Risk Factors of Early Onset Coronary Heart Disease in Tibetan Residents: A Cross-sectional Study_Chinese Journal of Evidence-Based Medicine

Authors：

 LIHong-wei ¹ , ZHOUYao ¹ , WANGHai-yan ¹ , YANGShu-juan ²

1. Department of Cardiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu 610041, China;
2. Education & Research Department of Child and Adolescent, West China School of Public Health, Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

Tibetan; Early onset coronary heart disease; Risk factor; Cross-sectional study

DOI：

10.7507/1672-2531.20140111

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore and discuss the risk factors of early onset coronary heart disease in Tibetan residents. Methods We selected Tibetan residents with coronary heart disease who were hospitalized in the Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region between January 2011 and May 2013, and then divided them into two groups by age (early onset and late onset coronary heart disease groups). Univariate analysis was performed between two groups by gender, family history, smoking, drinking, hypertension, diabetes, levels of blood lipid, respectively. The factors with significant differences were extracted for logistic regression. Data analysis was performed using SPSS 16.0 software. Results A total of 64 Tibetan residents with coronary heart disease were included, of which, 22 cases were in the early onset groups and 42 cases the late onset group. The results of univariate analysis showed that, significant differences were found in gender, family history, and levels of HDL-C and LDL-C (all P < 0.05). Besides, the results of logistic regression showed that, family history (OR=3.374, P < 0.05), high triglycerides level (OR=2.369, P < 0.05), low HDL-C level (OR=0.014, P < 0.05) and high level of LDL-C (OR=3.008, P < 0.05) were independent risk factors of early onset coronary heart disease in Tibetan residents. Conclusion Positive family history, high triglycerides level, low HDL-C level and high level of LDL-C are independent risk factors of early onset coronary heart disease in Tibetan residents.

Citation： LIHong-wei, ZHOUYao, WANGHai-yan, YANGShu-juan. Risk Factors of Early Onset Coronary Heart Disease in Tibetan Residents: A Cross-sectional Study. Chinese Journal of Evidence-Based Medicine, 2014, 14(6): 662-664. doi: 10.7507/1672-2531.20140111 Copy

1.	?Serena T, Arne W. Implementation of guidelines to screen relatives of patients with premature coronary heart disease in a hospital setting. Am J Cardiol, 2002, 90(11):1211-1214.
2.	中國高血壓防治指南修訂委員會.中國高血壓防治指南2010.中華高血壓雜志, 2011, 19(8):701-743.
3.	World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva, World Health Org, 1999.
4.	中國成人血脂異常防治指南制訂聯合委員會.中國成人血脂異常防治指南(2007).中華心血管病雜志, 2007, 35(5):390-409.
5.	于揚, 李建平, 霍勇.早發冠心病危險因素和冠狀動脈病變特點的研究.中國介入心臟病學雜志, 2007, 15(5):270-273.
6.	王秀英, 王紹紅, 張克峰.老年冠心病再發心臟事件的危險因素分析.心血管康復醫學雜志, 2000, 9(2):22-23.
7.	孫建琦, 章錫林, 胡劍平.不同性別早發冠心病患者危險因素及冠脈造影病變特點分析.安徽醫學, 2011, 32(2):213-214.
8.	陳忠, 馬根生, 黃峻.不同性別早發冠心病患者代謝綜合征特征分析.中華全科醫師雜志, 2006, 5(5):300-302.
9.	Taylor AJ, Bindeman J, Bhattarai S, et al. Subclinical calcified atherosclerosis in men and its association with a family history of premature coronary heart disease in first-and second-degree relatives. Prev Cardiol, 2004, 7(4):163-167.
10.	Nassar BA, Nanji AA, Ransom TP, et al. Role of the fractalkine receptor CX3CRl polymorphisms V2491 and T280Ma8 risk facton for early-onset coronary artery disease in patients with no classic risk factors. Seand J Clin lab Invest, 2008, 68(4):286-291.
11.	劉曉寧, 黃曉江, 宋燕, 等. G蛋白β3亞單位基因和α-內收蛋白基因多態性與早發冠心病的相關性研究.中華心血管病雜志, 2004, 32(8):708-711.
12.	Lamm G, Auer J, Weber T, et al. Cardiovascular risk factor profiles and angiography results in young patients. Acta Med Austriaca, 2003, 30(3):72-75.
13.	Hauser ER, Mooser V, Crossman AD, et al. Design of the genetics of early onset cardiovascular disease (GENECARD) study. Am Heart J, 2003, 145(4):602-613.
14.	劉志遠, 李綱, 李玉東, 等.早發冠心病患者冠狀動脈病變特點及危險因素的臨床研究.中國心血管病研究, 2008, 6(9):657-659.
15.	王立軍, 黃浙勇.早發冠心病患者危險因素與冠狀動脈病變的性別差異.疑難病雜志, 2006, 5(5):328-330.
16.	Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome:Importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrino Metab, 2004, 89(6):2601-2607.
17.	Angeja BG, Kermgard S, Chen MS, et al. The smokers paradox:insights from the angiographic substudies of the YMI trials. J Thromb Thrombolysis, 2002, 13(3):133-139.
18.	Radak D, Babic S, Peric M, et al. Distribution of risk factors in patients with premature coronary, supra-aortic branches and peripheral atherosclerotic disease. Med Princ Pract, 2012, 21(3):228-233.
19.	李玲, 楊天和, 李菊.男性早發冠心病急性心肌梗死的臨床研究.重慶醫學, 2009, 38(18):2339-2341.
20.	Hochner-Celnikier D, Manor O, Gotzman O, et al. Cender gap in coronary artery disease:Comparison of the extent, severity and risk factors in men and women aged 45-65 years. Cardiology, 2002, 97(1):18-23.

