Association between pregnancy induced hypertension and preterm birth and population attributable risk in pregnant females in mainland China: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Yanhong ¹ , YOU Dingyun ¹ , WANG Huaping ² , HUANG Ying ¹ ,  LIAO Rui ²

1. Department of Public Health, Kunming Medical University, Kunming, 650500, P.R.China;
2. Department of Library, Kunming Medical University, Kunming, 650500, P.R.China;

Corresponding?author：

LIAO Rui, Email: reneliao@foxmail.com

Keywords：

Mainland China; Premature delivery; Pregnancy-induced hypertension; Population attributable risk; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.201905079

Video：

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Objectives To systematically review the association between pregnancy-induced hypertension (PIH) and preterm birth in mainland China.Methods PubMed, The Cochrane Library, ScienceDirect, Web of Science, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect studies on the association between PIH and preterm birth in mainland China from January, 2007 to March, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies; then, meta-analysis was performed by using Stata 12.0 software.Results A total of 48 studies were included, involving 43 276 cases of premature birth, 527 995 cases of full-term control group, in which there were 3 446 cases of PIH in premature delivery, with a prevalence rate of 7.96%. There were 14 099 cases of PIH in the full-term control group, with a prevalence rate of 2.67%. The results of meta-analysis showed that PIH was associated with preterm birth (OR=3.27, 95%CI 2.64 to 4.05, P<0.001). The overall population attributable risk was 13.0%. Subgroup analysis was conducted for different study types, and the results were unaltered.Conclusions The current evidence shows that PIH is associated with preterm birth. During pregnancy, the management and intervention of pregnant females with gestational hypertension should be strengthened, and active treatment should be supervised to prevent the occurrence of premature birth.

Citation： YANG Yanhong, YOU Dingyun, WANG Huaping, HUANG Ying, LIAO Rui. Association between pregnancy induced hypertension and preterm birth and population attributable risk in pregnant females in mainland China: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2020, 20(1): 32-39. doi: 10.7507/1672-2531.201905079 Copy

