Traditional Chinese medicine paste in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials_Chinese Journal of Evidence-Based Medicine

Authors：

ZENG Yan , YAN Min , YI Qinyu , WU Lihua , WANG Shengjun ,  JIANG Hongli , MAO Bing

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China;

Corresponding?author：

Keywords：

Chronic obstructive pulmonary disease; Traditional Chinese medicine paste; Systematic review; Meta-analysis; Randomized controlled trials

DOI：

10.7507/1672-2531.201606067

Video：

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Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM) paste in treating chronic obstructive pulmonary disease (COPD) in stable stage. Methods We electronically searched databases including PubMed, EMbase, The Cochrane Library (Issue 12, 2016), VIP, WanFang Data, CNKI and CBM to collect randomized controlled trials (RCTs) regarding TCM paste in combination with conventional Western therapy versus Western therapy alone in treating stable COPD from inception to December 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. The meta-analysis was conducted by RevMan 5.3 software. Results A total of 9 RCTs involving 605 Chinese patients were included. The results of meta-analysis showed that: when compared with conventional Western medicine alone, TCM paste combined with the conventional Western medicine significantly improved clinical effective rate (RR=1.20, 95% CI 1.10 to 1.31,P<0.000 1), decreased SGRQ score (MD=–4.53, 95% CI –5.41 to –3.65,P<0.000 01) and CAT score (MD=–2.45, 95% CI –3.38 to –1.51,P<0.000 01), increased FEV₁% (MD=3.80, 95% CI 0.40 to 7.20,P=0.03), and reduced the frequency of acute exacerbation (P<0.05). No serious adverse reaction occurred in both groups. Conclusion The current evidence shows that combination of TCM paste and conventional Western medicine may improve clinical effective rate, quality of life, increase FEV₁%, and reduce the frequency of acute exacerbation in patients with stable COPD. Due to the limited quality and quantity of included studies, the above results are needed to verify by more studies.

Citation： ZENG Yan, YAN Min, YI Qinyu, WU Lihua, WANG Shengjun, JIANG Hongli, MAO Bing. Traditional Chinese medicine paste in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine, 2017, 17(3): 340-346. doi: 10.7507/1672-2531.201606067 Copy

1.	?中華醫學會呼吸病學分會慢性阻塞性肺疾病學組慢性阻塞性肺疾病診治指南(2013 年修訂版). 中華結核和呼吸雜志, 2013, 36(4): 255-264.
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10.	張麗, 趙輝, 季輝. 膏方治療慢性阻塞性肺病穩定期肺腎兩虛型的臨床觀察. 四川中醫, 2013, 31(6): 106-107.
11.	朱理芬, 邊永君, 鄭菲. 補肺益腎膏對慢性阻塞性肺疾病穩定期患者生活質量影響的評價研究. 中國中醫藥信息雜志, 2009, 16(12): 13-14.
12.	王唯益, 劉建博, 雷源. 肺康膏方調治慢性阻塞性肺疾病穩定期肺脾兩虛證的臨床療效觀察. 新中醫, 2013, 45(11): 43-45.
13.	王振偉, 楊佩蘭, 沈麗. 百部養肺煎膏治療 COPD 穩定期患者的臨床研究. 西部中醫藥, 2015, 28(5): 56-59.
14.	邱念念, 劉良麗, 劉億淑. 養肺保元膏對慢性阻塞性肺疾病穩定期患者血清白介素–2 及白介素–10 的影響. 中國中醫急癥, 2015, 24(2): 255-257.
15.	王振偉, 楊佩蘭, 沈麗. 百部養肺煎膏治療慢性阻塞性肺疾病療效及機制. 吉林中醫藥, 2014, 34(9): 899-902.
16.	趙建軍, 秦建平, 唐書福. 補肺化濁膏方對慢性阻塞性肺疾病穩定期的臨床觀察. 中國實驗方劑學雜志, 2014, 20(7): 216-219.
17.	王浩, 張念志, 紀娟. 從脾論治慢阻肺的概述. 光明中醫, 2015, 30(11): 2476-2479.
18.	Resch KL, Ernst E. Research methodologies in complementary medicine: making sure it works. In: Ernst E, edited. Complementary Medicine: An Objective Appraisal. Oxford, Butterworth, 1996.
19.	Gordon HG, Andrew DO, Victor M, et al. Grade 指南證據質量評價—發表偏倚. 中國循證醫學雜志, 2011, 11(12): 1430-1434.
20.	王玉光, 周平安. 腎不納氣證新繹. 中國中醫基礎醫學雜志, 2004, 10(5): 27.

