Correlation between Adenoviral Infection and Encephalitis in Children: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIYa-min ,  TANWen-jie

Biotech Center for Viral Disease Emergency, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China;

Corresponding?author：

TANWen-jie, Email: tanwj28@hotmail.com

Keywords：

Adenoviral infection; Encephalitis; Correlation; Meta-analysis

DOI：

10.7507/1672-2531.20140139

Video：

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Objective To systematically review the correlation between adenoviral infection and encephalitis in children. Methods Studies on the correlation between adenoviral infection and encephalitis among children were retrieved in the databases of CHKD, CNKI, WanFang Data, CMCC, PubMed, Ovid, EBSCO, and Science New during 1978-2013. According to our inclusion and exclusion criteria, literature was screened. After data extraction, meta-analysis was conducted using Comprehensive Meta Analysis 2.0. Results A total of 18 studies were enrolled. The results of meta-analysis indicated that:the prevalence of infection of human adenovirus in children with encephalitis was p₁=10.8% (95%CI 6.5% to 15.2%, P < 0.000 01). The incidence of encephalitis in children with adenoviral infection was p₂=31.4% (95%CI 14.1% to 48.6%, P < 0.000 01). The results of two studies showed that, the correlation coefficients between adenoviral infection and encephalitis were OR₁=2.22 (95%CI 0.32 to 14.79, P > 0.05), and OR₂=1.12 (95%CI 0.14 to 9.10, P > 0.05), respectively, both with no significant difference. In addition, the subgenus B adenoviruses, including type 3 and type 7 were more associated with encephalitis, followed by type 1 and type 2 in subgenus C and type 8 in subgenus D. Conclusion Current evidence shows that no correlation exists between adenoviral infection and encephalitis in children. However, the above conclusion needs to be verified by conducting more rationally-designed studies so as to clarify the correlation.

Citation： LIYa-min, TANWen-jie. Correlation between Adenoviral Infection and Encephalitis in Children: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(7): 835-840. doi: 10.7507/1672-2531.20140139 Copy

