CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY
Supervisor：Ministry of Education of the People’s Republic of ChinaSponsor：West China Hospital, Sichuan University Editor-in-chief：Wu Hong Publishing period：
Monthly
ISSN：1007-9424CN：51-1505/R
National Clinical Key Specialty (General Surgery), Sub-center of National Clinical Research Center for Digestive Diseases; Sichuan Clinical Research Center for Digestive Diseases; Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
Objective To summarize the current status and challenges in the diagnosis and treatment of colorectal cancer (CRC) in patients with situs inversus totalis (SIT) , and to provide insights for clinical diagnosis and treatment.Methods By literature researching, we systematically reviewed the clinical manifestations, molecular pathogenesis, individualized surgical strategies, and prognosis of SIT-CRC. Results Current studies indicate a general lack of awareness of SIT-CRC, and its mirror-image anatomy significantly increases diagnostic and therapeutic challenges. SIT-CRC is extremely rare, with tumors predominantly located in the sigmoid colon and ascending colon. Molecular studies suggest that SIT-CRC may harbor unique genetic mutation profiles. Treatment involves using systematic preoperative assessment of vascular variations using three-dimensional CT angiography, multidisciplinary team discussions, and implementation of individualized surgical planning. Postoperative attention should be paid to complication management, individualized adjuvant therapy, and long-term follow-up. Conclusion Enhancing the awareness of SIT-CRC and adopting a systematic, multidisciplinary, and individualized approach are crucial for optimizing patients’ outcomes.
Citation：SU Bowen, CHEN Jiahan, ZHONG Yang, SUN Songlin, ZHANG Guangjun. Colorectal cancer in situs inversus totalis: diagnostic and therapeutic challenges in the context of a rare anatomic anomaly. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2026, 33(2): 287-292. doi: 10.7507/1007-9424.202509060Copy
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Citation：SU Bowen, CHEN Jiahan, ZHONG Yang, SUN Songlin, ZHANG Guangjun. Colorectal cancer in situs inversus totalis: diagnostic and therapeutic challenges in the context of a rare anatomic anomaly. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2026, 33(2): 287-292. doi: 10.7507/1007-9424.202509060
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