Clinical Effectiveness and Safety of Carvedilol for Arrhythmia in Patients with Hypertension Complicated with Diabetes Mellitus: A Randomized Controlled Trial_Chinese Journal of Evidence-Based Medicine

Authors：

 LIJing ¹ , ZHUBao-yue ¹ , LIYing ² , ZHANGJian-jun ¹ , WANGWei-zhan ¹

1. Emergency Intensive Care Unit, Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui 053000, China;
2. Hengshui Second Hospital, Hengshui 053000, China;

Corresponding?author：

Keywords：

Carvedilol; Hypertension; Diabetes Mellitus; Arrhythmia; Randomized controlled trial

DOI：

10.7507/1672-2531.20140026

Video：

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Objective To investigate the clinical efficacy and safety of carvedilol in the treatment of arrhythmia in patients with hypertension complicated with diabetes mellitus. Methods We selected the patients with hypertension complicated with diabetes mellitus who were hospitalized in the Harrison International Peace Hospital Affiliated to Hebei Medical University for treatment from Oct. 2011 to Oct. 2013. The cases were divided into a trial group and a control group. The control group was given routine treatment (eg., hypoglycaemic drugs, angiotensin converting enzyme inhibitors). On the basis of the same treatment of the control group, the trial group was given carvedilol. The efficacy and adverse reaction were observed, recorded and then analyzed between the two groups. Results A total of 140 patients were included (70 cases in each group). With the loss of 10 cases in the control group, the data of 70 cases in the trial group and 60 cases in the control group were finally analyzed. The results showed that the trial group was superior to the control group in the total effectiveness (χ²=8.320, P=0.004) and the dynamic ECG improvement of premature ventricular contraction (χ²=5.333, P=0.014) with significant differences. Both groups were significantly improved in blood pressure and heart beats compared with the situation before treatment (Both P < 0.05), and the trial group was better than the control group with a significant difference. During the treatment, three cases in the trial group had mild gastrointestinal symptoms which spontaneously disappeared later. Conclusion The clinical effectiveness of carvedilol for arrhythmia in patients with hypertension complicated with diabetes mellitus is significant. It is safe and effective which is recommended in clinical application.

Citation： LIJing, ZHUBao-yue, LIYing, ZHANGJian-jun, WANGWei-zhan. Clinical Effectiveness and Safety of Carvedilol for Arrhythmia in Patients with Hypertension Complicated with Diabetes Mellitus: A Randomized Controlled Trial. Chinese Journal of Evidence-Based Medicine, 2014, 14(2): 152-155. doi: 10.7507/1672-2531.20140026 Copy

1.	王龍, 張鉦, 彭瑜.原發性高血壓合并2型糖尿病患者的心律失常.中華高血壓雜志, 2008, 3(16):220-224.
2.	Greenberg JD, Tiwari A, Raian M, et al. Determinants of sustained uncontrolled blood pressure in a national cohort of persons with diabetes. Am J Hypertens, 2006, 19(2):161-169.
3.	樓建英. 2型糖尿病合并高血壓診斷治療新視野.實用老年醫學, 2013, 4(27):272-276.
4.	任古松, 張春霞.卡維地洛治療老年慢性充血性心衰合并快速型心律失常60例療效觀察.山東醫藥, 2013, 25(53):103-104.
5.	中國高血壓防治指南修訂委員會.中國高血壓防治指南2010.中華高血壓雜志, 2011, 8(19):701-743.
6.	中華醫學會糖尿病學分會.中國2型糖尿病防治指南(2010年版).中國糖尿病雜志, 2012, 1(20):1-37.
7.	于賽華, 于金華.參松養心膠囊聯合美托洛爾治療女性更年期室性早搏的臨床研究.中西醫結合心腦血管病雜志, 2013, 11(2):163-164.
8.	劉國仗, 吳寧, 胡大一, 等.心血管藥物治療臨床試驗評價方法的建議.中華心血管病雜志, 1998, 26(1):405-413.
9.	賈淑杰, 周蕓, 楊紅霞, 等.高血壓合并冠心病患者的冠脈病變特點.中國循證醫學雜志, 2011, 11(6):640-643.
10.	Varugbese GI, Tahrani AA, Scarpello JH. The putative link between glycemic control and cardiac arrhythmias. Arch Intern Med, 2007, 167(13):1433-1434.
11.	彭朝勝, 曹悅鞍, 張文洛, 等.老年2型糖尿病患者血糖波動與室性心律失常的關系.中國老年學雜志, 2011, 4(31):1423-1424.
12.	丁軍, 慈書平. 258例老年糖尿病與心律失常關系的臨床觀察.實用老年醫學, 2010, 10(24):424-425.
13.	張中亞, 於席芳, 劉鮮梅, 等.糖尿病家兔的心室電重構與心律失常的關系.臨床心血管病雜志, 2013, 29(6):475-478.
14.	田芳, 畢會民, 朱駿科, 等. 2型糖尿病患者心律失常及相關因素分析.臨床心血管病雜志, 2010, 10(26):726-729.
15.	劉青青, 陳瑤, 肖雨婷.卡維地洛和美托洛爾治療高血壓的療效及其糖脂代謝影響的對比分析.中國老年學雜志, 2013, 3(16):1035-1037.
16.	胡小亮, 路方紅, 劉振東, 等.降壓降脂聯合治療對老年高血壓患者動脈僵硬度的影響.中國循證醫學雜志, 2011, 11(9):1008-1011.
17.	袁華兵, 齊曉勇, 等.卡維地洛對急性心肌梗死家兔室性心律失常的影響.中國老年學雜志, 2011, 4(31):1172-1174.
18.	任古松, 張春霞.卡維地洛治療老年慢性充血性心衰合并快速型心律失常60例療效觀察.山東醫藥, 2013, 25(53):103-104.
19.	高昕.卡維地洛與比索洛爾治療慢性心力衰竭患者的療效及安全性對比分析.陜西醫學雜志, 2013, 8(42):1061-1063.

