Prevalence of cognitive impairment in patients with chronic obstructive pulmonary disease: a meta-analysis_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Jieyun ¹ , HE Cuiying ² , LU Zhao ¹ , YE Changguang ³ , CAI Zhaoqiang ³ , HUANG Chunli ¹ , PAN Dongzan ¹ ,  SHEN Yin ¹

1. International Medical Services, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R.China;
2. Guangxi Medical University, Nanning, Guangxi 530007, P.R. China;
3. Department of Respiratory and Critical Care Medicine, HePu People's Hospital, Hepu, Guangxi 536100, P.R. China;

Corresponding?author：

SHEN Yin, Email: sy_doctor@sina.cn

Keywords：

Chronic obstructive pulmonary disease; Cognitive impairment; Prevalence; Meta-analysis

DOI：

10.7507/1671-6205.202309064

Video：

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Objective To systematically analyze the prevalence of cognitive impairment in patients with COPD.Methods An electronic search in PubMed, Embase, CNKI, WanFang Data and VIP databases to identify studies describing the prevalence of cognitive impairment in patients with COPD from inception to 3 May 2023. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, the meta-analysis was performed by using Stata16.0 software. Results A total of 40 studies involving 9, 988 patients with COPD were included. Meta-analysis showed that the total prevalence of cognitive impairment in patients with COPD was 48.26% (95%CI 42.39% to 54.20%). The results of subgroup analysis revealed that the prevalence of cognitive impairment in patients with acute exacerbation of COPD was higher than that in patients with stable-phase (58.62% vs. 49.71%). The prevalence of cognitive impairment in COPD patients was 29.07% before 2015, while the prevalence between 2015-2019 and 2020-2023 were higher, with rates of 53.06% and 48.26% respectively. The prevalence of cognitive impairment in domestic COPD patients was significantly higher than that in foreign patients (52.66% vs. 37.06%). Conclusion The prevalence of cognitive impairment is relatively high in COPD patients, highlighting the need to strengthen the screening for cognitive impairment in COPD patients and provide early assessment and intervention.

Citation： ZHU Jieyun, HE Cuiying, LU Zhao, YE Changguang, CAI Zhaoqiang, HUANG Chunli, PAN Dongzan, SHEN Yin. Prevalence of cognitive impairment in patients with chronic obstructive pulmonary disease: a meta-analysis. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(9): 625-633. doi: 10.7507/1671-6205.202309064 Copy

