Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 AIJin-wei ^1,2 ^# ,  LIUYing ^1,2 ^# , GUANXiang-fei ² , CHENQiong ² , ZHANGWei ² , DENGJin ² ,  PEIBin ^1,2

1. Evidence-based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
2. Department of Micro-orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;

Corresponding?author：

PEIBin, Email: xyxzyxzx@163.com

Keywords：

HLA-B27; Ankylosing spondylitis; Diagnostic test; Chinese population; Meta-analysis

DOI：

10.7507/1672-2531.20160124

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Objective To explore the diagnostic value of HLA-B27 for ankylosing spondylitis (AS) in Chinese population. Methods We searched PubMed, EMbase, The Cochrane Library (Issue 8, 2015), CNKI, and WanFang data from inception to August 2015, to collect diagnostic studies about HLA-B27 for AS in Chinese population. Two reviewers independently screened literature, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed by using Stata12.0 software. Results A total of 16 studies involving 3137 AS and 5617 suspect patients were finally included. The results of meta-analysis showed that the pooled Sen, Spe, +LR, -LR and DOR were 0.91(95%CI 0.89 to 0.93), 0.94(95%CI 0.91 to 0.96), 14.90(95%CI 9.60 to 23.10), 0.09(95%CI 0.08 to 0.12) and 157.00(95%CI 90.00 to 275.00), respectively. The AUC of SROC was 0.98(95%CI 0.93 to 0.97). Conclusions HLA-B27 detection is of great diagnostic value for AS in Chinese population. However, due to the limited quality and quantity of the included studies, more long-term follow-up prospective studies are needed to verify the above conclusion.

Citation： AIJin-wei, LIUYing, GUANXiang-fei, CHENQiong, ZHANGWei, DENGJin, PEIBin. Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(7): 802-808. doi: 10.7507/1672-2531.20160124 Copy

