Relationship between Birth Number and Breast Cancer Risk of Chinese Female: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHANGJin , YANGYu-huan , MEIYong ,  CHENGGuang-wen

School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China;

Corresponding?author：

CHENGGuang-wen, Email: chenggw@wust.edu.cn

Keywords：

Breast cancer; Number of birth; Meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.20150191

Video：

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Objective To systematically review the correlation between the birth number and the risk of breast cancer of Chinese female. Methods We electronically searched databases including the CNKI, WanFang Data and VIP databases from inception to September 1^st 2015, to collect case-control studies about the correlation between the number of births and the risk of breast cancer among Chinese female. Two reviewers independently screened literature, extracted data, and evaluated the risk of bias of included studies. Then meta-analysis was performed by using Stata software. Results A total of 14 case-control studies involving 3 428 patients and 3 906 controls were included. The results of meta-analysis showed that:the females who had term birth had significant lower incidence of breast cancer than those without childbirth history (OR=0.429, 95%CI 0.322 to 0.571). Subgroup analysis based on the number of term birth showed that:Compared with the female without childbirth history, those who had term birth of one time (OR=0.464, 95%CI 0.321 to 0.670), two times (OR=0.394, 95%CI 0.269 to 0.576) and≥3 times (OR=0.340, 95%CI 0.232 to 0.499) had significant lower incidence of breast cancer. Conclusion Term birth is a protective factor for breast cancer of Chinese female, and more times of term birth will decrease the risk of breast cancer.

Citation： ZHANGJin, YANGYu-huan, MEIYong, CHENGGuang-wen. Relationship between Birth Number and Breast Cancer Risk of Chinese Female: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(10): 1148-1152. doi: 10.7507/1672-2531.20150191 Copy

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22.	李博涵. 單獨二胎政策的出臺對我國人口規模及結構的影響研究. 知識經濟, 2014, (2):20-21.

1. 李業達, 郭正義, 劉春麗. 乳腺癌危險因素分析. 社區醫學雜志, 2010, 8(18):25-27.
2. 林本耀. 乳腺癌. 北京:中國醫藥科技出版社, 2007.
3. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of non-randomized studies in meta-analyses. European Journal of Epidemiology, 2010, 25(9):603-605.
4. 張夏, 王興泰. 蘭州市女性乳腺癌生育因素危險性病例對照研究. 解放軍醫學高等專科學校學報, 1998, 26(3):25-29.
5. 任曉南. 乳腺癌危險因素的1︰1病例對照研究. 大連醫科大學, 2008.
6. 曾艷, 徐茂盛, 譚世奇, 等. 乳腺癌危險因素分析. 南方醫科大學學報, 2010, 30(3):622-623.
7. 李玉陽, 劉奇. 山東省乳腺疾病調查報告與乳腺癌危險因素分析. 濟南:山東大學, 2011.
8. 俞順章, 陸瑞芳, 黃敬亨, 等. 上海市六所醫院102例乳腺癌流行因素調查. 腫瘤, 1984, 4(1):21-24.
9. 錢云, 沈洪兵, 張敬平, 等. 無錫市女性乳腺癌危險因素病例對照研究. 中國公共衛生, 2009, 25(10):1177-1178.
10. 高君. 月經、生殖因素及環氧化酶2基因多態性與乳腺癌關系的流行病學研究. 南京:南京醫科大學, 2007.
11. 李泓瀾, 高立峰. 月經生育因素與女性乳腺癌關系的病例對照研究. 腫瘤, 2000, 20(2):88-92.
12. 龐軼, 李卉, 雷放鳴, 等. 婦女生殖生育因素與乳腺癌病例對照研究. 中國公共衛生, 2009, 25(10):1172-1174.
13. 趙揚冰, 史宗道, 劉立岷, 等. 成都地區女性乳腺癌危險因素的病例對照研究. 中華流行病學雜志, 1999, 20(2):91-94.
14. 黃向明, 王春霞, 周永生, 等. 深圳市寶安區女性乳腺癌發病危險因素的初步調查. 中原醫刊, 2006, 33(22):37-39.
15. 姜愛仁, 高長明, 丁建華, 等. 流產與乳腺癌發病風險關系的病例對照研究. 中國腫瘤, 2012, 21(4):264-267.
16. 王映青. 基于隊列人群的乳腺癌危險因素病例對照研究. 杭州:浙江大學, 2006.
17. 曹蘭青, 李卉, 劉莉, 等. 四川省女性ERα基因多態性與乳腺癌風險關系的病例對照研究. 腫瘤預防與治療, 2014, 27(4):171-175.
18. Dell DD. Spread the word about breast cancer. Nursing, 2005, 35(10):56-63.
19. Okobia MN, Bunker CH. Epidemiological risk factors for breast cancer:a review. Niger J Clin Pract, 2005, 8(1):35-42.
20. 李保義, 宋志軍, 白濤, 等. 女性乳腺癌危險因素研究進展. 首都醫藥, 2007, 14(4X):30-31.
21. 蘇慶光, 揚波, 王增艷. 乳腺癌的危險因素. 中國腫瘤, 2000, 9(11):514-516.
22. 李博涵. 單獨二胎政策的出臺對我國人口規模及結構的影響研究. 知識經濟, 2014, (2):20-21.

Chinese Journal of Evidence-Based Medicine

Relationship between Birth Number and Breast Cancer Risk of Chinese Female: A Meta-analysis

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