Registration of acupuncture clinical trials on WHO ICTRP from 2014 to 2018_Chinese Journal of Evidence-Based Medicine

Authors：

YIN Zihan , SUN Mingsheng , XU Guixing , XIE Yujie , YAN Mingxi , LI Zhiwei , ZHAO Ling ,  LIANG Fanrong

School of Acupuncture-moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, P.R.China;

Corresponding?author：

LIANG Fanrong, Email: acuresearch@126.com

Keywords：

Acupuncture; Clinical trial registration; Data mining; WHO international clinical trial registration platform

DOI：

10.7507/1672-2531.201906023

Video：

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Objectives To analyze the development of acupuncture registered trials based on WHO international clinical trial registration platform (ICTRP) in the past 5 years.Methods WHO ICTRP database was electronically searched to collect acupuncture-related clinical trials registered from January 1^st, 2014 to December 31^st, 2018. Two reviewers independently screened items, extracted data, and descriptive analysis was performed for the included trials.Results The results showed that there were 1 556 registered clinical trials on acupuncture, and the most registered year was 2017. China was in the main country in applying for acupuncture-related clinical trials, however, the most registered unit was Kyung Hee University in Korea. The trials were mainly interventional research, mostly used randomized, blinded methods, and design modes were mainly based on parallel trials. In clinical trial phase, the majority were in the clinical trial period of treatment of new technologies. The field of clinical research was expected to be on pain in the future.Conclusions Although acupuncture research is currently in a good stage of development, it should still value on the quality and innovative training of relevant trials, strengthen Chinese ties with other countries, focus on regional, domestic and international cooperation, expand research types, and enhance acupuncture applicability.

Citation： YIN Zihan, SUN Mingsheng, XU Guixing, XIE Yujie, YAN Mingxi, LI Zhiwei, ZHAO Ling, LIANG Fanrong. Registration of acupuncture clinical trials on WHO ICTRP from 2014 to 2018. Chinese Journal of Evidence-Based Medicine, 2019, 19(12): 1395-1399. doi: 10.7507/1672-2531.201906023 Copy

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11.	習近平主席向世界衛生組織贈送" 針灸銅人”. 習近平主席向世界衛生組織贈送" 針灸銅人”. 針刺研究, 2017, 42(1): 55.
12.	孫忠人, 田洪昭, 尹洪娜, 等. 基于" 醫工結合”探討針灸發展演變. 中華中醫藥雜志, 2019, 34(3): 1117-1119.
13.	Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain, 2006, 10(4): 287-333.
14.	O'Regan D, Filshie J. Acupuncture and cancer. Auton Neurosci, 2010, 157(1-2): 96-100.
15.	Khalil R, Khalil R, Shao X. Battlefield acupuncture for pain management after hip surgery. J Ame Med Direct Associa, 2018, 19(3): B5-B6.
16.	Ezzo J, Vickers A, Richardson MA, et al. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol, 2005, 23(28): 7188-7198.
17.	Sarzi-Puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum, 2005, 35(1 Suppl 1): 1-10.
18.	石云舟, 周思遠, 鄭倩華, 等. 國際高質量針灸隨機對照試驗特征分析. 世界中醫藥, 2018, 13(7): 1580-1583.
19.	Ma Y, Dong M, Zhou K, et al. Publication trends in acupuncture research: a 20-year bibliometric analysis based on PubMed. PLoS One, 2016, 11(12): e0168123.
20.	李政杰, 劉邁蘭, 王君南, 等. 針灸臨床研究的國際注冊方法及現狀. 針刺研究, 2012, 37(1): 86-87.
21.	胥瑩, 陳波, 郭義. 針灸臨床研究注冊現狀分析與探討. 中國針灸, 2015, 35(6): 605-607.
22.	黃明安. 中醫藥現狀與發展趨勢研究. 時珍國醫國藥, 2016, 27(8): 1956-1960.
23.	Zeng F, Qin W, Liang F, et al. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology, 2011, 141(2): 499-506.
24.	Zhao L, Chen J, Li Y, et al. The long-term effect of acupuncture for migraine prophylaxis: a randomized clinical trial. JAMA Intern Med, 2017, 177(4): 508-515.
25.	Liu Z, Liu Y, Xu H, et al. Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial. JAMA, 2017, 60(24): 2493.

