Correlation between Polymorphism in Tumor Necrosis Factor <i>α</i> Gene-308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 RUANXiao-lan ^1,2 , LISheng ² , AOXu-bin ¹ , HUANGJing-yu ² ,  WENGHong ²

1. Department of Hematology, Renmin Hospital of Wuhan University, Wuhan 430000, China;
2. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430000, China;

Corresponding?author：

WENGHong, Email: wengh92@163.com

Keywords：

Tumor necrosis factor; Gene polymorphism; Ankylosing spondylitis; Chinese population; Meta-analysis

DOI：

10.7507/1672-2531.20160140

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the relationship between tumor necrosis factor-α (TNF-α) gene promoter-308 G/A polymorphism and ankylosing spondylitis (AS) in Chinese population by meta-analysis. Methods The casecontrol studies about the correlation between TNF-α gene polymorphism and AS in Chinese population were retrieved from PubMed, EMbase, CNKI, CBM, WanFang Data and VIP database by two researchers. The retrieval time was from their establishment to December, 2015. After the paper screening, data extraction, and assessment of bias risk, the metaanalysis was conducted by Stata 12.0 software. Results A total of 11 case-control studies involving 1 154 AS patients and 1 458 controls were included. The results of meta-analysis showed that, for Chinese population, there was no significant association between TNF-α-308 G/A polymorphism and AS susceptibility (A vs. G: OR=0.96, 95% CI 0.63 to 1.47, P=0.86; AA vs. AG: OR=0.97, 95% CI 0.51 to 1.84, P=0.93; AA vs. GG: OR=0.92, 95% CI 0.32 to 2.61, P=0.87; AA+AG vs. GG; OR=1.04, 95% CI 0.60 to 1.80, P=0.89; AA vs. AG+GG: OR=1.03, 95% CI 0.58 to 1.82, P=0.92). Conclusion To date, it has not found the relationship between TNF-α gene promoter-308 G/A polymorphism and AS in Chinese population. For the quantity and quality limitation of the included studies, the conclusion has to be verified by more large-scale highquality studies.

Citation： RUANXiao-lan, LISheng, AOXu-bin, HUANGJing-yu, WENGHong. Correlation between Polymorphism in Tumor Necrosis Factor α Gene-308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(8): 906-912. doi: 10.7507/1672-2531.20160140 Copy

1.	?馮方, 孫永強.強直性脊柱炎的研究進展.風濕病與關節炎, 2015, 4(5):77-80.
2.	Brown MA, Kenna T, Wordsworth BP. Genetics of ankylosing spondylitis--insights into pathogenesis. Nat Rev Rheumatol, 2016, 12(2):81-91.
3.	Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15):2008-2012.
4.	曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四:觀察性研究的質量評價工具.中國循證心血管醫學雜志, 2012, 4(4):297-299.
5.	Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid Based Med, 2015, 8(1):2-10.
6.	賀藝, 何子奇, 劉菊芳, 等.血管內皮生長因子基因936C/T多態性與子癇前期相關性的Meta分析.中國循證醫學雜志, 2015, 15(6): 639-645.
7.	翁鴻, 鄢金柱, 田國祥, 等.牙周病與高血壓發病相關性:一項基于觀察性研究的Meta分析.中國循證心血管醫學雜志, 2015, 7(1): 16-19.
8.	曾憲濤, Joey S. W. Kwong, 田國祥, 等. Meta分析系列之二:Meta分析的軟件.中國循證心血管醫學雜志, 2012, 4(2):89-91.
9.	Higgins J, Thompson S. Quantifying heterogeneity in a metaanalysis. Stat Med, 2002, 21(11):1539-1559.
10.	林經安, 葉德富, 陳君敏, 等.腫瘤壞死因子-α-308基因多態性與強直性脊柱炎相關性研究.中華風濕病學雜志, 2003, 7(7):420-422.
11.	劉巧紅, 吳清敏, 滕云, 等.強直性脊柱炎與腫瘤壞死因子基因啟動子-308位點多態性相關的假設驗證(英文).中國臨床康復, 2004, 8(27):5974-5976.
12.	陳蕊雯.中國漢族人群強直性脊柱炎候選基因的研究.上海:第二軍醫大學, 2005.
13.	韓星海, 陳蕊雯, 段世偉, 等.腫瘤壞死因子α基因多態性對強直性脊柱炎發病易感性和臨床病變程度的影響(英文).中國臨床康復, 2005, 9(22):252-254.
14.	Shiau MY, Lo MK, Chang CP, et al. Association of tumour necrosis factor alpha promoter polymorphisms with ankylosing spondylitis in Taiwan. Ann Rheum Dis, 2007, 66(4):562-563.
15.	蔡慶, 劉成剛, 王雅靜, 等.強直性脊柱炎患者腫瘤壞死因子α啟動子308位點基因多態性分析.軍醫進修學院學報, 2007, 28(4):279-281.
16.	Lu MC, Yang KL, Tung CH, et al. Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with-308G/A polymorphism in promoter region of tumor necrosis factor:association with distinct A33/B58/Cw10 haplotypes. Rheumatol Int, 2008, 29(2):189-195.
17.	梅永君, 李志軍, 陳琳潔, 等. TNF-α啟動子基因多態性與強直性脊柱炎的易感性.中華臨床免疫和變態反應雜志, 2009, 3(3):173-177.
18.	陳進偉, 彭文鋒, 毛妮, 等.強直性脊柱炎患者TNF-α-308位點基因多態性對依那西普療效的影響.新醫學, 2011, 42(3):157-159.
19.	Ji Y, Yang X, Yang L, et al. Studies on correlation between singlenucleotide polymorphisms of tumor necrosis factor gene and different stages of ankylosing spondylitis. Cell Biochem Biophys, 2013, 67(3):915-922.
20.	Sun R, Huang Y, Zhang H, et al. MMP-2, TNF-alpha and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis. Mol Biol Rep, 2013, 40(11):6303-6308.
21.	Hohler T, Schaper T, Schneider PM, et al. Association of different tumor necrosis factor alpha promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum, 1998, 41(8):1489-1492.
22.	Braun J, Bollow M, Neure L, et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum, 1995, 38(4):499-505.
23.	任昌菊, 張超, 鄢金柱, 等.載脂蛋白E基因多態性與中國人群散發型阿爾茨海默病相關性的Meta分析.中國循證醫學雜志, 2014, 14(7):813-820.
24.	Yan Y, Weng H, Shen ZH, et al. Association between interleukin-4 gene-590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility:a meta-analysis. J Periodontol, 2014, 85(11):e354-e362.
25.	Weng H, Zhang C, Hu YY, et al. Association between Estrogen Receptor-alpha Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility:A Meta-Analysis. Dis Markers, 2015, 2015:741972.