1.	Jones MS, Harrach B, Ganac RD, et al. New adenovirus species found in a patient presenting with gastroenteritis. J Virol, 2007, 81(11):5978-5984.
2.	Lenaerts L, Clercq E, Naesens L, et al. Clinical features and treatment of adenovirus infections. Rev Med Virol, 2008, 18(6):357-374.
3.	Monath TP. Japanese encephalitis-a plague of the Orient. N Engl J Med, 1988, 319(10):641-643.
4.	Sawyer MH. Enterovirus infections:diagnosis and treatment. Pediatr Infect Dis, 1999, 18:1033-1040.
5.	符貽峰, 黃茲寶, 黃壯福, 等.病毒性腦炎126例的臨床及病原學分析.中國美容醫學雜志, 2012, 21(8):71-73.
6.	李靜, 李幼平.不斷完善與發展的Cochrane系統評價.中國循證醫學雜志, 2008, 8(9):742-743.
7.	李盈, 顧懷婷. 《中國循證醫學雜志》發表系統評價/Meta分析的文獻計量分析.中國循證醫學雜志, 2012, 12(10):1279-1282.
8.	Chalmers I, Hedges L, Cooper H, et al. A brief history of research synthesis. Evaluation & the Health Professions, 2002, 25(1):12-37.
9.	Solomon T, Thao TT, Lewthwaite P, et al. A cohort study to assess the new WHO Japanese encephalitis surveillance standards. Bull World Health Organ, 2008, 86(3):178-186.
10.	許梅驪.小兒腺病毒腦炎24例報道.蚌埠醫學院學報, 1981, 6(1):42-45.
11.	白漢玉, 沐桂藩, 孫月英, 等.病毒性腦炎、腦膜炎的病原學探討.北京醫學雜志, 1982, 4(4):193-194.
12.	楊善存, 王一力, 黃麗春, 等.小兒散發性腦炎病原學和臨床的探討.中國神經精神疾病雜志, 1986, 12(1):4-7.
13.	郭植材, 涂地勤, 姜德昭, 等.小兒散發性腦炎70例臨床分析及病毒學檢測.廣西醫學院學報, 1987, 4(1), 6-8.
14.	謝若男, 費選文, 曾嫦, 等.潮汕地區散發性病毒性腦膜炎的病毒病原學分析.中華傳染病雜志, 2005, 23(4):260-262.
15.	金玉, 余唯琪, 薛君莉, 等.兒童病毒性腦炎腦膜炎98例臨床分析.中國實用兒科雜志, 2003, 18(4):212-214.
16.	邵新華, 吳潔, 汪梅先.小兒病毒性腦炎與抗病毒抗體IgM的臨床意義.海南醫學, 2004, 15(9):50-52.
17.	費選文, 謝若男, 曾嫦, 等.潮汕地區散發性病毒性腦膜炎的病毒病原學分析.中華傳染病雜志, 2005, 23(4):260-262.
18.	馮同豹, 湯政, 劉凌, 等.病毒性腦炎的早期診斷及更昔洛韋療效評價.實用兒科臨床雜志. 2007, 22(9):696-697.
19.	曹青.兒童病毒性腦炎、腦膜炎92例臨床及病毒病原學分析.醫學理論與實踐. 2007, 20(3):259-260.
20.	Belsy A, Odalys V, Luis S, et al. Molecular characterization of adenoviral infections in Cuba:report of an unusual association of species D adenoviruses with different clinical syndromes. Arch Virol, 2009, 154(4):619-627.
21.	陳煥輝, 陳翊, 林濤, 等.廣州地區兒童病毒性腦炎病原構成和流行特點.廣州醫藥, 2012, 43(1):18-21.
22.	Simila S, Joupila R, Salmi A, et al. Encephalomeningitis in children associated with an adenovirus type 7 epidemic. Acta Pediatr Scand, 1970, 59(4):310-316.
23.	樓方岑.腺病毒感染.四川醫學, 1983, 2(5):300.
24.	傅文永, 劉為民, 許忠, 等.腺病毒與小兒中樞神經系感染:附31例臨床分析.臨床兒科雜志, 1991, 9(2):111-112.
25.	Hon KL, Leung E, Tang J, et al. Premorbid factors and outcome associated with respiratory virus infection in a pediatric intensive care unit. Pediatr Pulmonol, 2008, 43(4):275-280.
26.	Lai CY, Lee CJ, Lee PL, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011. PLoS ONE, 8(1):e53614.
27.	朱汝南, 鄧潔, 王芳, 等. 2000年秋冬至2002年夏北京地區急性呼吸道感染病毒病原學研究.臨床兒科雜志, 2003, 21(1):25-28.
28.	Carballal G, Videla CM, Espinosa MA, et al. Multi-centered study of viral acute lower respiratory infections in children from four cities of Argentina. J Med Virol, 2001, 64(2):167-174.
29.	Fujimoto T, Chikahira M, Kase T, et al. Single-tube multiplex PCR for rapid and sensitive diagnosis of subgenus B and other subgenera adenoviruses in clinical samples. Microbiol Immunol, 2000, 44(10):821-826.
30.	Dubberke ER, Tu B, Rivet DJ, et al. Acute meningoencephalitis caused by adenovirus serotype 26. J Neurovirol, 2006, 12(3):235-240.
31.	The Cochrane Collaboration. 9.1.4 When not to use Meta-analysis in a review. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0. March 2011. Available at:http://www.cochrane-handbook.org.
32.	Kelsey DS, Adenovirus meningoencephalitis. Pediatrics, 1978, 61(3):291-293.
33.	Chou SM, Roos R, Burnell R, et al. Subacute focal adenovirus encephalitis. J Neuropathol Exp Neurol, 1973, 32(1):34-50.
34.	Straussberg R, Harel L, Levy Y, et al. A syndrome of transient encephalopathy associated with adenovirus infection. Pediatrics, 2001, 107(5):E69.
35.	Munoz-Almagro C, Gonzalez-Cuevas A, Cambra FJ, et al. Rapid diagnosis of therapeutic meningoencephalitis by PCR. Enferm Infet Microbiol Clin, 2002, 20(3):110-121.