1. 劉佳, 何麗云, 趙玉鳳, 等. 基于真實世界國際針灸病例注冊登記研究的關鍵技術. 世界科學技術-中醫藥現代化, 2017, 19(12): 1920-1923.
2. 魏輝, 鞏昌鎮, 田海河, 等. 針灸發展方向訪談(一). 中醫藥導報, 2018, 24(9): 1-7.
3. 中國腫瘤. 凡臨床試驗都應在中國臨床試驗注冊中心注冊. 中國腫瘤, 2018, 27(10): 812.
4. 楊德強. 國際針灸臨床試驗注冊研究. 北京: 北京中醫藥大學, 2008.
5. 鄔蘭, 田國祥, 王行環, 等. 臨床試驗的注冊及注冊平臺比較分析. 中國循證心血管醫學雜志, 2017, 9(2): 129-134.
6. 吳泰相, 米娜瓦爾·阿不都, 郝園, 等. 中國臨床試驗注冊10年: 現狀與問題. 中國循證醫學雜志, 2018, 18(6): 522-525.
7. 吳泰相, 卞兆祥, 李幼平, 等. 臨床試驗原始數據透明化與共享: 關于醫學研究倫理的哲學命題及其對臨床試驗的意義. 中國循證醫學雜志, 2018, 18(6): 538-542.
8. 吳泰相, 米娜瓦爾·阿不都, 卞兆祥, 等. 基于臨床試驗注冊信息調查影響我國臨床試驗質量的因素. 中國循證醫學雜志, 2018, 18(6): 526-531.
9. Goldacre B. The WHO joint statement from funders on trials transparency. BMJ, 2017, 357: j2816.
10. 陳君超. 從試驗注冊到結果公開進一步提高臨床試驗的透明化. 中國新藥雜志, 2018, 27(20): 2357-2360.
11. 習近平主席向世界衛生組織贈送" 針灸銅人”. 習近平主席向世界衛生組織贈送" 針灸銅人”. 針刺研究, 2017, 42(1): 55.
12. 孫忠人, 田洪昭, 尹洪娜, 等. 基于" 醫工結合”探討針灸發展演變. 中華中醫藥雜志, 2019, 34(3): 1117-1119.
13. Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain, 2006, 10(4): 287-333.
14. O'Regan D, Filshie J. Acupuncture and cancer. Auton Neurosci, 2010, 157(1-2): 96-100.
15. Khalil R, Khalil R, Shao X. Battlefield acupuncture for pain management after hip surgery. J Ame Med Direct Associa, 2018, 19(3): B5-B6.
16. Ezzo J, Vickers A, Richardson MA, et al. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol, 2005, 23(28): 7188-7198.
17. Sarzi-Puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum, 2005, 35(1 Suppl 1): 1-10.
18. 石云舟, 周思遠, 鄭倩華, 等. 國際高質量針灸隨機對照試驗特征分析. 世界中醫藥, 2018, 13(7): 1580-1583.
19. Ma Y, Dong M, Zhou K, et al. Publication trends in acupuncture research: a 20-year bibliometric analysis based on PubMed. PLoS One, 2016, 11(12): e0168123.
20. 李政杰, 劉邁蘭, 王君南, 等. 針灸臨床研究的國際注冊方法及現狀. 針刺研究, 2012, 37(1): 86-87.
21. 胥瑩, 陳波, 郭義. 針灸臨床研究注冊現狀分析與探討. 中國針灸, 2015, 35(6): 605-607.
22. 黃明安. 中醫藥現狀與發展趨勢研究. 時珍國醫國藥, 2016, 27(8): 1956-1960.
23. Zeng F, Qin W, Liang F, et al. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology, 2011, 141(2): 499-506.
24. Zhao L, Chen J, Li Y, et al. The long-term effect of acupuncture for migraine prophylaxis: a randomized clinical trial. JAMA Intern Med, 2017, 177(4): 508-515.
25. Liu Z, Liu Y, Xu H, et al. Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial. JAMA, 2017, 60(24): 2493.

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