Efficacy and Safety Radio-chemotherapy Combined with Thermotherapy for Cervical Cancer: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANXiang-yong ¹ ,  LIUWen-chao ¹ , YANZhong-sheng ² , MAJi ¹

1. Department of Clinical Oncology, The Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;
2. Department of Integrative Medicine, Lanzhou Military Region General Hospital, Lanzhou 730050, China;

Corresponding?author：

LIUWen-chao, Email: liuch@fmmu.edu.cn

Keywords：

Cervical cancer; Thermotherapy; Radio-chemotherapy; Meta-analysis; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20140126

Video：

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Objective To systematically review the efficacy and safety of radio-chemotherapy combined with thermotherapy for cervical cancer. Methods Literature about the efficacy and safety of radio-chemotherapy combined with thermotherapy for patients with cervical cancer at mid-term/advanced stage was retrieved from digital databases of The Cochrane Library (Issue 7, 2013), PubMed, EMbase, CBM, VIP, CNKI, and WanFang Data, and from their established dates to July, 2013. Data extraction and quality assessment of included studies were conducted by two reviewers independently. RevMan 5.2 software was then used to perform meta-analysis. Results A total of 9 randomized controlled trials involving 693 patients were included. The results of meta-analysis showed that, compared with the radio-chemotherapy alone group, the radio-chemotherapy combined with thermotherapy group had significant increased 1-year survival rates (OR=3.05, 95%CI 1.70 to 6.68, P=0.005), 2-year survival rates (OR=2.29, 95%CI 1.19 to 4.38, P=0.01), and overall effective rates (OR=3.66, 95%CI 2.31 to 5.81, P < 0.000 01). The incidence of adverse reactions was no statistically significant between the two groups. Conclusion Radio-chemotherapy combined with thermotherapy improves long-term survival rates and short-term curative effects for patients with cervical cancer at mid-term/advanced stage. However, due to the limited quantity and quality of the included studies, more high quality studies with large sample size and long-term follow-up are still needed to verify the above conclusion.

Citation： YANXiang-yong, LIUWen-chao, YANZhong-sheng, MAJi. Efficacy and Safety Radio-chemotherapy Combined with Thermotherapy for Cervical Cancer: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(6): 752-758. doi: 10.7507/1672-2531.20140126 Copy

1.	?Shi JF, Canfell K, Lew JB, et al. The burden of cervical cancer in China:Synthesis of the evidence. Int J Cancer, 2011, 130(3):641-652.
2.	楊蕓.宮頸癌治療進展.中外醫療, 2009, 27(9):169.
3.	Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol, 2002, 3(8):487-497.
4.	高琨, 張彩紅, 陳心秋, 等.同步熱放化療治療中晚期宮頸癌的近期療效觀察.重慶醫學, 2013, 42(7):736-738.
5.	石興源, 周同沖, 林曉丹, 等.深部熱療聯合放化療與單純放化療治療中晚期子宮頸癌的隨機對照研究.實用腫瘤雜志, 2012, 27(4):386-390.
6.	李凱新, 張江靈.深部熱療加同步放化療治療局部晚期宮頸癌的臨床研究.現代腫瘤醫學, 2012, 20(3):595-598.
7.	陳文娟, 王捷忠, 潘建基, 等.中晚期巨塊型宮頸癌熱療配合同步放化療的近期療效觀察.中國醫藥指南, 2012, 10(27):54-55.
8.	許江蘭, 王也, 任磊.深部熱療聯合順鉑增敏同步放療治療中晚期宮頸癌的臨床研究.內蒙古醫學雜志, 2011, 43(9):1045-1047.
9.	袁春鑾, 王忠明, 蔣華. PF方案同步化放療聯合熱療治療中晚期宮頸癌的臨床觀察.實用臨床醫藥雜志, 2010, 14(23):139-140.
10.	李緒彤, 張彩霞, 于洪莉.熱療聯合放化療治療局部晚期子宮頸癌的臨床分析.腫瘤研究與臨床, 2009, 21(11):734-736.
11.	劉甲炎, 馬愛平, 李菲.深部熱療加同步放化療治療晚期宮頸癌的近期療效觀察.中國實用醫藥, 2009, 4(6):132-134.
12.	方繩權, 張潔清, 高琨, 等.深部熱療加同步放化療治療Ⅲb期宮頸癌的臨床價值.中國實用婦科與產科雜志, 2008, 24(11):827-829.
13.	Symonds P. Chemoradiation:the new gold standard for non-surgical treatment of cervical cance. Clin Oncol (R Coll Radiol), 2002, 14(3):201-202.
14.	丁素銀, 李青山.腫瘤熱療的基礎及臨床研究進展.承德醫學院學報, 2010, 27(4):415-419.
15.	Westermann AM, Grosen EA, Katschinski DM, et al. A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer. Eur J Cancer, 2001, 37(9):1111-1117.
16.	Takahashi I, Emi Y, Hasuda S, et al. Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors. Surgery, 2002, 131(suppl1):78-84.
17.	李征, 楊克虎, 米登海, 等.進展期胃癌術后腹腔熱灌注化療有效性和安全性的系統評價.中國循證醫學雜志, 2011, 11(12):1402-1408.
18.	李征, 米登海, 楊克虎, 等. NP化療聯合熱療治療非小細胞肺癌的Meta分析.甘肅醫藥, 2011, 30(8):451-456.
19.	de Haas-Kock DF, Buijsen J, Pijls-Johannesma M, et al. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database Syst Rev, 2009, (3): CD006269.
20.	Lutgens L, van der Zee J, Pijls-Johannesma M, et al. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma. Cochrane Database Syst Rev, 2010, (1): CD006377.
21.	Bergs JW, Franken NA, Haveman J, et al. Hyperthermia, cisplatin and radiation trimodality treatment:a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia, 2007, 23(4):329-341.

