Efficacy of Chinese Medicine for Endometrial Hypoplasia: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 SUNYang ^1,2 , CHENYa-qiong ¹ , HOUHai-yan ¹ , LANXiao-xia ² , LIANGJing ³

1. Obstetric and Gynecologic Department, Armed Police Rear Service Institute Affiliated Hospital, Tianjin 300162, China;
2. Department of Epidemiology and Principle of Statistics, Armed Police Rear Service Institute, Tianjin 300309, China;
3. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;

Corresponding?author：

Keywords：

Endometrial hypoplasia; Chinese medicine; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.20150037

Video：

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Objective To systematically review the efficacy of Chinese medicine for endometrial hypoplasia. Methods Databases such as PubMed, EMbase, MEDLINE (Ovid), The Cochrane Library (Issue 8, 2014), CNKI, VIP and WanFang Data were searched for randomized controlled trials (RCTs) and quasi-RCTs concerning the efficacy of Chinese medicine for endometrial hypoplasia up to August 2014. According to the inclusion and exclusion criteria, two reviewers screened literature, extracted data, and assessed methodological quality of included studies. Then meta-analysis was performed using RevMan 5.3 software. Results A total of 5 RCTs and 6 quasi-RCTs involving 914 patients were included. The results of meta-analysis showed that Chinese medicine group was superior to control group in endometrial thickness (MD=0.86, 95%CI 0.35 to 1.37, P=0.000 01), clinical pregnancy rates (RR=2.62, 95%CI 2.02 to 3.38, P<0.000 01), endometrial morphous (RR=1.23, 95%CI 1.06 to 1.42, P=0.005), PI of uterine artery blood flow (MD=-0.54, 95%CI -0.80 to -0.28, P<0.000 1), RI of uterine artery blood flow (MD=-0.12, 95%CI -0.17 to -0.08, P<0.000 1), and estradiol level (MD=96.03, 95%CI 44.32 to 144.74, P=0.003); However, the two groups were alike in progesterone level without significant difference (MD=2.00, 95%CI -0.64 to 4.65, P=0.14). Conclusion Current evidence indicated that, Chinese medicine is beneficial for endometrial hypoplasia. Due to limited quantity and quality of the included studies, the above conclusion still needs to be verified by conducting more high quality studies.

Citation： SUNYang, CHENYa-qiong, HOUHai-yan, LANXiao-xia, LIANGJing. Efficacy of Chinese Medicine for Endometrial Hypoplasia: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 215-222. doi: 10.7507/1672-2531.20150037 Copy

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2.	Al-Ghamdi A, Coskun S, Al-Hassan S, et al. The correlation between endometrial thickness and outcome of invitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocinol, 2008, 6(37):1-5.
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6.	周茂溪, 馮雪花, 李玉, 等. 血流方對腎虛血瘀型凍融胚胎移植患者子宮內容受性影響. 遼寧中醫藥大學學報, 2013, 15(10):183-184.
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9.	劉昱磊, 王俊玲, 騰輝. 活血補腎方治療子宮內膜生長不良性不孕癥30例. 陜西中醫學院學報, 2011, 34(1):60-61.
10.	陳文英. 溫經湯直腸滴入對體外受精-胚胎移植失敗患者子宮內膜容受性的影響. 陜西中醫, 2013, 34(3):266-268.
11.	馮雪花, 楊楠, 陳曉會, 等. 內膜方對促排卵周期中腎虛型患者子宮內膜容受性的影響. 遼寧中醫藥大學學報, 2012, 14(10):66-67.
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13.	王利紅, 趙麗穎, 夏天. 補腎調沖方改善促排卵周期中子宮內膜容受性的臨床觀察. 天津中醫藥大學學報, 2011, 30(3):150-152.
14.	徐艷, 王磊, 馬兆文. 溫陽化瘀顆粒治療不孕癥患者臨床療效觀察研究. 中醫臨床研究, 2011, 3(22):64-66.
15.	劉元文, 蓋德美, 孫建欣, 等. 益腎生膜顆粒治療子宮內膜發育不良性不孕120例. 山東中醫雜志, 2012, 31(7):481-483.
16.	田甜, 趙靜. 薄型子宮內膜治療的研究進展. 國際生殖健康/計劃生育雜志, 2013, 32(3):214-217.
17.	郭佳, 王麗娜, 李東. 改善子宮內膜血流狀態提高體外受精-胚胎移植成功率的中醫研究與思考. 中西醫結合學報, 2011, 9(12):1301-1306.
18.	羅江霞, 覃愛平, 張海英. 子宮內膜厚度與容受性的研究. 實用婦產科雜志, 2010, 26(8):608-610.
19.	Wang L, Qiao J, Li R, et al. Role of Endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles. Reprod Biol Endocrinol, 2010, 8(1):122.
20.	Lilic V, Tubic-Pavlvic A, Radovic-Janosevic D, et al. Assessment of endometrial receptivity by color Doppler and ultrasound imaging. Med Pregl, 2007, 60(5-6):237-240.
21.	Amir W, Micha B, Ariel H, et al. Predicting factors for endometrial thickness during treatment with assisted reproductive technology. Fertil Steril, 2007, 87:799-804.

