Traditional Chinese Medicine for Cough Variant Asthma: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 WULi-hua , JIANGHong-li , MINJie , FANTao , LIGuan-hong , LIUWei , DONGShou-jin , CAILin-li , QUBo ,  MAOBing

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

MAOBing, Email: maobing2013@yeah.net

Keywords：

Cough variant asthma; Traditional Chinese medicine; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20150179

Video：

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Objective To systematically review the clinical effect and safety of traditional Chinese medicine (TCM) in the treatment of cough variant asthma (CVA). Methods We searched MEDLINE (Ovid), PubMed, EMbase, The Cochrane Library, VIP, WanFang Data, CNKI and CBM databases to collect randomized controlled trials (RCTs) about TCM for CVA from inception to May 2014. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by RevMan 5.2 software. Results A total of 17 RCTs were included. The results of qualitative analysis showed that:in improving cough symptom, three of four RCTs showed that TCM was superior to western medicine alone. In improving airway hyper responsiveness and overall treatment effect, the difference between TCM and western medicine alone remained uncertain. No serious adverse reactions related to TCM was reported in 17 RCTs. Conclusion Based on the current evidence, some trials suggest the TCM is superior to western medicine alone in improving cough symptom, however in the improvement of airway hyper responsiveness and overall efficacy, the difference between TCM and western medicine alone remains uncertain. Due to the variety of TCM and western medicine as well as limited methodological quality and different intervention of the included studies, more high-quality RCTs with large scale are needed to verify the above conclusion.

Citation： WULi-hua, JIANGHong-li, MINJie, FANTao, LIGuan-hong, LIUWei, DONGShou-jin, CAILin-li, QUBo, MAOBing. Traditional Chinese Medicine for Cough Variant Asthma: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2015, 15(9): 1084-1089. doi: 10.7507/1672-2531.20150179 Copy

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11.	黃翠. 祛風解痙方治療咳嗽變異性哮喘的臨床研究. 廣州:廣州中醫藥大學, 2009.
12.	葉秀兒. 祛風解痙湯對咳嗽變異性哮喘免疫免疫細胞因子和氣道反應性的影響. 廣州:廣州中醫藥大學, 2011.
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15.	羅社文. 疏風宣肺法對咳嗽變異性哮喘患者氣道高反應的影響. 中國醫藥學報, 2004, 19(5):288-289.
16.	朱金鳳. 固本平喘湯治療咳嗽變異型哮喘的臨床觀察. 湖北中醫雜志, 2006, 28(8):12-14.
17.	劉秀茹. 中西醫結合治療咳嗽變異性哮喘的臨床研究. 北京:北京中醫藥大學, 2008.
18.	何淑嫻. 溫腎鎮咳方治療咳嗽變異性哮喘療效觀察. 遼寧中醫藥大學學報, 2007, 9(7):7-8.
19.	杜文堅. 桑白皮湯加減治療咳嗽變異性哮喘30例. 陜西中醫, 2007, 28(7):839-840.
20.	范博音, 孫許濤, 史雅倩, 等. 咳嗽變異性哮喘的中醫藥研究進展. 中醫藥信息, 2013, 4(30):148-151.
21.	鐘永紅. 潤肺咳喘膠囊治療咳嗽變異性哮喘的臨床研究. 北京:北京中醫藥大學, 2011.
22.	Resch KL, Ernst E. Research methodologies in complementary medicine:making sure it works. In:Ernst E, ed. Complementary Medicine:An Objective Appraisal. Oxford, Butterworth, 1996.

1. 馬高峰. 抗敏止嗽顆粒治療咳嗽變異性哮喘89例. 中醫研究, 2006, 19(5):37-39.
2. 支艷. 楊明會教授治療氣道高反應性咳嗽的臨證經驗研究. 北京:中國人民解放軍軍醫進修學院, 2010.
3. 馮文杰, 李向林. 咳嗽變異性哮喘的中醫治療現狀. 臨床肺科雜志, 2011, 16(1):99-100.
4. The Cochrane Collaboration. Cochrane for Systematic Review of Interventions. Version 5.1. Available at:http://www.cochrane.org/.htm.
5. Miao Q. Clinical study on treatment of cough variant asthma by Chinese medicine. Chin J Integr Med, 2013, 19(7):539-545.
6. 叢曉東. 溫潤辛金方對咳嗽變應性哮喘(風寒戀肺型)療效及其生活質量的影響. 北京:北京中醫藥大學, 2013.
7. 陳俊榕. 加味三葉湯治療咳嗽變異性哮喘的臨床療效觀察. 廣州:廣州中醫藥大學, 2010.
8. 馮德華. "祛風止痙方"聯合孟魯司特鈉治療咳嗽變異性哮喘40例臨床研究. 江蘇中醫藥, 2012, 44(7):16-18.
9. 熊艷云. 培土肅金法治療痰濕壅肺型咳嗽變異性哮喘肝火犯肺證30例臨床觀察. 廣州:廣州中醫藥大學, 2011.
10. 游柏穩, 游海, 杜海燕. 清肝寧肺方治療咳嗽變異性哮喘肝火犯肺證30例臨床觀察. 中醫藥導報, 2012, 18(8):40-42.
11. 黃翠. 祛風解痙方治療咳嗽變異性哮喘的臨床研究. 廣州:廣州中醫藥大學, 2009.
12. 葉秀兒. 祛風解痙湯對咳嗽變異性哮喘免疫免疫細胞因子和氣道反應性的影響. 廣州:廣州中醫藥大學, 2011.
13. 賈明月. 蘇黃止咳膠囊治療咳嗽變異性哮喘的臨床療效評價. 北京:北京中醫藥大學, 2012.
14. 曾慶霖. 風咳方治療咳嗽變異性哮喘臨床觀察. 長沙:湖南中醫藥大學, 2011.
15. 羅社文. 疏風宣肺法對咳嗽變異性哮喘患者氣道高反應的影響. 中國醫藥學報, 2004, 19(5):288-289.
16. 朱金鳳. 固本平喘湯治療咳嗽變異型哮喘的臨床觀察. 湖北中醫雜志, 2006, 28(8):12-14.
17. 劉秀茹. 中西醫結合治療咳嗽變異性哮喘的臨床研究. 北京:北京中醫藥大學, 2008.
18. 何淑嫻. 溫腎鎮咳方治療咳嗽變異性哮喘療效觀察. 遼寧中醫藥大學學報, 2007, 9(7):7-8.
19. 杜文堅. 桑白皮湯加減治療咳嗽變異性哮喘30例. 陜西中醫, 2007, 28(7):839-840.
20. 范博音, 孫許濤, 史雅倩, 等. 咳嗽變異性哮喘的中醫藥研究進展. 中醫藥信息, 2013, 4(30):148-151.
21. 鐘永紅. 潤肺咳喘膠囊治療咳嗽變異性哮喘的臨床研究. 北京:北京中醫藥大學, 2011.
22. Resch KL, Ernst E. Research methodologies in complementary medicine:making sure it works. In:Ernst E, ed. Complementary Medicine:An Objective Appraisal. Oxford, Butterworth, 1996.

Chinese Journal of Evidence-Based Medicine

Traditional Chinese Medicine for Cough Variant Asthma: A Systematic Review

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