The risk factors of urolithiasis: a case-control study_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Xingnian ¹ , XU Chang ^1,2 , ZHANG Chao ³ , LIU Tongzu ¹ ,  WANG Xinghuan ¹

1. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China;
2. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan, 430071, P.R.China;
3. Center for Evidence-based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, P.R.China;

Corresponding?author：

WANG Xinghuan, Email: wangxinghuan@whu.edu.cn

Keywords：

Urolithiasis; Risk factor; Case-control study

DOI：

10.7507/1672-2531.201606049

Video：

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Objective To investigate the correlation between smoking, alcohol, chronic diseases, fasting plasma glucose levels, uric acid and the incidence of urolithiasis. Methods A 1∶1 pair-wise matching design was used in case-control study. We randomly selected 150 samples from 459 patients with urolithiasis in Zhongnan Hospital of Wuhan University from May 2015 to November 2015. Patient with intact information were identified as case group. The control group were patients who hospitalized in the same period without urolithiasis matched by gender, ethnic, and marital status. Univariate ANOVA and multivariate conditional logistic regression were used to test the differences between the two groups. Results A total of 125 patients in case group and 125 patients in control group were included. The peak age of urolithiasis was 50 to 70 years old, male patients accounted for 70.75% of the population, and one side urolithiasis accounted for 62.24% of the stone types. The results of multivariate conditional logistic regression showed that hyperuricemia was the related factor of urolithiasis (OR=5.19, 95%CI 2.27 to 11.91, P<0.01). Conclusions Hyperuricemia is a high risk factor for urolithiasis.

Citation： LIU Xingnian, XU Chang, ZHANG Chao, LIU Tongzu, WANG Xinghuan. The risk factors of urolithiasis: a case-control study. Chinese Journal of Evidence-Based Medicine, 2017, 17(10): 1131-1134. doi: 10.7507/1672-2531.201606049 Copy

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10.	陳希, 諶衛, 丁家榮, 等. 泌尿系結石患者血脂及相關影響因素的研究. 中國全科醫學, 2011, 14(34): 3924-3926.0.
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1. 那彥群, 葉章群, 孫穎浩, 等. 2014 版中國泌尿外科疾病診斷治療指南. 北京: 人民衛生出版社, 2013: 129-165.
2. Scales CD, Smith AC, Hanley JM, et al. Prevalence of kidney stones in the United States. Eur Urol, 2012, 62(1): 160-165.
3. Türk C, Pet?ík A, Sarica K, et al. EAU guidelines on interventional treatment for urolithiasis. Eur Urol, 2016, 69(3): 475-482.
4. 張立峰, 方志輝, 靳勇, 等. 影響泌尿系結石的多因素研究. 黑龍江醫藥, 2015, 28(1): 170-172.0.
5. 周璠婭. 泌尿系結石患者發病危險因素調查研究. 河北醫學, 2016, 22(3): 458-461.0.
6. Pearle MS, Goldfarb DS, Assimos DG, et al. Medical management of kidney stones: AUA guideline. J Urol, 2014, 192(2): 316-324.
7. 孫振球, 徐勇. 醫學統計學(第四版). 北京: 人民衛生出版社, 2014: 529-536.
8. 胡正委, 曹全富, 王洛夫, 等. 超重肥胖泌尿系結石患者 133 例結石成分分析. 現代泌尿外科雜志, 2017, 22(1): 25-28.0.
9. 殷晶晶, 諶衛, 丁家榮, 等. 糖尿病、高血壓對腎結石患者首次發病年齡的影響. 國際泌尿系統雜志, 2012, 32(6): 763-767.0.
10. 陳希, 諶衛, 丁家榮, 等. 泌尿系結石患者血脂及相關影響因素的研究. 中國全科醫學, 2011, 14(34): 3924-3926.0.
11. 王堅, 吳舟, 李普云. 上尿路結石與代謝. 河北醫學, 2002, 8(5): 409-411.0.

Chinese Journal of Evidence-Based Medicine

The risk factors of urolithiasis: a case-control study

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