1. 胡倩, 中醫改善子宮內膜研究進展. 內蒙古中醫藥, 2012, 2:137-138.
2. Al-Ghamdi A, Coskun S, Al-Hassan S, et al. The correlation between endometrial thickness and outcome of invitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocinol, 2008, 6(37):1-5.
3. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011].The Cochrane Collaboration, 2011. Available at:www.cochranehandbook.org.
4. 劉艷, 席麗軍. 紫河車膠囊用于治療子宮內膜過薄不孕癥的探討. 中醫藥信息, 2011, 28(4):118-119.
5. 王海文, 阮祥燕. 資癸女貞膠囊應用于子宮內膜薄性不育癥的臨床研究. 首都醫科大學學報, 2014, 35(2):248-252.
6. 周茂溪, 馮雪花, 李玉, 等. 血流方對腎虛血瘀型凍融胚胎移植患者子宮內容受性影響. 遼寧中醫藥大學學報, 2013, 15(10):183-184.
7. 馬翠霞. 定坤丹對子宮內膜發育不良不孕患者的臨床療效觀察. 中醫中藥, 2013, (1):260-261.
8. 高志云, 高修安, 馬文敏, 等. 中藥周期療法對體外受精-胚胎移植失敗患者子宮內膜厚度影響的研究. 長春中醫藥大學學報, 2012, 28(3):417-419.
9. 劉昱磊, 王俊玲, 騰輝. 活血補腎方治療子宮內膜生長不良性不孕癥30例. 陜西中醫學院學報, 2011, 34(1):60-61.
10. 陳文英. 溫經湯直腸滴入對體外受精-胚胎移植失敗患者子宮內膜容受性的影響. 陜西中醫, 2013, 34(3):266-268.
11. 馮雪花, 楊楠, 陳曉會, 等. 內膜方對促排卵周期中腎虛型患者子宮內膜容受性的影響. 遼寧中醫藥大學學報, 2012, 14(10):66-67.
12. 李秀然. 助孕增膜方對促排卵周期子宮內膜容受性的影響. 中醫藥臨床雜志, 2011, 23(7):624-626.
13. 王利紅, 趙麗穎, 夏天. 補腎調沖方改善促排卵周期中子宮內膜容受性的臨床觀察. 天津中醫藥大學學報, 2011, 30(3):150-152.
14. 徐艷, 王磊, 馬兆文. 溫陽化瘀顆粒治療不孕癥患者臨床療效觀察研究. 中醫臨床研究, 2011, 3(22):64-66.
15. 劉元文, 蓋德美, 孫建欣, 等. 益腎生膜顆粒治療子宮內膜發育不良性不孕120例. 山東中醫雜志, 2012, 31(7):481-483.
16. 田甜, 趙靜. 薄型子宮內膜治療的研究進展. 國際生殖健康/計劃生育雜志, 2013, 32(3):214-217.
17. 郭佳, 王麗娜, 李東. 改善子宮內膜血流狀態提高體外受精-胚胎移植成功率的中醫研究與思考. 中西醫結合學報, 2011, 9(12):1301-1306.
18. 羅江霞, 覃愛平, 張海英. 子宮內膜厚度與容受性的研究. 實用婦產科雜志, 2010, 26(8):608-610.
19. Wang L, Qiao J, Li R, et al. Role of Endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles. Reprod Biol Endocrinol, 2010, 8(1):122.
20. Lilic V, Tubic-Pavlvic A, Radovic-Janosevic D, et al. Assessment of endometrial receptivity by color Doppler and ultrasound imaging. Med Pregl, 2007, 60(5-6):237-240.
21. Amir W, Micha B, Ariel H, et al. Predicting factors for endometrial thickness during treatment with assisted reproductive technology. Fertil Steril, 2007, 87:799-804.

Chinese Journal of Evidence-Based Medicine

Efficacy of Chinese Medicine for Endometrial Hypoplasia: A Systematic Review

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