Efficacy of long-acting antibacterial material in the prevention of secondary urinary infection: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

GAI Qiongyan ^1,2 , LI Yi ³ , ZHOU Xiaoqin ^1,2 , WANG Juan ^1,2 , YANG Xuemei ¹ , WEI Zhihong ¹ , GUO Yan ^1,2 ,  WANG Zhiping ^1,2

1. School of Nursing, Lanzhou University, Lanzhou, 730000, P.R.China;
2. Institute of Urology, the Second Hospital of Lanzhou University; Gansu Key Laboratory of Urological Diseases; Gansu Nephro-Urological Clinical Center, Lanzhou, 730030, P.R.China;
3. The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding?author：

WANG Zhiping, Email: erywzp@lzu.edu.cn

Keywords：

Long-acting antibacterial material; Urinary infection; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.201707048

Video：

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Objective To systematically review the efficacy of long-acting antibacterial material in the prevention of secondary urinary infection. Methods PubMed, The Cochrane Library, CNKI, CBM, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials (RCTs) on the efficacy of long-acting antibacterial material in the prevention of secondary urinary infection from inception to November, 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software. Results A total of 16 RCTs were included. The results of meta-analysis showed that: the long-acting antibacterial material group was superior to the general intervention group in morbidity of secondary urinary infection (Peto OR=0.17, 95%CI 0.13 to 0.23, P<0.000 01), and bacterial positive rate of secondary urinary infection (Peto OR=0.15, 95%CI 0.08 to 0.27,P<0.000 01). Conclusion Current evidence shows that long-acting antibacterial material can effectively reduce the infection rates of secondary urinary infection. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.

Citation： GAI Qiongyan, LI Yi, ZHOU Xiaoqin, WANG Juan, YANG Xuemei, WEI Zhihong, GUO Yan, WANG Zhiping. Efficacy of long-acting antibacterial material in the prevention of secondary urinary infection: a systematic review. Chinese Journal of Evidence-Based Medicine, 2017, 17(11): 1312-1317. doi: 10.7507/1672-2531.201707048 Copy

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2.	Haley RW, Culver DH, White JW, et al. The nationwide nosocomial infection rate. A new need for vital statistics. Am J Epidemiol, 1985, 121(2): 159-167.
3.	Raad I, Kassar R, Ghannam D, et al. Management of the catheter in documented catheter-related coagulase-negative staphylococcal bacteremia: remove or retain?. Clin Infect Dis, 2009, 49(8): 1187-1194.
4.	Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev, 2002, 15(2): 167-193.
5.	Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (5.0). Available at: http://www. cochranehandbook.org.2008.
6.	江桂林, 穆成云, 朱敏. 長效抑菌材料抗菌劑預防留置尿管逆行感染效果觀察. 基層醫學論壇, 2010, (15): 430-431.
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11.	周艷瓊, 李惠玲. 抗菌材料" 潔悠神”對留置尿管病人預防尿路感染的臨床觀察. 四川省衛生管理干部學院學報, 2007, 26(4): 289-290.
12.	張瑜, 梅紅兵, 鄭碧霞. 探討潔悠神在預防留置尿管性尿路感染的護理效果. 現代預防醫學, 2010, 37(18): 3562-3563.
13.	楊小蕓, 王宇婷, 胡亞麗. " 潔悠神”用于預防男性經尿道手術后尿路感染的研究. 中華醫學創新, 2009, 6(18): 30-31.
14.	劉有蓮. 長效抑菌材料" 潔憂神”對重癥患者留置導尿管伴尿路感染的預防. 廣州醫藥, 2012, 43(6): 69-71.
15.	邵愛艷. 潔悠神預防卒中患者留置尿管致尿路感染的臨床分析. 中華美容醫學, 2012, 21(8): 250-251.
16.	張瓊. 長效抑菌材料潔悠神預防留置尿管逆行感染的臨床觀察. 當代護士(中旬刊), 2012, (6): 131-132.
17.	沈蒙文. 潔悠神在預防留置導尿管并發尿路感染中的應用效果. 當代護士(中旬刊), 2013, (1): 129-130.
18.	張彥, 鞠進, 侯海霞. 潔悠神在預防留置尿管逆行感染的臨床效果觀察. 醫學信息, 2015, (z3): 70.
19.	黃潤. 潔悠神在預防留置導尿管并發尿路感染中的臨床護理體會. 中國繼續醫學教育, 2016, 8(18): 249-250.
20.	李杰. 潔悠神預防留置尿管性尿路感染的有效性觀察. 護士進修雜志, 2016, 31(18): 1712-1713.
21.	南存金, 蘇紅俠, 何有華, 等. 外用抗菌劑長效抑菌材料聯合抗返流引流袋預防留置導尿伴隨性尿路感染. 中華全科醫學, 2016, 14(4): 569-570.

