Correlation of P53 Protein Expression in Nasopharyngeal Carcinoma: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 HOUWen-qun ¹ , YANGXiao-min ² , ZHANGSheng-nan ²

1. Guangdong Medical College, Zhanjiang 524000, China;
2. Huizhou Municipal Central People's Hospital, Huizhou 516000, China;

Corresponding?author：

Keywords：

Nasopharyngeal carcinoma; P53; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160160

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the correlation between the expression of P53 and nasopharyngeal carcinoma. Methods Databases including The Cochrane Library (Issue 1, 2016), PubMed, EMbase, CBM, CNKI, VIP, and WanFang Data were searched from the inception to January 1st 2016 to collect case-control studies about the correlation between the expression of P53 and nasopharyngeal carcinoma, as well as its clinically pathologic features. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan 5.2 software. Results Twelve studies were finally included in this meta-analysis. There were 630 cases of nasopharyngeal carcinoma and 253 controls. The results of meta-analysis showed that, the expression of P53 protein were significantly different between the nasopharyngeal carcinoma group and the control group (OR=21.34, 95%CI 13.59 to 33.50, P < 0.000 01), between the nasopharyngeal carcinoma with lymphatic node metastasis group and without lymphatic node metastasis group (OR=3.69, 95%CI 1.67 to 8.17, P=0.001), between the clinical stage Ⅰ to Ⅱ group and the clinical stage Ⅲ to Ⅳ group (OR=0.19, 95%CI 0.08 to 0.49, P=0.000 6). However, there were no significant differences in expression of P53 between the male nasopharyngeal carcinoma group and the female nasopharyngeal carcinoma group (OR=0.92, 95%CI 0.49 to 1.74, P=0.80), and between the < 50 nasopharyngeal carcinoma group and the≥50 nasopharyngeal carcinoma group (OR=1.70, 95%CI 0.70 to 4.11, P=0.24). Conclusions Current evidence shows that, the expression of P53 protein is associated with the occurrence, development of nasopharyngeal carcinoma and may be positively correlated to degree of tumor malignance. It may be an indicator poor prognosis.

Citation： HOUWen-qun, YANGXiao-min, ZHANGSheng-nan. Correlation of P53 Protein Expression in Nasopharyngeal Carcinoma: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(9): 1040-1046. doi: 10.7507/1672-2531.20160160 Copy

