2020, 15(4): 045005.
44.	Zema L, Melocchi A, Maroni A, et al. Three-dimensional printing of medicinal products and the challenge of personalized therapy. J Pharm Sci, 2017, 106(7): 1697-1705.
45.	Huang W, Zheng Q, Sun W, et al. Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique. Int J Pharm, 2007, 339(1-2): 33-38.
46.	Guerra AJ, Cano P, Rabionet M, et al. 3D-printed PCL/PLA composite stents: towards a new solution to cardiovascular problems. Materials (Basel), 2018, 11(9): 1679.
47.	Fouladian P, Kohlhagen J, Arafat M, et al. Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers. Biomater Sci, 2020, 8(23): 6625-6636.
48.	Benmassaoud MM, Kohama C, Kim TWB, et al. Efficacy of eluted antibiotics through 3D printed femoral implants. Biomed Microdevices, 2019, 21(3): 51.
49.	Ma X, Liu J, Zhu W, et al. 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev, 2018, 132: 235-251.
50.	Prasad LK, Smyth H. 3D printing technologies for drug delivery: a review. Drug Dev Ind Pharm, 2016, 42(7): 1019-1031.

1. Mao S, Pang Y, Liu T, et al. Bioprinting of in vitro tumor models for personalized cancer treatment: a review. Biofabrication, 2020, 12(4): 042001.
2. Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol, 2006, 7(3): 211-224.
3. Nyga A, Cheema U, Loizidou M. 3D tumour models: novel in vitro approaches to cancer studies. J Cell Commun Signal, 2011, 5(3): 239-248.
4. 陳國寧, 舒花, 余佩, 等. 3D 打印技術在藥學領域研究中的應用. 中國藥學雜志, 2016, 51(16): 1353-1359.
5. Wang J, Zhang Y, Aghda NH, et al. Emerging 3D printing technologies for drug delivery devices: Current status and future perspective. Adv Drug Deliv Rev, 2021, 174: 294-316.
6. Lim SH, Kathuria H, Tan JJY, et al. 3D printed drug delivery and testing systems—a passing fad or the future? Adv Drug Deliv Rev, 2018, 132: 139-168.
7. Nie J, Gao Q, Fu J, et al. Grafting of 3D bioprinting to in vitro drug screening: a review. Adv Healthc Mater, 2020, 9(7): e1901773.
8. Moro M, Casanova M, Roz L. Patient-derived xenografts, a multi-faceted in vivo model enlightening research on rare liver cancer biology. Hepatobiliary Surg Nutr, 2017, 6(5): 344-346.
9. Costa A, Sarmento B, Seabra V. An evaluation of the latest in vitro tools for drug metabolism studies. Expert Opin Drug Metab Toxicol, 2014, 10(1): 103-119.
10. Grigoryan B, Paulsen SJ, Corbett DC, et al. Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science, 2019, 364(6439): 458-464.
11. Horváth L, Umehara Y, Jud C, et al. Engineering an in vitro air-blood barrier by 3D bioprinting. Sci Rep, 2015, 5: 7974.
12. Huh DD. A human breathing lung-on-a-chip. Ann Am Thorac Soc, 2015, 12 Suppl 1(Suppl 1): S42-S44.
13. Liau B, Jackman CP, Li Y, et al. Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. Sci Rep, 2017, 7: 42290.
14. Zhang YS, Arneri A, Bersini S, et al. Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials, 2016, 110: 45-59.
15. Ma Z, Koo S, Finnegan MA, et al. Three-dimensional filamentous human diseased cardiac tissue model. Biomaterials, 2014, 35(5): 1367-1377.
16. Khetani SR, Bhatia SN. Microscale culture of human liver cells for drug development. Nat Biotechnol, 2008, 26(1): 120-126.
17. Hewitt NJ, Lechón MJ, Houston JB, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev, 2007, 39(1): 159-234.
18. Xie F, Xiao Y, Chen M. Three-dimensional bioprinted liver tissue for transplantation: hope or hype? Hepatobiliary Surg Nutr, 2020, 9(6): 788-790.
19. Kizawa H, Nagao E, Shimamura M, et al. Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery. Biochem Biophys Rep, 2017, 10: 186-191.
20. Ma X, Qu X, Zhu W, et al. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A, 2016, 113(8): 2206-2211.
21. Yang H, Sun L, Pang Y, et al. Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure. Gut, 2021, 70(3): 567-574.
22. Bhise NS, Manoharan V, Massa S, et al. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication, 2016, 8(1): 014101.
23. Ali M, Pr AK, Yoo JJ, et al. A photo-crosslinkable kidney ECM-derived bioink accelerates renal tissue formation. Adv Healthc Mater, 2019, 8(7): e1800992.
