Drug Resistance, Resistant Mechanisms and Resistant Phenotypes of Staphylococcus Aureus Isolated from Wound Secretion to Macrolides-Lincosamides-Streptogramins_Chinese Journal of Evidence-Based Medicine

Authors：

 WANGXiao-ying ¹ , YANYuan-fang ² , CHENXiong-yi ³ ,  MINGDe-song ³

1. Department of Medical Cosmetology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China;
2. Anxi County Hospital, Quanzhou 362000, China;
3. Department of Laboratory Medicine, the First Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China;

Corresponding?author：

MINGDe-song, Email: mds6430@126.com

Keywords：

Wound secretion; Staphylococcus aureus; Macrolides; Tigecycline; Quinolons; Tetracyclines; Linezolid; Inducible

DOI：

10.7507/1672-2531.20160041

Video：

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Objective To explore drug resistance, resistant mechanisms and resistant phenotypes of staphylococcus aureus (SA) isolated from wound secretion to macrolides-lincosamides-streptogramins (MLS). Methods A retrospective design was used to collect clinical data and antimicrobial resistance profiles of SA in the First Affiliated Hospital and the Second Affiliated Hospital of Fujian Medical University and Anxi County Hospital from June, 2008 to October, 2015. SPSS 19.0 software was used for data analysis. Results A total of 127 isolates were included. The distribution of four resistant phenotypes of SA to MLS were all susceptibility(S) type (n=48, 37.8%), ML type (n=41, 32.3%), M/iCR+ type (n=22, 17.3%) and MLS type (n=16, 12.6%), respectively; There were three kinds of phenotypes caused by target changing including ML type, M/iCR+ type and MLS type, respectively. Moreover, no moxicaxin, linezolid or tigecyline resistant strain was detected, while quinolons and tetracyclines showed low-level resistant. Conclusion Compared with the different samples, the resistant phenotypes of SA isolated from wound secretion to MLS are few, and the total resistance ratio is low.

Citation： WANGXiao-ying, YANYuan-fang, CHENXiong-yi, MINGDe-song. Drug Resistance, Resistant Mechanisms and Resistant Phenotypes of Staphylococcus Aureus Isolated from Wound Secretion to Macrolides-Lincosamides-Streptogramins. Chinese Journal of Evidence-Based Medicine, 2016, 16(3): 254-256. doi: 10.7507/1672-2531.20160041 Copy

1.	胡志東, 王鳳霞, 李金, 等. 2010年度衛生部全國細菌耐藥監測網報告:傷口感染病原菌分布及耐藥監測. 中華醫院感染學雜志, 2012, 22(1):23-27.
2.	馮平鋒, 柴志欣, 裘宇容, 等. 2042株傷口中常見病原菌種類及耐藥性分析. 國際檢驗醫學雜志, 2014, 35(6):709-711.
3.	繆應業, 謝國旗, 劉新, 等. 2009-2012年傷口分泌物病原菌分布及耐藥研究. 中華醫院感染學雜志, 2014, 24(3):585-587.
4.	瞿亞紅, 姜妙靜, 周程程. 不同種類標本分離的金黃色葡萄球菌的耐藥性比較及分析. 2014年浙江省檢驗醫學學術年會論文匯編, 2014.
5.	Lavallée C, Rouleau D, Gaudreau C, et al. Performance of an agar dilution method and a Vitek 2 card for detection of inducible clindamycinresistance in Staphylococcus spp. J Clin Microbiol, 2010, 48(4):1354-1357.
6.	劉曉強, 謝曉英, 曾華, 等. 1517株金黃色葡萄球菌的臨床分布及藥敏結果分析. 中國微生態學雜志, 2014, 26(8):944-946.
7.	Cetin ES, Gunes H, Kaya S, et al. Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. Int J Antimicrob Agents, 2008, 31(4):364-368.
8.	明德松, 吳一波, 朱焱, 等. 耐甲氧西林葡萄球菌對大環內酯類抗生素的耐藥性分析. 中國現代醫學雜志, 2004, 22(11):100-101.
9.	張志軍, 曹海燕, 劉延媛, 等. 醫院感染金黃色葡萄球菌耐藥表型與耐藥基因研究. 中華醫院感染學雜志, 2015, 25(9):1924-1926.
10.	Matsuoka M. Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus. Yakugaku Zasshi, 2000, 120(4):374-386.
11.	Uzun B, Güng?r S, Pekta? B, et al. Macrolide-lincosamide-streptogramin B (MLSB) resistance phenotypes in clinical Staphylococcus isolates and investigation of telithromycin activity. Mikrobiyol Bul, 2014, 48(3):469-476.
12.	葉應嫵, 王毓三. 全國臨床檢驗操作規程. 第3版. 南京:東南大學出版社, 2006:502-509.
13.	National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. M100-S15, NCCLS, 2005:1-133.
14.	Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; Twentieth informational supplement. CLSI documents M100-S20. CLSI, 2010.
15.	陳惠剛, 林艷, 李晰, 等. 河北地區皮膚病住院患者金黃色葡萄球菌耐藥基因檢測. 中國病原生物學雜志, 2015, 10(1):29-33.
16.	張志軍, 曹海燕, 劉延媛, 等. 醫院感染金黃色葡萄球菌耐藥表型與耐藥基因研究. 中華醫院感染學雜志, 2015, 25(9):1924-1926.

