Application of lipiodol<b>-</b>indocyanine green emulsion in fluorescence navigation during hepatectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HUANG Xujian ,  LI Jingdong

The First Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Institute of Hepato-Biliary-Pancreatic-Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding?author：

LI Jingdong, Email: lijingdong358@126.com

Keywords：

primary liver cancer; lipiodol–indocyanine green; fluorescent navigation; hepatectomy

DOI：

10.7507/1007-9424.202303084

Video：

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Abstract Full text Figures/Tables Video References Cited by

Indocyanine green fluorescence imaging has been widely used in hepatobiliary surgery, which can guide accurate hepatectomy and improve the prognosis of patients. Lipiodol–indocyanine green emulsion as a pure physical way to prepare lipiodol-drug mixed solvent can be used for primary interventional embolization and subsequent fluorescence-guided hepatectomy. In this paper, the application of iodized oil-indocyanine green emulsion in hepatectomy was summarized by reviewing relevant research progress at home and abroad, and further discussion and prospect were made.

Citation： HUANG Xujian, LI Jingdong. Application of lipiodol-indocyanine green emulsion in fluorescence navigation during hepatectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(6): 646-649. doi: 10.7507/1007-9424.202303084 Copy

1.	Spinoglio G, Priora F, Bianchi PP, et al. Real-time near-infrared (NIR) fluorescent cholangiography in single-site robotic cholecystectomy (SSRC): a single-institutional prospective study. Surg Endosc, 2013, 27(6): 2156-2162.
2.	Zhang Y, Zhang Y, Zhu J, et al. Clinical application of indocyanine green fluorescence imaging in laparoscopic lymph node dissection for intrahepatic cholangiocarcinoma: A pilot study (with video). Surgery, 2022, 171(6): 1589-1595.
3.	Ishizawa T, Saiura A, Kokudo N. Clinical application of indocyanine green-fluorescence imaging during hepatectomy. Hepatobiliary Surg Nutr, 2016, 5(4): 322-328.
4.	Mindt S, Karampinis I, John M, et al. Stability and degradation of indocyanine green in plasma, aqueous solution and whole blood. Photochem Photobiol Sci, 2018, 17(9): 1189-1196.
5.	石威, 趙好果. TACE綜合介入治療晚期原發性肝癌的臨床效果及對患者肝功能影響. 現代醫用影像學, 2021, 30(5): 900-902.
6.	Chen H, Cheng H, Dai Q, et al. A superstable homogeneous lipiodol-ICG formulation for locoregional hepatocellular carcinoma treatment. J Control Release, 2020, 323: 635-643.
7.	王小波, 魏永剛. 基于三維重建與ICG熒光引導的腹腔鏡下解剖性肝Ⅳ段切除術. 中國普外基礎與臨床雜志, 2021, 28(12): 1632-1636.
8.	鄭寧, 牟宇波, 樊海寧, 等. 吲哚菁綠熒光顯像在腹腔鏡解剖性肝切除術中的應用進展. 中國普外基礎與臨床雜志, 2021, 28(7): 952-955.
