Aminophylline combined with Traditional Chinese Medicine for Asthma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LISi-yu ¹ , LIRui ¹ , TIANWei-lan ¹ , SHANGHong-cai ² ,  ZHAIHua-qiang ¹

1. Institute of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China;
2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;

Corresponding?author：

ZHAIHua-qiang, Email: zhaihq@bucm.edu.cn

Keywords：

Bronchial asthma; Aminophylline; Traditional Chinese medicine; Systematic review; Meta-analysis; Randomized Controlled Trial

DOI：

10.7507/1672-2531.20150217

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the effects of aminophylline combined with traditional Chinese medicine (TCM) in the treatment of asthma. Methods Databases including The Cochrane Library(Issue 1, 2015), PubMed, EMbase, CNKI, VIP and WanFang Data databases were electronically searched from January 2005 to December 2014 to collect randomized controlled trials (RCTs) about the treatment of bronchial asthma combining aminophylline with TCM. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 10 RCTs involving 820 participants were included. The results of meta-analysis showed that: The total clinical effective rate in the aminophylline plus TCM group was higher than that of the aminophylline alone group (RR=1.22, 95%CI 1.11 to 1.33). The FEV1 in the aminophylline plus TCM group was also higher than that of the aminophylline alone group (MD=0.53, 95%CI 0.33 to 0.73). Conclusion Current evidence shows, the total clinical effective rate of aminophylline combined with TCM for asthma is better than that of aminophylline alone, and its mechanism may be related to the improvement of FEV1. Due to the limited quantity and quality of included studies, the above conclusion needs to be further verified by more high quality studies.

Citation： LISi-yu, LIRui, TIANWei-lan, SHANGHong-cai, ZHAIHua-qiang. Aminophylline combined with Traditional Chinese Medicine for Asthma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(11): 1322-1326. doi: 10.7507/1672-2531.20150217 Copy

1.	Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of GINA Dissemination Committee report. Allergy, 59(5):469-478.
2.	Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2014:36.
3.	中華醫學會呼吸病分會哮喘學組. 支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療和管理方案). 中華哮喘雜志, 2008, 2(1): 3-13.
4.	鐘文昭, 吳一龍, 谷力加. Review Manager (RevMan)--臨床醫生通向Meta分析的橋梁. 循證醫學, 2013, 3(4):234-246.
5.	周棉勇. 中西醫結合治療哮喘療效分析. 藥物與人, 2014, 4(27): 239-240. 圖3氨茶堿聯合中藥組與單用氨茶堿組FEV1比較的Meta分析.
6.	唐上英. 中西醫結合治療小兒支氣管哮喘的療效研究. 中華實用醫藥, 2008, 3(35):55-56.
7.	黃家聰. 加用小青龍湯合陽和湯治療寒性支氣管哮喘療效觀察. 廣西中醫藥, 2012, 35(6):30-31.
8.	黃杜寧. 中西醫結合治療支氣管哮喘療效觀察. 實用中醫藥雜志, 2014, 30(4):285-286.
9.	黃和祥. 中西醫結合治療40例支氣管哮喘臨床療效觀察. 現代診斷與治療, 2014, 25(8):1735.
10.	沙向紅, 朱慧平, 陳懷. 平喘湯配合西藥對兒童支氣管哮喘急性發作期的臨床對照觀察. 北京中醫藥, 2008, 27(2):102-103.
11.	林濤, 鄧治平, 楊瑩. 中西醫結合治療支氣管哮喘急性發作的臨床分析. 中國醫藥指南, 2013, 11(19):671-672.
12.	曹洪波. 中西醫結合治療支氣管哮喘臨床研究. 河南中醫, 2014, 34(3):502-503.
13.	李思深, 鄧智武. 中西醫結合治療支氣管哮喘70例臨床觀察. 中醫藥導報, 2014, 20(6):54-55.
14.	李學明, 陸煒青, 王克儉. 平喘補腎祛瘀煎方配合氨茶堿治療支氣管哮喘臨床觀察. 內蒙古中醫藥, 2014, 33(28):61.

1. Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of GINA Dissemination Committee report. Allergy, 59(5):469-478.
2. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2014:36.
3. 中華醫學會呼吸病分會哮喘學組. 支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療和管理方案). 中華哮喘雜志, 2008, 2(1): 3-13.
4. 鐘文昭, 吳一龍, 谷力加. Review Manager (RevMan)--臨床醫生通向Meta分析的橋梁. 循證醫學, 2013, 3(4):234-246.
5. 周棉勇. 中西醫結合治療哮喘療效分析. 藥物與人, 2014, 4(27): 239-240. 圖3氨茶堿聯合中藥組與單用氨茶堿組FEV1比較的Meta分析.
6. 唐上英. 中西醫結合治療小兒支氣管哮喘的療效研究. 中華實用醫藥, 2008, 3(35):55-56.
7. 黃家聰. 加用小青龍湯合陽和湯治療寒性支氣管哮喘療效觀察. 廣西中醫藥, 2012, 35(6):30-31.
8. 黃杜寧. 中西醫結合治療支氣管哮喘療效觀察. 實用中醫藥雜志, 2014, 30(4):285-286.
9. 黃和祥. 中西醫結合治療40例支氣管哮喘臨床療效觀察. 現代診斷與治療, 2014, 25(8):1735.
10. 沙向紅, 朱慧平, 陳懷. 平喘湯配合西藥對兒童支氣管哮喘急性發作期的臨床對照觀察. 北京中醫藥, 2008, 27(2):102-103.
11. 林濤, 鄧治平, 楊瑩. 中西醫結合治療支氣管哮喘急性發作的臨床分析. 中國醫藥指南, 2013, 11(19):671-672.
12. 曹洪波. 中西醫結合治療支氣管哮喘臨床研究. 河南中醫, 2014, 34(3):502-503.
13. 李思深, 鄧智武. 中西醫結合治療支氣管哮喘70例臨床觀察. 中醫藥導報, 2014, 20(6):54-55.
14. 李學明, 陸煒青, 王克儉. 平喘補腎祛瘀煎方配合氨茶堿治療支氣管哮喘臨床觀察. 內蒙古中醫藥, 2014, 33(28):61.

Previous Article
Effects of Exercise Therapy on Patients with Low Back Pain: A Meta-analysis
Next Article
Effects of Clinical Nursing Pathway in Femoral Neck Fracture Patients: A Meta-analysis

Chinese Journal of Evidence-Based Medicine

Aminophylline combined with Traditional Chinese Medicine for Asthma: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content