SG13S89 polymorphism in<i>ALOX5AP</i> and risk of ischemic stroke in Chinese population: a meta-analysis _Chinese Journal of Evidence-Based Medicine

Authors：

DAI Huixu , HE Qiao ,  SHI Jingpu

Department of Clinical Epidemiology, The First Affiliated Hospital, China Medical University, Shenyang, 110001, P.R.China;

Corresponding?author：

SHI Jingpu, Email: sjp562013@126.com

Keywords：

ALOX5AP; Polymorphism; Ischemic stroke; Meta-analysis

DOI：

10.7507/1672-2531.201612005

Video：

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Objective To systematically review the association between SG13S89 polymorphism inALOX5AP gene and ischemic stroke in Chinese population. Methods Web of Science, PubMed, CNKI, CBM, EMbase and WanFang Data databases were searched to collect studies about the association between SG13S89 polymorphism inALOX5AP gene and ischemic stroke from inception to October 2016. Two researchers independently screened literature, extracted data and evaluated the risk of bias of included studies. The meta-analysis was performed by STATA 12.0. Results A total of 11 case-control studies were included. The results of meta-analysis showed that SG13S89 polymorphism inALOX5AP gene was associated with the risk of ischemic stroke in Chinese (Avs. G: OR=1.192, 95%CI 1.029 to 1.381,P=0.019; AA+AGvs. GG: OR=1.20, 95%CI 1.029 to 1.400,P=0.020; AGvs. GG: OR=1.195, 95%CI 1.022 to 1.397,P=0.025). Conclusion SG13S89 polymorphism inALOX5AP gene may be related to ischemic stroke for Chinese, A allele may be a risk factor.

Citation： DAI Huixu, HE Qiao, SHI Jingpu. SG13S89 polymorphism inALOX5AP and risk of ischemic stroke in Chinese population: a meta-analysis . Chinese Journal of Evidence-Based Medicine, 2017, 17(4): 389-394. doi: 10.7507/1672-2531.201612005 Copy

1.	?Wu XM, Zhu B, Fu LY,et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2.	黎炳護, 張莉莉, 尹延偉, 等. 白細胞介素-6 基因 174G-C 多態性與缺血性腦卒中風險相關性的 Meta 分析. 中國循證醫學雜志, 2012, 12(5): 563-569.
3.	吳敵, 王擁軍. 卒中二級預防中落實證據的阻礙因素和改進措施. 中國卒中雜志, 2006, 1(8): 563-567.
4.	李海先, 吳海容, 李健業, 等. ALOX5AP 基因多態性及肥胖與缺血性腦卒中相關性. 青島大學醫學院學報, 2013, 49(4): 319-322.
5.	Helgadottir A, Manolescu A, Thorleifsson G,et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet, 2004. 36(3): 233-239.
6.	Shen CD, Zhang WL, Sun K,et al. Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study. Ann Hum Genet, 2007, 71(5): 620-629.
7.	Yang Y, Zhang D, Feng N,et al., Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis. Gastroenterology, 2014, 147(5): 1031-1042.
8.	邵敏潔, 易興陽, 池麗芬. 浙江南部地區人群 5-脂氧合酶激活蛋白和磷酸二酯酶 4D 基因突變與缺血性腦卒中的研究. 中華老年心腦血管病雜志, 2013, 15(6): 592-595.
9.	王劍南, 楊兆寧, 隋強. 5-脂氧合酶激活蛋白及磷酸二酯酶 4D 基因多態性與腦梗死易患性的分子流行病學研究. 蚌埠醫學院學報, 2015, 40(10): 1338-1340.
10.	徐佳亮. ALOX5AP 基因和 IL-1A 基因多態性與缺血性卒中的相關性. 沈陽: 中國醫科大學, 2009.
11.	姚倩倩, 周暢, 劉麗君, 等. ALOX5AP 基因多態性與動脈粥樣硬化性腦梗死相關性. 青島大學醫學院學報, 2013, 49(6): 471-475.
12.	高志嵩, 杜秦川. 缺血性腦卒中 ALOX5AP 基因 SG13S114T/A 和 SG13S89G/A 多態性研究. 寧夏醫學雜志, 2008, 30(5): 388-390.
13.	廖斷修, 易興陽, 張標, 等. ALOX5AP 和 CYP3A5 基因多態性與缺血性卒中后血栓事件的相關性. 西部醫學, 2016, 28(6): 823-828.
14.	馮學問, 吳偉林, 陳春友, 等. 5-脂氧合酶激活蛋白基因多態性與腦梗死易患性的臨床研究. 中國醫師雜志, 2016, 18(2): 212-215.
15.	高卓, 田國萍. 沈陽地區漢族人群腦梗死患者 ALOX5AP 基因 SNP 分析. 中風與神經疾病雜志, 2010, 27(11): 1022-1026.
16.	Zhang WL, Yang XM, Shi J,et al. Polymorphism of SG13S114T/A in the ALOX5AP Gene and the Risk for Stroke in a Large Chinese Cohort. Acta Genetica Sinica, 2006, 33(8): 678-684.
17.	Yang DZ, He Y, Li MY,et al. A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population. J Mol Neurosci, 2014, 53(3): 493-499.
18.	Qu ZY, Su F, Zhu YL,et al. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med, 2015, 8(11): 21343-21350.
19.	中華醫學會神經病學分會腦血管病學組缺血性腦卒中二級預防指南組. 中國缺血性腦卒中和短暫性腦缺血發作的二級預防指南 2010. 中華神經內科雜志, 2010, 43(2): 134-160.
20.	鄧淑敏, 何志義. 參與花生四烯酸代謝的酶單核苷酸多態性與腦卒中相關性研究進展. 中國神經免疫學和神經病學雜志, 2011, 18(5): 365-367.
21.	徐佳亮, 藺慕會, 陳曉虹, 等. 中國人群 ALOX5AP 基因 SG13S114A/T 多態性與缺血性卒中相關性的 Meta 分析. 中風與神經疾病雜志, 2010, 27(9): 811-814.
22.	張偉麗, 陳宇, 惠汝太, 等. 缺血性卒中的遺傳機制進展. 中國卒中雜志, 2010, 5(12): 988-995.