1. 胡志東, 王鳳霞, 李金, 等. 2010年度衛生部全國細菌耐藥監測網報告:傷口感染病原菌分布及耐藥監測. 中華醫院感染學雜志, 2012, 22(1):23-27.
2. 馮平鋒, 柴志欣, 裘宇容, 等. 2042株傷口中常見病原菌種類及耐藥性分析. 國際檢驗醫學雜志, 2014, 35(6):709-711.
3. 繆應業, 謝國旗, 劉新, 等. 2009-2012年傷口分泌物病原菌分布及耐藥研究. 中華醫院感染學雜志, 2014, 24(3):585-587.
4. 瞿亞紅, 姜妙靜, 周程程. 不同種類標本分離的金黃色葡萄球菌的耐藥性比較及分析. 2014年浙江省檢驗醫學學術年會論文匯編, 2014.
5. Lavallée C, Rouleau D, Gaudreau C, et al. Performance of an agar dilution method and a Vitek 2 card for detection of inducible clindamycinresistance in Staphylococcus spp. J Clin Microbiol, 2010, 48(4):1354-1357.
6. 劉曉強, 謝曉英, 曾華, 等. 1517株金黃色葡萄球菌的臨床分布及藥敏結果分析. 中國微生態學雜志, 2014, 26(8):944-946.
7. Cetin ES, Gunes H, Kaya S, et al. Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. Int J Antimicrob Agents, 2008, 31(4):364-368.
8. 明德松, 吳一波, 朱焱, 等. 耐甲氧西林葡萄球菌對大環內酯類抗生素的耐藥性分析. 中國現代醫學雜志, 2004, 22(11):100-101.
9. 張志軍, 曹海燕, 劉延媛, 等. 醫院感染金黃色葡萄球菌耐藥表型與耐藥基因研究. 中華醫院感染學雜志, 2015, 25(9):1924-1926.
10. Matsuoka M. Study of macrolide, lincosamide, and streptogramin B antibiotics resistance in Staphylococcus aureus. Yakugaku Zasshi, 2000, 120(4):374-386.
11. Uzun B, Güng?r S, Pekta? B, et al. Macrolide-lincosamide-streptogramin B (MLSB) resistance phenotypes in clinical Staphylococcus isolates and investigation of telithromycin activity. Mikrobiyol Bul, 2014, 48(3):469-476.
12. 葉應嫵, 王毓三. 全國臨床檢驗操作規程. 第3版. 南京:東南大學出版社, 2006:502-509.
13. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. M100-S15, NCCLS, 2005:1-133.
14. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; Twentieth informational supplement. CLSI documents M100-S20. CLSI, 2010.
15. 陳惠剛, 林艷, 李晰, 等. 河北地區皮膚病住院患者金黃色葡萄球菌耐藥基因檢測. 中國病原生物學雜志, 2015, 10(1):29-33.
16. 張志軍, 曹海燕, 劉延媛, 等. 醫院感染金黃色葡萄球菌耐藥表型與耐藥基因研究. 中華醫院感染學雜志, 2015, 25(9):1924-1926.

Chinese Journal of Evidence-Based Medicine

Drug Resistance, Resistant Mechanisms and Resistant Phenotypes of Staphylococcus Aureus Isolated from Wound Secretion to Macrolides-Lincosamides-Streptogramins

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