Correlation between Treg/Th17 cell immune balance disorder and disease progression of acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Tao ¹ , LI Zhiwei ² ,  XU Hui ¹

1. Department of Pancreatic Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, P. R. China;
2. Department of Clinical Laboratory Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, P. R. China;

Corresponding?author：

XU Hui, Email: xuhui197371@sina.com

Keywords：

acute pancreatitis; regulatory T cell; helper T cell 17; interleukin-10; interleukin-17

DOI：

10.7507/1007-9424.202110012

Video：

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Objective To analyze the relation between regulatory T cell (Treg)/ helper T cell 17 (Th17) imbalance and the pathogenesis of acute pancreatitis (AP) and to explore the relation between Treg/Th17 cell imbalance and helper T cells 1, helper T cells 2 and cytokines in patients with AP, so as to provide a new therapeutic target for immunotherapy of AP. Methods From January to December 2020, 40 patients diagnosed with AP ( AP group) in The People’s Hospital of Xinjiang Uygur Autonomous Region and 40 healthy subjects who underwent physical examination (normal control group) during the same period in this hospital were selected as the research objects. Their peripheral bloods were collected and the proportion of Treg and Th17 cells was detected by flow cytometry. Plasma levels of interleukin-10 (IL-10) and interleukin-17 (IL-17) were detected. Results Compared with the normal control group, the proportions of Treg and Th17 cells increased before treatment in the AP group, the differences were statistically significant (t=5.78, P<0.001; t=5.82, P<0.001). The levels of IL-10 and IL-17 increased, the differences were statistically significant (t=7.14, P<0.001; t=35.22, P<0.001). After treatment, the AP group as compared with the normal control group, the proportions of Treg and Th17 cells increased but the differences were not statistically significant (t=1.87, P>0.05; t=0.29, P>0.05), the level of IL-10 increased and the difference was statistically significant (t=3.98, P<0.001), the level of IL-17 increased but the difference was not statistically significant (t=1.67, P>0.05). After treatment as compared with before treatment in the AP group, the proportions of Treg and Th17 cells decreased, the differences were statistically significant (t=3.07, P<0.01; t=4.99, P<0.001). The levels of IL-10 and IL-17 decreased, the differences were statistically significant (t=3.38, P<0.001; t=30.63, P<0.001). Conclusion In AP, Treg cells mediate immunosuppression and Th17 cells mediate inflammatory response, promoting the occurrence and development of inflammation in the disease. IL-10 and IL-17 may play an important role in regulating their differentiation and homeostasis.

Citation： ZHANG Tao, LI Zhiwei, XU Hui. Correlation between Treg/Th17 cell immune balance disorder and disease progression of acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(7): 892-896. doi: 10.7507/1007-9424.202110012 Copy

