Prevalence and disease burden of knee osteoarthritis in China: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Bin ¹ ^# , XING Dan ² ^# , DONG Shengjie ³ , TIE Ruxiu ⁴ , ZHANG Zhiqiang ¹ ,  LIN Jianhao ² ,  WEI Xiaochun ¹

1. Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, P.R.China;
2. Arthritis Clinic & Research Center, Peking University People’s Hospital, Peking University, Beijing, 100044, P.R.China;
3. Department of Orthopaedics, Yantaishan Hospital, Yantai, 264025, P.R.China;
4. Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, P.R.China;

Corresponding?author：

LIN Jianhao, Email: linjianhao@pkuph.edu.cn; WEI Xiaochun, Email: weixiaochun11@126.com

Keywords：

Knee osteoarthritis; Prevalence; Quality of life; Disease burden; Cross-sectional study; Systematic review

DOI：

10.7507/1672-2531.201712031

Video：

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ObjectivesTo systematically review the prevalence and disease burden of knee osteoarthritis (KOA) in China.MethodsPubMed, EMbase, CNKI, WanFang Data and VIP databases were searched to collect cross-sectional studies about the prevalence and disease burden of KOA in China from January 1^st 1995 to August 31^st 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using R statistical software.ResultsA total of thirty-three studies were included. The results of meta-analysis showed the prevalance rate of KOA was 18% (95%CI 14% to 22%), and it was higher in women (19%, 95%CI 16% to 23%) than in men (11%, 95%CI 9% to 13%) (P<0.05). The prevalence rates of KOA in different regions were as follows: 11% (95%CI 8% to 14%) in north, 17% (95%CI 15% to 20%) in north-east, 21% (95%CI 13% to 32%) in east, 21% (95%CI 13% to 33%) in north-west, 22% (95%CI 6% to 57%) in south-west, and 18% (95%CI 13% to 23%) in south-central, respectively.ConclusionsThe prevalence of KOA in China is high, and the disease burden is heavy. Due to the quantity and quality of included studies, more high-quality studies are required to verify the above conclusions in future.

Citation： WANG Bin, XING Dan, DONG Shengjie, TIE Ruxiu, ZHANG Zhiqiang, LIN Jianhao, WEI Xiaochun. Prevalence and disease burden of knee osteoarthritis in China: a systematic review. Chinese Journal of Evidence-Based Medicine, 2018, 18(2): 134-142. doi: 10.7507/1672-2531.201712031 Copy

