Value of Contrast-enhanced Ultrasound in Diagnosis of Benign and Malignant Renal Tumors: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGYan ¹ , ZHAOYu-ling ² , ZENGChun-hong ¹ ,  YAOLan-hui ¹

1. Ultrasound Diagnostic Department, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;
2. Ultrasound Department, Maternal and Child Health Hospital of Xinjiang, Huocheng County 835200, Xinjiang, China;

Corresponding?author：

YAOLan-hui, Email: yaolanhui6082@yahoo.com.cn

Keywords：

Contrast-enhanced ultrasound; Renal tumor; Systematic review; Meta-analysis; Diagnostic test

DOI：

10.7507/1672-2531.20140195

Video：

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Objective To systematically review the value of contrast-enhanced ultrasound in diagnosis of benign and malignant renal tumors. Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 9, 2013), CBM, CNKI, WanFang Data and VIP were searched by Sep 31^st, 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed using Meta-Disc 1.4 software. Results Seven studies involving 462 patients were finally included. ROC curve showed shoulder-arm shape. The results of Spearman suggested significance of the threshold effect. The results of meta-analysis showed that, the area under curve (AUC) was 0.98. Conclusion Contrast-enhanced ultrasound can improve diagnostic accuracy, which is of important value in the diagnosis and differential diagnosis of benign and malignant renal tumors. Due to limited quality and quantity of the included studies, the abovementioned conclusion still needs to be verified by conducting more high quality studies.

Citation： WANGYan, ZHAOYu-ling, ZENGChun-hong, YAOLan-hui. Value of Contrast-enhanced Ultrasound in Diagnosis of Benign and Malignant Renal Tumors: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(10): 1206-1209. doi: 10.7507/1672-2531.20140195 Copy

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12.	程蔚然.超聲造影在腎臟腫瘤診斷及鑒別診斷中的應用價值.河北醫學, 2013, 19(7):977-980.
13.	Xu ZF, Xu XH, Xiu XY, et al. Renal cell carcinoma and renal angiomyolipoma, different diagnosis with real-time contrast-enhanced ultrasonography. J Ultrasound Med, 2010, 29(5):709-717.
14.	伍于添.超聲診斷方法和設備的前沿技術.中國超聲醫學雜志, 2004, 20(6):470-475.
15.	Salvatore S, Quaia E, Bertolotto M, et al. The application of ultrasound contrast agents in the characterization of renal tumors. World J Urol, 2004, 22(5):316-322.
16.	Mitterberger M, Pelzer A, Colleselli D, et al. Contrast-enhanced ultrasound for diagnosis of prostate cancer and kidney leisions. EJR, 2007, 64(2):231-238.
17.	杜聯芳, 李凡, 姜露瑩, 等.超聲造影在腎占位性病變中的應用.中華超聲影像學雜志, 2006, 11(51):813-815.
18.	傅寧華, 楊斌, 孟慶欣, 等.腎惡性腫瘤超聲造影與病理對照分析.中國醫學影像技術, 2008, 24(5):725-727.

1. Setola SV, Catalano O, Sandomenico F, et al. Contrast-enhanced sonography of the kidney. Abdom Imaging, 2007, 32(1):21-28.
2. Nilsson A. Contrast-enhanced ultrasound of kidneys. Eur Radiol, 2004, 14(suppl 8):104-109.
3. Tamai H, Takiguchi Y, Oka M, et al. Contrast-enhanced ultrasonography in the diagnosis of solid renal tumors. J Ultrasound Med, 2005, 24(12):1635-1640.
4. Siegel CL, Middleton WD, Teefey SA, et al. Angiomyolipoma and renal cell carcinoma:US differentiation. Radiology, 1996, 198(3):789-793.
5. Kim JK, Park SY, Shon JH, et al. Angiomyolipoma with minimal fat:differentiation from renal cell carcinoma at biphasic helical CT. Radiology, 2004, 230(3):677-684.
6. Whiting P, Rutjes Aw, Reitsma JB, et al. The development of QUADAS:a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol, 2003, 10(3):25-38.
7. 顧繼英, 杜聯芳, 李凡, 等.超聲造影對腎臟良惡性腫瘤的鑒別診斷價值.中國超聲醫學雜志, 2008, 24(1):1017-1019.
8. 金進曉, 臧國禮, 陳日曙, 等.超聲造影對腎臟良惡性腫瘤的診斷價值.浙江創傷外科, 2012, 17(4):566-567.
9. 王穎, 江怡, 趙云歆, 等.超聲造影在腎腫瘤診斷和鑒別診斷中的價值.上海醫學影像, 2009, 18(4):285-287.
10. 馬文琦, 杜曉鵬, 周琦, 等.實時超聲造影對腎臟腫瘤診斷價值的應用研究.現代泌尿外科雜志, 2013, 18(1):49-51.
11. 李萍.超聲造影在腎實質良惡性病灶診斷中的應用.上海交通大學, 2009.
12. 程蔚然.超聲造影在腎臟腫瘤診斷及鑒別診斷中的應用價值.河北醫學, 2013, 19(7):977-980.
13. Xu ZF, Xu XH, Xiu XY, et al. Renal cell carcinoma and renal angiomyolipoma, different diagnosis with real-time contrast-enhanced ultrasonography. J Ultrasound Med, 2010, 29(5):709-717.
14. 伍于添.超聲診斷方法和設備的前沿技術.中國超聲醫學雜志, 2004, 20(6):470-475.
15. Salvatore S, Quaia E, Bertolotto M, et al. The application of ultrasound contrast agents in the characterization of renal tumors. World J Urol, 2004, 22(5):316-322.
16. Mitterberger M, Pelzer A, Colleselli D, et al. Contrast-enhanced ultrasound for diagnosis of prostate cancer and kidney leisions. EJR, 2007, 64(2):231-238.
17. 杜聯芳, 李凡, 姜露瑩, 等.超聲造影在腎占位性病變中的應用.中華超聲影像學雜志, 2006, 11(51):813-815.
18. 傅寧華, 楊斌, 孟慶欣, 等.腎惡性腫瘤超聲造影與病理對照分析.中國醫學影像技術, 2008, 24(5):725-727.

Chinese Journal of Evidence-Based Medicine

Value of Contrast-enhanced Ultrasound in Diagnosis of Benign and Malignant Renal Tumors: A Meta-Analysis

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