Genetic loci in the NF-<i>κ</i>B pathway and lung cancer susceptibility: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

GUAN Haijian ¹ , SUN Gaofeng ² ,  XIE Huifang ¹

1. School of Public Health, Xinjiang Medical University, Urumqi, 830011, P.R.China;
2. Disease Control and Prevention Center of Urumqi, Urumqi, 830000, P.R.China;

Corresponding?author：

XIE Huifang, Email: xhfworld@sina.com

Keywords：

NFKB1 gene; NFKBIA gene; Lung cancer; Meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.201904095

Video：

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Objectives To systematically review the correlation between NFKB1 gene, NFKBIA gene and lung cancer susceptibility.Methods Web of Science, PubMed, VIP, CNKI and WanFang Data databases were electronically searched to collect case-control studies on the correlation between NFKB1 gene rs4648127, rs28362491 polymorphisms and NFKBIA gene rs696 polymorphism and lung cancer susceptibility from inception to November, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies; then, meta-analysis was performed by using Stata 12.0 software.Results A total of 7 case-control studies were included. The results of meta-analysis showed that: no correlation was found between rs4648127 and lung cancer susceptibility (C vs. T: OR=1.065, 95%CI 0.323 to 3.512, P=0.918). A positive correlation was found in hospital population between rs28362491 (D vs. I: OR=1.290, 95%CI 1.117 to 1.489, P=0.001; DD vs. II: OR=1.707, 95%CI 1.273 to 2.289, P<0.001; DD vs. ID+II: OR=1.409, 95%CI 1.100 to 1.806, P=0.008) and lung cancer. Rs696 polymorphism (A vs. G: OR=1.215, 95%CI 1.105 to 1.336, P<0.001; AA vs. GG: OR=1.438, 95%CI 1.194 to 1.731, P<0.001; GG vs. AG+AA: OR=1.566, 95%CI 1.341 to 1.829, P<0.001) was correlated with lung cancer susceptibility.Conclusions Current evidence shows that NFKB1 gene rs4648127 may not be associated with lung cancer. The rs28362491 pdymorphism of NFKB1 gene in hospital population and rs696 pdymorphism of NFKBIA gene may be positively correlated with lung cancer susceptibility. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

Citation： GUAN Haijian, SUN Gaofeng, XIE Huifang. Genetic loci in the NF-κB pathway and lung cancer susceptibility: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2019, 19(12): 1430-1435. doi: 10.7507/1672-2531.201904095 Copy

1.	鄭榮壽, 顧秀瑛, 李雪婷, 等. 2000-2014 年中國腫瘤登記地區癌癥發病趨勢及年齡變化分析. 中華預防醫學雜志, 2018, 52(6): 593-600.
2.	中國國家癌癥中心. 2018 年全國癌癥報告. Available at: http://www.sohu.com/a/226139022_100120288.
3.	陳秋生, 田文嫻, 董潤, 等. NF-κB, VEGF 及 ICAM-1 在非小細胞肺癌中的表達及意義. 臨床肺科雜志, 2018, 23(4): 587-590.
4.	Saxon JA, Yu H, Polosukhin VV, et al. p52 expression enhances lung cancer progression. Sci Rep, 2018, 8(1): 6078.
5.	翟建霞, 董潤. TLR4 與 NF-κB 在非小細胞肺癌組織中的表達和臨床意義分析. 甘肅醫藥, 2018, 37(5): 405-407.
6.	楊雷, 鄧進, 鄧志紅. NF-κB 及其基因多態性與炎癥及腫瘤關系的研究進展. 貴州醫藥, 2016, 40(10): 1098-1100.
7.	Xia L, Tan S, Zhou Y, et al. Role of the NFκB-signaling pathway in cancer. Onco Targets Ther, 2018, 11: 2063-2073.
8.	Yamamoto Y, Kiyohara C, Suetsugu-Ogata S, et al. Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in infla mmation and the risk of lung cancer: a case-control study in Japan. Oncol Lett, 2017, 13(5): 3873.
9.	Wang Y, Chen L, Pan L, et al. The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population. Int J Clin Exp Med, 2015, 8(5): 8153-8157.
10.	Zhang JW, Chen QS, Zhai JX, et al. Polymorphisms in NF-κB pathway genes & their association with risk of lung cancer in the Chinese population. Pak J Med Sci, 2015, 31(6): 1411-1416.
11.	黃冬生. NFκB1 和 IκBα 基因遺傳變異與慢性阻塞性肺疾病和肺癌易感性研究. 廣州: 廣州醫學院, 2012.
12.	Zhang M, Huang J, Tan X, et al. Common polymorphisms in the NFKBIA gene and cancer susceptibility: a meta-analysis. Med Sci Monit, 2015, 21: 3186-3196.
13.	Stang A. Critical evaluation of the Newcastle-Ottawa Scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
14.	湯金星. CHRNB4 基因和 NFKB1 基因位點的單核苷酸多態性與中國人群肺癌易感性關系的研究. 蘇州: 蘇州大學, 2015.
15.	Shiels MS, Engels EA, Jianxin S, et al. Genetic variation in innate immunity and inflame mation pathways associated with lung cancer risk. Cancer, 2013, 119(9): 1761.
16.	Oltulu YM, Coskunpinar E, Ozkan G, et al. Investigation of NF-κB1 and NF-κBIA gene polymorphism in non-small cell lung cancer. Biomed Res Int, 2014, 2014: 530381.
17.	曲世寧. NF-κB1 基因啟動子-94del/ins ATTG 與肺癌風險相關性研究. 北京: 中國協和醫科大學, 2004.
18.	趙旭, 王曉寒, 廣東, 等. NF-κB 對肺癌細胞生長、細胞周期及腫瘤壞死因子-α 分泌的影響. 中國老年學雜志, 2018, 38(17): 4223-4226.
19.	Fu W, Zhuo ZJ, Chen YC, et al. NFKB1-94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies. Oncotarget, 2017, 8(6): 9806-9822.
20.	姜一弘, 張丹, 張天擇, 等. 核因子 κB(NF-κB)信號通路在炎癥與腫瘤中作用的研究進展. 細胞與分子免疫學雜志, 2018, 34(12): 1130-1135.
21.	楊曉曉, 黃虹婷, 劉滿華, 等. NF-κB 參與調控細胞凋亡. 上海交通大學學報(醫學版), 2017, 37(10): 1446-1452.
22.	Szymura SJ, Zaemes JP, Allison DF, et al. NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. Cell Commun Signal, 2019, 17(1): 24.
23.	Rahnamoun H, Lu H, Duttke SH, et al. Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. Nat Commun, 2017, 8(1): 754.
24.	He F, Xiao RD, Lin T, et al. Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China. BMC Cancer, 2018, 18(1): 445.

