Calculation of information size of trial sequential analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WENG Hong ¹ , GUO Chengcheng ² , LV Jun ³ , MENG Xiangyu ¹ , GUO Zhongqiang ⁴ ,  ZENG Xiantao ^1,4

1. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University; Center for Evidence-Based and Translational Medicine, Wuhan University; Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College of Wuhan University, Wuhan, 430071, P.R.China;
2. Department of Communication Engineering, Electronic Information School of Wuhan University, Wuhan, 430072, P.R.China;
3. Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, P.R.China;
4. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China;

Corresponding?author：

ZENG Xiantao, Email: zengxiantao1128@163.com

Keywords：

Trial sequential analysis; Meta-analysis; Information size; Required information size

DOI：

10.7507/1672-2531.201607061

Video：

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Abstract Full text Figures/Tables Video References Cited by

Trial sequential analysis (TSA) can identify inclusive results of apparently conclusive of meta-analyses by providing require information size and monitoring boundary. Certain methods of calculating information size are existed. Our objective was to give a brief introduction of four methods to help readers to better perform TSA in making meta-analyses.

Citation： WENG Hong, GUO Chengcheng, LV Jun, MENG Xiangyu, GUO Zhongqiang, ZENG Xiantao. Calculation of information size of trial sequential analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(1): 113-116. doi: 10.7507/1672-2531.201607061 Copy

1.	?Brok J, Thorlund K, Gluud C,et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol, 2008, 61(8): 763-769.
2.	Wetterslev J, Thorlund K, Brok J,et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol, 2008, 61(1): 64-75.
3.	Brok J, Thorlund K, Wetterslev J,et al. Apparently conclusive meta-analyses may be inconclusive - Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol, 2009, 38(1): 287-298.
4.	Thorlund K, Devereaux PJ, Wetterslev J,et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol, 2009, 38(1): 276-286.
5.	曾憲濤, 冷衛東, 郭毅, 等. Meta 分析系列之一: Meta 分析的類型. 中國循證心血管醫學雜志, 2012, 4(1): 3-5.
6.	曾憲濤, 田國祥, 張超, 等. Meta 分析系列之十五: Meta 分析的進展與思考. 中國循證心血管醫學雜志, 2013, 5(6): 561-563.
7.	曾憲濤, 鄺心穎, 孫燕, 等. 什么是循證醫學?. 湖北醫藥學院學報, 2013, 32(1): 1-5.
8.	Pogue J, Yusuf S. Overcoming the limitations of current meta-analysis of randomised controlled trials. Lancet, 1998, 351(9095): 47-52.
9.	Pogue JM, Yusuf S. Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis. Control Clin Trials, 1997, 18(6): 580-593.
10.	Gordon H. Guyatt, Andrew D. Oxman, Regina Kunz, 等. GRADE指南: Ⅵ. 證據質量評價——不精確性(隨機誤差). 中國循證醫學雜志, 2011, 11(12): 1435-1443.
11.	曾憲濤, 冷衛東, 李勝, 等. 如何正確理解及使用 GRADE 系統. 中國循證醫學雜志, 2011, 11(9): 985-990.
12.	曾憲濤, 田國祥, 牛玉明, 等. GRADEprofiler 軟件的使用簡介. 中國循證心血管醫學雜志, 2011, 3(5): 390-392.
13.	陳耀龍, 姚亮, Norris S, 等. GRADE 在系統評價中應用的必要性及注意事項. 中國循證醫學雜志, 2013, 13(12): 1401-1404.
14.	陳昊, 王艷, 胡軒銘, 等. GRADEpro GDT 在干預性系統評價證據質量分級中的應用. 中國循證醫學雜志, 2015, 15(5): 600-606.
15.	Barrington KJ. Umbilical artery catheters in the newborn: effects of position of the catheter tip. Cochrane Database Syst Rev, 2000, (2): CD000505.
16.	Thorlund K, Engstr?m J, Wetterslev J,et al. User manual for trial sequential analysis (TSA). Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark. 2011. Available at: www.ctu.dk/tsa.
17.	翁鴻, 武珊珊, 張永剛, 等. 序貫 Meta 分析方法學簡介. 中國循證醫學雜志, 2016, 16(10): 1216-1220.
18.	翁鴻, 李勝, 曾憲濤, 等. 試驗序貫分析軟件在 Meta 分析中的應用. 中國循證醫學雜志, 2016, 16(5): 604-611.

1. ?Brok J, Thorlund K, Gluud C,et al. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol, 2008, 61(8): 763-769.
2. Wetterslev J, Thorlund K, Brok J,et al. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol, 2008, 61(1): 64-75.
3. Brok J, Thorlund K, Wetterslev J,et al. Apparently conclusive meta-analyses may be inconclusive - Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol, 2009, 38(1): 287-298.
4. Thorlund K, Devereaux PJ, Wetterslev J,et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol, 2009, 38(1): 276-286.
5. 曾憲濤, 冷衛東, 郭毅, 等. Meta 分析系列之一: Meta 分析的類型. 中國循證心血管醫學雜志, 2012, 4(1): 3-5.
6. 曾憲濤, 田國祥, 張超, 等. Meta 分析系列之十五: Meta 分析的進展與思考. 中國循證心血管醫學雜志, 2013, 5(6): 561-563.
7. 曾憲濤, 鄺心穎, 孫燕, 等. 什么是循證醫學?. 湖北醫藥學院學報, 2013, 32(1): 1-5.
8. Pogue J, Yusuf S. Overcoming the limitations of current meta-analysis of randomised controlled trials. Lancet, 1998, 351(9095): 47-52.
9. Pogue JM, Yusuf S. Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis. Control Clin Trials, 1997, 18(6): 580-593.
10. Gordon H. Guyatt, Andrew D. Oxman, Regina Kunz, 等. GRADE指南: Ⅵ. 證據質量評價——不精確性(隨機誤差). 中國循證醫學雜志, 2011, 11(12): 1435-1443.
11. 曾憲濤, 冷衛東, 李勝, 等. 如何正確理解及使用 GRADE 系統. 中國循證醫學雜志, 2011, 11(9): 985-990.
12. 曾憲濤, 田國祥, 牛玉明, 等. GRADEprofiler 軟件的使用簡介. 中國循證心血管醫學雜志, 2011, 3(5): 390-392.
13. 陳耀龍, 姚亮, Norris S, 等. GRADE 在系統評價中應用的必要性及注意事項. 中國循證醫學雜志, 2013, 13(12): 1401-1404.
14. 陳昊, 王艷, 胡軒銘, 等. GRADEpro GDT 在干預性系統評價證據質量分級中的應用. 中國循證醫學雜志, 2015, 15(5): 600-606.
15. Barrington KJ. Umbilical artery catheters in the newborn: effects of position of the catheter tip. Cochrane Database Syst Rev, 2000, (2): CD000505.
16. Thorlund K, Engstr?m J, Wetterslev J,et al. User manual for trial sequential analysis (TSA). Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark. 2011. Available at: www.ctu.dk/tsa.
17. 翁鴻, 武珊珊, 張永剛, 等. 序貫 Meta 分析方法學簡介. 中國循證醫學雜志, 2016, 16(10): 1216-1220.
18. 翁鴻, 李勝, 曾憲濤, 等. 試驗序貫分析軟件在 Meta 分析中的應用. 中國循證醫學雜志, 2016, 16(5): 604-611.

Chinese Journal of Evidence-Based Medicine

Calculation of information size of trial sequential analysis

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