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1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ, 2003, 81(9): 646-656.
2. Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol, 2014, 10(7): 437-441.
3. 曾小峰, 朱松林, 譚愛春, 等. 我國類風濕關節炎疾病負擔和生存質量研究的系統評價. 中國循證醫學雜志, 2013, 13(3): 300-307.
4. 周波, 陳欣, 時景璞, 等. 率的 Meta 分析及軟件實現. 中國循證醫學雜志, 2014, 14(8): 1009-1016.
5. 張乃崢, 施全勝, 張雪哲, 等. 膝骨關節炎的流行病學調查. 中華內科雜志, 1995, 15(2): 84-87.
6. Zhang Y, Xu L, Nevitt MC, et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: the beijing osteoarthritis study. Arthritis Rheum, 2001, 44(9): 2065-2071.
7. 顧斌, 朱秀龍, 張美花, 等. 上海市郊區老年人膝關節骨關節炎現患調查. 中國全科醫學, 2011, 34(29): 3374-3376.
8. 顧明士, 楊軍, 金哲峰, 等. 社區中老年人膝骨關節炎發病趨勢的分析. 中醫藥臨床雜志, 2005, 3(5): 246-247.
9. Du H, Chen S, Bao C, et al. Prevalence and risk factors of knee osteoarthritis in Huang-Pu District, Shanghai, China. Rheumatol Int, 2005, 25(8): 585-590.
10. 臧長海, 曾慶馀, 李小峰, 等. 太原市膝骨關節炎的流行病學研究. 中華內科雜志, 2006, 45(7): 533-536.
11. 張建新, 王和鳴, 吳超英, 等. 泉州市中老年人退行性膝骨關節炎的流行病學調查. 中國中醫骨傷科雜志, 2007, 15(2): 4-5.
12. 李寧華, 張耀南, 張毅, 等. 國內六大行政區域六城市中老年人群膝關節骨性關節炎患病危險因素比較. 中國組織工程研究與臨床康復, 2007, 11(39): 7758-7760.
13. 王偉, 王坤正, 黨小謙, 等. 中老年膝骨關節炎發病的相關因素. 中國臨床康復, 2006, 10(44): 15-18.
14. 李立強. 上海市中心城區老年人膝關節骨關節炎流行病學調查. 黑龍江醫藥, 2007, 20(4): 347-348.
15. 榮杰生, 陶天遵, 陶樹清, 等. 高寒地區城市漢族人群膝骨關節炎情況調查. 中國骨質疏松雜志, 2007, 13(10): 723-726.
16. 顏貽站, 曾云記, 謝作完, 等. 農村 50 歲以上 5 016 人退行性膝關節病流行病學調查. 浙江中西醫結合雜志, 2007, 17(7): 422, 456.
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19. Kang X, Fransen M, Zhang Y, et al. The high prevalence of knee osteoarthritis in a rural Chinese population: the wuchuan osteoarthritis study. Arthritis Rheum, 2009, 61(5): 641-647.
20. 楊靜, 孫官軍, 裴福興, 等. 四川省部分地區漢族中老年人骨關節炎的流行病學研究. 中國骨與關節損傷雜志, 2010, 25(8): 693-696.
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23. Jiang L, Rong J, Zhang Q, et al. Prevalence and associated factors of knee osteoarthritis in a community-based population in Heilongjiang, Northeast China. Rheumatol Int, 2012, 32(5): 1189-1195.
24. 仇立春, 冒四平. 兵團四師昭蘇墾區中老年膝關節骨性關節炎現狀普查及影響因素分析. 兵團醫學, 2013, 38(4): 7-8.
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26. 黃洪容. 我國社區中老年人膝骨關節炎的發病趨勢分析. 當代醫學, 2012, 18(12): 59-60.
27. 孫紅, 田文, 廖偉華, 等. 社區居民膝關節骨性關節炎流行病學調查分析. 海南醫學, 2013, 7(3): 1064-1066.
28. 唐江龍. 迪慶高原民族地區農村中老年人膝骨性關節炎的流行病學調查. 中國當代醫藥, 2013, 20(17): 159-160, 163.
29. 馬東華, 劉敏, 黃庭山, 等. 湖南省桑植縣膝關節骨性關節炎發病原因的流行病學調查. 醫學臨床研究, 2014, 31(4): 722-724.
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31. 王新軍, 劉俊昌, 木合塔爾·阿尤甫, 等. 新疆北疆牧區不同民族居民膝骨性關節炎患病現狀調查. 中國公共衛生, 2015, 31(7): 853-855.
32. Tang X, Wang S, Zhan S, et al. The prevalence of symptomatic knee osteoarthritis in China: results from the China health and retirement longitudinal study. Arthritis Rheum, 2016, 68(3): 648-653.
33. Liu Y, Zhang H, Liang N, et al. Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey. BMC Public Health, 2015, 16(1): 2782-2786.
34. Zhang JF, Song LH, Wei JN, et al. Prevalence of and risk factors for the occurrence of symptomatic osteoarthritis in rural regions of Shanxi Province, China. Int J Rheum Dis, 2016, 19(8): 781-789.
35. 安丙辰. 膝關節骨關節炎運動療法相關研究. 上海: 上海交通大學, 2008.
36. Pang J, Cao YL, Zheng YX, et al. Influence of pain severity on health-related quality of life in Chinese knee osteoarthritis patients. Int J Clin Exp Med, 2015, 8(3): 4472-4479.
37. 史方. 上海市關節炎疾病負擔評價. 上海: 復旦大學, 2004.
38. Woo J, Lau E, Lee P, et al. Impact of osteoarthritis on quality of life in a Hong Kong Chinese population. J Rheumatol, 2004, 31(12): 2433-2438.
39. 李寧秀, 劉朝杰, 李俊, 等. 四川省城鄉居民 SF-36 評價參考值. 華西醫科大學學報, 2001, 32(1): 43-47.
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Chinese Journal of Evidence-Based Medicine

Prevalence and disease burden of knee osteoarthritis in China: a systematic review

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