1. ?Serena T, Arne W. Implementation of guidelines to screen relatives of patients with premature coronary heart disease in a hospital setting. Am J Cardiol, 2002, 90(11):1211-1214.
2. 中國高血壓防治指南修訂委員會.中國高血壓防治指南2010.中華高血壓雜志, 2011, 19(8):701-743.
3. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva, World Health Org, 1999.
4. 中國成人血脂異常防治指南制訂聯合委員會.中國成人血脂異常防治指南(2007).中華心血管病雜志, 2007, 35(5):390-409.
5. 于揚, 李建平, 霍勇.早發冠心病危險因素和冠狀動脈病變特點的研究.中國介入心臟病學雜志, 2007, 15(5):270-273.
6. 王秀英, 王紹紅, 張克峰.老年冠心病再發心臟事件的危險因素分析.心血管康復醫學雜志, 2000, 9(2):22-23.
7. 孫建琦, 章錫林, 胡劍平.不同性別早發冠心病患者危險因素及冠脈造影病變特點分析.安徽醫學, 2011, 32(2):213-214.
8. 陳忠, 馬根生, 黃峻.不同性別早發冠心病患者代謝綜合征特征分析.中華全科醫師雜志, 2006, 5(5):300-302.
9. Taylor AJ, Bindeman J, Bhattarai S, et al. Subclinical calcified atherosclerosis in men and its association with a family history of premature coronary heart disease in first-and second-degree relatives. Prev Cardiol, 2004, 7(4):163-167.
10. Nassar BA, Nanji AA, Ransom TP, et al. Role of the fractalkine receptor CX3CRl polymorphisms V2491 and T280Ma8 risk facton for early-onset coronary artery disease in patients with no classic risk factors. Seand J Clin lab Invest, 2008, 68(4):286-291.
11. 劉曉寧, 黃曉江, 宋燕, 等. G蛋白β3亞單位基因和α-內收蛋白基因多態性與早發冠心病的相關性研究.中華心血管病雜志, 2004, 32(8):708-711.
12. Lamm G, Auer J, Weber T, et al. Cardiovascular risk factor profiles and angiography results in young patients. Acta Med Austriaca, 2003, 30(3):72-75.
13. Hauser ER, Mooser V, Crossman AD, et al. Design of the genetics of early onset cardiovascular disease (GENECARD) study. Am Heart J, 2003, 145(4):602-613.
14. 劉志遠, 李綱, 李玉東, 等.早發冠心病患者冠狀動脈病變特點及危險因素的臨床研究.中國心血管病研究, 2008, 6(9):657-659.
15. 王立軍, 黃浙勇.早發冠心病患者危險因素與冠狀動脈病變的性別差異.疑難病雜志, 2006, 5(5):328-330.
16. Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome:Importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrino Metab, 2004, 89(6):2601-2607.
17. Angeja BG, Kermgard S, Chen MS, et al. The smokers paradox:insights from the angiographic substudies of the YMI trials. J Thromb Thrombolysis, 2002, 13(3):133-139.
18. Radak D, Babic S, Peric M, et al. Distribution of risk factors in patients with premature coronary, supra-aortic branches and peripheral atherosclerotic disease. Med Princ Pract, 2012, 21(3):228-233.
19. 李玲, 楊天和, 李菊.男性早發冠心病急性心肌梗死的臨床研究.重慶醫學, 2009, 38(18):2339-2341.
20. Hochner-Celnikier D, Manor O, Gotzman O, et al. Cender gap in coronary artery disease:Comparison of the extent, severity and risk factors in men and women aged 45-65 years. Cardiology, 2002, 97(1):18-23.

Previous Article
Association between Mycoplasma Pneumonia Infection and Acute Urticaria: A Case-control Study
Next Article
Reasonable Path of Caloric Test in Videonystagmography Examination

Chinese Journal of Evidence-Based Medicine

Risk Factors of Early Onset Coronary Heart Disease in Tibetan Residents: A Cross-sectional Study

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content