Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study_Chinese Journal of Evidence-Based Medicine

Authors：

 QINKen ¹ , TANGGuo-hua ¹ , LILi ¹ , ZHANGFan ¹ , WUQin-qin ¹ , YANGYing ¹ , HUANGYan ¹ , LIAOXiao-yang ²

1. Department of Health Management Center, West China Hospital of Sichuan University, Chengdu 610041, China;
2. Department of General Medical Center, West China Hospital of Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

Hypothyroidism; Subclinical; Metabolic syndrome; Prevalence; Cross-sectional survey

DOI：

10.7507/1672-2531.20140070

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Objective To investigate the prevalence of subclinical hypothyroidism (SCH) in health check-up population of West China Hospital of Sichuan University from 2011 to 2012 and to discuss the relationship between SCH and metabolic syndrome (MS). Methods Those who received thyroid function tests and health examination in the West China Hospital of Sichuan University from 2011 to 2012 were enrolled in the study. The data of medical history, blood pressure, height, weight, thyroid function, TG, HDL-C, FPG were collected. All data were analyzed by SPSS 18.0 software. Results A total of 11 976 persons (7 488 male and 4 488 female) received thyroid function tests. There were 1 820 persons (884 males and 936 females, 15.20%) who suffered from SCH. The SCH prevalence was significantly higher in females (20.86%) than that in males (11.81%) (P < 0.01). The people over 60 years old had the highest SCH prevalence. There were 1 145 persons (1 005 males and 140 females) suffered from MS among all 11 976 persons. The MS prevalence was significantly higher in males (13.42%) than that in females (3.12%) (P < 0.01). The SCH prevalence of the MS group was higher, which in the health group was lower (P < 0.01). The TSH level in the MS group was higher, while it was lower in the health group. Conclusion The prevalence of SCH is higher in health check-up population; and SCH apparently increases the risk of morbidity of MS.

Citation： QINKen, TANGGuo-hua, LILi, ZHANGFan, WUQin-qin, YANGYing, HUANGYan, LIAOXiao-yang. Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(4): 404-407. doi: 10.7507/1672-2531.20140070 Copy

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2.	Beyhan Z, Ertrk K, Ukaya G, et al.Restoration of euthyroidism does not improve cardiovascular risk factors in patients with subclinical hypothyroidism in the short term.J Endocrinal Invest, 2006, 29(6):505-510.
3.	Owen PJ, Lazarus JH.Subclinical hypothyroidism:the case for treatment.Trends Endocrinol Metab, 2003, 14(2):257-261.
4.	Duntas LH, Wartofsky L.Cardiovascular risk and subclinical hypothyroidism:focus on lipids and new emerging risk factors.What is the evidence?Thyroid, 2007, 17(11):1075-1084.
5.	中華醫學會糖尿病學分會代謝綜合征研究協作組.中華醫學會糖尿病學分會關于代謝綜合征的建議.中華糖尿病雜志, 2004, 12(3):156-161.
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7.	滕衛平.開展亞臨床甲狀腺功能減退癥的臨床研究.中華內分泌代謝雜志, 2004, 20(2):93-95.
8.	王佳妮, 單忠艷, 滕衛平, 等.血清促甲狀腺激素與代謝綜合征及其組分的相關關系研究.中國實用內科雜志, 2010, 30(6):534-536.
9.	Roos A, Bakker SJ, Links TP, et al.Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects.J Clin Endocrinol Metab, 2007, 92(2):491-496.
10.	Duntas LH.Thyroid disease and lipids.Thyroid, 2002, 12(2):287-293.
11.	Walsh JP, Bremner AP, Bulsara MK, et al.Thyroid dysfunction and serum lipids:a community-based study.Clin Endocrinol (Oxf), 2005, 63(6):670-675.
12.	王微波, 金迎, 滕衛平.不同碘攝入量地區正常人群血清TSH水平的流行病學對比研究.中華內分泌代謝雜志, 2002, 18(3):355-356.
13.	Bandyopadhyay SK, Basu AK, Pal SK, et al.A study on dyslipidaemia in subclinical hypothyroidism.J Indian Med Assoc, 2006, 104(11):622-626.
14.	Saravanan P, Dayan CM.Thyroid autoantibodies.Endocrinnol Metab North Am, 2001, 30(3):315-338.
15.	Milionis HJ, Efstathiadou Z, Tselepis AD, et al.Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism:effect of treatment with levothyroxine.Thyroid, 2003, 13(3):365-369.
16.	Duggal J, Singh S, Barsano CP, et al.Cardiovascular risk with subclinical hyperthyroidism and hypothyroidism:pathophysiology and management.J Cardiometab Syndr, 2007, 2(3):198-206.
17.	Prisant LM, Gujral JS, Mulloy AL.Hyperthyroidism:a secondary cause of isolated systolic hypertension.J Clin Hypertens, 2006, 8(3):596-599.
18.	蔡云飛, 時景璞.亞臨床甲狀腺功能減退與收縮壓水平的關系.中華流行病學雜志, 2011, 32(1):55-59.
19.	Velkoska NV, Krstevska B, Bosevski M, et al.Dyslipidaemia and hypertension in patients with subclinical hypothyroidism.Prilozi, 2009, 30(2):93-102.
20.	Luboshitzky R, Aviv A, Herer P, et al.Risk factors for cardiovascular disease in women with subclinical hypothyroidism.Thyroid, 2002, 12(5):421-425.
21.	Ferreira MM, Teixeira PF, Mansur VA, et al.Ambulatory blood pressure monitoring in normotensive patients with subclinical hypothyroidism.Arq Bras Cardiol, 2010, 94(6):806-812.
22.	Waterhouse DF, Walsh CD, Sheehan F, et al.An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters:a study in healthy women.Thyroid, 2007, 17(3):243-248.
23.	VondraK, Vrbikova J, Dvorakova K.Thyroid gland disease in adult patients with diabetes mellitus.Minerva Endocrinol, 2005, 30(4):217.
24.	Chen H, Wu T, Jap T, et al.Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients.Diabetic Med, 2007, 24(12):1336-1344.
25.	劉建英, 章燕, 陳國蘭, 等.亞臨床甲狀腺功能減退與代謝綜合征和糖尿病的相關性研究進展.臨床薈萃, 2010, 25(5):449-451.

