Efficacy and safety of Yangyinqingfei decoction in the treatment of chronic cough and chronic obstructive pulmonary disease: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Yanfei ¹ ,  LIU Yue ² , CHENG Long ³ ,  WANG Hui ⁴

1. Beijing University of Chinese Medicine, Beijing, 100029, P.R.China;
2. Cardiovascular Diseases Centre, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, P.R.China;
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, P.R.China;
4. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, P.R.China;

Corresponding?author：

LIU Yue, Email: liuyue@188.com; WANG Hui, Email: wanghui9890@163.com

Keywords：

Yangyinqingfei decoction; Chronic cough; Chronic obstructive pulmonary disease; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.201701015

Video：

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ObjectiveTo systematically review the efficacy and safety of Yangyinqingfei decoction for chronic cough and chronic obstructive pulmonary disease (COPD) patients.MethodsWe electronically searched databases including PubMed, Web of Science, CBM, CNKI, VIP and WanFang Data for randomized controlled trials (RCTs) of Yangyinqingfei decoction for chronic cough and COPD patients from inception to August 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, RevMan 5.3 software was used for meta-analysis.ResultsTwenty-four RCTs involving 2 268 patients with COPD and chronic cough were included. The results of meta-analysis showed that compared with the control group, Yangyinqingfei decoction combined with the conventional medicine could significantly improve clinical effective rate (RR=1.21, 95%CI 1.16 to 1.27, P<0.000 01) and lung function (SMD=0.76, 95%CI 0.59 to 0.94, P<0.000 01) in patients with COPD. Yangyinqingfei decoction combined with the conventional medicine group was superior to the control group (RR=1.41, 95%CI 1.22 to 1.64, P<0.000 01) in clinical efficacy for adults patients with chronic cough. In terms of safety, seven cases occurred adverse reactions in the Yangyinqingfei decoction group, while 13 were found in the control group, the types and degree of adverse reactions in both groups were almost the same.ConclusionThe combination of Yangyinqingfei plus conventional medicine may significantly improve the clinical efficacy for chronic cough and COPD with reliable safety. However, due to the limited quality and quantity of included studies, the above conclusions are needed to verify by more high quality studies.

Citation： LIU Yanfei, LIU Yue, CHENG Long, WANG Hui. Efficacy and safety of Yangyinqingfei decoction in the treatment of chronic cough and chronic obstructive pulmonary disease: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(6): 698-704. doi: 10.7507/1672-2531.201701015 Copy

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11.	蘭映天. 養陰清肺湯治療老年慢性阻塞性肺氣腫的臨床觀察. 現代養生, 2012, 7(16): 71-73.
12.	謝杏愛. 養陰清肺湯治療老年慢性阻塞性肺氣腫療效分析. 按摩與康復醫學, 2014, 5(1): 126-127.
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15.	寧靜, 程永華. 養陰清肺湯治療痰熱郁肺型老年 COPD 的臨床觀察. 中醫臨床研究, 2015, 7(31): 78-80.
16.	蓋瑩. 中西醫結合治療慢性阻塞性肺氣腫臨床效果分析. 中國中醫藥咨訊, 2012, 4(1): 214.
17.	王建華, 李梅娟. 中西醫結合治療慢性阻塞性肺氣腫 30 例臨床觀察. 國際醫藥衛生導報, 2010, 16(5): 572-573.
18.	倪敏. 養陰清肺湯聯合糖皮質激素治療老年慢性阻塞性肺氣腫臨床觀察. 新中醫, 2015, 47(1): 70-71.
19.	董日. 養陰清肺湯治療老年慢性阻塞性肺氣腫 44 例. 江西中醫藥, 2014, 45(383): 33-34.
20.	岳團華. 養陰清肺湯治療老年慢性阻塞性肺氣腫臨床療效觀察. 亞太傳統醫藥, 2014, 10(20): 117-118.
21.	周明. 養陰清肺湯治療老年慢性阻塞性肺氣腫的療效觀察. 現代診斷與治療, 2013, 24(15): 3420-3421.
22.	鄭遠方. 中西結合治療慢性阻塞性肺氣腫 128 例臨床療效研究. 中外醫療, 2012, 31(19): 113.
23.	於志娟. 養陰清肺湯加減治療小兒上氣道咳嗽綜合征 75 例療效觀察. 內蒙古中醫藥, 2010, 29(22): 10.
24.	唐潔芬, 余培煌. 養陰清肺湯聯合孟魯司特治療小兒支原體感染肺炎后慢性咳嗽臨床觀察. 四川中醫, 2016, 34(8): 72-75.
25.	安立, 李林. 養陰清肺湯聯合西藥治療慢性咽炎隨機平行對照研究. 實用中醫內科雜志, 2016, 30(3): 61-63.
26.	趙秀貞. 用養陰清肺湯治療慢性咽炎的遠期療效與安全性分析. 當代醫藥論叢, 2014, 34(8): 14-16.
27.	穆傳軍, 李振山, 孫兆勛. 養陰清肺口服液治療慢性咽炎 80 例療效觀察. 山東中醫雜志, 2006, 25(2): 91-92.

1. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (updated 2016). Available at: http://goldcopd.org/global-strategy-diagnosis-management-prevention-copd-2016.
2. 中華醫學會呼吸病學分會哮喘學組. 咳嗽的診斷與治療指南 (2015). 中華結核和呼吸雜志, 2016, 39(5): 323-354.
3. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). Available at: http://www. cochranehandbook.org.
4. 杜萬朋. 養陰清肺湯聯合頭孢呋辛鈉治療慢性阻塞性肺氣腫 60 例臨床觀察. 中國民族民間醫藥, 2015, 24(14): 51-52.
5. 王寧德, 李莉. 養陰清肺湯聯合西藥治療老年慢性肺氣腫臨床療效. 陜西中醫, 2015, 36(7): 827-828.
6. 孔令魁. 養陰清肺湯在老年慢性阻塞性肺氣腫治療中的療效分析. 臨床心身疾病雜志, 2015, 21(z1): 256.
7. 高軼峰, 崔紅, 劉賓娜. 養陰清肺湯治療老年慢性阻塞性肺氣腫. 中國實驗方劑學雜志, 2011, 17(4): 204-205.
8. 譚國柱. 養陰清肺湯治療老年慢性阻塞性肺氣腫的臨床觀察. 中醫臨床研究, 2014, 6(23): 73-74.
9. 朱文平. 養陰清肺湯治療老年慢性阻塞性肺氣腫的臨床觀察. 大家健康(學術版), 2014, 8(4): 54.
10. 謝小芹, 元文峰, 鄒萍. 養陰清肺湯治療老年慢性阻塞性肺氣腫的臨床觀察. 醫學信息, 2013, 6(29): 134.
11. 蘭映天. 養陰清肺湯治療老年慢性阻塞性肺氣腫的臨床觀察. 現代養生, 2012, 7(16): 71-73.
12. 謝杏愛. 養陰清肺湯治療老年慢性阻塞性肺氣腫療效分析. 按摩與康復醫學, 2014, 5(1): 126-127.
13. 張定學, 張著勛. 養陰清肺湯治療老年慢性阻塞性肺氣腫療效觀察. 現代中西醫結合雜志, 2014, 23(13): 1447-1448.
14. 何龍. 養陰清肺湯治療慢性阻塞性肺氣腫的臨床療效觀察. 中國醫藥指南, 2016, 14(12): 8-9.
15. 寧靜, 程永華. 養陰清肺湯治療痰熱郁肺型老年 COPD 的臨床觀察. 中醫臨床研究, 2015, 7(31): 78-80.
16. 蓋瑩. 中西醫結合治療慢性阻塞性肺氣腫臨床效果分析. 中國中醫藥咨訊, 2012, 4(1): 214.
17. 王建華, 李梅娟. 中西醫結合治療慢性阻塞性肺氣腫 30 例臨床觀察. 國際醫藥衛生導報, 2010, 16(5): 572-573.
18. 倪敏. 養陰清肺湯聯合糖皮質激素治療老年慢性阻塞性肺氣腫臨床觀察. 新中醫, 2015, 47(1): 70-71.
19. 董日. 養陰清肺湯治療老年慢性阻塞性肺氣腫 44 例. 江西中醫藥, 2014, 45(383): 33-34.
20. 岳團華. 養陰清肺湯治療老年慢性阻塞性肺氣腫臨床療效觀察. 亞太傳統醫藥, 2014, 10(20): 117-118.
21. 周明. 養陰清肺湯治療老年慢性阻塞性肺氣腫的療效觀察. 現代診斷與治療, 2013, 24(15): 3420-3421.
22. 鄭遠方. 中西結合治療慢性阻塞性肺氣腫 128 例臨床療效研究. 中外醫療, 2012, 31(19): 113.
23. 於志娟. 養陰清肺湯加減治療小兒上氣道咳嗽綜合征 75 例療效觀察. 內蒙古中醫藥, 2010, 29(22): 10.
24. 唐潔芬, 余培煌. 養陰清肺湯聯合孟魯司特治療小兒支原體感染肺炎后慢性咳嗽臨床觀察. 四川中醫, 2016, 34(8): 72-75.
25. 安立, 李林. 養陰清肺湯聯合西藥治療慢性咽炎隨機平行對照研究. 實用中醫內科雜志, 2016, 30(3): 61-63.
26. 趙秀貞. 用養陰清肺湯治療慢性咽炎的遠期療效與安全性分析. 當代醫藥論叢, 2014, 34(8): 14-16.
27. 穆傳軍, 李振山, 孫兆勛. 養陰清肺口服液治療慢性咽炎 80 例療效觀察. 山東中醫雜志, 2006, 25(2): 91-92.

Chinese Journal of Evidence-Based Medicine

Efficacy and safety of Yangyinqingfei decoction in the treatment of chronic cough and chronic obstructive pulmonary disease: a meta-analysis

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