1. ?Shi JF, Canfell K, Lew JB, et al. The burden of cervical cancer in China:Synthesis of the evidence. Int J Cancer, 2011, 130(3):641-652.
2. 楊蕓.宮頸癌治療進展.中外醫療, 2009, 27(9):169.
3. Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. Lancet Oncol, 2002, 3(8):487-497.
4. 高琨, 張彩紅, 陳心秋, 等.同步熱放化療治療中晚期宮頸癌的近期療效觀察.重慶醫學, 2013, 42(7):736-738.
5. 石興源, 周同沖, 林曉丹, 等.深部熱療聯合放化療與單純放化療治療中晚期子宮頸癌的隨機對照研究.實用腫瘤雜志, 2012, 27(4):386-390.
6. 李凱新, 張江靈.深部熱療加同步放化療治療局部晚期宮頸癌的臨床研究.現代腫瘤醫學, 2012, 20(3):595-598.
7. 陳文娟, 王捷忠, 潘建基, 等.中晚期巨塊型宮頸癌熱療配合同步放化療的近期療效觀察.中國醫藥指南, 2012, 10(27):54-55.
8. 許江蘭, 王也, 任磊.深部熱療聯合順鉑增敏同步放療治療中晚期宮頸癌的臨床研究.內蒙古醫學雜志, 2011, 43(9):1045-1047.
9. 袁春鑾, 王忠明, 蔣華. PF方案同步化放療聯合熱療治療中晚期宮頸癌的臨床觀察.實用臨床醫藥雜志, 2010, 14(23):139-140.
10. 李緒彤, 張彩霞, 于洪莉.熱療聯合放化療治療局部晚期子宮頸癌的臨床分析.腫瘤研究與臨床, 2009, 21(11):734-736.
11. 劉甲炎, 馬愛平, 李菲.深部熱療加同步放化療治療晚期宮頸癌的近期療效觀察.中國實用醫藥, 2009, 4(6):132-134.
12. 方繩權, 張潔清, 高琨, 等.深部熱療加同步放化療治療Ⅲb期宮頸癌的臨床價值.中國實用婦科與產科雜志, 2008, 24(11):827-829.
13. Symonds P. Chemoradiation:the new gold standard for non-surgical treatment of cervical cance. Clin Oncol (R Coll Radiol), 2002, 14(3):201-202.
14. 丁素銀, 李青山.腫瘤熱療的基礎及臨床研究進展.承德醫學院學報, 2010, 27(4):415-419.
15. Westermann AM, Grosen EA, Katschinski DM, et al. A pilot study of whole body hyperthermia and carboplatin in platinum-resistant ovarian cancer. Eur J Cancer, 2001, 37(9):1111-1117.
16. Takahashi I, Emi Y, Hasuda S, et al. Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors. Surgery, 2002, 131(suppl1):78-84.
17. 李征, 楊克虎, 米登海, 等.進展期胃癌術后腹腔熱灌注化療有效性和安全性的系統評價.中國循證醫學雜志, 2011, 11(12):1402-1408.
18. 李征, 米登海, 楊克虎, 等. NP化療聯合熱療治療非小細胞肺癌的Meta分析.甘肅醫藥, 2011, 30(8):451-456.
19. de Haas-Kock DF, Buijsen J, Pijls-Johannesma M, et al. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database Syst Rev, 2009, (3): CD006269.
20. Lutgens L, van der Zee J, Pijls-Johannesma M, et al. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma. Cochrane Database Syst Rev, 2010, (1): CD006377.
21. Bergs JW, Franken NA, Haveman J, et al. Hyperthermia, cisplatin and radiation trimodality treatment:a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia, 2007, 23(4):329-341.

Chinese Journal of Evidence-Based Medicine

Efficacy and Safety Radio-chemotherapy Combined with Thermotherapy for Cervical Cancer: A Meta-Analysis

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