1.	黎勤云, 李志強.強直性脊柱炎相關HLA-B27的研究進展.中國輸血雜志, 2012, 25(11):1138-1140.
2.	Dougados M, Paternotte S, Braun J, et al. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis, 2011, 70(2):249-251.
3.	Linden S, Valkenburg H, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum, 1984, 27(4):361-388.
4.	Rachid B, Zorkany B, Youseif E, et al. Early diagnosis and treatment of ankylosing spondylitis in Africa and the Middle East. Clin Rheumatol, 2012, 31(11):1633-1639.
5.	Popa O, Bojinca M, Bojinca V, et al. Distribution of HLA-B27 in Romanian spondyloarthritides patients. Int J Immunopharmacol, 2010, 37(6):513-516.
6.	Acar M, Cora T, Tunc R, et al. HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. Rheumatol Int, 2012, 32(10):3103-3105.
7.	蔣娟, 熊小敏, 張衛云, 等.人白細胞抗原HLA-B27在強直性脊柱炎中的臨床意義.生物技術通訊, 2014, 25(3):410-411.
8.	于莉. PCR-SSP法、FCM法及MLCT法檢測強直性脊柱炎患者HLA-B27對比分析.風濕病與關節炎, 2014, 10(3):13-15.
9.	艾金偉, 李德勝, 劉羽, 等.國內HLA-B27診斷強直性脊柱炎價值的Meta分析.中國循證醫學雜志, 2015, 15(9):1059-1067.
10.	Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
11.	尹森林, 劉雪梅, 何林, 等.對系統評價/Meta分析報告規范的系統評價.中國循證醫學雜志, 2011, 11(8):971-977.
12.	曾憲濤, Joey S, 田國祥, 等. Meta分析系列之二:Meta分析的軟件.中國循證心血管醫學雜志, 2012, 4(2):89-91.
13.	徐建業, 林丁, 李偉道, 等.甲胎蛋白診斷原發性肝癌準確性的系統評價.中國循證醫學雜志, 2009, 9(5):525-530.
14.	王海軍, 李彥彥, 王慧春, 等.雙時相18F-FDG PET鑒別肺部良惡性病變準確性的Meta分析.中國循證醫學雜志, 2013, 13(11):1326-1332.
15.	張俊, 徐志偉, 李克.診斷性試驗Meta分析的效應指標評價.中國循證醫學雜志, 2013, 13(7):890-895.
16.	倪吳花, 胡曉霞, 章圣輝, 等.強直性脊柱炎867例HLA-B27的表達及意義.實用醫學雜志, 2008, 24(9):1511-1513.
17.	章濤, 方寧, 祁瑩, 等.強直性脊柱炎疑似患者HLA-B27檢測結果分析.山東醫藥, 2008, 48(37):83-84.
18.	何進才, 傅新文, 侯智輝, 等. HLA-B27基因檢測對強直性脊柱炎診斷的評價.江西醫學檢驗, 2003, 21(4):240-242.
19.	方寧, 章濤, 胡錫階, 等.外周血T淋巴細胞HLA-B27檢測輔助診斷強直性脊柱炎.免疫學雜志, 2009, 25(2):210-213.
20.	鄧小軍, 謝志雄, 張陽根. HLA-B27抗原檢測在診斷AS中的意義.實用醫技雜志, 2006, 13(4):505-507.
21.	陳建華, 魏文寧, 喻喜. PCR-SSP法與流式細胞儀檢測強直性脊柱炎患者HLA-B27的比較.檢驗醫學與臨床, 2007, 4(3):161-162.
22.	吳娟.檢測強直性脊柱炎患者人類白細胞抗原B27的Il缶床意義.檢驗醫學與臨床, 2013, 10(6):663-665.
23.	胡慶宏, 易誠予, 彭燕, 等.江西地區強直性脊柱炎與HLA-B27基因關聯性.中國組織工程研究與臨床康復, 2009, 13(46):9183-9186.
24.	蔣娟, 熊小敏, 張衛云, 等.人白細胞抗原HLA-B27在強直性脊柱炎中的臨床意義.生物技術通訊, 2014, 25(3):410-411.
25.	林靜華, 方琳麗, 陳彥融, 等. HLA-B27抗原檢測在強直性脊柱炎診斷中的價值.中國熱帶醫學, 2013, 8(11):1946-1948.
26.	邱金英.流式細胞術檢測HLA-B27抗原在強直性脊柱炎診斷中的價值.現代醫院, 2009, 9(Suppl):171-173.
27.	劉波, 邱萌.早中期強直性脊柱炎患者兩種檢測HLA-B27方法比較.中國醫藥導報, 2011, 8(13):47-48.
28.	羅玲, 嚴海燕, 羅曉紅. HLA-B27/B7抗原檢測在診斷強直性脊柱炎中的臨床價值.中國實用醫藥, 2013, 8(4):8-9.
29.	劉永杰, 張小芳, 張運剛, 等. HLA-B27檢測對強直性脊柱炎診斷的臨床意義.國際檢驗醫學雜志, 2014, 35(10):1285-1286.
30.	謝能軒, 章健, 黃曉超, 等.強直性脊柱炎患者CD3+ T細胞HLA-B27表達水平.臨床檢驗雜志, 2008, 26(4):281.
31.	黃傳英.強直性脊柱炎免疫指標檢測及臨床價值.臨床輸血與檢驗, 2006, 8(3):187-189.
32.	Browerton D, Hart F, Nichous N, et al. Ankylosing spondylitis and HLA-B27. Lancet, 1973, 1(8):904-907.
33.	曾憲濤, 何明武.診斷準確性試驗Meta分析軟件一本通.北京:軍事醫學科學出版社, 2014:7-8.

