Drug Resistance of Common Bacteria Isolated from the Mohnarin Cerebrospinal Fluid, Blood and Bile: A Literature Study_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENLi-xia ^1,2 , GONGGuo-mei ² , LINMei ² ,  MINGDe-song ^1,3

1. Department of Basic Medicine, Quanzhou Medical College, Quanzhou 362011, China;
2. Department of Nursing, Quanzhou Medical College, Quanzhou 362011, China;
3. Department of Clinical Laboratory, the First Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China;

Corresponding?author：

MINGDe-song, Email: mds6430@126.com

Keywords：

Antimicrobial agents; Drug resistance; Cerebrospinal fluid; Blood stream; Bile; Mohnarin

DOI：

10.7507/1672-2531.20150219

Video：

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Objective To compare and analyze the differences of bacterial resistance of 3 different strains of bacteria isolated from Mohnarin cerebrospinal fluid (CSF), blood and bile of literature published in China, to provide the basis for clinical rational drug use. Methods We searched databases including CNKI and WanFang Data for reports about bacterial resistance from Mohnarin CSF, blood and bile from 2006 to 2014. Two reviewers independently screened literature, extracted data, and analyzed the differences of bacterial resistance from CSF, blood and bile by SPSS 19.0 software. Results Composition ratio of the gram positive bacteria from CSF specimens was much higher than those of the blood and the bile (χ²=383.118, P<0.001). The separation of E. coli, K. pneumoniae, E. cloacae, P. aeruginosa, A. baumannii, E. faecium and E. faecalis from CSF exhibited multi-drug resistance, and their resistance rates to commonly used antimicrobial agents were significantly higher than those from blood and bile (P<0.001), especially the A. baumannii, K. pneumoniae, E. cloacae and E. faeciu, and their overall resistance rates to commonly used antimicrobial drugs were 68.1%, 60.5%, 59.8%, and 59.4%, respectively. The top three antibiotics with higher resistance rate were piperacillin, sulfamethoxazole/trimethoprim and cefotaxime in A. baumannii, piperacillin, ceftriaxone and cefotaxime in K. pneumoniae, cefoxitin, Ampicillin/sulbactam and cefuroxime in E. cloacae, penicillin G, ampicillin and erythromycin in E. faecium. The resistant rates of quinolone in E. coli, E. cloacae, A. baumannii and E. faecium from CSF specimens were high, but low in K. pneumoniae, P. aeruginosa and E. faecalis. Conclusion There are differences for drug resistance of the bacteria from different specimens from Mohnarin, the bacteria from CSF specimens exhibits multi-drug resistance, the resistances are significantly higher than those from blood and bile.

Citation： CHENLi-xia, GONGGuo-mei, LINMei, MINGDe-song. Drug Resistance of Common Bacteria Isolated from the Mohnarin Cerebrospinal Fluid, Blood and Bile: A Literature Study. Chinese Journal of Evidence-Based Medicine, 2015, 15(11): 1334-1342. doi: 10.7507/1672-2531.20150219 Copy

1.	文蘭, 劉雙全, 曾琳, 等. 腦脊液標本926例細菌培養結果及耐藥性分析. 南華大學學報(醫學版), 2009, 37(6):714-715.
2.	廖國林, 王海紅, 王穎翔, 等. 膽道感染患者膽汁培養病原菌分布及耐藥性分析. 國際檢驗醫學雜志, 2013, 34(22):3077-3078.
3.	陳文思, 朱家馨, 陳偉. 醫院血培養的病原菌分布及耐藥性分析. 中國微生態學雜志, 2009, 21(7):646-648.
4.	李耘, 呂媛, 王珊. 2010年度衛生部全國細菌耐藥監測報告:腦脊液分離細菌耐藥監測. 中華醫院感染學雜志, 2012, 21(24):5152-5156.
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6.	周春妹, 胡必杰, 呂媛. 2010年度衛生部全國細菌耐藥監測網報告:膽汁培養病原菌的構成及耐藥性監測. 中華醫院感染學雜志, 2012, 22(1):18-22.
7.	靳穎, 馬鐵柱, 吳玉秀, 等. 臨床神經內外科連續3年腦脊液培養的菌群分布和耐藥性分析. 中國康復理論與實踐, 2010, 16(11): 1060-1061.
8.	王輝, 陳民鈞, 孫宏莉, 等. 革蘭陰性桿菌耐藥狀況研究-2008中國美羅培南敏感性監測(CMSS)報告. 中國實用內科雜志, 2010, 30(1):44-48.
9.	王明美, 張媛媛, 俞燕紅. 膽汁標本中病原菌的分布及耐藥性分析. 中國衛生檢驗雜志, 2011, 21(6):1432-1433.
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11.	劉楊, 歐寧. 喹諾酮類藥物的作用機制耐藥機制及研究進展. 藥學與臨床研究, 2014, 22(2):140-143.

1. 文蘭, 劉雙全, 曾琳, 等. 腦脊液標本926例細菌培養結果及耐藥性分析. 南華大學學報(醫學版), 2009, 37(6):714-715.
2. 廖國林, 王海紅, 王穎翔, 等. 膽道感染患者膽汁培養病原菌分布及耐藥性分析. 國際檢驗醫學雜志, 2013, 34(22):3077-3078.
3. 陳文思, 朱家馨, 陳偉. 醫院血培養的病原菌分布及耐藥性分析. 中國微生態學雜志, 2009, 21(7):646-648.
4. 李耘, 呂媛, 王珊. 2010年度衛生部全國細菌耐藥監測報告:腦脊液分離細菌耐藥監測. 中華醫院感染學雜志, 2012, 21(24):5152-5156.
5. 馬序竹, 呂媛, 薛峰. 2010年度衛生部全國細菌耐藥監測報告:血流感染細菌耐藥監測. 中華醫院感染學雜志, 2012, 21(24):5147-5151.
6. 周春妹, 胡必杰, 呂媛. 2010年度衛生部全國細菌耐藥監測網報告:膽汁培養病原菌的構成及耐藥性監測. 中華醫院感染學雜志, 2012, 22(1):18-22.
7. 靳穎, 馬鐵柱, 吳玉秀, 等. 臨床神經內外科連續3年腦脊液培養的菌群分布和耐藥性分析. 中國康復理論與實踐, 2010, 16(11): 1060-1061.
8. 王輝, 陳民鈞, 孫宏莉, 等. 革蘭陰性桿菌耐藥狀況研究-2008中國美羅培南敏感性監測(CMSS)報告. 中國實用內科雜志, 2010, 30(1):44-48.
9. 王明美, 張媛媛, 俞燕紅. 膽汁標本中病原菌的分布及耐藥性分析. 中國衛生檢驗雜志, 2011, 21(6):1432-1433.
10. 胡必佳, 宗志勇, 顧克菊, 主編. 多重耐藥菌感染控制最佳實踐. 上海:上海科學技術出版社, 2012.
11. 劉楊, 歐寧. 喹諾酮類藥物的作用機制耐藥機制及研究進展. 藥學與臨床研究, 2014, 22(2):140-143.

Chinese Journal of Evidence-Based Medicine

Drug Resistance of Common Bacteria Isolated from the Mohnarin Cerebrospinal Fluid, Blood and Bile: A Literature Study

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