ZHANG Lishuang , JIN Xinyao , ZHANG Junhua , YANG Fengwen , ZHANG Mingyan , ZHAO Hongjie , LI Yue , JI Zhaochen
  • Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P.R.China;
ZHANG Junhua, Email: zjhtcm@foxmail.com
Yangzhengxiaoji capsule; Digestive tract; Malignant tumor; Systematic review; Meta-analysis; Randomized controlled trial
10.7507/1672-2531.201710035
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Objectives  To systematically review the efficacy and safety of Yangzhengxiaoji capsule combined with chemotherapy for malignant digestive tract tumor. Methods  CNKI, WanFang Data, PubMed, EMbase, SinoMed and The Cochrane Library databases were searched online to collect randomized controlled trials (RCTs) of Yangzhengxiaoji capsule combined with chemotherapy for malignant tumor of digestive tract from inception to November 20th, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was then performed using ReMan 5.3 software. Resluts  A total of 15 RCTs were included. The results of meta-analysis showed that: compared with the chemotherapy alone, Yangzhengxiaoji capsule combined with chemotherapy could significantly improve the disease control rate (RR=1.26, 95%CI 1.07 to 1.49, P<0.000 01), the clinical efficacy of TCM syndrome (RR=1.71, 95%CI 1.50 to 1.96,P<0.000 01), and the quality of life scores of patients (RR=1.44, 95%CI 1.13 to 1.82,P=0.003). The combination therapy could also improve the immune function of patients and reduce the incidence of adverse reactions. Conclusions  Current evidence shows that chemotherapy combined with Yangzhengxiaoji capsule is superior to chemotherapy alone for disease control of malignant tumor of digestive tract, clinical efficacy of TCM syndrome, the quality of life, and improving immune function. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

Citation： ZHANG Lishuang, JIN Xinyao, ZHANG Junhua, YANG Fengwen, ZHANG Mingyan, ZHAO Hongjie, LI Yue, JI Zhaochen. Efficacy and safety of Yangzhengxiaoji capsule combined with chemotherapy for malignant digestive tract tumor: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2018, 18(1): 59-66. doi: 10.7507/1672-2531.201710035 Copy

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