SIRT1、SIRT3、SIRT6和SIRT7調控肺纖維化機制的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

康弟 ,  李洪波

濱州醫學院附屬醫院（第一臨床醫學院）呼吸與危重癥醫學科（山東濱州 256603）;

Corresponding?author：

李洪波, Email: lihongbo0516@sina.com

Keywords：

DOI：

10.7507/1671-6205.202308002

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Citation： 康弟, 李洪波. SIRT1、SIRT3、SIRT6和SIRT7調控肺纖維化機制的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(1): 64-68. doi: 10.7507/1671-6205.202308002 Copy

1.	Wu QJ, Zhang TN, Chen HH, et al. The sirtuin family in health and disease. Signal Transduct Target Ther, 2022, 7(1): 402.
2.	Lin QZ, Zuo WY, Liu YZ, et al. NAD⁺ and cardiovascular diseases. Clin Chim Acta, 2021, 515: 104-110.
3.	Mazumder S, Barman M, Bandyopadhyay U, et al. Sirtuins as endogenous regulators of lung fibrosis: a current perspective. Life Sci, 2020, 258: 118201.
4.	Moss BJ, Ryter SW, Rosas IO. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu Rev Pathol, 2022, 17: 515-546.
5.	Liang JR, Huang GL, Liu X, et al. The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis. J Clin Invest, 2022, 132(11): e157338.
6.	Cui ZF, Zhao XT, Amevor FK, et al. Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism. Front Immunol, 2022, 13: 943321.
7.	Xu C, Wang L, Fozouni P, et al. SIRT1 is downregulated by autophagy in senescence and ageing. Nat Cell Biol, 2020, 22(10): 1170-1179.
8.	Jiang H, Jiang YN, Xu YR, et al. Bronchial epithelial SIRT1 deficiency exacerbates cigarette smoke induced emphysema in mice through the FOXO3/PINK1 pathway. Exp Lung Res, 2022: 1-16.
9.	Brenmoehl J, Hoeflich A. Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion, 2013, 13(6): 755-761.
10.	Zhang Y, Huang W, Zheng Z, et al. Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. Free Radic Biol Med, 2021, 166: 116-127.
11.	Zhang Y, Li T, Pan M, et al. SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism. J Transl Med, 2022, 20(1): 222.
12.	Konikov-Rozenman J, Breuer R, Kaminski N, et al. CMH-small molecule docks into SIRT1, elicits human IPF-lung fibroblast cell death, inhibits Ku70-deacetylation, FLIP and experimental pulmonary fibrosis. Biomolecules, 2020, 10(7): 997.
13.	Han B, Li SY, Lv YY, et al. Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Food Funct, 2019, 10(9): 5555-5565.
14.	Foster PS, Tay HL, Oliver BG. Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis. J Clin Invest, 2022, 132(11): e160595.
15.	Zhou J, Chen H, Wang Q, et al. Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription. Aging Cell, 2022, 21(8): e13680.
16.	Qian WB, Cai XR, Qian QH. Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition. Aging (Albany NY), 2020, 12(5): 4322-4336.
17.	Xie T, Yuan J, Mei L, et al. Hyperoside ameliorates TNF-α-induced inflammation, ECM degradation and ER stress-mediated apoptosis via the SIRT1/NF-κB and Nrf2/ARE signaling pathways in vitro. Mol Med Rep, 2022, 26(2): 260.
18.	Saha P, Durugkar S, Jain S, et al. Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition by modulating the SIRT1/Nrf2 Axis. Int J Mol Sci, 2022, 23(23): 14722.
