How to use GRADEpro GDT to Rate the Quality of Evidence in Systematic Reviews of Intervention Studies: An Introduction_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENHao ¹ , WANGYan ² , HUXuan-ming ¹ , ZHOUFang ¹ , ZENGXian-tao ³ ,  GUYi-huang ¹

1. The Second Clinical College, Nanjing University of Chinese Medicine, Nanjing 210023, China;
2. Nanjing Hospital of Red Cross, Nanjing 210023, China;
3. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;

Corresponding?author：

GUYi-huang, Email: tcsgc@sina.com

Keywords：

GRADE; GDT; Grading of evidence; Evidence-based medicine; Systematic review; Clinical practice guideline

DOI：

10.7507/1672-2531.20150099

Video：

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GRADEpro GDT-Guideline Development Tool, is an online tool for the integration of important data and process of clinical practice guidelines and diagnostic guidelines. It is a new methodology progress of the GRADE system. This paper introduced how to use GRADEpro GDT to rate the quality of evidence in systematic reviews of intervention studies with an example.

Citation： CHENHao, WANGYan, HUXuan-ming, ZHOUFang, ZENGXian-tao, GUYi-huang. How to use GRADEpro GDT to Rate the Quality of Evidence in Systematic Reviews of Intervention Studies: An Introduction. Chinese Journal of Evidence-Based Medicine, 2015, 15(5): 600-606. doi: 10.7507/1672-2531.20150099 Copy

1.	Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454):1490.
2.	曾憲濤, 田國祥, 牛玉明, 等. GRADEprofiler軟件使用簡介. 中國循證心血管醫學雜志, 2011, 12(3):390-392.
3.	Guyatt GH, Oxman AD, Vist GE, et al. GRADE:an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008, 336(7650):924-926.
4.	Guyatt GH, Oxman AD, Kunz R, et al. What is "quality of evidence" and why is it important to clinicians? BMJ, 2008, 336(7651):995-998.
5.	Guyatt GH, Oxman AD, Kunz R, et al. Going from evidence to recommendations. BMJ, 2008, 336(7652):1049-1051.
6.	Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 2008, 336(7653):1106-1110.
7.	Guyatt GH, Oxman AD, Kunz R, et al. Incorporating considerations of resources use into grading recommendations. BMJ, 2008, 336(7654):1170-1173.
8.	Jaeschke R, Guyatt GH, Dellinger P, et al. Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ, 2008, 337:a744.
9.	陳耀龍, 楊克虎, 姚亮, 等. GRADE系統方法學進展. 中國循證兒科雜志, 2013, 8(1):64-65.
10.	曾憲濤, 冷衛東, 李勝, 等. 如何正確理解及使用GRADE系統. 中國循證醫學雜志, 2011, 11(9):985-990.
11.	陳耀龍, 姚亮, Norris S, 等. GRADE在系統評價中應用的必要性及注意事項. 中國循證醫學雜志, 2013, 13(12):1401-1404.
12.	陳耀龍, 姚亮, 杜亮, 等. GRADE在診斷準確性試驗系統評價中應用的原理、方法、挑戰及發展趨勢. 中國循證醫學雜志, 2014, 14(11):1402-1406.
13.	姚亮, 陳耀龍, 杜亮, 等. GRADE在診斷準確性試驗系統評價中的應用實例解析. 中國循證醫學雜志, 2014, 14(11):1407-1412.
14.	Puhan MA, Schünemann HJ, Murad MH, et al. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ, 2014, 24, 349:g5630.
15.	Lorio A, Spencer FA, Falavigna M, et al. Use of GRADE for assessment of evidence about prognosis:rating confidence in estimates of event rates in broad categories of patients. BMJ, 2015, 350:h870.
16.	Guyatt GH, Schünemann HJ, Djulbegovic B, et al. Guideline panels should not GRADE good practice statements. J Clin Epidemiol, 2015, 68(5):597-600.
17.	曾憲濤, 金晶, 向招燕, 等. 思密達與錫類散比較治療小兒口腔潰瘍的Meta分析. 中國循證醫學雜志, 2012, 12(3):326-333.
18.	Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines:4. Rating the quality of evidence-study limitations(risk of bias) and publication bias. J Clin Epidemiol, 2011, 64(4):407-415.
19.	Nolting A, Perleth M, Langer G, et al. GRADE guidelines:5. Rating the quality of evidence:publication bias. J Clin Epidemiol, 2012, 106(9):670-676.
20.	Kulig M, Perleth M, Langer G, et al. GRADE guidelines:6. Rating the quality of evidence:imprecision. J Clin Epidemiol, 2012, 106(9):677-88.
21.	Perleth M, Langer G, Meerpohl JJ, et al. GRADE guidelines:7. Rating the quality of evidence-inconsistency. J Clin Epidemiol, 2012, 106(10):733-744.
22.	Rasch A, Perleth M, Langer G, et al. GRADE guidelines:8. Rating the quality of evidence-indirectness. J Clin Epidemiol, 2012, 106(10):745-753.
23.	Kien C, Gartiehner G, Kaminski-Hartenthaler A, et al. GRADE guidelines:9. Rating up the quality of evidence. J Clin Epidemiol, 2013, 107(3):249-255.

1. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454):1490.
2. 曾憲濤, 田國祥, 牛玉明, 等. GRADEprofiler軟件使用簡介. 中國循證心血管醫學雜志, 2011, 12(3):390-392.
3. Guyatt GH, Oxman AD, Vist GE, et al. GRADE:an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008, 336(7650):924-926.
4. Guyatt GH, Oxman AD, Kunz R, et al. What is "quality of evidence" and why is it important to clinicians? BMJ, 2008, 336(7651):995-998.
5. Guyatt GH, Oxman AD, Kunz R, et al. Going from evidence to recommendations. BMJ, 2008, 336(7652):1049-1051.
6. Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 2008, 336(7653):1106-1110.
7. Guyatt GH, Oxman AD, Kunz R, et al. Incorporating considerations of resources use into grading recommendations. BMJ, 2008, 336(7654):1170-1173.
8. Jaeschke R, Guyatt GH, Dellinger P, et al. Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ, 2008, 337:a744.
9. 陳耀龍, 楊克虎, 姚亮, 等. GRADE系統方法學進展. 中國循證兒科雜志, 2013, 8(1):64-65.
10. 曾憲濤, 冷衛東, 李勝, 等. 如何正確理解及使用GRADE系統. 中國循證醫學雜志, 2011, 11(9):985-990.
11. 陳耀龍, 姚亮, Norris S, 等. GRADE在系統評價中應用的必要性及注意事項. 中國循證醫學雜志, 2013, 13(12):1401-1404.
12. 陳耀龍, 姚亮, 杜亮, 等. GRADE在診斷準確性試驗系統評價中應用的原理、方法、挑戰及發展趨勢. 中國循證醫學雜志, 2014, 14(11):1402-1406.
13. 姚亮, 陳耀龍, 杜亮, 等. GRADE在診斷準確性試驗系統評價中的應用實例解析. 中國循證醫學雜志, 2014, 14(11):1407-1412.
14. Puhan MA, Schünemann HJ, Murad MH, et al. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ, 2014, 24, 349:g5630.
15. Lorio A, Spencer FA, Falavigna M, et al. Use of GRADE for assessment of evidence about prognosis:rating confidence in estimates of event rates in broad categories of patients. BMJ, 2015, 350:h870.
16. Guyatt GH, Schünemann HJ, Djulbegovic B, et al. Guideline panels should not GRADE good practice statements. J Clin Epidemiol, 2015, 68(5):597-600.
17. 曾憲濤, 金晶, 向招燕, 等. 思密達與錫類散比較治療小兒口腔潰瘍的Meta分析. 中國循證醫學雜志, 2012, 12(3):326-333.
18. Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines:4. Rating the quality of evidence-study limitations(risk of bias) and publication bias. J Clin Epidemiol, 2011, 64(4):407-415.
19. Nolting A, Perleth M, Langer G, et al. GRADE guidelines:5. Rating the quality of evidence:publication bias. J Clin Epidemiol, 2012, 106(9):670-676.
20. Kulig M, Perleth M, Langer G, et al. GRADE guidelines:6. Rating the quality of evidence:imprecision. J Clin Epidemiol, 2012, 106(9):677-88.
21. Perleth M, Langer G, Meerpohl JJ, et al. GRADE guidelines:7. Rating the quality of evidence-inconsistency. J Clin Epidemiol, 2012, 106(10):733-744.
22. Rasch A, Perleth M, Langer G, et al. GRADE guidelines:8. Rating the quality of evidence-indirectness. J Clin Epidemiol, 2012, 106(10):745-753.
23. Kien C, Gartiehner G, Kaminski-Hartenthaler A, et al. GRADE guidelines:9. Rating up the quality of evidence. J Clin Epidemiol, 2013, 107(3):249-255.

Chinese Journal of Evidence-Based Medicine

How to use GRADEpro GDT to Rate the Quality of Evidence in Systematic Reviews of Intervention Studies: An Introduction

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