9.	劉勝, 尹新民, 劉毅, 等. ICG熒光顯影引導腹腔鏡解剖性右半肝切除治療肝臟腫瘤安全性及可行性研究. 中國實用外科雜志, 2019, 39(9): 944-948.
10.	盧鵬, 王宏光. 腹腔鏡肝切除: 超聲與熒光的地位. 肝膽外科雜志, 2020, 28(1): 8-12.
11.	López-Ben S, Albiol MT, Falgueras L, et al. Pure laparoscopic anatomic resection of the segment 8 dorsal area using the dorsal approach of the right hepatic vein. Ann Surg Oncol, 2021, 28(7): 3697. doi: 10.1245/s10434-020-09462-x.
12.	Ibukuro K, Takeguchi T, Fukuda H, et al. Spatial relationship between the hepatic artery and portal vein based on the fusion image of CT angiography and CT arterial portography: the left hemiliver. AJR Am J Roentgenol, 2013, 200(5): 1160-1166.
13.	Diana M, Liu YY, Pop R, et al. Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept. Surg Endosc, 2017, 31(3): 1451-1460.
14.	Ueno M, Hayami S, Sonomura T, et al. Indocyanine green fluorescence imaging techniques and interventional radiology during laparoscopic anatomical liver resection (with video). Surg Endosc, 2018, 32(2): 1051-1055.
15.	Ueno M, Hayami S, Sonomura T, et al. Concomitant Use of Indocyanine Green Fluorescence Imaging and Interventional Radiology for Detection of Liver Segments During Laparoscopic Anatomical Liver Resection: Pilot Feasibility Study. Surg Laparosc Endosc Percutan Tech, 2019, 29(4): 242-246.
16.	Li WF, Al-Taher M, Yu CY, et al. Super-selective intra-arterial indocyanine green administration for near-infrared fluorescence-based positive staining of hepatic segmentation: A feasibility study. Surg Innov, 2021, 28(6): 669-678.
17.	Qian X, Hu W, Gao L, et al. Trans-arterial positive ICG staining-guided laparoscopic liver watershed resection for hepatocellular carcinoma. Front Oncol, 2022, 12: 966626. doi: 10.3389/fonc.2022.966626.
18.	張洪瑞, 陳虎, 朱靖, 等. 新型碘油制劑及肝癌介入治療研究進展. 中國材料進展, 2022, 41(9): 742-748,677-678.
19.	Cheng H, Yang X, Liu G. Superstable homogeneous iodinated formulation technology: revolutionizing transcatheter arterial chemoembolization. Sci Bull (Beijing), 2020, 65(20): 1685-1687.
20.	Zhang Y, Cheng H, Chen H, et al. A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Eur J Nucl Med Mol Imaging, 2022, 49(8): 2605-2617.
21.	He P, Xiong Y, Ye J, et al. A clinical trial of super-stable homogeneous lipiodol-nanoICG formulation-guided precise fluorescent laparoscopic hepatocellular carcinoma resection. J Nanobiotechnology, 2022, 20(1): 250. doi: 10.1186/s12951-022-01467-w.
22.	He P, Xiong Y, Luo B, et al. An exploratory human study of superstable homogeneous lipiodol-indocyanine green formulation for precise surgical navigation in liver cancer. Bioeng Transl Med, 2022, 8(2): e10404. doi: 10.1002/btm2.10404.