1. Surks MI, OrtizE, Daniels GH, et al.Subclinical thyroid disease:scientific review and guide lines for diagnosis and management.JAMA, 2004, 291(2):228-238.
2. Beyhan Z, Ertrk K, Ukaya G, et al.Restoration of euthyroidism does not improve cardiovascular risk factors in patients with subclinical hypothyroidism in the short term.J Endocrinal Invest, 2006, 29(6):505-510.
3. Owen PJ, Lazarus JH.Subclinical hypothyroidism:the case for treatment.Trends Endocrinol Metab, 2003, 14(2):257-261.
4. Duntas LH, Wartofsky L.Cardiovascular risk and subclinical hypothyroidism:focus on lipids and new emerging risk factors.What is the evidence?Thyroid, 2007, 17(11):1075-1084.
5. 中華醫學會糖尿病學分會代謝綜合征研究協作組.中華醫學會糖尿病學分會關于代謝綜合征的建議.中華糖尿病雜志, 2004, 12(3):156-161.
6. 史軼繁.協和內分泌和代謝學.第2版.科學出版社, 2000:1012.
7. 滕衛平.開展亞臨床甲狀腺功能減退癥的臨床研究.中華內分泌代謝雜志, 2004, 20(2):93-95.
8. 王佳妮, 單忠艷, 滕衛平, 等.血清促甲狀腺激素與代謝綜合征及其組分的相關關系研究.中國實用內科雜志, 2010, 30(6):534-536.
9. Roos A, Bakker SJ, Links TP, et al.Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects.J Clin Endocrinol Metab, 2007, 92(2):491-496.
10. Duntas LH.Thyroid disease and lipids.Thyroid, 2002, 12(2):287-293.
11. Walsh JP, Bremner AP, Bulsara MK, et al.Thyroid dysfunction and serum lipids:a community-based study.Clin Endocrinol (Oxf), 2005, 63(6):670-675.
12. 王微波, 金迎, 滕衛平.不同碘攝入量地區正常人群血清TSH水平的流行病學對比研究.中華內分泌代謝雜志, 2002, 18(3):355-356.
13. Bandyopadhyay SK, Basu AK, Pal SK, et al.A study on dyslipidaemia in subclinical hypothyroidism.J Indian Med Assoc, 2006, 104(11):622-626.
14. Saravanan P, Dayan CM.Thyroid autoantibodies.Endocrinnol Metab North Am, 2001, 30(3):315-338.
15. Milionis HJ, Efstathiadou Z, Tselepis AD, et al.Lipoprotein (a) levels and apolipoprotein (a) isoform size in patients with subclinical hypothyroidism:effect of treatment with levothyroxine.Thyroid, 2003, 13(3):365-369.
16. Duggal J, Singh S, Barsano CP, et al.Cardiovascular risk with subclinical hyperthyroidism and hypothyroidism:pathophysiology and management.J Cardiometab Syndr, 2007, 2(3):198-206.
17. Prisant LM, Gujral JS, Mulloy AL.Hyperthyroidism:a secondary cause of isolated systolic hypertension.J Clin Hypertens, 2006, 8(3):596-599.
18. 蔡云飛, 時景璞.亞臨床甲狀腺功能減退與收縮壓水平的關系.中華流行病學雜志, 2011, 32(1):55-59.
19. Velkoska NV, Krstevska B, Bosevski M, et al.Dyslipidaemia and hypertension in patients with subclinical hypothyroidism.Prilozi, 2009, 30(2):93-102.
20. Luboshitzky R, Aviv A, Herer P, et al.Risk factors for cardiovascular disease in women with subclinical hypothyroidism.Thyroid, 2002, 12(5):421-425.
21. Ferreira MM, Teixeira PF, Mansur VA, et al.Ambulatory blood pressure monitoring in normotensive patients with subclinical hypothyroidism.Arq Bras Cardiol, 2010, 94(6):806-812.
22. Waterhouse DF, Walsh CD, Sheehan F, et al.An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters:a study in healthy women.Thyroid, 2007, 17(3):243-248.
23. VondraK, Vrbikova J, Dvorakova K.Thyroid gland disease in adult patients with diabetes mellitus.Minerva Endocrinol, 2005, 30(4):217.
24. Chen H, Wu T, Jap T, et al.Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients.Diabetic Med, 2007, 24(12):1336-1344.
25. 劉建英, 章燕, 陳國蘭, 等.亞臨床甲狀腺功能減退與代謝綜合征和糖尿病的相關性研究進展.臨床薈萃, 2010, 25(5):449-451.

Chinese Journal of Evidence-Based Medicine

Subclinical Hypothyroidism of Health Check-up Population of West China Hospital, Sichuan University: A Cross-sectional Study

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