The first clinical verification of near-infrared fluorescence projection navigation technology in liver cancer surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FANG Cheng ^1,2,3 , WANG Piao ^1,2,3 , LI Bo ^1,2,3 , SU Song ^1,2,3 , CHENG Zhen ⁴ , GAN Yu ^1,2,3 , YANG Xiaoli ^1,2,3 , PENG Fangyi ^1,2,3 ,  SUO Yongkuan ⁴

1. Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P. R. China;
2. Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan 646000, P. R. China;
3. Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan 646000, P. R. China;
4. Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China;

Corresponding?author：

SUO Yongkuan, Email: suoyongkuan@simm.ac.cn

Keywords：

near-infrared fluorescence; projection imaging; surgical navigation; liver cancer

DOI：

10.7507/1007-9424.202206071

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Objective The aim of this article is to verify the clinical effect of the near-infrared fluorescent liver cancer surgery projection navigation system without display screen. Methods Three patients who need to undergo open hepatectomy for liver cancer in the Affiliated Hospital of Southwest Medical University from March 2021 to May 2021 were included, verifying the accuracy, stability, and time delay effect of the self-developed near-infrared fluorescence projection navigation system for the location of tumor in surgeries. Results The intraoperative tumor location could be accurately displayed by the near-infrared fluorescence projection system and there was no significant difference between the location of the tumor displayed by intraoperative ultrasound. The tumor location displayed by the near-infrared fluorescence projection system was not influenced by the tumor movement and had no visual-time delay. Postoperative pathology confirmed that the projection range was consistent with the tumor range. Conclusion This near-infrared fluorescence projection technology innovates the intraoperative tumor imaging mode and can accurately navigate open hepatectomy in small sample trials, and it is expected to achieve wide clinical application through subsequent iterative optimization and verification.

Citation： FANG Cheng, WANG Piao, LI Bo, SU Song, CHENG Zhen, GAN Yu, YANG Xiaoli, PENG Fangyi, SUO Yongkuan. The first clinical verification of near-infrared fluorescence projection navigation technology in liver cancer surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(8): 1001-1005. doi: 10.7507/1007-9424.202206071 Copy

1.	Hu Z, Fang C, Li B, et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-Ⅰ/Ⅱ windows. Nat Biomed Eng, 2020, 4(3): 259-271.
2.	Chen QY, Xie JW, Zhong Q, et al. Safety and efficacy of endocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial. JAMA Surg, 2020, 155(4): 300-311.
3.	Nakaseko Y, Ishizawa T, Saiura A. Fluorescence-guided surgery for liver tumors. J Surg Oncol, 2018, 118(2): 324-331.
4.	劉允怡, 方馳華, 王曉穎, 等. 吲哚菁綠分子熒光影像技術診斷原發性肝癌與術中導航操作診療規范 (2021版). 中國實用外科雜志, 2021, 41(9): 1002-1013.
5.	方程, 王飄, 蘇松, 等. 吲哚菁綠熒光成像在再次膽道探查術中的對照研究. 中國普外基礎與臨床雜志, 2022, 29(6): 711-715.
6.	Frumovitz M, Plante M, Lee PS, et al. Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial. Lancet Oncol, 2018, 19(10): 1394-1403.
7.	Ishizawa T, Fukushima N, Shibahara J, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer, 2009, 115(11): 2491-2504.

1. Hu Z, Fang C, Li B, et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-Ⅰ/Ⅱ windows. Nat Biomed Eng, 2020, 4(3): 259-271.
2. Chen QY, Xie JW, Zhong Q, et al. Safety and efficacy of endocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial. JAMA Surg, 2020, 155(4): 300-311.
3. Nakaseko Y, Ishizawa T, Saiura A. Fluorescence-guided surgery for liver tumors. J Surg Oncol, 2018, 118(2): 324-331.
4. 劉允怡, 方馳華, 王曉穎, 等. 吲哚菁綠分子熒光影像技術診斷原發性肝癌與術中導航操作診療規范 (2021版). 中國實用外科雜志, 2021, 41(9): 1002-1013.
5. 方程, 王飄, 蘇松, 等. 吲哚菁綠熒光成像在再次膽道探查術中的對照研究. 中國普外基礎與臨床雜志, 2022, 29(6): 711-715.
6. Frumovitz M, Plante M, Lee PS, et al. Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial. Lancet Oncol, 2018, 19(10): 1394-1403.
7. Ishizawa T, Fukushima N, Shibahara J, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer, 2009, 115(11): 2491-2504.

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The first clinical verification of near-infrared fluorescence projection navigation technology in liver cancer surgery

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