1. Spinoglio G, Priora F, Bianchi PP, et al. Real-time near-infrared (NIR) fluorescent cholangiography in single-site robotic cholecystectomy (SSRC): a single-institutional prospective study. Surg Endosc, 2013, 27(6): 2156-2162.
2. Zhang Y, Zhang Y, Zhu J, et al. Clinical application of indocyanine green fluorescence imaging in laparoscopic lymph node dissection for intrahepatic cholangiocarcinoma: A pilot study (with video). Surgery, 2022, 171(6): 1589-1595.
3. Ishizawa T, Saiura A, Kokudo N. Clinical application of indocyanine green-fluorescence imaging during hepatectomy. Hepatobiliary Surg Nutr, 2016, 5(4): 322-328.
4. Mindt S, Karampinis I, John M, et al. Stability and degradation of indocyanine green in plasma, aqueous solution and whole blood. Photochem Photobiol Sci, 2018, 17(9): 1189-1196.
5. 石威, 趙好果. TACE綜合介入治療晚期原發性肝癌的臨床效果及對患者肝功能影響. 現代醫用影像學, 2021, 30(5): 900-902.
6. Chen H, Cheng H, Dai Q, et al. A superstable homogeneous lipiodol-ICG formulation for locoregional hepatocellular carcinoma treatment. J Control Release, 2020, 323: 635-643.
7. 王小波, 魏永剛. 基于三維重建與ICG熒光引導的腹腔鏡下解剖性肝Ⅳ段切除術. 中國普外基礎與臨床雜志, 2021, 28(12): 1632-1636.
8. 鄭寧, 牟宇波, 樊海寧, 等. 吲哚菁綠熒光顯像在腹腔鏡解剖性肝切除術中的應用進展. 中國普外基礎與臨床雜志, 2021, 28(7): 952-955.
9. 劉勝, 尹新民, 劉毅, 等. ICG熒光顯影引導腹腔鏡解剖性右半肝切除治療肝臟腫瘤安全性及可行性研究. 中國實用外科雜志, 2019, 39(9): 944-948.
10. 盧鵬, 王宏光. 腹腔鏡肝切除: 超聲與熒光的地位. 肝膽外科雜志, 2020, 28(1): 8-12.
11. López-Ben S, Albiol MT, Falgueras L, et al. Pure laparoscopic anatomic resection of the segment 8 dorsal area using the dorsal approach of the right hepatic vein. Ann Surg Oncol, 2021, 28(7): 3697. doi: 10.1245/s10434-020-09462-x.
12. Ibukuro K, Takeguchi T, Fukuda H, et al. Spatial relationship between the hepatic artery and portal vein based on the fusion image of CT angiography and CT arterial portography: the left hemiliver. AJR Am J Roentgenol, 2013, 200(5): 1160-1166.
13. Diana M, Liu YY, Pop R, et al. Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept. Surg Endosc, 2017, 31(3): 1451-1460.
14. Ueno M, Hayami S, Sonomura T, et al. Indocyanine green fluorescence imaging techniques and interventional radiology during laparoscopic anatomical liver resection (with video). Surg Endosc, 2018, 32(2): 1051-1055.
15. Ueno M, Hayami S, Sonomura T, et al. Concomitant Use of Indocyanine Green Fluorescence Imaging and Interventional Radiology for Detection of Liver Segments During Laparoscopic Anatomical Liver Resection: Pilot Feasibility Study. Surg Laparosc Endosc Percutan Tech, 2019, 29(4): 242-246.
16. Li WF, Al-Taher M, Yu CY, et al. Super-selective intra-arterial indocyanine green administration for near-infrared fluorescence-based positive staining of hepatic segmentation: A feasibility study. Surg Innov, 2021, 28(6): 669-678.
17. Qian X, Hu W, Gao L, et al. Trans-arterial positive ICG staining-guided laparoscopic liver watershed resection for hepatocellular carcinoma. Front Oncol, 2022, 12: 966626. doi: 10.3389/fonc.2022.966626.
18. 張洪瑞, 陳虎, 朱靖, 等. 新型碘油制劑及肝癌介入治療研究進展. 中國材料進展, 2022, 41(9): 742-748,677-678.
19. Cheng H, Yang X, Liu G. Superstable homogeneous iodinated formulation technology: revolutionizing transcatheter arterial chemoembolization. Sci Bull (Beijing), 2020, 65(20): 1685-1687.
20. Zhang Y, Cheng H, Chen H, et al. A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Eur J Nucl Med Mol Imaging, 2022, 49(8): 2605-2617.
21. He P, Xiong Y, Ye J, et al. A clinical trial of super-stable homogeneous lipiodol-nanoICG formulation-guided precise fluorescent laparoscopic hepatocellular carcinoma resection. J Nanobiotechnology, 2022, 20(1): 250. doi: 10.1186/s12951-022-01467-w.
22. He P, Xiong Y, Luo B, et al. An exploratory human study of superstable homogeneous lipiodol-indocyanine green formulation for precise surgical navigation in liver cancer. Bioeng Transl Med, 2022, 8(2): e10404. doi: 10.1002/btm2.10404.

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Application of lipiodol-indocyanine green emulsion in fluorescence navigation during hepatectomy

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