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1. Gemmell L, Martin L, Murphy KE, et al. Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation. J Perinatol, 2016, 36(12): 1067-1072.
2. Seyom E, Abera M, Tesfaye M, et al. Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl Referral Hospital, Ethiopia. J Ovarian Res, 2015, 8(1): 10.
3. Lu CQ, Jie L, Lin Y, et al. Authors of manusript pregnancy induced hypertension and outcomes in early and moderate preterm infant. Pregnan Hypert, 2018: S2210778917303665.
4. Bramham K, Parnell B, Nelson-Piercy C, et al. Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ, 2014, 348(15): g2301.
5. Razak A, Florendo-Chin A, Banfield L, et al. Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis. J Perinatol, 2018, 38(1): 46-53.
6. 中華醫學會婦產科學分會產科學組. 早產的臨床診斷和治療指南(2014). 中國實用鄉村醫生雜志, 2015, (12): 9-11.
7. 吳琳琳, 周欣, 牛建民. 《妊娠期高血壓疾病: 國際妊娠期高血壓研究學會分類、診斷和管理指南(2018)》解讀. 中國實用婦科與產科雜志, 2018, 34(7): 758-763.
8. Lo KL, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Meth, 2014, 14(1): 45.
9. 王麗紅, 安篆仙, 侯麗蓉, 等. 162 例早產原因及對母嬰影響的分析. 中國婦幼保健, 2007, 22(6): 752-753.
10. 陳麗娟, 強萍. 早產相關因素 87 例分析. 臨床和實驗醫學雜志, 2007, (12): 72-73.
11. 朱軼. 早產及其預后相關因素分析. 重慶: 重慶醫科大學, 2008.
12. 陶真蘭. 早產危險因素臨床觀察與防治. 現代預防醫學, 2008, (9): 1632, 1635.
13. 黃蕾, 趙玉環. 徐州地區 334 例早產兒臨床分析. 中國優生與遺傳雜志, 2008, 16(5): 89-90.
14. 陳寶蓮. 早產相關臨床因素 608 例分析. 重慶醫學, 2008, 37(20): 2340-2342.
15. 王晶清. 早產 236 例原因分析. 中國醫藥導報, 2009, 6(10): 50-51.
16. 李文紅. 220 例產科病例的早產危險因素分析. 長春: 吉林大學, 2009.
17. 張艷波. 早產病因的分析與防治. 中國婦幼保健, 2010, 25(2): 284-285.
18. 彭來勤. 引起早產相關因素的病例-對照研究. 中國現代醫生, 2010, 48(17): 132, 141.
19. 徐燕. 早產 268 例臨床分析. 蘇州: 蘇州大學, 2011.
20. 丁琥. 母血 CRP 水平與早產及早產兒近期不良預后的相關性分析. 南京: 東南大學, 2011.
21. 鄒海燕. 258 例早產的臨床因素分析. 現代預防醫學, 2012, 39(13): 3250-3251, 3256.
22. 劉曉紅, 張運平, 高素紅, 等. 早產影響因素的多中心病例-對照研究. 中國婦產科臨床雜志, 2012, 13(5): 345-348.
23. 馮軼, 藺莉. 自發性早產高危因素的分析. 首都醫科大學學報, 2012, 33(1): 45-49.
24. Sun L, Tao F, Hao J, et al. First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China. J Matern Fetal Neonatal Med, 2012, 25(8): 1297-1301.
25. Zhang YP, Liu XH, Gao SH, et al. Risk factors for preterm birth in five maternal and child health hospitals in Beijing. PLoS One, 2012, 7(12): e52780.
26. 顧春健, 林梅芳. 393 例晚期早產兒早產危險因素及并發癥分析. 浙江預防醫學, 2013, 25(9): 74-75, 78.
27. 張建偉. 200 例早產危險因素分析. 中國生育健康雜志, 2014, 25(6): 553-555.
28. 原孟. 241 例早產相關因素及早產兒結局病例分析. 大連: 大連醫科大學, 2014.
29. 蔣秀. 早產相關因素的臨床研究. 鄭州: 鄭州大學, 2014.
30. 翟曉蔚, 吳田英, 梁思銘, 等. 早產低出生體質量兒影響因素探討. 蚌埠醫學院學報, 2014, 39(11): 1544-1546.
31. 林國敬, 黃水清, 王俊平. 408 例晚期早產兒臨床分析. 中國婦幼保健, 2014, 29(13): 2033-2036.
32. 張瑩, 赫英東, 陳倩. 晚期早產的危險因素及圍產期并發癥分析. 中華圍產醫學雜志, 2014, (6): 379-383.
33. Chen YP, Lu YP, Li J, et al. Fetal and maternal angiotensin (1-7) are associated with preterm birth. J Hypertens, 2014, 32(9): 1833-1841.
34. 劉秋明. 北京市大興區早產兒危險因素分析. 實用預防醫學, 2015, 22(3): 330-332.
35. 王彩芳, 劉妙珍, 黃麗君. 應用 logistic 回歸模型分析孕婦早產的高危因素. 全科醫學臨床與教育, 2015, 13(5): 522-525.
36. 藺茹, 王衛凱, 白巖, 等. 母親既往生育史與早產兒發生的相關性分析. 中國婦幼保健, 2015, 30(29): 5023-5026.
37. 陳艷, 孫小英. 自發性早產高危因素及其對早產兒窒息影響的流行病學研究. 中國婦幼保健, 2015, 30(18): 2966-2968.
38. 翁葉蕊, 符愛貞. 162 例早產危險因素分析. 中國婦幼保健, 2015, 30(30): 5153-5154.
39. Lu L, Qu Y, Tang J, et al. Risk factors associated with late preterm births in the underdeveloped region of China: a cohort study and systematic review. Taiwan J Obstet Gynecol, 2015, 54(6): 647-653.
40. Yang Y, He Y, Li Q, et al. Preconception blood pressure and risk of preterm birth: a large historical cohort study in a Chinese rural population. Fertil Steril, 2015, 104(1): 124-130.
41. 王文第, 陳亞, 張春花, 等. 母親不良孕產史對早產發生的影響. 中國優生與遺傳雜志, 2016, 24(9): 56-59, 68.
42. 張丹丹, 談迪心, 王斌, 等. 孕期增重與早產關聯的流行病學分析. 中華流行病學雜志, 2016, 37(7): 1012-1016.
43. 王立芳, 周虹, 張妍, 等. 孕前體質指數與早產的關系. 北京大學學報(醫學版), 2016, 48(3): 414-417.
44. 張小松, 趙更力, 楊慧霞, 等. 15 家城市醫療機構早產發生情況及影響因素分析. 中華圍產醫學雜志, 2016, 19(6): 456-461.
45. 王海霞. 應用多元 COX 回歸模型分析早產的危險因素. 中國婦幼保健, 2016, 31(2): 268-270.
46. 胡彥, 李嵐, 黃文珍, 等. 我院近 10 年早產危險因素改變的回顧性研究. 海南醫學, 2016, 27(20): 3356-3358.
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Association between pregnancy induced hypertension and preterm birth and population attributable risk in pregnant females in mainland China: a meta-analysis

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