19.	Song XW, Cao WY, Wang ZX, et al. Nicotinamide n-oxide attenuates HSV-1-induced microglial inflammation through sirtuin-1/NF-κB signaling. Int J Mol Sci, 2022, 23(24): 16085.
20.	Chu HY, Jiang S, Liu QM, et al. Sirtuin1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes. Am J Respir Cell Mol Biol, 2018, 58(1): 28-39.
21.	Sosulski ML, Gongora R, Feghali-Bostwick C, et al. Sirtuin 3 deregulation promotes pulmonary fibrosis. J Gerontol A Biol Sci Med Sci, 2017, 72(5): 595-602.
22.	Jablonski RP, Kim SJ, Cheresh P, et al. SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis. FASEB J, 2017, 31(6): 2520-2532.
23.	Cheresh P, Kim SJ, Jablonski R, et al. SIRT3 overexpression ameliorates asbestos-induced pulmonary fibrosis, mt-DNA damage, and lung fibrogenic monocyte recruitment. Int J Mol Sci, 2021, 22(13): 6856.
24.	Bindu S, Pillai VB, Kanwal A, et al. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol, 2017, 312(1): L68-L78.
25.	Chang AR, Ferrer CM, Mostoslavsky R. SIRT6, a mammalian deacylase with multitasking abilities. Physiological reviews, 2020, 100(1): 145-169.
26.	Zhang Q, Tu W, Tian K, et al. Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts. J Cell Biochem, 2019, 120(1): 93-104.
27.	Takasaka N, Araya J, Hara H, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 2014, 192(3): 958-968.
28.	Tao ZJ, Jin ZH, Wu JB, et al. Sirtuin family in autoimmune diseases. Front Immunol, 2023, 14: 1186231.
29.	Zhang XY, Li W, Zhang JR, et al. Roles of sirtuin family members in chronic obstructive pulmonary disease. Respir Res, 2022, 23(1): 66.
30.	Wang XX, Wang XL, Tong MM, et al. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms. Basic Res Cardiol, 2016, 111(2): 13.
31.	Kratz EM, So?kiewicz K, Kubis-Kubiak A, et al. Sirtuins as important factors in pathological states and the role of their molecular activity modulators. Int J Mol Sci, 2021, 22(2): 630.
32.	33Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability. Trends Cell Biol, 2021, 31(12): 994-1006.
33.	Lagunas-Rangel FA. SIRT7 in the aging process. Cell Mol Life Sci, 2022, 79(6): 297.
34.	Wyman AE, Noor Z, Fishelevich R, et al. Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol, 2017, 312(6): L945-L958.
35.	Choudhury M, Yin X, Schaefbauer KJ, et al. SIRT7-mediated modulation of glutaminase 1 regulates TGF-β-induced pulmonary fibrosis. FASEB J, 2020, 34(7): 8920-8940.
36.	Wu ST, Jia SN. Functional diversity of SIRT7 across cellular compartments: insights and perspectives. Cell Biochem Biophys, 2023, 81(3): 409-419.
37.	Zhao XT, Zhang MM, Wang JH, et al. NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7. Free Radic Biol Med, 2022, 193(Pt 1): 342-353.
38.	Wyman AE, Nguyen TTT, Karki P, et al. SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells. Sci Rep, 2020, 10(1): 12497.
39.	Deskata K, Malli F, Jagirdar R, et al. Evaluation of sirtuin 1 levels in peripheral blood mononuclear cells of patients with idiopathic pulmonary fibrosis. Cureus, 2022, 14(10): e30862.
40.	Sharma A, Mahur P, Muthukumaran J, et al. Shedding light on structure, function and regulation of human sirtuins: a comprehensive review. 3 Biotech, 2023, 13(1): 29.

