Clinical Characteristics of Immunity Function in Patients with Nosocomial Infection in Intensive Care Unit_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LongPan , ShenGuofeng ,  LiXiang , NiJindi , ShenYunle , XiaZhuye

Intensive Care Unit of Minhang Hospital, Fudan University, Shanghai, 201199, China;

Corresponding?author：

LiXiang, Email: 18918169826@163.com

Keywords：

Nosocomial infection; Community acquired pneumonia; T lymphocytes; Immunity function

DOI：

10.7507/1671-6205.2016006

Video：

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Objective To evaluate the role of CD3⁺CD4⁺T cells in patients with nosocomial infection in ICU. Methods One-hundred and eleven patients who admitted in ICU and in respiratory department from March to December in 2014 were recruited in the study.There were 33 patients with community-acquired pneumonia (CAP group), 31 patients without nosocomial infection (NNI group), and 47 patients with hospital-acquired pneumonia (HAP group).The counts of T cells, B cells, CD3⁺CD4⁺ T cells, CD3⁺CD8⁺ T cells, and NK cells were compared among three groups. Results The comparison among the groups had no statistical significance in sex and age(P > 0.05).The three groups had statistical significance in APACHEⅡscore, CD3⁺CD4⁺T cells, T cells and B cells, but had no statistical significance in CD3⁺CD8⁺T cells, CD3⁺CD4⁺/CD3⁺CD8⁺ T cells, NK cells, white blood cells, neutrophils, procalcitonin or C reactive protein.CD3⁺CD4⁺T cells of HAP group were less than other two groups.The area under the ROC curve (AUC) was 0.660, with a threshold of 29.96%, a sensitivity of 93.8%, and a specificity of 40.4%. Conclusion CD3⁺CD4⁺ T cell is an independent predictor for nosocomial infection.

Citation： LongPan, ShenGuofeng, LiXiang, NiJindi, ShenYunle, XiaZhuye. Clinical Characteristics of Immunity Function in Patients with Nosocomial Infection in Intensive Care Unit. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(1): 22-25. doi: 10.7507/1671-6205.2016006 Copy

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4.	Kleppa E, Klinge KF, Galaphaththi-Arachchige HN, et al. Schistosoma haematobium infection and CD4⁺ T-Cell levels:a cross-sectional study of young South African women. PLoS One, 2015, 10:1-10.
5.	吳麗娟, 劉丁, 陳偉, 等.外周血T淋巴細胞免疫功能與醫院感染的關系.重慶醫學, 2006, 35:2124-2125.
6.	Monneret G, Lepape A, Venet F. Reversing ICU-acquired immunosuppression:an innovative biomarker-guided therapeutic strategy for decreasing sepsis mortality and nosocomial infection rate. Pathol Biol (Paris), 2011, 59:329-333.
7.	張麗娜, 吳鐵軍, 劉志軍.膿毒癥患者血中CD4⁺CD25⁺調節性T細胞水平檢測的臨床意義.中國呼吸與危重監護雜志, 2010, 9:416-418.
8.	Yin Y, Qin J, Dai Y, et al. The CD4+/CD8+ ratio in pulmonary tuberculosis:systematic and meta-analysis article. Iran J Public Health, 2015, 44:185-193.
9.	程明霞, 蔣坤, 蔡靜, 等.腦卒中患者免疫功能與醫院感染的調查分析.中華醫院感染學雜志, 2014, 8:1926-1927.
10.	李純, 林穎穎, 高暢, 等. CD4⁺T細胞在CD8⁺T細胞介導的排斥反應中的作用.中華醫學雜志, 2014, 34:2690-2694.

1. 王蔚, 周愚, 趙靈, 等.侵襲性肺曲霉菌感染診治進展.中國呼吸與危重監護雜志, 2011, 10:500-504.
2. Geginat J, Paroni M, Maglie S, et al. Plasticity of human CD4 T cell subsets. Front Immunol, 2014, 16:630-640.
3. Geffers C, Gastmeier P. Nosocomial infections and multidrug-resistant organisms in Germany:epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int, 2011, 108:87-93.
4. Kleppa E, Klinge KF, Galaphaththi-Arachchige HN, et al. Schistosoma haematobium infection and CD4⁺ T-Cell levels:a cross-sectional study of young South African women. PLoS One, 2015, 10:1-10.
5. 吳麗娟, 劉丁, 陳偉, 等.外周血T淋巴細胞免疫功能與醫院感染的關系.重慶醫學, 2006, 35:2124-2125.
6. Monneret G, Lepape A, Venet F. Reversing ICU-acquired immunosuppression:an innovative biomarker-guided therapeutic strategy for decreasing sepsis mortality and nosocomial infection rate. Pathol Biol (Paris), 2011, 59:329-333.
7. 張麗娜, 吳鐵軍, 劉志軍.膿毒癥患者血中CD4⁺CD25⁺調節性T細胞水平檢測的臨床意義.中國呼吸與危重監護雜志, 2010, 9:416-418.
8. Yin Y, Qin J, Dai Y, et al. The CD4+/CD8+ ratio in pulmonary tuberculosis:systematic and meta-analysis article. Iran J Public Health, 2015, 44:185-193.
9. 程明霞, 蔣坤, 蔡靜, 等.腦卒中患者免疫功能與醫院感染的調查分析.中華醫院感染學雜志, 2014, 8:1926-1927.
10. 李純, 林穎穎, 高暢, 等. CD4⁺T細胞在CD8⁺T細胞介導的排斥反應中的作用.中華醫學雜志, 2014, 34:2690-2694.

Chinese Journal of Respiratory and Critical Care Medicine

Clinical Characteristics of Immunity Function in Patients with Nosocomial Infection in Intensive Care Unit

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