1.	樓建軍, 朱小東, 曲頌, 等. P53基因多態性與鼻咽癌遺傳易感性的關系.中國老年學雜志, 2012, 32(18): 3867-3870.
2.	Colubovskava VM, Conway-Dorset K, Edmiston SN, et al. EAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer, 2009, 125(7): 1735-1738.
3.	Wickremasinghe RG, Prentice AG, Steele AJ. P53 and Notch signaling in chronic lymphocytic leukemia; clues to identifying novel therapeutic strategies. Leukemia, 2011, 25(9): 1400-1407.
4.	朱瀟月. P53基因在鼻咽癌治療中的研究進展.醫學信息, 2015, 28(1): 387-388.
5.	張健, 郇小鳳, 張平, 等.口腔鱗狀細胞癌中CK19表達及其臨床意義的Meta分析.中國循證醫學雜志, 2015, 15(10): 1142-1147.
6.	Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 2015, 8(1): 2-10.
7.	王丹, 翟俊霞, 牟振云, 等. Meta分析中的異質性及其處理方法.中國循證醫學雜志, 2009, 9(10): 1115-1118.
8.	蔡曉, 鐘慧玲, 甘青, 等. COX-2、P53在鼻咽癌中的表達及臨床意義.青海醫學院學報, 2011, 32(3): 172-175.
9.	蔣正舉, 陳天會, 謝天宏, 等. P53、P63、P73在鼻咽癌中的表達及臨床意義.現代預防醫學, 2012, 39(18): 4870-4875.
10.	楊冶花, 折虹. P14ARF、mdm2、P53蛋白在鼻咽癌中表達的研究.寧夏醫學院學報, 2008, 30(2): 155-156.
11.	張維彬, 胡少為, 何青蓮, 等. PTEN和突變型p53蛋白在鼻咽癌組織中的表達及臨床意義.山東醫藥, 2009, 49(3): 62-63.
12.	李康, 張志茂, 萬敏婕. p53和nm23-H1在鼻咽癌組織中的表達及其意義.腫瘤研究與臨床, 2014, 26(1): 52-55.
13.	程慶, 魏晶晶, 黃翔.增殖細胞核抗原和p53基因在鼻咽癌中的表達及相關性研究.臨床耳鼻咽喉科雜志, 2005, 19(4): 643-645.
14.	苗北平, 盧永田, 許安廷. COX-2, PCNA及p53在鼻咽癌中的表達及意義.山東大學耳鼻喉眼學報, 2007, 21(3): 193-196.
15.	陳誼輝. survivin和p53的表達與鼻咽搔發生、發展的關系.陜西醫學雜志, 2008, 37(6): 693-694.
16.	洪麗, 吳立連, 胡艷明. P53基因在鼻咽癌組織中的表達.咸寧學院學報(醫學版), 2010, 24(1): 21-22.
17.	唐之雅, 涂青松.鼻咽癌c-src, p53與VEGF表達及其相關性研究.基礎學, 2007: 107-108.
18.	鐘守軍, 姚運紅.李飛虹, 等. EGR-1與p53, p16, Cyclin D 1在鼻咽癌中的表達及意義.腫瘤研究與臨床, 2006, 10(18): 664-666.
19.	Liu XD, Ji MF. Expressions of p53 pathway genes and EZH2 in undifferentiated nasopharyngeal carcinoma. Nan Fang Yi Ke Da Xue Xue Bao, 2011, 31(6): 1029-1033.
20.	莫浩元, 張昌卿, 馮凱濤, 等.鼻咽癌組織中P53和PCNA表達與臨床分期、VCA/ IgA, EA/ IgA、放射敏感性和預后的關系.癌癥, 2004, 23(11): 1551-1554.
21.	Porter Ms, Field JK, Lee Jck, et al. Detection of the tumour suppressor gene p53 in nasopharyngeal carcinoma in Hong Kong Chinese. Anticancer Res, 1994, 14(2): 1357-1360.
22.	蘭會華, 莫武寧, 黃華藝. WWOX, p53及Bcl-2在鼻咽癌中的表達及意義.華中科技大學學報(醫學版), 2014, 43(1): 59-65.
23.	Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature, 2000, 408(6810): 307-310.
24.	Meek DW. Tumour suppression by p53: a role for the DNA damale responseb. Nat Rev Caucer, 2009, 9(10): 714-723.
25.	鐘碧玲, 宗水生.鼻咽癌中p53蛋自積聚對瘤細胞有LPL分裂和凋亡的影響.癌癥, 2000, 19(5): 432.
26.	Chang LJ, Eastman A. Decreased translation of p21(wafl)mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cyc1e, 2012, 11(9): 1818-1826.
27.	Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates p53 function through Ser15 phosphorylation. J Biol Chem, 2012, 15(25): 20797-20810.