1. 王龍, 張鉦, 彭瑜.原發性高血壓合并2型糖尿病患者的心律失常.中華高血壓雜志, 2008, 3(16):220-224.
2. Greenberg JD, Tiwari A, Raian M, et al. Determinants of sustained uncontrolled blood pressure in a national cohort of persons with diabetes. Am J Hypertens, 2006, 19(2):161-169.
3. 樓建英. 2型糖尿病合并高血壓診斷治療新視野.實用老年醫學, 2013, 4(27):272-276.
4. 任古松, 張春霞.卡維地洛治療老年慢性充血性心衰合并快速型心律失常60例療效觀察.山東醫藥, 2013, 25(53):103-104.
5. 中國高血壓防治指南修訂委員會.中國高血壓防治指南2010.中華高血壓雜志, 2011, 8(19):701-743.
6. 中華醫學會糖尿病學分會.中國2型糖尿病防治指南(2010年版).中國糖尿病雜志, 2012, 1(20):1-37.
7. 于賽華, 于金華.參松養心膠囊聯合美托洛爾治療女性更年期室性早搏的臨床研究.中西醫結合心腦血管病雜志, 2013, 11(2):163-164.
8. 劉國仗, 吳寧, 胡大一, 等.心血管藥物治療臨床試驗評價方法的建議.中華心血管病雜志, 1998, 26(1):405-413.
9. 賈淑杰, 周蕓, 楊紅霞, 等.高血壓合并冠心病患者的冠脈病變特點.中國循證醫學雜志, 2011, 11(6):640-643.
10. Varugbese GI, Tahrani AA, Scarpello JH. The putative link between glycemic control and cardiac arrhythmias. Arch Intern Med, 2007, 167(13):1433-1434.
11. 彭朝勝, 曹悅鞍, 張文洛, 等.老年2型糖尿病患者血糖波動與室性心律失常的關系.中國老年學雜志, 2011, 4(31):1423-1424.
12. 丁軍, 慈書平. 258例老年糖尿病與心律失常關系的臨床觀察.實用老年醫學, 2010, 10(24):424-425.
13. 張中亞, 於席芳, 劉鮮梅, 等.糖尿病家兔的心室電重構與心律失常的關系.臨床心血管病雜志, 2013, 29(6):475-478.
14. 田芳, 畢會民, 朱駿科, 等. 2型糖尿病患者心律失常及相關因素分析.臨床心血管病雜志, 2010, 10(26):726-729.
15. 劉青青, 陳瑤, 肖雨婷.卡維地洛和美托洛爾治療高血壓的療效及其糖脂代謝影響的對比分析.中國老年學雜志, 2013, 3(16):1035-1037.
16. 胡小亮, 路方紅, 劉振東, 等.降壓降脂聯合治療對老年高血壓患者動脈僵硬度的影響.中國循證醫學雜志, 2011, 11(9):1008-1011.
17. 袁華兵, 齊曉勇, 等.卡維地洛對急性心肌梗死家兔室性心律失常的影響.中國老年學雜志, 2011, 4(31):1172-1174.
18. 任古松, 張春霞.卡維地洛治療老年慢性充血性心衰合并快速型心律失常60例療效觀察.山東醫藥, 2013, 25(53):103-104.
19. 高昕.卡維地洛與比索洛爾治療慢性心力衰竭患者的療效及安全性對比分析.陜西醫學雜志, 2013, 8(42):1061-1063.

Chinese Journal of Evidence-Based Medicine

Clinical Effectiveness and Safety of Carvedilol for Arrhythmia in Patients with Hypertension Complicated with Diabetes Mellitus: A Randomized Controlled Trial

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