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26.	張改明. 老年COPD患者認知功能水平及其與血漿S-100β和Hcy的相關性研究. 繼續醫學教育, 2019, 33(09): 101-103.
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1. 常瀟丹, 黃丹輝, 蔡紹曦. 慢性阻塞性肺疾病合并癥——認知障礙. 中國臨床新醫學, 2021, 14(4): 333-339.
2. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. https: //goldcopd. org/2021-gold-reports.
3. 羅晨陽, 何志義. 慢性阻塞性肺疾病與合并癥. 結核與肺部疾病雜志, 2023, 4(05): 407-412.
4. Chang SS, Chen S, McAvay GJ, et al. Effect of coexisting chronic obstructive pulmonary disease and cognitive impairment on health outcomes in older adults. J Am Geriatr Soc. 2012, 60(10): 1839-1846.
5. 高志欣, 贠相華, 王宏艷. 慢性阻塞性肺疾病急性加重期患者認知障礙臨床分析. 齊齊哈爾醫學院學報, 2016, 37(9): 1145-1147.
6. 方蒡, 牛華, 張芹, 等. 老年慢性阻塞性肺疾病患者認知變化及影響因素分析. 中國社區醫師, 2017, 33(9): 71-72.
7. 王蘭, 江蓮, 唐良法, 等. 慢性阻塞性肺疾病患者急性加重期認知功能障礙相關因素分析. 中華老年醫學雜志, 2015, 34(4): 391-393.
8. Yohannes AM, Chen W, Moga AM, et al. Cognitive Impairment in Chronic Obstructive Pulmonary Disease and Chronic Heart Failure: A Systematic Review and Meta-analysis of Observational Studies. J Am Med Dir Assoc, 2017, 18(5): 451.e1-451. e1-451.
9. 朱曉穎, 劉聰輝, 戈艷蕾, 等. 慢性阻塞性肺疾病患者血清8-羥基脫氧鳥苷酸、內皮素-1水平與認知功能障礙的相關性. 中國呼吸與危重監護雜志, 2019, 18(1): 10-14.
10. 苗玲, 王敏, 秦景云, 等. 血清同型半胱氨酸和半胱氨酸天冬酶-3水平與慢性阻塞性肺疾病患者認知障礙的關系研究. 實用心腦肺血管病雜志, 2020, 28(02): 53-57.
11. 蔣澤文, 鐘金, 劉賢文, 等. 血清25(OH)D、SAA、Hcy水平對慢性阻塞性肺疾病患者認知障礙的診斷價值. 檢驗醫學與臨床, 2022, 19(18): 2463-2466.
12. 曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四: 觀察性研究的質量評價工具. 中國循證心血管醫學雜志. 2012, 4 (4): 297-299.
13. 何勝東, 楊樹棟, 文禮, 等. 6MWD與慢性阻塞性肺疾病患者認知功能受損相關性研究. 國際呼吸雜志, 2020, 40(23): 1791-1795.
14. 于冰, 孫艷華. 慢性阻塞性肺疾病患者血漿NGAL、ET-1水平變化及其與認知功能障礙的關系. 山東醫藥, 2018, 58(25): 78-80.
15. 沙正凱, 蔣燕升, 張祥杰, 等. 慢性阻塞性肺疾病急性加重期伴發認知功能障礙的影響因素. 臨床心身疾病雜志, 2019, 25(5): 101-104.
16. 裴嘉宇. 慢性阻塞性肺疾病患者輕度認知障礙風險預警模型的構建.山西醫科大學, 2021.
17. 孫志峰, 馮麗芳, 李雪, 等. 老年慢性阻塞性肺疾病患者認知功能障礙調查. 中國醫藥導報, 2013, 10(08): 130-131.
18. 高寶銀. 穩定期慢性阻塞性肺疾病患者認知功能相關因素研究. 河北醫學, 2015, 21(06): 887-891.
19. 李艷. 老年慢性阻塞性肺疾病患者的認知功能評價及其相關影響因素分析. 延安大學, 2017.
20. 葛潔明, 岳淑玲, 賈紅光, 等. 慢性阻塞性肺疾病患者認知功能狀況及影響因素分析. 中國病案, 2017, 18(10): 105-109.
21. 韓英明, 尚祥. 慢性阻塞性肺疾病患者認知功能障礙危險因素調查. 中國鄉村醫藥, 2018, 25(8): 16-17.
22. 劉亞男. 慢性阻塞性肺疾病患者認知功能狀況及影響因素研究. 湖南師范大學, 2018.
23. 劉聰輝, 戈艷蕾, 李真真, 等. 血清IL-17、HCY水平對COPD患者認知功能損傷的診斷效能. 中國老年學雜志, 2019, 39(8): 1866-1868.
24. 閆俊毅. 同型半胱氨酸與COPD患者輕度認知功能障礙的相關性研究. 青海大學, 2019.
25. 馬肖龍, 朱曉東, 戴利菊, 等. 慢性阻塞性肺疾病患者認知功能障礙與維生素D的關系研究. 中國現代醫生, 2019, 57(19): 13-17.
26. 張改明. 老年COPD患者認知功能水平及其與血漿S-100β和Hcy的相關性研究. 繼續醫學教育, 2019, 33(09): 101-103.
27. 胡先緯, 涂友慧, 祝清清, 等. 慢性阻塞性肺疾病病患的認知功能探討. 臨床肺科雜志, 2020, 25(04): 505-509.
28. 王文靜. 慢性阻塞性肺疾病患者認知功能障礙及腦功能改變的研究. 南昌大學, 2020.
29. 謝星, 徐翠容, 賈坤林. COPD患者血清HIF-1α、caspase-3、Hcy水平與認知功能損傷關系. 醫學信息, 2021, 34(12): 97-100.
30. 牛麗紅, 張曉黎, 王曉娜. 慢性阻塞性肺疾病穩定期患者認知功能障礙影響因素. 臨床心身疾病雜志, 2021, 27(5): 63-66.
31. 員新昊. 慢性阻塞性肺疾病穩定期患者的病情嚴重程度與認知功能關系的研究. 承德醫學院, 2022.
32. 陳柏茹, 陳貴華, 李琴. COPD患者認知功能障礙影響因素模型研究. 現代醫藥衛生, 2022, 38(10): 1639-1644.
33. 曹瑞蓮, 侯會娜. 慢性阻塞性肺疾病患者認知功能調查及影響因素. 中國衛生工程學, 2021, 20(2): 242-243.
34. Incalzil RA, Bellia V, Maggi S, et al. Salute Respiratoria nell’ Anziano Study Group. Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction. Aging Clin Exp Res, 2002, 14: 395e401.
35. Antonelli-Incalzi R, Corsonello A, Pedone C, et al. Drawing impairment predicts mortality in severe COPD. Chest, 2006, 130(6): 1687-1694.
36. Singh B, Parsaik AK, Mielke MM, et al. Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging. Mayo Clin Proc, 2013, 88(11): 1222-1230.
37. Dal Negro RW, Bonadiman L, Tognella S, et al. Extent and prevalence of cognitive dysfunction in chronic obstructive pulmonary disease, chronic non-obstructive bronchitis, and in asymptomatic smokers, compared to normal reference values. Int J Chron Obstruct Pulmon Dis, 2014, 9: 675-683.
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Chinese Journal of Respiratory and Critical Care Medicine

Prevalence of cognitive impairment in patients with chronic obstructive pulmonary disease: a meta-analysis

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