1. 鄭榮壽, 顧秀瑛, 李雪婷, 等. 2000-2014 年中國腫瘤登記地區癌癥發病趨勢及年齡變化分析. 中華預防醫學雜志, 2018, 52(6): 593-600.
2. 中國國家癌癥中心. 2018 年全國癌癥報告. Available at: http://www.sohu.com/a/226139022_100120288.
3. 陳秋生, 田文嫻, 董潤, 等. NF-κB, VEGF 及 ICAM-1 在非小細胞肺癌中的表達及意義. 臨床肺科雜志, 2018, 23(4): 587-590.
4. Saxon JA, Yu H, Polosukhin VV, et al. p52 expression enhances lung cancer progression. Sci Rep, 2018, 8(1): 6078.
5. 翟建霞, 董潤. TLR4 與 NF-κB 在非小細胞肺癌組織中的表達和臨床意義分析. 甘肅醫藥, 2018, 37(5): 405-407.
6. 楊雷, 鄧進, 鄧志紅. NF-κB 及其基因多態性與炎癥及腫瘤關系的研究進展. 貴州醫藥, 2016, 40(10): 1098-1100.
7. Xia L, Tan S, Zhou Y, et al. Role of the NFκB-signaling pathway in cancer. Onco Targets Ther, 2018, 11: 2063-2073.
8. Yamamoto Y, Kiyohara C, Suetsugu-Ogata S, et al. Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in infla mmation and the risk of lung cancer: a case-control study in Japan. Oncol Lett, 2017, 13(5): 3873.
9. Wang Y, Chen L, Pan L, et al. The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population. Int J Clin Exp Med, 2015, 8(5): 8153-8157.
10. Zhang JW, Chen QS, Zhai JX, et al. Polymorphisms in NF-κB pathway genes & their association with risk of lung cancer in the Chinese population. Pak J Med Sci, 2015, 31(6): 1411-1416.
11. 黃冬生. NFκB1 和 IκBα 基因遺傳變異與慢性阻塞性肺疾病和肺癌易感性研究. 廣州: 廣州醫學院, 2012.
12. Zhang M, Huang J, Tan X, et al. Common polymorphisms in the NFKBIA gene and cancer susceptibility: a meta-analysis. Med Sci Monit, 2015, 21: 3186-3196.
13. Stang A. Critical evaluation of the Newcastle-Ottawa Scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
14. 湯金星. CHRNB4 基因和 NFKB1 基因位點的單核苷酸多態性與中國人群肺癌易感性關系的研究. 蘇州: 蘇州大學, 2015.
15. Shiels MS, Engels EA, Jianxin S, et al. Genetic variation in innate immunity and inflame mation pathways associated with lung cancer risk. Cancer, 2013, 119(9): 1761.
16. Oltulu YM, Coskunpinar E, Ozkan G, et al. Investigation of NF-κB1 and NF-κBIA gene polymorphism in non-small cell lung cancer. Biomed Res Int, 2014, 2014: 530381.
17. 曲世寧. NF-κB1 基因啟動子-94del/ins ATTG 與肺癌風險相關性研究. 北京: 中國協和醫科大學, 2004.
18. 趙旭, 王曉寒, 廣東, 等. NF-κB 對肺癌細胞生長、細胞周期及腫瘤壞死因子-α 分泌的影響. 中國老年學雜志, 2018, 38(17): 4223-4226.
19. Fu W, Zhuo ZJ, Chen YC, et al. NFKB1-94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies. Oncotarget, 2017, 8(6): 9806-9822.
20. 姜一弘, 張丹, 張天擇, 等. 核因子 κB(NF-κB)信號通路在炎癥與腫瘤中作用的研究進展. 細胞與分子免疫學雜志, 2018, 34(12): 1130-1135.
21. 楊曉曉, 黃虹婷, 劉滿華, 等. NF-κB 參與調控細胞凋亡. 上海交通大學學報(醫學版), 2017, 37(10): 1446-1452.
22. Szymura SJ, Zaemes JP, Allison DF, et al. NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. Cell Commun Signal, 2019, 17(1): 24.
23. Rahnamoun H, Lu H, Duttke SH, et al. Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. Nat Commun, 2017, 8(1): 754.
24. He F, Xiao RD, Lin T, et al. Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China. BMC Cancer, 2018, 18(1): 445.

Chinese Journal of Evidence-Based Medicine

Genetic loci in the NF-κB pathway and lung cancer susceptibility: a meta-analysis

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