1.	Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
2.	Paul J. Recent advances in diagnosis and severity assessment of acute pancreatitis. Prague Med Rep, 2020, 121(2): 65-86.
3.	Petrov MS, Yalav D. Global epidemiology and holistic prevenlion of pancreatitis. Nat Rey Gastenteral Hepatol, 2019, 16(3): 175-184.
4.	劉靜. 多學科協作診療模式對老年重癥急性胰腺炎合并腎衰竭患者預后的影響. 中國老年學雜志, 2021, 41(2): 311-315.
5.	張智鵬, 張偉輝. 非編碼RNA在急性胰腺炎中的研究進展. 中國普外基礎與臨床雜志, 2021, 28(11): 1536-1540.
6.	Quero G, Covino M, Ojetti V, et al. Acute pancreatitis in oldest old: a 10-year retrospective analysis of patients referred to the emergency department of a large tertiary hospital. Eur J Gastroenterol Hepatol, 2020, 32(2): 159-165.
7.	中華醫學會消化病學分會胰腺疾病學組, 《中華胰腺病雜志》編輯委員會, 《中華消化雜志》編輯委員會. 中國急性胰腺炎診治指南(2019, 沈陽). 中華胰腺病雜志, 2019, 19(5): 321-331.
8.	Zhang Q, Qin M, Liang Z, et al. The relationship between serum triglyceride levels and acute pancreatitis in an animal model and a 14-year retrospective clinical study. Lipids Health Dis, 2019, 18(1): 183. doi: 10.1186/s12944-019-1126-0.
9.	Tsukamoto A, Ohgoda M, Haruki N, et al. The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis. J Vet Med Sci 2018, 80(3): 492-498.
10.	劉廣林, 張文成, 陳凱, 等. 慢性胰腺炎發病機制的研究進展. 中華胰腺病雜志, 2020, 20(4): 314-317.
11.	王立明, 馮輝, 牛澤群, 等. 血紅素加氧酶-1對急性重癥胰腺炎相關肺損傷TLR4/NF-κB通路的影響. 現代生物醫學進展, 2020, 20(4): 661-664.
12.	伍洋, 劉英, 劉濟滔, 等. 大黃素對重癥急性胰腺炎小鼠Treg/Th17平衡的影響及機制研究. 重慶醫科大學學報, 2019, 44(5): 617-621.
13.	徐勁, 蔣鑫, 嚴永峰, 等. 80歲以上老年急性胰腺炎患者的臨床特征分析. 臨床肝膽病雜志, 2021, 37(1): 142-146.
14.	陳英, 陳岳亮, 馮彬彬, 等. 耐碳青霉烯類肺炎克雷伯菌感染與急性胰腺炎嚴重程度的臨床關系. 中華消化外科雜志, 2021, 20(11): 1201-1205.
15.	朱磊, 顧洪柱, 李珊珊, 等. 新輔助化療前后系統免疫炎癥指數的變化對進展期胰腺癌患者預后的臨床價值. 中國普外基礎與臨床雜志, 2021, 28(1): 12-17.
16.	楊陳, 曹小瑤, 劉明宗, 等. miR-324-5p靶向調控CARD9對急性胰腺炎腺泡細胞增殖、凋亡的影響及機制. 中國老年學雜志, 2021, 41(2): 379-385.
17.	Zhang Z, Liu Q, Zang H, et al. Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signaling. Pharm Biol, 2019, 57(1): 595-603.
18.	孫立新, 彭凡嶺, 紀前. Toll樣受體4通路在重癥急性胰腺炎小鼠肺損傷中的作用及其機制. 中華實驗外科雜志, 2019, 36(6): 1055-1057.
19.	徐鷗, 董金輝, 岳麗艷, 等. Treg細胞和TICAM-1分子對重度變應性鼻炎患者免疫調節機制研究. 中國煤炭工業醫學雜志, 2020, 23(3): 303-306.
20.	唐義龍, 方晨光, 吳文偉, 等. 急性膽源性胰腺炎繼發胰腺壞死高危因素及預測模型分析. 創傷與急危重病醫學, 2020, 8(2): 104-106, 109.唐義龍, 方晨光, 吳文偉, 等. 急性膽源性胰腺炎繼發胰腺壞死高危因素及預測模型分析. 創傷與急危重病醫學, 2020, 8(2): 104-106, 109.
21.	解松齡, 蔣正, 趙濤, 等. 輔助性T細胞17及其細胞因子在急性胰腺炎患者診治中的作用. 中華肝膽外科雜志, 2020, 26(2): 134-138.
22.	趙瑞臣, 次多, 何春婭, 等. 重癥急性胰腺炎外周血miR-9、miR-155表達水平與淀粉酶、炎性反應及Th17/Treg平衡的關系. 疑難病雜志, 2021, 20(8): 795-800.
23.	姚超, 朱琦琦, 成向進. 中藥聯合生長抑素治療急性胰腺炎臨床療效及對血清Th17/Treg細胞平衡變化的影響. 長春中醫藥大學學報, 2021, 37(6): 1313-1316.
24.	呂春婷, 付黎明, 岳磊. 雜合式血液凈化在重癥急性胰腺炎并發MODS患者中的應用. 實用醫藥雜志, 2021, 38(7): 602-604.
25.	馬志蘭, 孫雪婷, 梁艷琴. 血液凈化對重癥急性胰腺炎合并MODS患者 Th17/Treg細胞平衡的影響. 中華醫院感染學雜志, 2020, 30(15): 2347-2351.

1. Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
2. Paul J. Recent advances in diagnosis and severity assessment of acute pancreatitis. Prague Med Rep, 2020, 121(2): 65-86.
3. Petrov MS, Yalav D. Global epidemiology and holistic prevenlion of pancreatitis. Nat Rey Gastenteral Hepatol, 2019, 16(3): 175-184.
4. 劉靜. 多學科協作診療模式對老年重癥急性胰腺炎合并腎衰竭患者預后的影響. 中國老年學雜志, 2021, 41(2): 311-315.
5. 張智鵬, 張偉輝. 非編碼RNA在急性胰腺炎中的研究進展. 中國普外基礎與臨床雜志, 2021, 28(11): 1536-1540.
6. Quero G, Covino M, Ojetti V, et al. Acute pancreatitis in oldest old: a 10-year retrospective analysis of patients referred to the emergency department of a large tertiary hospital. Eur J Gastroenterol Hepatol, 2020, 32(2): 159-165.
7. 中華醫學會消化病學分會胰腺疾病學組, 《中華胰腺病雜志》編輯委員會, 《中華消化雜志》編輯委員會. 中國急性胰腺炎診治指南(2019, 沈陽). 中華胰腺病雜志, 2019, 19(5): 321-331.
8. Zhang Q, Qin M, Liang Z, et al. The relationship between serum triglyceride levels and acute pancreatitis in an animal model and a 14-year retrospective clinical study. Lipids Health Dis, 2019, 18(1): 183. doi: 10.1186/s12944-019-1126-0.
9. Tsukamoto A, Ohgoda M, Haruki N, et al. The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis. J Vet Med Sci 2018, 80(3): 492-498.
10. 劉廣林, 張文成, 陳凱, 等. 慢性胰腺炎發病機制的研究進展. 中華胰腺病雜志, 2020, 20(4): 314-317.
11. 王立明, 馮輝, 牛澤群, 等. 血紅素加氧酶-1對急性重癥胰腺炎相關肺損傷TLR4/NF-κB通路的影響. 現代生物醫學進展, 2020, 20(4): 661-664.
12. 伍洋, 劉英, 劉濟滔, 等. 大黃素對重癥急性胰腺炎小鼠Treg/Th17平衡的影響及機制研究. 重慶醫科大學學報, 2019, 44(5): 617-621.
13. 徐勁, 蔣鑫, 嚴永峰, 等. 80歲以上老年急性胰腺炎患者的臨床特征分析. 臨床肝膽病雜志, 2021, 37(1): 142-146.
14. 陳英, 陳岳亮, 馮彬彬, 等. 耐碳青霉烯類肺炎克雷伯菌感染與急性胰腺炎嚴重程度的臨床關系. 中華消化外科雜志, 2021, 20(11): 1201-1205.
15. 朱磊, 顧洪柱, 李珊珊, 等. 新輔助化療前后系統免疫炎癥指數的變化對進展期胰腺癌患者預后的臨床價值. 中國普外基礎與臨床雜志, 2021, 28(1): 12-17.
16. 楊陳, 曹小瑤, 劉明宗, 等. miR-324-5p靶向調控CARD9對急性胰腺炎腺泡細胞增殖、凋亡的影響及機制. 中國老年學雜志, 2021, 41(2): 379-385.
17. Zhang Z, Liu Q, Zang H, et al. Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signaling. Pharm Biol, 2019, 57(1): 595-603.
18. 孫立新, 彭凡嶺, 紀前. Toll樣受體4通路在重癥急性胰腺炎小鼠肺損傷中的作用及其機制. 中華實驗外科雜志, 2019, 36(6): 1055-1057.
19. 徐鷗, 董金輝, 岳麗艷, 等. Treg細胞和TICAM-1分子對重度變應性鼻炎患者免疫調節機制研究. 中國煤炭工業醫學雜志, 2020, 23(3): 303-306.
20. 唐義龍, 方晨光, 吳文偉, 等. 急性膽源性胰腺炎繼發胰腺壞死高危因素及預測模型分析. 創傷與急危重病醫學, 2020, 8(2): 104-106, 109.唐義龍, 方晨光, 吳文偉, 等. 急性膽源性胰腺炎繼發胰腺壞死高危因素及預測模型分析. 創傷與急危重病醫學, 2020, 8(2): 104-106, 109.
21. 解松齡, 蔣正, 趙濤, 等. 輔助性T細胞17及其細胞因子在急性胰腺炎患者診治中的作用. 中華肝膽外科雜志, 2020, 26(2): 134-138.
22. 趙瑞臣, 次多, 何春婭, 等. 重癥急性胰腺炎外周血miR-9、miR-155表達水平與淀粉酶、炎性反應及Th17/Treg平衡的關系. 疑難病雜志, 2021, 20(8): 795-800.
23. 姚超, 朱琦琦, 成向進. 中藥聯合生長抑素治療急性胰腺炎臨床療效及對血清Th17/Treg細胞平衡變化的影響. 長春中醫藥大學學報, 2021, 37(6): 1313-1316.
24. 呂春婷, 付黎明, 岳磊. 雜合式血液凈化在重癥急性胰腺炎并發MODS患者中的應用. 實用醫藥雜志, 2021, 38(7): 602-604.
25. 馬志蘭, 孫雪婷, 梁艷琴. 血液凈化對重癥急性胰腺炎合并MODS患者 Th17/Treg細胞平衡的影響. 中華醫院感染學雜志, 2020, 30(15): 2347-2351.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation between Treg/Th17 cell immune balance disorder and disease progression of acute pancreatitis

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