1. 黎勤云, 李志強.強直性脊柱炎相關HLA-B27的研究進展.中國輸血雜志, 2012, 25(11):1138-1140.
2. Dougados M, Paternotte S, Braun J, et al. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis, 2011, 70(2):249-251.
3. Linden S, Valkenburg H, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum, 1984, 27(4):361-388.
4. Rachid B, Zorkany B, Youseif E, et al. Early diagnosis and treatment of ankylosing spondylitis in Africa and the Middle East. Clin Rheumatol, 2012, 31(11):1633-1639.
5. Popa O, Bojinca M, Bojinca V, et al. Distribution of HLA-B27 in Romanian spondyloarthritides patients. Int J Immunopharmacol, 2010, 37(6):513-516.
6. Acar M, Cora T, Tunc R, et al. HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. Rheumatol Int, 2012, 32(10):3103-3105.
7. 蔣娟, 熊小敏, 張衛云, 等.人白細胞抗原HLA-B27在強直性脊柱炎中的臨床意義.生物技術通訊, 2014, 25(3):410-411.
8. 于莉. PCR-SSP法、FCM法及MLCT法檢測強直性脊柱炎患者HLA-B27對比分析.風濕病與關節炎, 2014, 10(3):13-15.
9. 艾金偉, 李德勝, 劉羽, 等.國內HLA-B27診斷強直性脊柱炎價值的Meta分析.中國循證醫學雜志, 2015, 15(9):1059-1067.
10. Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
11. 尹森林, 劉雪梅, 何林, 等.對系統評價/Meta分析報告規范的系統評價.中國循證醫學雜志, 2011, 11(8):971-977.
12. 曾憲濤, Joey S, 田國祥, 等. Meta分析系列之二:Meta分析的軟件.中國循證心血管醫學雜志, 2012, 4(2):89-91.
13. 徐建業, 林丁, 李偉道, 等.甲胎蛋白診斷原發性肝癌準確性的系統評價.中國循證醫學雜志, 2009, 9(5):525-530.
14. 王海軍, 李彥彥, 王慧春, 等.雙時相18F-FDG PET鑒別肺部良惡性病變準確性的Meta分析.中國循證醫學雜志, 2013, 13(11):1326-1332.
15. 張俊, 徐志偉, 李克.診斷性試驗Meta分析的效應指標評價.中國循證醫學雜志, 2013, 13(7):890-895.
16. 倪吳花, 胡曉霞, 章圣輝, 等.強直性脊柱炎867例HLA-B27的表達及意義.實用醫學雜志, 2008, 24(9):1511-1513.
17. 章濤, 方寧, 祁瑩, 等.強直性脊柱炎疑似患者HLA-B27檢測結果分析.山東醫藥, 2008, 48(37):83-84.
18. 何進才, 傅新文, 侯智輝, 等. HLA-B27基因檢測對強直性脊柱炎診斷的評價.江西醫學檢驗, 2003, 21(4):240-242.
19. 方寧, 章濤, 胡錫階, 等.外周血T淋巴細胞HLA-B27檢測輔助診斷強直性脊柱炎.免疫學雜志, 2009, 25(2):210-213.
20. 鄧小軍, 謝志雄, 張陽根. HLA-B27抗原檢測在診斷AS中的意義.實用醫技雜志, 2006, 13(4):505-507.
21. 陳建華, 魏文寧, 喻喜. PCR-SSP法與流式細胞儀檢測強直性脊柱炎患者HLA-B27的比較.檢驗醫學與臨床, 2007, 4(3):161-162.
22. 吳娟.檢測強直性脊柱炎患者人類白細胞抗原B27的Il缶床意義.檢驗醫學與臨床, 2013, 10(6):663-665.
23. 胡慶宏, 易誠予, 彭燕, 等.江西地區強直性脊柱炎與HLA-B27基因關聯性.中國組織工程研究與臨床康復, 2009, 13(46):9183-9186.
24. 蔣娟, 熊小敏, 張衛云, 等.人白細胞抗原HLA-B27在強直性脊柱炎中的臨床意義.生物技術通訊, 2014, 25(3):410-411.
25. 林靜華, 方琳麗, 陳彥融, 等. HLA-B27抗原檢測在強直性脊柱炎診斷中的價值.中國熱帶醫學, 2013, 8(11):1946-1948.
26. 邱金英.流式細胞術檢測HLA-B27抗原在強直性脊柱炎診斷中的價值.現代醫院, 2009, 9(Suppl):171-173.
27. 劉波, 邱萌.早中期強直性脊柱炎患者兩種檢測HLA-B27方法比較.中國醫藥導報, 2011, 8(13):47-48.
28. 羅玲, 嚴海燕, 羅曉紅. HLA-B27/B7抗原檢測在診斷強直性脊柱炎中的臨床價值.中國實用醫藥, 2013, 8(4):8-9.
29. 劉永杰, 張小芳, 張運剛, 等. HLA-B27檢測對強直性脊柱炎診斷的臨床意義.國際檢驗醫學雜志, 2014, 35(10):1285-1286.
30. 謝能軒, 章健, 黃曉超, 等.強直性脊柱炎患者CD3+ T細胞HLA-B27表達水平.臨床檢驗雜志, 2008, 26(4):281.
31. 黃傳英.強直性脊柱炎免疫指標檢測及臨床價值.臨床輸血與檢驗, 2006, 8(3):187-189.
32. Browerton D, Hart F, Nichous N, et al. Ankylosing spondylitis and HLA-B27. Lancet, 1973, 1(8):904-907.
33. 曾憲濤, 何明武.診斷準確性試驗Meta分析軟件一本通.北京:軍事醫學科學出版社, 2014:7-8.

Chinese Journal of Evidence-Based Medicine

Diagnostic Value of HLA-B27 Tests for Ankylosing Spondylitis in Chinese Population: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

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