Situation of application and funding of evidenced-based research projects on traditional Chinese medicine (TCM) of National Natural Science Foundation of China in 2019_Chinese Journal of Evidence-Based Medicine

Authors：

JIANG Jing ¹ , SHEN Li ² , LI Weidong ³ , YAN Qianhua ⁴ , LIU Qi ⁵ , CUI Shuna ⁶ ,  BI Minggang ⁷

1. Beijing University of Chinese Medicine, Beijing 100029, P.R.China;
2. Institue of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100070, P.R.China;
3. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R.China;
4. Affiliated Hospital of Nanjing Chinese Medicine University, Nanjing 210023, P.R.China;
5. Shanxi University of Chinese Medicine, Shanxi 712046, P.R.China;
6. Yangzhou University, Yangzhou 225000, P.R.China;
7. National Natural Science Foundation of China, Beijing 100081, P.R.China;

Corresponding?author：

BI Minggang, Email: bimg@nsfc.gov.cn

Keywords：

traditional Chinese medicine; Evidence-based research; National Natural Science Foundation of China; Project application; Project funding

DOI：

10.7507/1672-2531.201912044

Video：

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This paper introduces the application and funding of evidence-based research projects on traditional Chinese medicine (TCM) of the National Natural Science Foundation of China (NSFC) in 2019 in terms of clinical research and methodology research, summarizes the primary problems existing in evidence-based research on TCM, discusses the quality of evidence-based research on TCM in clinical research, highlights the characteristics of TCM and reveals the evidence-based methodology on TCM.

Citation： JIANG Jing, SHEN Li, LI Weidong, YAN Qianhua, LIU Qi, CUI Shuna, BI Minggang. Situation of application and funding of evidenced-based research projects on traditional Chinese medicine (TCM) of National Natural Science Foundation of China in 2019. Chinese Journal of Evidence-Based Medicine, 2020, 20(6): 628-633. doi: 10.7507/1672-2531.201912044 Copy