1. 樓建軍, 朱小東, 曲頌, 等. P53基因多態性與鼻咽癌遺傳易感性的關系.中國老年學雜志, 2012, 32(18): 3867-3870.
2. Colubovskava VM, Conway-Dorset K, Edmiston SN, et al. EAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer, 2009, 125(7): 1735-1738.
3. Wickremasinghe RG, Prentice AG, Steele AJ. P53 and Notch signaling in chronic lymphocytic leukemia; clues to identifying novel therapeutic strategies. Leukemia, 2011, 25(9): 1400-1407.
4. 朱瀟月. P53基因在鼻咽癌治療中的研究進展.醫學信息, 2015, 28(1): 387-388.
5. 張健, 郇小鳳, 張平, 等.口腔鱗狀細胞癌中CK19表達及其臨床意義的Meta分析.中國循證醫學雜志, 2015, 15(10): 1142-1147.
6. Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med, 2015, 8(1): 2-10.
7. 王丹, 翟俊霞, 牟振云, 等. Meta分析中的異質性及其處理方法.中國循證醫學雜志, 2009, 9(10): 1115-1118.
8. 蔡曉, 鐘慧玲, 甘青, 等. COX-2、P53在鼻咽癌中的表達及臨床意義.青海醫學院學報, 2011, 32(3): 172-175.
9. 蔣正舉, 陳天會, 謝天宏, 等. P53、P63、P73在鼻咽癌中的表達及臨床意義.現代預防醫學, 2012, 39(18): 4870-4875.
10. 楊冶花, 折虹. P14ARF、mdm2、P53蛋白在鼻咽癌中表達的研究.寧夏醫學院學報, 2008, 30(2): 155-156.
11. 張維彬, 胡少為, 何青蓮, 等. PTEN和突變型p53蛋白在鼻咽癌組織中的表達及臨床意義.山東醫藥, 2009, 49(3): 62-63.
12. 李康, 張志茂, 萬敏婕. p53和nm23-H1在鼻咽癌組織中的表達及其意義.腫瘤研究與臨床, 2014, 26(1): 52-55.
13. 程慶, 魏晶晶, 黃翔.增殖細胞核抗原和p53基因在鼻咽癌中的表達及相關性研究.臨床耳鼻咽喉科雜志, 2005, 19(4): 643-645.
14. 苗北平, 盧永田, 許安廷. COX-2, PCNA及p53在鼻咽癌中的表達及意義.山東大學耳鼻喉眼學報, 2007, 21(3): 193-196.
15. 陳誼輝. survivin和p53的表達與鼻咽搔發生、發展的關系.陜西醫學雜志, 2008, 37(6): 693-694.
16. 洪麗, 吳立連, 胡艷明. P53基因在鼻咽癌組織中的表達.咸寧學院學報(醫學版), 2010, 24(1): 21-22.
17. 唐之雅, 涂青松.鼻咽癌c-src, p53與VEGF表達及其相關性研究.基礎學, 2007: 107-108.
18. 鐘守軍, 姚運紅.李飛虹, 等. EGR-1與p53, p16, Cyclin D 1在鼻咽癌中的表達及意義.腫瘤研究與臨床, 2006, 10(18): 664-666.
19. Liu XD, Ji MF. Expressions of p53 pathway genes and EZH2 in undifferentiated nasopharyngeal carcinoma. Nan Fang Yi Ke Da Xue Xue Bao, 2011, 31(6): 1029-1033.
20. 莫浩元, 張昌卿, 馮凱濤, 等.鼻咽癌組織中P53和PCNA表達與臨床分期、VCA/ IgA, EA/ IgA、放射敏感性和預后的關系.癌癥, 2004, 23(11): 1551-1554.
21. Porter Ms, Field JK, Lee Jck, et al. Detection of the tumour suppressor gene p53 in nasopharyngeal carcinoma in Hong Kong Chinese. Anticancer Res, 1994, 14(2): 1357-1360.
22. 蘭會華, 莫武寧, 黃華藝. WWOX, p53及Bcl-2在鼻咽癌中的表達及意義.華中科技大學學報(醫學版), 2014, 43(1): 59-65.
23. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature, 2000, 408(6810): 307-310.
24. Meek DW. Tumour suppression by p53: a role for the DNA damale responseb. Nat Rev Caucer, 2009, 9(10): 714-723.
25. 鐘碧玲, 宗水生.鼻咽癌中p53蛋自積聚對瘤細胞有LPL分裂和凋亡的影響.癌癥, 2000, 19(5): 432.
26. Chang LJ, Eastman A. Decreased translation of p21(wafl)mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cyc1e, 2012, 11(9): 1818-1826.
27. Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates p53 function through Ser15 phosphorylation. J Biol Chem, 2012, 15(25): 20797-20810.

Chinese Journal of Evidence-Based Medicine

Correlation of P53 Protein Expression in Nasopharyngeal Carcinoma: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content