The distribution and drug-resistance of <i>pseudomonas aeruginosa</i> in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016 _Chinese Journal of Evidence-Based Medicine

Authors：

CHENG Jun ¹ , GENG Jie ¹ , LI Feng ¹ , ZHANG Siming ¹ , GAO Xiaojing ¹ , ZHANG Yanbo ² ,  WANG Feiyan ¹

1. Clinical Laboratory Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, P.R.China;
2. ICU of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, P.R.China;

Corresponding?author：

WANG Feiyan, Email: wang_feiyanfw@sina.com

Keywords：

Cardiovascular disease; Pseudomonas aeruginosa; Drug-resistance; Antibiotics

DOI：

10.7507/1672-2531.201712006

Video：

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Objectives To retrospectively analyze the isolation rate and drug-resistance of pseudomonas aeruginosa in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016. Methods The specimens were collected and cultured. If the isolated bacteria were from the same part of the same patient, the first isolated strains were only counted. The isolated pathogens were identified and the drug-resistance were analyzed. Results A total of 1 404 pseudomonas aeruginosa were isolated. The majority of them were from postoperative recovery room of surgery department (62.1%) and ICU of internal medicine (22.3%). The specimen source were mainly from respiratory tract (75.7%), followed by blood (10.0%) and venous catheter (5.5%). The resistance rate of piperacillin and piperacillin/sulbactam to pseudomonas aeruginosa was 0.6% to 10.4%. The resistance rate of ceftazidime and cefepime was 0.3% to 11.7%. The resistance rate of imipenem and meropenem was 7.6% to 20.1%. The resistance rate of amikacin, gentamicin, and tobramycin was 0.3% to 3.2%. The resistance rate of ciprofloxacin and levofloxacin was 0.6% to 5.2%. Conclusions The isolates of pseudomonas aeruginosa are mainly from postoperative recovery room of surgery department and ICU of internal medicine . Imipenem and meropenem are not the best choices for pseudomonas aeruginosa infection. It has great value to combine piperacillin, piperacillin/sulbactam, ceftazidime and cefepime with aminoglycoside or quinolone antibiotics for the treatment of pseudomonas aeruginosa infection which will reduce drug resistance.

Citation： CHENG Jun, GENG Jie, LI Feng, ZHANG Siming, GAO Xiaojing, ZHANG Yanbo, WANG Feiyan. The distribution and drug-resistance of pseudomonas aeruginosa in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016 . Chinese Journal of Evidence-Based Medicine, 2018, 18(5): 450-453. doi: 10.7507/1672-2531.201712006 Copy

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1. Mocanu V, Buth KJ, Johnston LB, et al. Importance of continued quality improvement efforts in monitoring hospital-acquired infection rates: a cardiac surgery experience. Ann Thorac Surg, 2015, 99(6): 2061-2069.
2. Tago S, Hirai Y, Ainoda Y, et al. Gram-negative rod bacteremia after cardiovascular surgery: Clinical features and prognostic factors. J Microbiol Immunol Infect, 2017, 50(3): 333-338.
3. Sonmezer MC, Ertem G, Erdinc FS, et al. Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa. Can J Infect Dis Med Microbiol, 2016, 2016: 1321487.
4. 中華醫學會呼吸病學分會感染學組. 銅綠假單胞菌下呼吸道感染診治專家共識. 中華結核和呼吸雜志, 2014, 37(1): 9-15.
5. 汪復, 朱德妹, 胡付品, 等. 2012 年中國 CHINET 細菌耐藥性監測. 中國感染與化療雜志, 2013, 13(5): 321-330.
6. 胡付品, 朱德妹, 汪復, 等. 2013 年中國 CHINET 細菌耐藥性監測. 中國感染與化療雜志, 2014, 14(5): 365-374.
7. 胡付品, 朱德妹, 汪復, 等. 2014 年 CHINET 中國細菌耐藥性監測. 中國感染與化療雜志, 2015, 15(5): 401-410.
8. 生偉, 池一凡, 侯文明, 等. 心臟直視術后呼吸機相關性肺炎的臨床分析. 中華心血管病雜志, 2012, 40(10): 825-829.
9. 王昌明, 王晨, 何宗廣, 等. 銅綠假單胞菌致呼吸機相關性肺炎的臨床分析. 中華醫院感染學雜志, 2011, 21(2): 376-378.
10. 韓江, 章可謂, 葛丹楓. 醫院感染呼吸機相關肺炎及致病菌調查. 中國消毒學雜志, 2012, 29(1): 69-70.
11. 胡曉紅, 鄧敏, 史嘉瑋. 心血管外科 ICU66 例心臟移植患者醫院感染發病率. 中國感染控制雜志, 2016, 15(8): 552-555.

Chinese Journal of Evidence-Based Medicine

The distribution and drug-resistance of pseudomonas aeruginosa in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016

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