1.	Djulbegovic B, Guyatt GH. Progress in evidence-based medicine: a quarter century on. Lancet, 2017, 390(10092): 415-423.
2.	Tenny S, Varacallo M. Evidence Based Medicine. Treasure Island: StatPearls Publishing, 2020.
3.	張俊華, 李幼平, 張伯禮. 循證中醫藥學: 理論與實踐. 中國中藥雜志, 2018, 43(1): 1-7.
4.	張俊華, 孫鑫, 李幼平, 等. 循證中醫藥學的現在和未來. 中國循證醫學雜志, 2019, 19(5): 515-520.
5.	荀楊芹, 成鵬, 李秀霞, 等. 中國臨床路徑的證據來源調查. 中國循證醫學雜志, 2018, 18(10): 1032-1036.
6.	劉建平. 循證中醫藥臨床研究方法. 北京: 人民衛生出版社, 2015.
7.	《2019 年度國家自然科學基金項目指南》編輯委員會. 2019 年度國家自然科學基金項目指南. Aaviable from: http://www.nsfc.gov.cn/nsfc/cen/xmzn/2019xmzn/index.html.
8.	de Vet HC, Verhagen AP, Logghe I, et al. Literature research: aims and design of systematic reviews. Aust J Physiother, 2005, 51(2): 125-128.
9.	張俊華, 孫鑫. 循證中醫藥學. 上海: 上海科學技術出版社, 2018.
10.	胡嘉元, 趙晨, 田然, 等. 中醫藥臨床研究報告規范體系研究. 中國循證醫學雜志, 2018, 18(11): 1151-1157.
11.	張曉雨, 陳詩琪, 李承羽, 等. 循證中醫藥學理論研究與應用實踐. 中國循證醫學雜志, 2018, 18(1): 86-91.
12.	費菲, 劉姍姍. 張伯禮: 以循證醫學的方法學推動中醫藥研究國際化. 中國醫藥科學, 2015, 5(17): 1-3.
13.	Whitehead AL, Sully BG, Campbell MJ. Pilot and feasibility studies: is there a difference from each other and from a randomised controlled trial? Contemp Clin Trials, 2014, 38(1): 130-133.
14.	張澤, 李博. 基于循證醫學談中醫藥臨床試驗的現狀和對策. 廣州中醫藥大學學報, 2015, 32(5): 946-948+959.
15.	Hróbjartsson A, Emanuelsson F, Skou TAS, et al. Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies. Int J Epidemiol, 2014, 43(4): 1272-1283.
16.	Page SJ, Persch AC. Recruitment, retention, and blinding in clinical trials. Am J Occup Ther, 2013, 67(2): 154-161.
17.	張穎, 賈麗燕, 邵建柱, 等. 中醫藥臨床研究中實施盲法的原則, 問題和評價. 北京中醫藥, 2018, 37(12): 1159-1162.
18.	王麗瓊, 李青, 蘇春香, 等. 中醫藥隨機對照試驗中盲法的應用與評價. 中醫雜志, 2014, 55(1): 28-33.
19.	Kube T, Rief W. Are placebo and drug-specific effects additive? Questioning basic assumptions of double-blinded randomized clinical trials and presenting novel study designs. Drug Discov Today, 2017, 22(4): 729-735.
20.	韓春雯, 李海昌, 溫成平, 等. 中醫藥隨機對照臨床試驗安慰劑選擇的探討. 中華中醫藥雜志, 2014, 29(4): 1165-1167.
21.	黃珊珊. 安慰劑在中醫藥臨床研究中的應用原則探討. 北京: 北京中醫藥大學, 2018.
22.	劉麗輝, 李國信. 中醫藥臨床療效評價方法研究進展. 實用中醫內科雜志, 2013, 27(1): 151-152.
23.	Porcino AJ, Punja S, Chan AW, et al. Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines. Syst Rev, 2017, 6(1): 132.
24.	井含光, 孟慶剛. 單病例隨機對照試驗在中醫藥臨床療效評價中的應用與思考. 北京中醫藥大學學報, 2018, 41(10): 842-847.
25.	朱文慧, 孟慶剛. 單病例隨機對照試驗的周期設計在中醫藥臨床療效評價中的應用研究. 中華中醫藥學刊, 2018, 36(10): 2509-2512.
26.	薛晶晶, 楊佩蘭, 王潔, 等. 評價中醫個體化治療: 單病例隨機對照試驗的初步研究. 循證醫學, 2016, 16(2): 103-108.
27.	Margolis A, Giuliano C. Making the switch: From case studies to N-of-1 trials. Epilepsy Behav Rep, 2019, 12: 100336.
28.	崗衛娟, 孟醒, 景向紅. 臨床試驗中針刺方案充分性評價: 現狀與建議. 中國針灸, 2019, 39(3): 229-233.
29.	丁樂, 楊人澤. 中醫藥療效評價的特殊性及建議. 中華中醫藥雜志, 2016, 31(11): 4399-4401.
30.	陶立元, 劉玨, 商洪才. 中醫藥療效評價研究熱點的雙向聚類計量學分析. 世界中醫藥, 2019, 14(10): 2568-2572.
31.	趙鑫, 王階, 陳光. 循證醫學理論與傳統中醫臨床療效評價. 中華中醫藥雜志, 2019, 34(8): 3362-3365.
32.	陳智慧, 裴宇鵬, 關紅陽, 等. 中醫藥臨床療效評價量表臨床療效判定閾值研究的構想. 中華中醫藥學刊, 2019, 37(6): 1342-1344.

