Association between rs1799971 Polymorphism in OPRM1 Gene on Opioid Requirements after Surgery in Asians: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 YANGJing , ZHENGbin , ZENGXiao-fang , LINa ,  LIUMao-bai

Department of Pharmacy, the Union Hospital of Fujian Medical University, FuZhou 350001, China;

Corresponding?author：

LIUMao-bai, Email: liumb0591@sina.com

Keywords：

Polymorphism; rs1799971; Opioids; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.20160210

Video：

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Objective To evaluate the relationship between OPRM1 gene rs1799971 polymorphism and opioid analgesics requirement after surgery in Asians. Methods We electronically searched databases including CNKI, CBM, VIP, WanFang Data, EMbase and MEDLINE to collect studies about the correlation between OPRM1 gene rs1799971 polymorphism and opioid analgesics requirement after surgery in Asia. The retrieval time was from the establishment to March 1st, 2015. Two reviewers independently screened literature, extracted data and assessed the risk bias of including studies, and then meta-analysis was performed by using RevMan 5.2 software. Results A total of 10 case-control studies involving 1 612 patients were included. The results of meta-analysis showed that the requirement of opioid analgesics after surgery for GG genotype carriers was more than AG carriers (SMD=-0.44, 95%CI -0.61 to -0.28, P<0.000 01), AA genotype carriers (SMD=-0.55, 95%CI -0.71 to -0.38, P<0.000 01), and AA+AG genotype carriers (SMD=-0.50, 95%CI -0.66 to -0.35, P<0.000 01). Conclusion The current evidence showed that the requirement of opioid analgesics after surgery for GG genotype of rs1799971 polymorphism in OPRM1 gene is higher in Asians. Due to the limited quality and quantity of included studies, the above results are needed to be further validated by more studies.

Citation： YANGJing, ZHENGbin, ZENGXiao-fang, LINa, LIUMao-bai. Association between rs1799971 Polymorphism in OPRM1 Gene on Opioid Requirements after Surgery in Asians: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(12): 1388-1393. doi: 10.7507/1672-2531.20160210 Copy

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11.	張衛. OPRM1和CYP3A基因多態性對芬太尼鎮痛效應的影響. 鄭州:鄭州大學, 2009.
12.	張雙全, 李少英, 譚秀華. μ受體基因118A→G突變對芬太尼椎管內鎮痛作用的影響. 南方醫科大學學報, 2013, 33(2):309-311.
13.	Zhang W, Zhang YZ, Kan QC, et al. Association of human l-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia, 2010, 65:130-135.
14.	Zhang J, Yuan J, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva Anestesiologica, 2011, 77(1):33-39.
15.	Haysshida M, Nagashima M, Satoh Y, et al. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and halotype. Pharmacogenomics, 2008, 9(11):1605-1616.
16.	Liu J, Hu D, Jiang Y, et al. Association between single nucleotide polymorphisms in the OPRM1 Gene and intraoperative remifentanil consumption in northern Chinese women. Pharmacology, 2014, 94(5-6):273-279.
17.	Xu GH, Gao M, Sheng QY, et al. Opioid receptor A118G polymorphism does not affect the consumption of sufentanil and ropivacaine by patient-controlled epidural analgesia after cesarean section. The Drug Monit, 2015, 37(1):53-57.
18.	Klepstad P, Rakvag TT, Kaasa S, et al. The 118A>G polymorphism in the human m-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand, 2004, 48(10):1232-1239.
19.	Tsai FF, Fan SZ, Yang YM, et al. Human opioid m-receptor A118G polymorphism may protect against central pruritus by epidural morphine for post-cesarean analgesia. Acta Anaesthesiol Scand, 2010, 54(10):1265-1269.
20.	Sia AT, Lim Y, Lim EC, et al. A118G single nucleotide polymorphism of human m-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology, 2008, 109(3):520-526.

1. 中華醫學會麻醉學分會. 成人術后疼痛處理專家共識. 臨床麻醉學雜志, 2010, 26(3):190-196.
2. Macintyre PE, Jarvis DA. Age is the best predictor of postoperative morphine requirements. Pain, 1996, 64(2):357-364.
3. Aubrun F, Salvi N, Coriat P, et al. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology, 2005, 103(1):156-160.
4. Lloret LC, Decleves X, Oppert JM, et al. Pharmacology of morphine in obese patients:clinical implications. Clin Pharmacokinet, 2009, 48(10):635-651.
5. 周晨. 術后阿片類藥物代謝與μ-阿片受體基因OPRM1A118G位點多態性之間關系的Meta 分析. 杭州:浙江大學, 2010.
6. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9):603-605.
7. 鄭明華, 主編. Meta分析軟件的應用與實例解析. 第一版. 北京:人民衛生出版社, 2013:5.
8. 陳杰. u阿片受體A118G基因多態性對舒芬太尼術后病人自控鎮痛的影響. 沈陽:中國醫科大學, 2008.
9. 諸光峰, 上官王寧, 張高嬌. 浙南地區女性人群OPRM1基因多態性(rs1799971)與舒芬太尼自控鎮痛效果的研究. 浙江醫學雜志, 2014, 36(24):1997-1999.
10. 梁惠霞, 徐漾漾, 包金榮. OPRM1, CYP3A 基因多態性對芬太尼腹式子宮全切術鎮痛效果的影響. 中國基層醫藥, 2014, 21(20):3078-3080.
11. 張衛. OPRM1和CYP3A基因多態性對芬太尼鎮痛效應的影響. 鄭州:鄭州大學, 2009.
12. 張雙全, 李少英, 譚秀華. μ受體基因118A→G突變對芬太尼椎管內鎮痛作用的影響. 南方醫科大學學報, 2013, 33(2):309-311.
13. Zhang W, Zhang YZ, Kan QC, et al. Association of human l-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients. Anaesthesia, 2010, 65:130-135.
14. Zhang J, Yuan J, Kan QC, et al. Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. Minerva Anestesiologica, 2011, 77(1):33-39.
15. Haysshida M, Nagashima M, Satoh Y, et al. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and halotype. Pharmacogenomics, 2008, 9(11):1605-1616.
16. Liu J, Hu D, Jiang Y, et al. Association between single nucleotide polymorphisms in the OPRM1 Gene and intraoperative remifentanil consumption in northern Chinese women. Pharmacology, 2014, 94(5-6):273-279.
17. Xu GH, Gao M, Sheng QY, et al. Opioid receptor A118G polymorphism does not affect the consumption of sufentanil and ropivacaine by patient-controlled epidural analgesia after cesarean section. The Drug Monit, 2015, 37(1):53-57.
18. Klepstad P, Rakvag TT, Kaasa S, et al. The 118A>G polymorphism in the human m-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand, 2004, 48(10):1232-1239.
19. Tsai FF, Fan SZ, Yang YM, et al. Human opioid m-receptor A118G polymorphism may protect against central pruritus by epidural morphine for post-cesarean analgesia. Acta Anaesthesiol Scand, 2010, 54(10):1265-1269.
20. Sia AT, Lim Y, Lim EC, et al. A118G single nucleotide polymorphism of human m-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology, 2008, 109(3):520-526.

Chinese Journal of Evidence-Based Medicine

Association between rs1799971 Polymorphism in OPRM1 Gene on Opioid Requirements after Surgery in Asians: A Meta-analysis

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