Research progress on factors contributing to pulmonary infection after gastric cancer surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Jie ,  HE Yuhua , LI Ka

West China School of Nursing, Sichuan University / Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

HE Yuhua, Email: heyuhua1006@163.com

Keywords：

gastric cancer; pulmonary infection; risk factors; review

DOI：

10.7507/1007-9424.202207021

Video：

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Obejective To summarize the research progress of risk factors contributing to postoperative pulmonary infection in gastric cancer, so as to provide reference for medical decision-makers and clinical practitioners to effectively control the incidence of postoperative pulmonary infection in gastric cancer, ensure medical safety and improve the quality of life of patients. Method The researches at home and abroad on the factors contributing to pulmonary infection after gastric cancer surgery in recent years were reviewed and analyzed. Results There was currently no uniform diagnostic standard for pulmonary infection. The incidence of postoperative pulmonary infection for gastric cancer varied in the different countries and regions. The pathogenic bacteria that caused postoperative pulmonary infection of gastric cancer was mainly gram-negative bacteria, especially Pseudomonas aeruginosa, Escherichia coli, Acinetobacter boulardii, and Klebsiella pneumoniae. The patient’s age, history of smoking, preoperative pulmonary function, preoperative laboratory indicators, preoperative comorbidities, preoperative nutritional status, preoperative weakness, anesthesia, tumor location, surgical modality, duration of surgery, blood transfusion, indwelling gastrointestinal decompression tube, wound pain, and so on were possible factors associated with postoperative pulmonary infection of gastric cancer. Conclusions The incidence of postoperative pulmonary infection for gastric cancer is not promising. Based on the recognition of related factors, it is proposed that it is necessary to develop a risk prediction model for postoperative pulmonary infection of gastric cancer to identify high-risk patients. In addition to the conventional intervention strategy, taking the pathogenesis as the breakthrough, finding the key factors that lead to the occurrence of postoperative pulmonary infection of gastric cancer is the fundamental way to reduce its occurrence.

Citation： YANG Jie, HE Yuhua, LI Ka. Research progress on factors contributing to pulmonary infection after gastric cancer surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(1): 99-104. doi: 10.7507/1007-9424.202207021 Copy