1. ?中華醫學會呼吸病學分會慢性阻塞性肺疾病學組慢性阻塞性肺疾病診治指南(2013 年修訂版). 中華結核和呼吸雜志, 2013, 36(4): 255-264.
2. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease 2017. Available at: .
3. 中華中醫藥學會內科分會肺系疾病專業委員會. 慢性阻塞性肺疾病中醫診療指南 2011 版. 中醫雜志, 2012, 53(1): 80-84.
4. 楊欣瑩. 慢性阻塞性肺疾病穩定期的中醫藥治療研究進展. 中醫藥學報, 2015, 43(5): 115-117.
5. 何綠苑, 臧敏, 陳秀華. 冬令膏方對慢性阻塞性肺疾病生活質量和近期預后的影響. 山東中醫藥大學學報, 2015, 39(6): 533-535.
6. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南(2007 年修訂版). 中華內科雜志, 2007, 30(3): 254-261.
7. 鄭筱萸. 中藥新藥臨床研究指導原則. 中國醫藥科技出版社, 2002: 53-66.
8. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). Available at: .
9. 姜明華, 王延輝, 李泱. 益腎斂肺膏治療慢性阻塞性肺疾病臨床分析. 實用中醫藥雜志, 2015, 31(2): 86-87.
10. 張麗, 趙輝, 季輝. 膏方治療慢性阻塞性肺病穩定期肺腎兩虛型的臨床觀察. 四川中醫, 2013, 31(6): 106-107.
11. 朱理芬, 邊永君, 鄭菲. 補肺益腎膏對慢性阻塞性肺疾病穩定期患者生活質量影響的評價研究. 中國中醫藥信息雜志, 2009, 16(12): 13-14.
12. 王唯益, 劉建博, 雷源. 肺康膏方調治慢性阻塞性肺疾病穩定期肺脾兩虛證的臨床療效觀察. 新中醫, 2013, 45(11): 43-45.
13. 王振偉, 楊佩蘭, 沈麗. 百部養肺煎膏治療 COPD 穩定期患者的臨床研究. 西部中醫藥, 2015, 28(5): 56-59.
14. 邱念念, 劉良麗, 劉億淑. 養肺保元膏對慢性阻塞性肺疾病穩定期患者血清白介素–2 及白介素–10 的影響. 中國中醫急癥, 2015, 24(2): 255-257.
15. 王振偉, 楊佩蘭, 沈麗. 百部養肺煎膏治療慢性阻塞性肺疾病療效及機制. 吉林中醫藥, 2014, 34(9): 899-902.
16. 趙建軍, 秦建平, 唐書福. 補肺化濁膏方對慢性阻塞性肺疾病穩定期的臨床觀察. 中國實驗方劑學雜志, 2014, 20(7): 216-219.
17. 王浩, 張念志, 紀娟. 從脾論治慢阻肺的概述. 光明中醫, 2015, 30(11): 2476-2479.
18. Resch KL, Ernst E. Research methodologies in complementary medicine: making sure it works. In: Ernst E, edited. Complementary Medicine: An Objective Appraisal. Oxford, Butterworth, 1996.
19. Gordon HG, Andrew DO, Victor M, et al. Grade 指南證據質量評價—發表偏倚. 中國循證醫學雜志, 2011, 11(12): 1430-1434.
20. 王玉光, 周平安. 腎不納氣證新繹. 中國中醫基礎醫學雜志, 2004, 10(5): 27.

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Traditional Chinese medicine paste in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials

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