Effects of Shenlingcao Oral Liquid on 64 Asymptomatic Chronic Hepatitis B Virus Carriers: A Self Control Before-after Trial_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHAOHai-ping , CHENHe-li , LIUHong-ning , KANGLin-zhi , WANGPing , ZHUYi-min ,  ZHUWei-feng

Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

Corresponding?author：

ZHUWei-feng, Email: zef0322@126.com

Keywords：

Shenlingcao oral liquid; Chronic asymptomatic HBV carrier; Self control before-after trial

DOI：

10.7507/1672-2531.20150022

Video：

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Objective To observe intervention effect of Shenlingcao oral liquid on asymptomatic chronic hepatitis B virus carriers (AsC). Methods A self control before-after trial was conducted in the First Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine and the Ninth People's Hospital of Nanchang City from November 2011 to May 2012. A total of 64 AsCs were treated by Shenlingcao oral liquid (1 bottle/d, 200 mL, once daily for 6 months). Serum HBV viral load, six specific serum markers of HBV and 11 liver function index were tested and recorded before and at the 1^th, 3^th, 6^th months of the treatment. Analysis of variance of repeated data was conducted. Results After one month of the treatment, 35/57 (61.40%) AsCs' serum HBV-DNA loads decreased, 1 log decrease was observed in 15 cases, 2 log decrease was observed in 4 cases, and decrease under the detection limit was observed in 12 cases. 41/57 (71.93%) AsCs' serum HBV-DNA loads decreased after 3 months of treatment, 1 log decrease was observed in 21 cases, 2 log decrease was observed in 5 cases, and decrease under the detection limit was observed in 15 cases. 31/49 (63.26%) AsCs' serum HBV-DNA loads decreased after 6 months of the treatment, 1 log decrease was observed in 19 cases, decrease more than 2 log was observed in 7 cases, and decrease under the detection limit was observed in 12 cases. The serum HBV viral loads at different time points of the treatment were significantly different (P<0.001). As medication time went, AsCs' serum HBV viral loads presented a decrease trend after taking Shenlingcao oral liquid, especially obvious at the 3^th month. Conclusion Shenlingcao oral liquid could help promote AsCs' ability of clearing virus and controlling serum HBVDNA loads.

Citation： ZHAOHai-ping, CHENHe-li, LIUHong-ning, KANGLin-zhi, WANGPing, ZHUYi-min, ZHUWei-feng. Effects of Shenlingcao Oral Liquid on 64 Asymptomatic Chronic Hepatitis B Virus Carriers: A Self Control Before-after Trial. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 125-129. doi: 10.7507/1672-2531.20150022 Copy

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16.	陳曉凡, 朱衛豐, 陳和利, 等. 參靈草口服液治療無癥狀HIV感染者療效的自身前后對照研究. 中國循證醫學雜志, 2014, 14(11):1299-1303.

1. 中華人民共和國衛生部. 衛生部公布2006年全國人群乙肝血清流行病學調查結果(2008-4-21)[2013-09-03].
2. 于麗妍, 盧秉久. 中醫防治無癥狀乙肝病毒攜帶者. 實用中醫內科雜志, 2013, 27(10):90-91.
3. 陳大明. 乙肝防治的情報學研究. 中國科學院研究生院(上海生命科學研究院), 2007.
4. 吳芬芬, 吳國營. 近十年乙肝病毒攜帶者的中醫治療概況與展望. 環球中醫藥, 2009, 2(5):390-395.
5. 曲桂玉. 慢性無癥狀乙肝病毒攜帶者的健康教育. 衛生職業教育, 2005, 23(1):110-112.
6. 施伯安, 崔麗安, 邵鳳珍, 等. 健脾益腎法治療慢性乙肝病毒攜帶者100例. 中西醫結合肝病雜志, 2010, 20(1):45-46.
7. 蔣瑞. 論《內經》"治未病"及其與未來中醫走向的關系. 光明中醫, 2000, 15(2):9-11.
8. 劉德山.《金匱要略》"治未病"思想探析. 山東醫科大學學報社會科學版,1999,(1):46-47.
9. 王非, 劉林, 王媛. 內經治未病的基本涵義. 中醫藥學報, 1996, (1):6-7.
10. 中華醫學會肝病學分會、感染病學分會. 慢性乙型肝炎防治指南. 中華肝臟病雜志, 2005, 12(13):881-889.
11. 當知百科·乙肝病毒攜帶者. Available at:http://baike.dangzhi.com/wiki/乙肝病毒攜帶者.
12. 廖振賢. 中醫治未病思想治療無癥狀乙肝病毒攜帶者的臨床研究. 廣州中醫藥大學碩士學位論文, 2006, 5.
13. 尹雪萍. 論未病和未病學說. 山東中醫學院學報, 1993, 17(3):45-47.
14. 蘇勛莊. "老年病"并非"老年"病. 山東中醫藥大學學報, 1999, 23(3):181-183.
15. 宋為民. "未病"現代觀. 南京中醫學院學報, 1995, 11(1):4-6.
16. 陳曉凡, 朱衛豐, 陳和利, 等. 參靈草口服液治療無癥狀HIV感染者療效的自身前后對照研究. 中國循證醫學雜志, 2014, 14(11):1299-1303.

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Chinese Journal of Evidence-Based Medicine

Effects of Shenlingcao Oral Liquid on 64 Asymptomatic Chronic Hepatitis B Virus Carriers: A Self Control Before-after Trial

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