Analysis of the status of evidence for disease burden research_Chinese Journal of Evidence-Based Medicine

Authors：

ZHOU Wenjing ¹ , YANG Xiao ¹ , LI Yanfei ^1,2 , WANG Weini ¹ , GUO Kangle ^1,2 ,  LI Xiuxia ^1,2 , YANG Kehu ^1,2,3

1. Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, P.R.China;
2. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, P.R.China;
3. Evidence-Based Medicine Center, School of Basic Medicine, Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding?author：

LI Xiuxia, Email: lixiuxia@lzu.edu.cn

Keywords：

Disease burden; Medical economics; Status analysis; Bibliometric analysis

DOI：

10.7507/1672-2531.201906027

Video：

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Objectives To conduct a bibliometric analysis to research the status of disease burden domestically and overseas so as to understand the status of diseases burden, and to provide scientific and reasonable reference for health disease prevention, control strategies formulation and future research.Methods PubMed, Web of Science, EMbase, The Cochrane Library, WanFang Data, CBM and CNKI databases were electronically searched to collect literature on disease burden from inception to October, 2018. Two reviewers independently screened literature and extracted data. EndNote X7 software was used for literature management, Excel 2016 software and VOS viewer software were also used to analyze data. Literature was classified by the aspects of literature publication characteristics, diseases, background areas, influencing factors, evaluation indicators and poverty caused by illness.Results A total of 325 studies were included in the bibliometric analysis. 41 articles (12.6%) were published in journals indexed by SCIE; original research evidence accounted for 97.0% (315 articles); 272 articles were from China (83.7%). The main diseases involved were malignant tumors (58 articles, 17.8%), diabetes (29 articles, 8.9%) and hypertension (24 articles, 7.4%). Factors affecting the disease burden primarily included hospitalization days (9 articles, 2.8%), complications (5 articles, 1.5%), delays in treatment (5 articles, 1.5%), and economic income (4 articles, 1.2%). Sixity-one articles (18.8%) reported poverty due to illness, and related diseases were chronic obstructive pulmonary disease (12 articles, 3.7%), hypertension (10 articles, 3.1%), diabetes (10 articles, 3.1%), malignant tumors (9 articles, 2.8%) and hepatitis B (6 articles, 1.8%).Conclusions At present, the disease burden research are focusing more on the burden of chronic non-communicable diseases such as malignant tumors, hypertension, diabetes, cardiovascular and cerebrovascular diseases in developing countries and regions. Medical costs vary from different diseases and treatment, different demographic characteristics of patients, and the coverage medical security of different population are the primary reasons for the " expensive in medical treatment” of current residents and the heavy burden of disease. DALY and total direct medical expenses are the main evaluation indexes of epidemiological burden and economic burden of disease, respectively. Future researches should focus on strengthening the scientific nature of study design to improve the quality of research, as well as paying more attention to diseases and aspects that are rarely involved, such as major diseases caused by poverty due to illness, comprehensive analysis of multiple diseases and aspects of health investment measurement, and comprehensively use the evaluation indicators of disease burden to strengthen the research on the comparability index of disease economic burden.

Citation： ZHOU Wenjing, YANG Xiao, LI Yanfei, WANG Weini, GUO Kangle, LI Xiuxia, YANG Kehu. Analysis of the status of evidence for disease burden research. Chinese Journal of Evidence-Based Medicine, 2019, 19(11): 1317-1324. doi: 10.7507/1672-2531.201906027 Copy

