Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

DAI Huixu , HE Qiao ,  SHI Jingpu

Department of Clinical Epidemiology, the First Affiliated Hospital, China Medical University, Shenyang, 110001, P.R.China;

Corresponding?author：

SHI Jingpu, Email: sjp562013@126.com

Keywords：

ALDH2; Polymorphism; Ischemic stroke; Meta-analysis

DOI：

10.7507/1672-2531.201611024

Video：

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Objective To systematically review the association between ALDH2 polymorphism and ischemic stroke. Methods Web of Science, PubMed, CNKI, CBM and WanFang data were searched to collect case-control studies about the association between ALDH2 polymorphism and ischemic stroke from the inception to October 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using Stata 12.0 software. Results A total of seven case-control studies were included. The results of meta-analysis showed that the A allele and AA genotype in ALDH2 was associated with the risk of ischemic stroke (Avs. G: OR=1.430, 95%CI 1.006 to 2.033,P=0.046; AAvs. AG+GG: OR=1.734, 95%CI 1.267 to 2.373,P=0.001; AAvs. GG: OR=1.757, 95%CI 1.274 to 2.424,P=0.001). Conclusion ALDH2 gene polymorphism may related to ischemic stroke for Chinese and A allele of ALDH2 may be the risk factors.

Citation： DAI Huixu, HE Qiao, SHI Jingpu. Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(1): 72-77. doi: 10.7507/1672-2531.201611024 Copy

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2.	Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke, 2006, 37(6): 1583-1633.
3.	黎炳護, 張莉莉, 尹延偉, 等. 白細胞介素-6基因 174G-C 多態性與缺血性腦卒中風險相關性的 Meta 分析. 中國循證醫學雜志, 2012, 12(5): 563-569.
4.	吳敵, 王擁軍. 卒中二級預防中落實證據的阻礙因素和改進措施. 中國卒中雜志, 2006(8): 563-567.
5.	Teramoto T, Sasaki J, Ueshima H, et al. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb, 2007, 14(2): 45-50.
6.	Chen YC, Peng GS, Tsao TP, et al. Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics, 2009, 19(8): 588-599.
7.	潘強強, 高琴, 王洪巨. 乙醛脫氫酶2與心血管疾病研究進展. 中國老年學雜志, 2013, 33: 1962-1964.
8.	孫華林. 乙醛脫氫酶 2 基因多態性與腦梗死患者頸動脈粥樣硬化斑塊形成的相關性. 山東大學學報(醫學版), 2012, 50(7): 65-68.
9.	Takagi S, Iwai N, Yamauchi R, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res, 2002, 25(5): 677-681.
10.	Nagasawa H, Wada M, Arawaka S, et al. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Eur J Neurol, 2007, 14(4): 428-434.
11.	Macgregor S, Lind PA, Bucholz KK, et al. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet, 2009, 18(3): 580-593.
12.	王耕銀, 陳乃耀, 徐應軍. 乙醛脫氫酶2基因多態性與腦梗死相關性研究. 中國煤炭工業醫學雜志, 2014, 17(1): 29-31.
13.	徐筱婧. ALDH2 基因單核苷酸多態性與腦梗死的關聯分析. 遵義: 遵義醫學院, 2012.
14.	張春媛, 戴艷萍, 李軍, 等. 黑龍江省漢族乙醛脫氫酶2基因多態性與急性腦梗死相關性的研究. 中國校醫, 2014, 28(5): 334-335.
15.	周青. ALDH2 基因多態性與腦卒中易感性的關系. 泰安: 泰山醫學院, 2014.
16.	Sung YF, Lu CC, Lee JT, et al. Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. Stroke, 2016, 47(9): 2174-2179.
17.	Li QY, Zhao NM, Ma JJ, et al. ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women. Biochem Genet, 2015, 53(9-10): 260-267.
18.	陳娟. 4-羥基壬烯醛在疾病發生機制方面的研究進展. 國際呼吸雜志, 2006, 11: 821-824.
19.	李夢, 陳陽美. 缺血性腦卒中患者頸動脈粥樣硬化斑塊危險因素的分析. 中國循證醫學雜志, 2006, 6(5): 385-389.

1. Wu X, Zhu B, Fu L, et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2. Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke, 2006, 37(6): 1583-1633.
3. 黎炳護, 張莉莉, 尹延偉, 等. 白細胞介素-6基因 174G-C 多態性與缺血性腦卒中風險相關性的 Meta 分析. 中國循證醫學雜志, 2012, 12(5): 563-569.
4. 吳敵, 王擁軍. 卒中二級預防中落實證據的阻礙因素和改進措施. 中國卒中雜志, 2006(8): 563-567.
5. Teramoto T, Sasaki J, Ueshima H, et al. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb, 2007, 14(2): 45-50.
6. Chen YC, Peng GS, Tsao TP, et al. Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics, 2009, 19(8): 588-599.
7. 潘強強, 高琴, 王洪巨. 乙醛脫氫酶2與心血管疾病研究進展. 中國老年學雜志, 2013, 33: 1962-1964.
8. 孫華林. 乙醛脫氫酶 2 基因多態性與腦梗死患者頸動脈粥樣硬化斑塊形成的相關性. 山東大學學報(醫學版), 2012, 50(7): 65-68.
9. Takagi S, Iwai N, Yamauchi R, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res, 2002, 25(5): 677-681.
10. Nagasawa H, Wada M, Arawaka S, et al. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Eur J Neurol, 2007, 14(4): 428-434.
11. Macgregor S, Lind PA, Bucholz KK, et al. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet, 2009, 18(3): 580-593.
12. 王耕銀, 陳乃耀, 徐應軍. 乙醛脫氫酶2基因多態性與腦梗死相關性研究. 中國煤炭工業醫學雜志, 2014, 17(1): 29-31.
13. 徐筱婧. ALDH2 基因單核苷酸多態性與腦梗死的關聯分析. 遵義: 遵義醫學院, 2012.
14. 張春媛, 戴艷萍, 李軍, 等. 黑龍江省漢族乙醛脫氫酶2基因多態性與急性腦梗死相關性的研究. 中國校醫, 2014, 28(5): 334-335.
15. 周青. ALDH2 基因多態性與腦卒中易感性的關系. 泰安: 泰山醫學院, 2014.
16. Sung YF, Lu CC, Lee JT, et al. Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. Stroke, 2016, 47(9): 2174-2179.
17. Li QY, Zhao NM, Ma JJ, et al. ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women. Biochem Genet, 2015, 53(9-10): 260-267.
18. 陳娟. 4-羥基壬烯醛在疾病發生機制方面的研究進展. 國際呼吸雜志, 2006, 11: 821-824.
19. 李夢, 陳陽美. 缺血性腦卒中患者頸動脈粥樣硬化斑塊危險因素的分析. 中國循證醫學雜志, 2006, 6(5): 385-389.

Chinese Journal of Evidence-Based Medicine

Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis

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