1. ?Wu XM, Zhu B, Fu LY,et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2. 黎炳護, 張莉莉, 尹延偉, 等. 白細胞介素-6 基因 174G-C 多態性與缺血性腦卒中風險相關性的 Meta 分析. 中國循證醫學雜志, 2012, 12(5): 563-569.
3. 吳敵, 王擁軍. 卒中二級預防中落實證據的阻礙因素和改進措施. 中國卒中雜志, 2006, 1(8): 563-567.
4. 李海先, 吳海容, 李健業, 等. ALOX5AP 基因多態性及肥胖與缺血性腦卒中相關性. 青島大學醫學院學報, 2013, 49(4): 319-322.
5. Helgadottir A, Manolescu A, Thorleifsson G,et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet, 2004. 36(3): 233-239.
6. Shen CD, Zhang WL, Sun K,et al. Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study. Ann Hum Genet, 2007, 71(5): 620-629.
7. Yang Y, Zhang D, Feng N,et al., Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis. Gastroenterology, 2014, 147(5): 1031-1042.
8. 邵敏潔, 易興陽, 池麗芬. 浙江南部地區人群 5-脂氧合酶激活蛋白和磷酸二酯酶 4D 基因突變與缺血性腦卒中的研究. 中華老年心腦血管病雜志, 2013, 15(6): 592-595.
9. 王劍南, 楊兆寧, 隋強. 5-脂氧合酶激活蛋白及磷酸二酯酶 4D 基因多態性與腦梗死易患性的分子流行病學研究. 蚌埠醫學院學報, 2015, 40(10): 1338-1340.
10. 徐佳亮. ALOX5AP 基因和 IL-1A 基因多態性與缺血性卒中的相關性. 沈陽: 中國醫科大學, 2009.
11. 姚倩倩, 周暢, 劉麗君, 等. ALOX5AP 基因多態性與動脈粥樣硬化性腦梗死相關性. 青島大學醫學院學報, 2013, 49(6): 471-475.
12. 高志嵩, 杜秦川. 缺血性腦卒中 ALOX5AP 基因 SG13S114T/A 和 SG13S89G/A 多態性研究. 寧夏醫學雜志, 2008, 30(5): 388-390.
13. 廖斷修, 易興陽, 張標, 等. ALOX5AP 和 CYP3A5 基因多態性與缺血性卒中后血栓事件的相關性. 西部醫學, 2016, 28(6): 823-828.
14. 馮學問, 吳偉林, 陳春友, 等. 5-脂氧合酶激活蛋白基因多態性與腦梗死易患性的臨床研究. 中國醫師雜志, 2016, 18(2): 212-215.
15. 高卓, 田國萍. 沈陽地區漢族人群腦梗死患者 ALOX5AP 基因 SNP 分析. 中風與神經疾病雜志, 2010, 27(11): 1022-1026.
16. Zhang WL, Yang XM, Shi J,et al. Polymorphism of SG13S114T/A in the ALOX5AP Gene and the Risk for Stroke in a Large Chinese Cohort. Acta Genetica Sinica, 2006, 33(8): 678-684.
17. Yang DZ, He Y, Li MY,et al. A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population. J Mol Neurosci, 2014, 53(3): 493-499.
18. Qu ZY, Su F, Zhu YL,et al. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med, 2015, 8(11): 21343-21350.
19. 中華醫學會神經病學分會腦血管病學組缺血性腦卒中二級預防指南組. 中國缺血性腦卒中和短暫性腦缺血發作的二級預防指南 2010. 中華神經內科雜志, 2010, 43(2): 134-160.
20. 鄧淑敏, 何志義. 參與花生四烯酸代謝的酶單核苷酸多態性與腦卒中相關性研究進展. 中國神經免疫學和神經病學雜志, 2011, 18(5): 365-367.
21. 徐佳亮, 藺慕會, 陳曉虹, 等. 中國人群 ALOX5AP 基因 SG13S114A/T 多態性與缺血性卒中相關性的 Meta 分析. 中風與神經疾病雜志, 2010, 27(9): 811-814.
22. 張偉麗, 陳宇, 惠汝太, 等. 缺血性卒中的遺傳機制進展. 中國卒中雜志, 2010, 5(12): 988-995.

Chinese Journal of Evidence-Based Medicine

SG13S89 polymorphism inALOX5AP and risk of ischemic stroke in Chinese population: a meta-analysis

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