1. Wu QJ, Zhang TN, Chen HH, et al. The sirtuin family in health and disease. Signal Transduct Target Ther, 2022, 7(1): 402.
2. Lin QZ, Zuo WY, Liu YZ, et al. NAD⁺ and cardiovascular diseases. Clin Chim Acta, 2021, 515: 104-110.
3. Mazumder S, Barman M, Bandyopadhyay U, et al. Sirtuins as endogenous regulators of lung fibrosis: a current perspective. Life Sci, 2020, 258: 118201.
4. Moss BJ, Ryter SW, Rosas IO. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu Rev Pathol, 2022, 17: 515-546.
5. Liang JR, Huang GL, Liu X, et al. The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis. J Clin Invest, 2022, 132(11): e157338.
6. Cui ZF, Zhao XT, Amevor FK, et al. Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism. Front Immunol, 2022, 13: 943321.
7. Xu C, Wang L, Fozouni P, et al. SIRT1 is downregulated by autophagy in senescence and ageing. Nat Cell Biol, 2020, 22(10): 1170-1179.
8. Jiang H, Jiang YN, Xu YR, et al. Bronchial epithelial SIRT1 deficiency exacerbates cigarette smoke induced emphysema in mice through the FOXO3/PINK1 pathway. Exp Lung Res, 2022: 1-16.
9. Brenmoehl J, Hoeflich A. Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion, 2013, 13(6): 755-761.
10. Zhang Y, Huang W, Zheng Z, et al. Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. Free Radic Biol Med, 2021, 166: 116-127.
11. Zhang Y, Li T, Pan M, et al. SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism. J Transl Med, 2022, 20(1): 222.
12. Konikov-Rozenman J, Breuer R, Kaminski N, et al. CMH-small molecule docks into SIRT1, elicits human IPF-lung fibroblast cell death, inhibits Ku70-deacetylation, FLIP and experimental pulmonary fibrosis. Biomolecules, 2020, 10(7): 997.
13. Han B, Li SY, Lv YY, et al. Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Food Funct, 2019, 10(9): 5555-5565.
14. Foster PS, Tay HL, Oliver BG. Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis. J Clin Invest, 2022, 132(11): e160595.
15. Zhou J, Chen H, Wang Q, et al. Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription. Aging Cell, 2022, 21(8): e13680.
16. Qian WB, Cai XR, Qian QH. Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition. Aging (Albany NY), 2020, 12(5): 4322-4336.
17. Xie T, Yuan J, Mei L, et al. Hyperoside ameliorates TNF-α-induced inflammation, ECM degradation and ER stress-mediated apoptosis via the SIRT1/NF-κB and Nrf2/ARE signaling pathways in vitro. Mol Med Rep, 2022, 26(2): 260.
18. Saha P, Durugkar S, Jain S, et al. Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition by modulating the SIRT1/Nrf2 Axis. Int J Mol Sci, 2022, 23(23): 14722.
19. Song XW, Cao WY, Wang ZX, et al. Nicotinamide n-oxide attenuates HSV-1-induced microglial inflammation through sirtuin-1/NF-κB signaling. Int J Mol Sci, 2022, 23(24): 16085.
20. Chu HY, Jiang S, Liu QM, et al. Sirtuin1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes. Am J Respir Cell Mol Biol, 2018, 58(1): 28-39.
21. Sosulski ML, Gongora R, Feghali-Bostwick C, et al. Sirtuin 3 deregulation promotes pulmonary fibrosis. J Gerontol A Biol Sci Med Sci, 2017, 72(5): 595-602.
22. Jablonski RP, Kim SJ, Cheresh P, et al. SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis. FASEB J, 2017, 31(6): 2520-2532.
23. Cheresh P, Kim SJ, Jablonski R, et al. SIRT3 overexpression ameliorates asbestos-induced pulmonary fibrosis, mt-DNA damage, and lung fibrogenic monocyte recruitment. Int J Mol Sci, 2021, 22(13): 6856.
24. Bindu S, Pillai VB, Kanwal A, et al. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol, 2017, 312(1): L68-L78.
25. Chang AR, Ferrer CM, Mostoslavsky R. SIRT6, a mammalian deacylase with multitasking abilities. Physiological reviews, 2020, 100(1): 145-169.
26. Zhang Q, Tu W, Tian K, et al. Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts. J Cell Biochem, 2019, 120(1): 93-104.
27. Takasaka N, Araya J, Hara H, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 2014, 192(3): 958-968.
28. Tao ZJ, Jin ZH, Wu JB, et al. Sirtuin family in autoimmune diseases. Front Immunol, 2023, 14: 1186231.
29. Zhang XY, Li W, Zhang JR, et al. Roles of sirtuin family members in chronic obstructive pulmonary disease. Respir Res, 2022, 23(1): 66.
30. Wang XX, Wang XL, Tong MM, et al. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms. Basic Res Cardiol, 2016, 111(2): 13.
31. Kratz EM, So?kiewicz K, Kubis-Kubiak A, et al. Sirtuins as important factors in pathological states and the role of their molecular activity modulators. Int J Mol Sci, 2021, 22(2): 630.
32. 33Korotkov A, Seluanov A, Gorbunova V. Sirtuin 6: linking longevity with genome and epigenome stability. Trends Cell Biol, 2021, 31(12): 994-1006.
33. Lagunas-Rangel FA. SIRT7 in the aging process. Cell Mol Life Sci, 2022, 79(6): 297.
34. Wyman AE, Noor Z, Fishelevich R, et al. Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol, 2017, 312(6): L945-L958.
35. Choudhury M, Yin X, Schaefbauer KJ, et al. SIRT7-mediated modulation of glutaminase 1 regulates TGF-β-induced pulmonary fibrosis. FASEB J, 2020, 34(7): 8920-8940.
36. Wu ST, Jia SN. Functional diversity of SIRT7 across cellular compartments: insights and perspectives. Cell Biochem Biophys, 2023, 81(3): 409-419.
37. Zhao XT, Zhang MM, Wang JH, et al. NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7. Free Radic Biol Med, 2022, 193(Pt 1): 342-353.
38. Wyman AE, Nguyen TTT, Karki P, et al. SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells. Sci Rep, 2020, 10(1): 12497.
39. Deskata K, Malli F, Jagirdar R, et al. Evaluation of sirtuin 1 levels in peripheral blood mononuclear cells of patients with idiopathic pulmonary fibrosis. Cureus, 2022, 14(10): e30862.
40. Sharma A, Mahur P, Muthukumaran J, et al. Shedding light on structure, function and regulation of human sirtuins: a comprehensive review. 3 Biotech, 2023, 13(1): 29.

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Chinese Journal of Respiratory and Critical Care Medicine

SIRT1、SIRT3、SIRT6和SIRT7調控肺纖維化機制的研究進展

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