1.	胡善聯. 疾病負擔的研究(上). 衛生經濟研究, 2005, (5): 22-27.
2.	周尚成, 萬崇華, 蔡樂. 疾病負擔研究現狀及問題. 國外醫學(衛生經濟分冊), 2004, 21(4): 145-149.
3.	徐張燕, 張敏, 崔亞萍. 疾病負擔研究的發展與應用. 中國腫瘤, 2013, 22(8): 638-643.
4.	中華人民共和國國家衛生健康委員會. 國家衛生計生委、國務院扶貧辦啟動建檔立卡農村貧困人口" 因病致貧、因病返貧”調查工作. Available at: http://www.nhfpc.gov.cn/caiwusi/s7786/201604/fc6d02a21134e5ebf71bb7f19cb1216.shtml.
5.	Sackett DL, Straus SE, Richardson WS, et al. Evidence based medicine: how to practice and teach EBM (2nd edition). New York: Churchill Livingstone, 2000: 1-2.
6.	Guyatt G, Rennie D, Meade M, et al. Users' guides to the medical literature: a manual for evidence-based clinical practice (2nd edition). New York: McGraw-Hill Professional, 2008.
7.	張潔, 錢序, 陳英耀. 疾病負擔研究進展. 中國衛生經濟, 2005, 24(5): 69-71.
8.	World Health Organization.ICD-11 for mortality and morbidity statistics. Available at: https://icd.who.int/browse11/l-m/en.
9.	盧國萍. 慢性病成為全球健康的主要威脅. 第45屆亞太地區公共衛生聯盟大會, 2013: 10-27.
10.	劉竟芳, 陳哲, 楊非柯, 等. 我國老年人慢性病現狀及應對策略. 中外醫療, 2014, (23): 194-195, 198.
11.	國家食品藥品監督管理總局. 中共中央國務院關于深化醫藥衛生體制改革的意見. Available at: http://www.sda.gov.cn/WS01/CL0611/41193.html.
12.	王亭艷, 曹鳳, 胡剛, 等. 新疆肺癌患者疾病經濟負擔及其影響因素分析. 衛生軟科學, 2016, 30(09): 17-20.
13.	孟慶躍, 馬彥強, 劉興柱, 等. 山東省麻風病人疾病經濟負擔分析. 中國衛生事業管理, 1997, (11): 606-607.
14.	羅惠文, 豐燕, 季明, 等. 江蘇某農村地區結核病患者疾病經濟負擔及其影響因素分析. 中華疾病控制雜志, 2012, 16(10): 877-880.
15.	羅惠文, 戴垚垚, 王建明. 肺結核病患者疾病經濟負擔及其影響因素分析. 中國初級衛生保健, 2012, 26(3): 4-7.
16.	辛英, 饒克勤, 徐玲. 我國城鄉居民家庭高血壓疾病經濟負擔分析. 中國衛生經濟, 2010, 29(5): 69-71.
17.	馮達, 趙銳, 田淼淼, 等. 山西省農村慢性病疾病經濟負擔與風險研究. 中國衛生經濟, 2013, (10): 48-50.
18.	門可, 殷尚炯, 徐德忠, 等. 精神分裂癥危險因素的病例對照研究. 中國公共衛生, 2003, 19(5): 599-600.
19.	王琳, 李革. 精神障礙的社會心理因素研究現況. 中國公共衛生, 2006, 22(2): 130-131.
20.	仇冰玉, 孫尚文, 王延祜, 等. 山東省重性精神疾病患者門診診療和家庭經濟負擔情況調查. 預防醫學論壇, 2014, (01): 4-7.
21.	崔俊丹, 周子深, 田慶豐, 等. 河南省終末期腎病透析患者門診診療和家庭經濟負擔研究. 醫藥論壇雜志, 2017, 38(10): 7-14.
22.	楊莉, 李欣雅, 陳政淳, 等. 我國透析患者高磷血癥疾病負擔研究. 中國醫療保險, 2015, (7): 57-60.
23.	王敏, 張開金, 姜麗, 等. 惡性腫瘤住院患者直接經濟負擔影響因素及醫療保障制度研究. 中國全科醫學, 2010, (36): 4115-4118.
24.	桑新剛, 尹愛田, 宋春燕, 等. 農村慢性病患者疾病負擔及新農合補償分析. 中國公共衛生, 2010, (05): 606-608.
25.	Black CM, Fillit H, Xie L, et al. Economic burden, mortality, and institutionalization in patients newly diagnosed with Alzheimer's disease. J Alzheimers Dis, 2018, 61(1): 185-193.
26.	王霞, 王文志. 卒中的疾病負擔評價. 國外醫學(腦血管疾病分冊), 2004, (7): 487-490.
27.	Essink-Bot ML, Pereira J, Packer C, et al. Cross-national comparability of burden of disease estimates: the European Disability Weights Project. Bull World Health Organ, 2002, 80(8): 644-652.
28.	楊克虎, 李秀霞, 拜爭剛. 循證社會科學研究方法: 系統評價與 Meta 分析（第 1 版）. 蘭州: 蘭州大學出版社, 2018.