24. Tr?ndle K, Rizzo L, Pichler R, et al. Scalable fabrication of renal spheroids and nephron-like tubules by bioprinting and controlled self-assembly of epithelial cells. Biofabrication, 2021 Jan 29. Online ahead of print.
25. Jang KJ, Mehr AP, Hamilton GA, et al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb), 2013, 5(9): 1119-1129.
26. Marino D, Colombi F, Ribero D, et al. Targeted agents: how can we improve the outcome in biliary tract cancer? Hepatobiliary Surg Nutr, 2013, 2(1): 31-33.
27. Usón Junior PLS, Ahn D, Sonbol MB, et al. Perspectives on immunotherapy utilization for hepatobiliary cancers in the United States. Hepatobiliary Surg Nutr, 2020, 9(4): 501-504.
28. Zhao Y, Yao R, Ouyang L, et al. Three-dimensional printing of Hela cells for cervical tumor model in vitro. Biofabrication, 2014, 6(3): 035001.
29. Zhou XW, Liu C, Zhao XR, et al. A 3D bioprinting liver tumor model for drug screening. World J Pharm Pharm Sci, 2016, 5(4): 196-213.
30. Yang Y, Du T, Zhang J, et al. A 3D-engineered conformal implant releases DNA nanocomplexs for eradicating the postsurgery residual glioblastoma. Adv Sci (Weinh), 2017, 4(8): 1600491.
31. Mao S, He J, Zhao Y, et al. Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing. Biofabrication, 2020, 12(4): 045014.
32. 王曉麗, 常民. 一種靶向—穿膜肽的設計、合成及活性研究. 蘭州: 蘭州大學, 2017.
33. Rosenholm JM, Zhang J, Linden M, et al. Mesoporous silica nanoparticles in tissue engineering—a perspective. Nanomedicine (Lond), 2016, 11(4): 391-402.
34. 何冬林, 韓福國, 王釗, 等. 基于熔融沉積成型的 3D 打印在藥物制劑中的研究進展. 藥學學報, 2016, 51(11): 1659-1665.
35. Beck RCR, Chaves PS, Goyanes A, et al. 3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems. Int J Pharm, 2017, 528(1-2): 268-279.
36. Yu DG, Shen XX, Branford-White C, et al. Novel oral fast-disintegrating drug delivery devices with predefined inner structure fabricated by three-dimensional printing. J Pharm Pharmacol, 2009, 61(3): 323-329.
37. Scoutaris N, Ross SA, Douroumis D. 3D printed “Starmix” drug loaded dosage forms for paediatric applications. Pharm Res, 2018, 35(2): 34.
38. Goyanes A, Det-Amornrat U, Wang J, et al. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. J Control Release, 2016, 234: 41-48.
39. Muwaffak Z, Goyanes A, Clark V, et al. Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings. Int J Pharm, 2017, 527(1-2): 161-170.
40. Lim SH, Ng JY, Kang L. Three-dimensional printing of a microneedle array on personalized curved surfaces for dual-pronged treatment of trigger finger. Biofabrication, 2017, 9(1): 015010.
41. Sun Y, Ruan X, Li H, et al. Fabrication of non-dissolving analgesic suppositories using 3D printed moulds. Int J Pharm, 2016, 513(1-2): 717-724.
42. Fu J, Yu X, Jin Y. 3D printing of vaginal rings with personalized shapes for controlled release of progesterone. Int J Pharm, 2018, 539(1-2): 75-82.
43. Zhao C, Wang Z, Hua C, et al. Design, modeling and 3D printing of a personalized cervix tissue implant with protein release function. Biomed Mater, 2020, 15(4): 045005.
44. Zema L, Melocchi A, Maroni A, et al. Three-dimensional printing of medicinal products and the challenge of personalized therapy. J Pharm Sci, 2017, 106(7): 1697-1705.
45. Huang W, Zheng Q, Sun W, et al. Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique. Int J Pharm, 2007, 339(1-2): 33-38.
46. Guerra AJ, Cano P, Rabionet M, et al. 3D-printed PCL/PLA composite stents: towards a new solution to cardiovascular problems. Materials (Basel), 2018, 11(9): 1679.
47. Fouladian P, Kohlhagen J, Arafat M, et al. Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers. Biomater Sci, 2020, 8(23): 6625-6636.
48. Benmassaoud MM, Kohama C, Kim TWB, et al. Efficacy of eluted antibiotics through 3D printed femoral implants. Biomed Microdevices, 2019, 21(3): 51.
49. Ma X, Liu J, Zhu W, et al. 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev, 2018, 132: 235-251.
50. Prasad LK, Smyth H. 3D printing technologies for drug delivery: a review. Drug Dev Ind Pharm, 2016, 42(7): 1019-1031.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

展望個性化治療：生物3D打印與藥物篩選和遞送

Abstract Full text Figures/Tables Video References Cited by

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