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2.	中華醫學會呼吸病學分會感染學組. 中國成人醫院獲得性肺炎與呼吸機相關性肺炎診斷和治療指南(2018年版). 中華結核和呼吸雜志, 2018, 41(4): 255-280.
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1. Liu X, Xue Z, Yu J, et al. Risk factors for postoperative infectious complications in elderly patients with gastric cancer. Cancer Manag Res, 2020, 12: 4391-4398.
2. 中華醫學會呼吸病學分會感染學組. 中國成人醫院獲得性肺炎與呼吸機相關性肺炎診斷和治療指南(2018年版). 中華結核和呼吸雜志, 2018, 41(4): 255-280.
3. Dilworth JP, White RJ. Postoperative chest infection after upper abdominal surgery: an important problem for smokers. Respir Med, 1992, 86(3): 205-210.
4. Mori M, Shuto K, Hirano A, et al. Preoperative neutrophil-to-lymphocyte ratio may predict postoperative pneumonia in stage Ⅰ–Ⅲ gastric cancer patients after curative gastrectomy: a retrospective study. World J Surg, 2021, 45(11): 3359-3369.
5. 鄭燕國, 陳殷曉, 葉仙華, 等. 不同麻醉方法對胃癌患者術后肺部感染的影響. 中華醫院感染學雜志, 2015, 25(6): 1391-1392, 1395.
6. 趙金輝, 谷順通, 田麗, 等. 腹腔鏡胃癌根治術患者術后肺部感染與影響因素分析. 中華醫院感染學雜志, 2019, 29(3): 403-406.
7. 朱根英, 吳辰, 魏云海, 等. 腹腔鏡胃癌根治術患者術后肺部感染與影響因素分析. 中國現代醫生, 2021, 59(19): 7-9, 43.
8. 余愛平, 張忠華, 張江南. 腹腔鏡胃癌切除術后肺部感染的影響因素分析. 江西醫藥, 2019, 54(12): 1535-1537.
9. 王超珺, 劉昭暉. 腹腔鏡下根治性胃癌切除術后并發肺部感染的危險因素分析. 中國醫學創新, 2021, 18(21): 142-145.
10. 方俊, 洪依, 陳秀英, 等. 老年患者胃癌切除聯合D2淋巴結清掃術后肺部感染危險因素. 熱帶醫學雜志, 2021, 21(5): 600-604.
11. 李曉君, 李新麗, 胡佳揚, 等. 老年胃癌根治術后肺部感染IL-33和Th1/Th2表達及意義. 中華醫院感染學雜志, 2021, 31(14): 2189-2192.
12. 白靜, 巴楠, 張小娟, 等. 胃癌根治術后肺部感染病原菌及危險因素. 中華醫院感染學雜志, 2020, 30(21): 3316-3320.
13. 沈薦, 李敏哲, 杜燕夫. 影響腹腔鏡胃癌根治術后肺部感染的多因素分析. 中國微創外科雜志, 2021, 21(8): 700-704.
14. 謝建忠, 李林, 黃彬, 等. 胃癌腔鏡手術后肺部感染危險因素. 中國感染控制雜志, 2020, 19(7): 653-656.
15. Miki Y, Makuuchi R, Tokunaga M, et al. Risk factors for postoperative pneumonia after gastrectomy for gastric cancer. Surg Today, 2016, 46(5): 552-556.
16. Shibata C, Ogawa H, Nakano T, et al. Influence of age on postoperative complications especially pneumonia after gastrectomy for gastric cancer. BMC Surg, 2019, 19(1): 1-7.
17. Gong EJ, Kim DH, Jung HY, et al. Pneumonia after endoscopic resection for gastric neoplasm. Dig Dis Sci, 2014, 59(11): 2742-2748.
18. Wong Fok Lung T, Charytonowicz D, Beaumont KG, et al. Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metab, 2022, 34(5): 761-774.
19. 余喜梅, 高紅梅. 胃癌術后肺部感染影響因素和病原菌分布及其耐藥性. 中華醫院感染學雜志, 2022, 32(17): 2638-2641.
20. Aratani K, Sakuramoto S, Chuman M, et al. Laparoscopy-assisted distal gastrectomy for gastric cancer in elderly patients: surgical outcomes and prognosis. Anticancer Res, 2018, 38(3): 1721-1725.
21. 韓曉光, 步召德, 季加孚. 胃癌根治術后肺部感染相關危險因素分析. 中華胃腸外科雜志, 2017, 20(11): 1279-1282.
22. Chen WZ, Dong QT, Zhang FM, et al. Laparoscopic versus open resection for elderly patients with gastric cancer: a double-center study with propensity score matching method. Langenbecks Arch Surg, 2021, 406(2): 449-461.
23. Togo M, Akazawa Y, Akashi T, et al. Comprehensive prospective analysis of the factors contributing to aspiration pneumonia following endoscopic submucosal dissection in patients with early gastric neoplasms. Acta Med Okayama, 2020, 74(5): 407-413.
24. Takama T, Okano K, Kondo A, et al. Predictors of postoperative complications in elderly and oldest old patients with gastric cancer. Gastric Cancer, 2015, 18(3): 653-661.
25. Nienhueser H, Kunzmann R, Sisic L, et al. Surgery of gastric cancer and esophageal cancer: does age matter? J Surg Oncol, 2015, 112(4): 387-395.
26. 彭懷力, 彭慧茹, 劉永鋒, 等. ICU老年患者肺部真菌感染的危險因素以及搶先治療的臨床效果. 江西醫藥, 2017, 52(4): 332-334.
27. Chen S, Hu Y, Zhang W, et al. Analysis of clinical features and related factors of silent aspiration in hospitalized COPD patients. Altern Ther Health Med, 2022, 28(7): 125-131.
28. Matsumi A, Takenaka R, Ando C, et al. Preoperative pulmonary function tests predict aspiration pneumonia after gastric endoscopic submucosal dissection. Dig Dis Sci, 2017, 62(11): 3084-3090.
29. 劉大勇, 張劍, 陳坤, 等. 胃癌患者胃切除術后肺部感染的影響因素回顧性調查分析. 中華醫院感染學雜志, 2017, 27(7): 1576-1579.
30. Shoka M, Kanda M, Ito S, et al. Systemic inflammation score as a predictor of pneumonia after radical resection of gastric cancer: analysis of a multi-institutional dataset. Dig Surg, 2020, 37(5): 401-410.
31. Sato B, Kanda M, Tanaka C, et al. Significance of preoperative systemic inflammation score in short-term and long-term outcomes of patients with pathological T2-4 gastric cancer after radical gastrectomy. World J Surg, 2018, 42(10): 3277-3285.
32. Kanda M, Fujii T, Kodera Y, et al. Nutritional predictors of postoperative outcome in pancreatic cancer. Br J Surg, 2011, 98(2): 268-274.
33. Inaoka K, Kanda M, Uda H, et al. Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer. World J Gastroenterol, 2017, 23(14): 2519-2526.
34. Chan JC, Chan DL, Diakos CI, et al. The lymphocyte-to-monocyte ratio is a superior predictor of overall survival in comparison to established biomarkers of resectable colorectal cancer. Ann Surg, 2017, 265(3): 539-546.
35. 孫偉. 胃癌根治術后肺部感染的血清炎癥指標、病原菌分布及危險因素. 臨床與病理雜志, 2021, 41(8): 1748-1752.
36. Madouri F, Barada O, Kervoaze G, et al. Production of interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae. EBioMedicine, 2018, 37: 417-427.
37. Suzuki H, Matsuda Y, Noda M, et al. Management of de novo mycobacterial infection after lung transplantation without rifampicin: case series of a single institution. Transplant Proc, 2018, 50(9): 2764-2767.
38. Stojanovic J, Tognetto A, Tiziano DF, et al. MicroRNAs expression profiles as diagnostic biomarkers of gastric cancer: a systematic literature review. Biomarkers, 2019, 24(2): 110-119.
39. 王鑫, 姜波, 劉世育, 等. 脂肪因子對2型糖尿病合并胃癌患者預后的影響. 胃腸病學和肝病學雜志, 2019, 28(10): 1128-1133.
40. Zekavat SM, Honigberg M, Pirruccello JP, et al. Elevated blood pressure increases pneumonia risk: epidemiological association and mendelian randomization in the UK biobank. Med (NY), 2021, 2(2): 137-148.
41. Jin X, Wu S, Bai Y. Risk factors and characteristics of bacterial infection during first-line chemotherapy for metastatic gastric or gastroesophageal junction adenocarcinoma. Support Care Cancer, 2022, 30(3): 2121-2129.
42. Meng Y, Zhao P, Yong R. Modified frailty index independently predicts postoperative pulmonary infection in elderly patients undergoing radical gastrectomy for gastric cancer. Cancer Manag Res, 2021, 13: 9117-9126.
43. Bellumkonda L, Tyrrell D, Hummel SL, et al. Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell, 2017, 16(3): 444-450.
44. 王澤華, 胡文慶, 郭焱, 等. 全身麻醉復合硬膜外麻醉對胃癌根治術患者肺功能及術后肺部感染的影響. 中華醫院感染學雜志, 2017, 27(6): 1301-1304.
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