1. 胡善聯. 疾病負擔的研究(上). 衛生經濟研究, 2005, (5): 22-27.
2. 周尚成, 萬崇華, 蔡樂. 疾病負擔研究現狀及問題. 國外醫學(衛生經濟分冊), 2004, 21(4): 145-149.
3. 徐張燕, 張敏, 崔亞萍. 疾病負擔研究的發展與應用. 中國腫瘤, 2013, 22(8): 638-643.
4. 中華人民共和國國家衛生健康委員會. 國家衛生計生委、國務院扶貧辦啟動建檔立卡農村貧困人口" 因病致貧、因病返貧”調查工作. Available at: http://www.nhfpc.gov.cn/caiwusi/s7786/201604/fc6d02a21134e5ebf71bb7f19cb1216.shtml.
5. Sackett DL, Straus SE, Richardson WS, et al. Evidence based medicine: how to practice and teach EBM (2nd edition). New York: Churchill Livingstone, 2000: 1-2.
6. Guyatt G, Rennie D, Meade M, et al. Users' guides to the medical literature: a manual for evidence-based clinical practice (2nd edition). New York: McGraw-Hill Professional, 2008.
7. 張潔, 錢序, 陳英耀. 疾病負擔研究進展. 中國衛生經濟, 2005, 24(5): 69-71.
8. World Health Organization.ICD-11 for mortality and morbidity statistics. Available at: https://icd.who.int/browse11/l-m/en.
9. 盧國萍. 慢性病成為全球健康的主要威脅. 第45屆亞太地區公共衛生聯盟大會, 2013: 10-27.
10. 劉竟芳, 陳哲, 楊非柯, 等. 我國老年人慢性病現狀及應對策略. 中外醫療, 2014, (23): 194-195, 198.
11. 國家食品藥品監督管理總局. 中共中央國務院關于深化醫藥衛生體制改革的意見. Available at: http://www.sda.gov.cn/WS01/CL0611/41193.html.
12. 王亭艷, 曹鳳, 胡剛, 等. 新疆肺癌患者疾病經濟負擔及其影響因素分析. 衛生軟科學, 2016, 30(09): 17-20.
13. 孟慶躍, 馬彥強, 劉興柱, 等. 山東省麻風病人疾病經濟負擔分析. 中國衛生事業管理, 1997, (11): 606-607.
14. 羅惠文, 豐燕, 季明, 等. 江蘇某農村地區結核病患者疾病經濟負擔及其影響因素分析. 中華疾病控制雜志, 2012, 16(10): 877-880.
15. 羅惠文, 戴垚垚, 王建明. 肺結核病患者疾病經濟負擔及其影響因素分析. 中國初級衛生保健, 2012, 26(3): 4-7.
16. 辛英, 饒克勤, 徐玲. 我國城鄉居民家庭高血壓疾病經濟負擔分析. 中國衛生經濟, 2010, 29(5): 69-71.
17. 馮達, 趙銳, 田淼淼, 等. 山西省農村慢性病疾病經濟負擔與風險研究. 中國衛生經濟, 2013, (10): 48-50.
18. 門可, 殷尚炯, 徐德忠, 等. 精神分裂癥危險因素的病例對照研究. 中國公共衛生, 2003, 19(5): 599-600.
19. 王琳, 李革. 精神障礙的社會心理因素研究現況. 中國公共衛生, 2006, 22(2): 130-131.
20. 仇冰玉, 孫尚文, 王延祜, 等. 山東省重性精神疾病患者門診診療和家庭經濟負擔情況調查. 預防醫學論壇, 2014, (01): 4-7.
21. 崔俊丹, 周子深, 田慶豐, 等. 河南省終末期腎病透析患者門診診療和家庭經濟負擔研究. 醫藥論壇雜志, 2017, 38(10): 7-14.
22. 楊莉, 李欣雅, 陳政淳, 等. 我國透析患者高磷血癥疾病負擔研究. 中國醫療保險, 2015, (7): 57-60.
23. 王敏, 張開金, 姜麗, 等. 惡性腫瘤住院患者直接經濟負擔影響因素及醫療保障制度研究. 中國全科醫學, 2010, (36): 4115-4118.
24. 桑新剛, 尹愛田, 宋春燕, 等. 農村慢性病患者疾病負擔及新農合補償分析. 中國公共衛生, 2010, (05): 606-608.
25. Black CM, Fillit H, Xie L, et al. Economic burden, mortality, and institutionalization in patients newly diagnosed with Alzheimer's disease. J Alzheimers Dis, 2018, 61(1): 185-193.
26. 王霞, 王文志. 卒中的疾病負擔評價. 國外醫學(腦血管疾病分冊), 2004, (7): 487-490.
27. Essink-Bot ML, Pereira J, Packer C, et al. Cross-national comparability of burden of disease estimates: the European Disability Weights Project. Bull World Health Organ, 2002, 80(8): 644-652.
28. 楊克虎, 李秀霞, 拜爭剛. 循證社會科學研究方法: 系統評價與 Meta 分析（第 1 版）. 蘭州: 蘭州大學出版社, 2018.

Chinese Journal of Evidence-Based Medicine

Analysis of the status of evidence for disease burden research

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