1. Djulbegovic B, Guyatt GH. Progress in evidence-based medicine: a quarter century on. Lancet, 2017, 390(10092): 415-423.
2. Tenny S, Varacallo M. Evidence Based Medicine. Treasure Island: StatPearls Publishing, 2020.
3. 張俊華, 李幼平, 張伯禮. 循證中醫藥學: 理論與實踐. 中國中藥雜志, 2018, 43(1): 1-7.
4. 張俊華, 孫鑫, 李幼平, 等. 循證中醫藥學的現在和未來. 中國循證醫學雜志, 2019, 19(5): 515-520.
5. 荀楊芹, 成鵬, 李秀霞, 等. 中國臨床路徑的證據來源調查. 中國循證醫學雜志, 2018, 18(10): 1032-1036.
6. 劉建平. 循證中醫藥臨床研究方法. 北京: 人民衛生出版社, 2015.
7. 《2019 年度國家自然科學基金項目指南》編輯委員會. 2019 年度國家自然科學基金項目指南. Aaviable from: http://www.nsfc.gov.cn/nsfc/cen/xmzn/2019xmzn/index.html.
8. de Vet HC, Verhagen AP, Logghe I, et al. Literature research: aims and design of systematic reviews. Aust J Physiother, 2005, 51(2): 125-128.
9. 張俊華, 孫鑫. 循證中醫藥學. 上海: 上海科學技術出版社, 2018.
10. 胡嘉元, 趙晨, 田然, 等. 中醫藥臨床研究報告規范體系研究. 中國循證醫學雜志, 2018, 18(11): 1151-1157.
11. 張曉雨, 陳詩琪, 李承羽, 等. 循證中醫藥學理論研究與應用實踐. 中國循證醫學雜志, 2018, 18(1): 86-91.
12. 費菲, 劉姍姍. 張伯禮: 以循證醫學的方法學推動中醫藥研究國際化. 中國醫藥科學, 2015, 5(17): 1-3.
13. Whitehead AL, Sully BG, Campbell MJ. Pilot and feasibility studies: is there a difference from each other and from a randomised controlled trial? Contemp Clin Trials, 2014, 38(1): 130-133.
14. 張澤, 李博. 基于循證醫學談中醫藥臨床試驗的現狀和對策. 廣州中醫藥大學學報, 2015, 32(5): 946-948+959.
15. Hróbjartsson A, Emanuelsson F, Skou TAS, et al. Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies. Int J Epidemiol, 2014, 43(4): 1272-1283.
16. Page SJ, Persch AC. Recruitment, retention, and blinding in clinical trials. Am J Occup Ther, 2013, 67(2): 154-161.
17. 張穎, 賈麗燕, 邵建柱, 等. 中醫藥臨床研究中實施盲法的原則, 問題和評價. 北京中醫藥, 2018, 37(12): 1159-1162.
18. 王麗瓊, 李青, 蘇春香, 等. 中醫藥隨機對照試驗中盲法的應用與評價. 中醫雜志, 2014, 55(1): 28-33.
19. Kube T, Rief W. Are placebo and drug-specific effects additive? Questioning basic assumptions of double-blinded randomized clinical trials and presenting novel study designs. Drug Discov Today, 2017, 22(4): 729-735.
20. 韓春雯, 李海昌, 溫成平, 等. 中醫藥隨機對照臨床試驗安慰劑選擇的探討. 中華中醫藥雜志, 2014, 29(4): 1165-1167.
21. 黃珊珊. 安慰劑在中醫藥臨床研究中的應用原則探討. 北京: 北京中醫藥大學, 2018.
22. 劉麗輝, 李國信. 中醫藥臨床療效評價方法研究進展. 實用中醫內科雜志, 2013, 27(1): 151-152.
23. Porcino AJ, Punja S, Chan AW, et al. Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines. Syst Rev, 2017, 6(1): 132.
24. 井含光, 孟慶剛. 單病例隨機對照試驗在中醫藥臨床療效評價中的應用與思考. 北京中醫藥大學學報, 2018, 41(10): 842-847.
25. 朱文慧, 孟慶剛. 單病例隨機對照試驗的周期設計在中醫藥臨床療效評價中的應用研究. 中華中醫藥學刊, 2018, 36(10): 2509-2512.
26. 薛晶晶, 楊佩蘭, 王潔, 等. 評價中醫個體化治療: 單病例隨機對照試驗的初步研究. 循證醫學, 2016, 16(2): 103-108.
27. Margolis A, Giuliano C. Making the switch: From case studies to N-of-1 trials. Epilepsy Behav Rep, 2019, 12: 100336.
28. 崗衛娟, 孟醒, 景向紅. 臨床試驗中針刺方案充分性評價: 現狀與建議. 中國針灸, 2019, 39(3): 229-233.
29. 丁樂, 楊人澤. 中醫藥療效評價的特殊性及建議. 中華中醫藥雜志, 2016, 31(11): 4399-4401.
30. 陶立元, 劉玨, 商洪才. 中醫藥療效評價研究熱點的雙向聚類計量學分析. 世界中醫藥, 2019, 14(10): 2568-2572.
31. 趙鑫, 王階, 陳光. 循證醫學理論與傳統中醫臨床療效評價. 中華中醫藥雜志, 2019, 34(8): 3362-3365.
32. 陳智慧, 裴宇鵬, 關紅陽, 等. 中醫藥臨床療效評價量表臨床療效判定閾值研究的構想. 中華中醫藥學刊, 2019, 37(6): 1342-1344.

Chinese Journal of Evidence-Based Medicine

Situation of application and funding of evidenced-based research projects on traditional Chinese medicine (TCM) of National Natural Science Foundation of China in 2019

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