1. WHO/CDS/CSR/EPH. Prevention of hospital-acquired infections. A practical guide. 2nd edition. 2002, 12. Available at: http://www.who.int/csr/resources/publications/drugresist/WHO_CDS_CSR_EPH_2002_12/en/.
2. Haley RW, Culver DH, White JW, et al. The nationwide nosocomial infection rate. A new need for vital statistics. Am J Epidemiol, 1985, 121(2): 159-167.
3. Raad I, Kassar R, Ghannam D, et al. Management of the catheter in documented catheter-related coagulase-negative staphylococcal bacteremia: remove or retain?. Clin Infect Dis, 2009, 49(8): 1187-1194.
4. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev, 2002, 15(2): 167-193.
5. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions (5.0). Available at: http://www. cochranehandbook.org.2008.
6. 江桂林, 穆成云, 朱敏. 長效抑菌材料抗菌劑預防留置尿管逆行感染效果觀察. 基層醫學論壇, 2010, (15): 430-431.
7. 吳玲, 王良梅, 程蓓, 等. 潔悠神用于留置導尿尿路感染預防的研究. 護理研究, 2005, 19(3): 242.
8. 陳蘭英, 陸勤美, 張躍. 潔悠神預防宮頸癌根治術后留置尿管伴隨性尿路感染的效果觀察. 全科護理, 2010, 8(6): 494-495.
9. 陳麗莉, 李燕, 張少容. 潔悠神在留置尿管病人中應用的療效觀察. 嶺南現代臨床外科, 2009, 9(5): 395-396.
10. 龐翠華. 長效抑菌材料潔悠神對預防留置導尿患者尿路感染的效果. 中華現代護理雜志, 2011, 17(16): 1949-1950.
11. 周艷瓊, 李惠玲. 抗菌材料" 潔悠神”對留置尿管病人預防尿路感染的臨床觀察. 四川省衛生管理干部學院學報, 2007, 26(4): 289-290.
12. 張瑜, 梅紅兵, 鄭碧霞. 探討潔悠神在預防留置尿管性尿路感染的護理效果. 現代預防醫學, 2010, 37(18): 3562-3563.
13. 楊小蕓, 王宇婷, 胡亞麗. " 潔悠神”用于預防男性經尿道手術后尿路感染的研究. 中華醫學創新, 2009, 6(18): 30-31.
14. 劉有蓮. 長效抑菌材料" 潔憂神”對重癥患者留置導尿管伴尿路感染的預防. 廣州醫藥, 2012, 43(6): 69-71.
15. 邵愛艷. 潔悠神預防卒中患者留置尿管致尿路感染的臨床分析. 中華美容醫學, 2012, 21(8): 250-251.
16. 張瓊. 長效抑菌材料潔悠神預防留置尿管逆行感染的臨床觀察. 當代護士(中旬刊), 2012, (6): 131-132.
17. 沈蒙文. 潔悠神在預防留置導尿管并發尿路感染中的應用效果. 當代護士(中旬刊), 2013, (1): 129-130.
18. 張彥, 鞠進, 侯海霞. 潔悠神在預防留置尿管逆行感染的臨床效果觀察. 醫學信息, 2015, (z3): 70.
19. 黃潤. 潔悠神在預防留置導尿管并發尿路感染中的臨床護理體會. 中國繼續醫學教育, 2016, 8(18): 249-250.
20. 李杰. 潔悠神預防留置尿管性尿路感染的有效性觀察. 護士進修雜志, 2016, 31(18): 1712-1713.
21. 南存金, 蘇紅俠, 何有華, 等. 外用抗菌劑長效抑菌材料聯合抗返流引流袋預防留置導尿伴隨性尿路感染. 中華全科醫學, 2016, 14(4): 569-570.

Chinese Journal of Evidence-Based Medicine

Efficacy of long-acting antibacterial material in the prevention of secondary urinary infection: a systematic review

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