1. ?馮方, 孫永強.強直性脊柱炎的研究進展.風濕病與關節炎, 2015, 4(5):77-80.
2. Brown MA, Kenna T, Wordsworth BP. Genetics of ankylosing spondylitis--insights into pathogenesis. Nat Rev Rheumatol, 2016, 12(2):81-91.
3. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15):2008-2012.
4. 曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四:觀察性研究的質量評價工具.中國循證心血管醫學雜志, 2012, 4(4):297-299.
5. Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline:a systematic review. J Evid Based Med, 2015, 8(1):2-10.
6. 賀藝, 何子奇, 劉菊芳, 等.血管內皮生長因子基因936C/T多態性與子癇前期相關性的Meta分析.中國循證醫學雜志, 2015, 15(6): 639-645.
7. 翁鴻, 鄢金柱, 田國祥, 等.牙周病與高血壓發病相關性:一項基于觀察性研究的Meta分析.中國循證心血管醫學雜志, 2015, 7(1): 16-19.
8. 曾憲濤, Joey S. W. Kwong, 田國祥, 等. Meta分析系列之二:Meta分析的軟件.中國循證心血管醫學雜志, 2012, 4(2):89-91.
9. Higgins J, Thompson S. Quantifying heterogeneity in a metaanalysis. Stat Med, 2002, 21(11):1539-1559.
10. 林經安, 葉德富, 陳君敏, 等.腫瘤壞死因子-α-308基因多態性與強直性脊柱炎相關性研究.中華風濕病學雜志, 2003, 7(7):420-422.
11. 劉巧紅, 吳清敏, 滕云, 等.強直性脊柱炎與腫瘤壞死因子基因啟動子-308位點多態性相關的假設驗證(英文).中國臨床康復, 2004, 8(27):5974-5976.
12. 陳蕊雯.中國漢族人群強直性脊柱炎候選基因的研究.上海:第二軍醫大學, 2005.
13. 韓星海, 陳蕊雯, 段世偉, 等.腫瘤壞死因子α基因多態性對強直性脊柱炎發病易感性和臨床病變程度的影響(英文).中國臨床康復, 2005, 9(22):252-254.
14. Shiau MY, Lo MK, Chang CP, et al. Association of tumour necrosis factor alpha promoter polymorphisms with ankylosing spondylitis in Taiwan. Ann Rheum Dis, 2007, 66(4):562-563.
15. 蔡慶, 劉成剛, 王雅靜, 等.強直性脊柱炎患者腫瘤壞死因子α啟動子308位點基因多態性分析.軍醫進修學院學報, 2007, 28(4):279-281.
16. Lu MC, Yang KL, Tung CH, et al. Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with-308G/A polymorphism in promoter region of tumor necrosis factor:association with distinct A33/B58/Cw10 haplotypes. Rheumatol Int, 2008, 29(2):189-195.
17. 梅永君, 李志軍, 陳琳潔, 等. TNF-α啟動子基因多態性與強直性脊柱炎的易感性.中華臨床免疫和變態反應雜志, 2009, 3(3):173-177.
18. 陳進偉, 彭文鋒, 毛妮, 等.強直性脊柱炎患者TNF-α-308位點基因多態性對依那西普療效的影響.新醫學, 2011, 42(3):157-159.
19. Ji Y, Yang X, Yang L, et al. Studies on correlation between singlenucleotide polymorphisms of tumor necrosis factor gene and different stages of ankylosing spondylitis. Cell Biochem Biophys, 2013, 67(3):915-922.
20. Sun R, Huang Y, Zhang H, et al. MMP-2, TNF-alpha and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis. Mol Biol Rep, 2013, 40(11):6303-6308.
21. Hohler T, Schaper T, Schneider PM, et al. Association of different tumor necrosis factor alpha promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum, 1998, 41(8):1489-1492.
22. Braun J, Bollow M, Neure L, et al. Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum, 1995, 38(4):499-505.
23. 任昌菊, 張超, 鄢金柱, 等.載脂蛋白E基因多態性與中國人群散發型阿爾茨海默病相關性的Meta分析.中國循證醫學雜志, 2014, 14(7):813-820.
24. Yan Y, Weng H, Shen ZH, et al. Association between interleukin-4 gene-590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility:a meta-analysis. J Periodontol, 2014, 85(11):e354-e362.
25. Weng H, Zhang C, Hu YY, et al. Association between Estrogen Receptor-alpha Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility:A Meta-Analysis. Dis Markers, 2015, 2015:741972.

Chinese Journal of Evidence-Based Medicine

Correlation between Polymorphism in Tumor Necrosis Factor α Gene-308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content