1. Jones MS, Harrach B, Ganac RD, et al. New adenovirus species found in a patient presenting with gastroenteritis. J Virol, 2007, 81(11):5978-5984.
2. Lenaerts L, Clercq E, Naesens L, et al. Clinical features and treatment of adenovirus infections. Rev Med Virol, 2008, 18(6):357-374.
3. Monath TP. Japanese encephalitis-a plague of the Orient. N Engl J Med, 1988, 319(10):641-643.
4. Sawyer MH. Enterovirus infections:diagnosis and treatment. Pediatr Infect Dis, 1999, 18:1033-1040.
5. 符貽峰, 黃茲寶, 黃壯福, 等.病毒性腦炎126例的臨床及病原學分析.中國美容醫學雜志, 2012, 21(8):71-73.
6. 李靜, 李幼平.不斷完善與發展的Cochrane系統評價.中國循證醫學雜志, 2008, 8(9):742-743.
7. 李盈, 顧懷婷. 《中國循證醫學雜志》發表系統評價/Meta分析的文獻計量分析.中國循證醫學雜志, 2012, 12(10):1279-1282.
8. Chalmers I, Hedges L, Cooper H, et al. A brief history of research synthesis. Evaluation & the Health Professions, 2002, 25(1):12-37.
9. Solomon T, Thao TT, Lewthwaite P, et al. A cohort study to assess the new WHO Japanese encephalitis surveillance standards. Bull World Health Organ, 2008, 86(3):178-186.
10. 許梅驪.小兒腺病毒腦炎24例報道.蚌埠醫學院學報, 1981, 6(1):42-45.
11. 白漢玉, 沐桂藩, 孫月英, 等.病毒性腦炎、腦膜炎的病原學探討.北京醫學雜志, 1982, 4(4):193-194.
12. 楊善存, 王一力, 黃麗春, 等.小兒散發性腦炎病原學和臨床的探討.中國神經精神疾病雜志, 1986, 12(1):4-7.
13. 郭植材, 涂地勤, 姜德昭, 等.小兒散發性腦炎70例臨床分析及病毒學檢測.廣西醫學院學報, 1987, 4(1), 6-8.
14. 謝若男, 費選文, 曾嫦, 等.潮汕地區散發性病毒性腦膜炎的病毒病原學分析.中華傳染病雜志, 2005, 23(4):260-262.
15. 金玉, 余唯琪, 薛君莉, 等.兒童病毒性腦炎腦膜炎98例臨床分析.中國實用兒科雜志, 2003, 18(4):212-214.
16. 邵新華, 吳潔, 汪梅先.小兒病毒性腦炎與抗病毒抗體IgM的臨床意義.海南醫學, 2004, 15(9):50-52.
17. 費選文, 謝若男, 曾嫦, 等.潮汕地區散發性病毒性腦膜炎的病毒病原學分析.中華傳染病雜志, 2005, 23(4):260-262.
18. 馮同豹, 湯政, 劉凌, 等.病毒性腦炎的早期診斷及更昔洛韋療效評價.實用兒科臨床雜志. 2007, 22(9):696-697.
19. 曹青.兒童病毒性腦炎、腦膜炎92例臨床及病毒病原學分析.醫學理論與實踐. 2007, 20(3):259-260.
20. Belsy A, Odalys V, Luis S, et al. Molecular characterization of adenoviral infections in Cuba:report of an unusual association of species D adenoviruses with different clinical syndromes. Arch Virol, 2009, 154(4):619-627.
21. 陳煥輝, 陳翊, 林濤, 等.廣州地區兒童病毒性腦炎病原構成和流行特點.廣州醫藥, 2012, 43(1):18-21.
22. Simila S, Joupila R, Salmi A, et al. Encephalomeningitis in children associated with an adenovirus type 7 epidemic. Acta Pediatr Scand, 1970, 59(4):310-316.
23. 樓方岑.腺病毒感染.四川醫學, 1983, 2(5):300.
24. 傅文永, 劉為民, 許忠, 等.腺病毒與小兒中樞神經系感染:附31例臨床分析.臨床兒科雜志, 1991, 9(2):111-112.
25. Hon KL, Leung E, Tang J, et al. Premorbid factors and outcome associated with respiratory virus infection in a pediatric intensive care unit. Pediatr Pulmonol, 2008, 43(4):275-280.
26. Lai CY, Lee CJ, Lee PL, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011. PLoS ONE, 8(1):e53614.
27. 朱汝南, 鄧潔, 王芳, 等. 2000年秋冬至2002年夏北京地區急性呼吸道感染病毒病原學研究.臨床兒科雜志, 2003, 21(1):25-28.
28. Carballal G, Videla CM, Espinosa MA, et al. Multi-centered study of viral acute lower respiratory infections in children from four cities of Argentina. J Med Virol, 2001, 64(2):167-174.
29. Fujimoto T, Chikahira M, Kase T, et al. Single-tube multiplex PCR for rapid and sensitive diagnosis of subgenus B and other subgenera adenoviruses in clinical samples. Microbiol Immunol, 2000, 44(10):821-826.
30. Dubberke ER, Tu B, Rivet DJ, et al. Acute meningoencephalitis caused by adenovirus serotype 26. J Neurovirol, 2006, 12(3):235-240.
31. The Cochrane Collaboration. 9.1.4 When not to use Meta-analysis in a review. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0. March 2011. Available at:http://www.cochrane-handbook.org.
32. Kelsey DS, Adenovirus meningoencephalitis. Pediatrics, 1978, 61(3):291-293.
33. Chou SM, Roos R, Burnell R, et al. Subacute focal adenovirus encephalitis. J Neuropathol Exp Neurol, 1973, 32(1):34-50.
34. Straussberg R, Harel L, Levy Y, et al. A syndrome of transient encephalopathy associated with adenovirus infection. Pediatrics, 2001, 107(5):E69.
35. Munoz-Almagro C, Gonzalez-Cuevas A, Cambra FJ, et al. Rapid diagnosis of therapeutic meningoencephalitis by PCR. Enferm Infet Microbiol Clin, 2002, 20(3):110-121.

Chinese Journal of Evidence-Based Medicine

Correlation between Adenoviral Infection and Encephalitis in Children: A Meta-Analysis

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