Efficacy of moxibustion in the treatment of knee osteoarthritis in model rabbit: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

HUA Fanghui ¹ ,  XIONG Jun ² , XIANG Jie ¹ , HUANG Shouqiang ¹

1. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P.R.China;
2. The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, P.R.China;

Corresponding?author：

XIONG Jun, Email: xiongjun196071@163.com

Keywords：

Moxibustion; Knee osteoarthritis; Systematic review; Meta-analysis; Animal experiment; Rabbit

DOI：

10.7507/1672-2531.202011115

Video：

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Objective To systematically review the efficacy of moxibustion in the treatment of model rabbits with knee osteoarthritis (KOA).Methods CNKI, WanFang Data, VIP, CBM, PubMed, EMbase and The Cochrane Library databases were electronically searched to collect animal experiments on moxibustion in the treatment of model rabbits with KOA from inception to January 31^st, 2019. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was then performed by using RevMan 5.3 software.Results A total of 13 articles involving 226 model rabbits were included. The results of meta-analysis showed that moxibustion could reduce Mankin score (MD=?6.47, 95%CI ?7.63 to ?5.32, P<0.000 01), positive expression rate of chondrocyte apoptosis (MD=?22.21, 95%CI ?23.22 to ?21.21, P<0.000 01), level of IL-1β in joint fluid (SMD=?8.40, 95%CI ?15.09 to ?1.72, P=0.01), NO content in joint fluid (SMD=?11.03, 95%CI ?17.87 to ?4.19, P=0.002), the level of serum IL-1β (MD=?19.94, 95%CI ?23.61 to ?16.27, P<0.05), and serum NO content (MD=?22.69, 95%CI ?28.77 to ?16.61, P<0.05) of model rabbits with KOA.Conclusions Current evidence shows that moxibustion can improve articular cartilage injury, strengthen chondrocyte activity, inhibit the inflammatory response, and inhibit chondrocyte apoptosis of model rabbits with KOA. Due to the limited quality and quantity of the included studies, more high-quality studies are required to verify the above conclusions.

Citation： HUA Fanghui, XIONG Jun, XIANG Jie, HUANG Shouqiang. Efficacy of moxibustion in the treatment of knee osteoarthritis in model rabbit: a systematic review. Chinese Journal of Evidence-Based Medicine, 2021, 21(6): 683-688. doi: 10.7507/1672-2531.202011115 Copy

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2.	van Dijk GM, Veenhof C, Schellevis F, et al. Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord, 2008, 9: 95.
3.	Litwic A, Edwards MH, Dennison EM, et al. Epidemiology and burden of osteoarthritis. Br Med Bull, 2013, 105: 185-199.
4.	任燕, 石婭婭, 譚波, 等. 中國人群膝骨關節炎危險因素的 Meta 分析. 現代預防醫學, 2015, 42(12): 2282-2284, 2292.
5.	林雪娟, 陳朝陽. 中藥內治腰椎間盤突出癥研究進展. 中國中藥雜志, 2007, 32(3): 186-191.
6.	于雋, 熊俊. 熱敏灸治療膝骨性關節炎臨床療效的系統評價與 Meta 分析. 廣州中醫藥大學學報, 2015, 32(1): 60-66.
7.	Choi TY, Lee MS, Kim JI, et al. Moxibustion for the treatment of osteoarthritis: an updated systematic review and meta-analysis. Maturitas, 2017, 100: 33-48.
8.	Song GM, Tian X, Jin YH, et al. Moxibustion is an alternative in treating knee osteoarthritis: the evidence from systematic review and meta-analysis. Medicine (Baltimore), 2016, 95(6): e2790.
9.	陳匡陽, 馬彬, 王亞楠, 等. SYRCLE 動物實驗偏倚風險評估工具簡介. 中國循證醫學雜志, 2014, 14(10): 1281-1285.
10.	廖緒亮, 姜彥彪, 王歡, 等. 如何提高動物實驗系統評價質量—基于動物實驗系統評價與臨床試驗系統評價的比較研究. 中國循證心血管醫學雜志, 2019, 11(5): 526-529, 533.
11.	熊勇, 彭銳, 夏數數. 兔膝骨性關節炎關節液中白細胞介素 1β 和腫瘤壞死因子 α 表達與艾灸的影響. 中國組織工程研究與臨床康復, 2010, 14(41): 7700-7703.
12.	熊勇. 艾灸對膝骨性關節炎的防治作用及其機理的實驗研究. 武漢: 湖北中醫藥大學, 2010.
13.	熊勇, 彭銳, 王華. “雙固一通”溫針灸實驗性膝骨性關節炎模型兔 Bcl-2 及 Bax 蛋白的表達. 中國組織工程研究, 2012, 16(2): 261-264.
14.	肖琳. 艾灸對兔膝骨性關節炎的治療作用及其機理的研究. 武漢: 武漢體育學院, 2006.
15.	肖琳. 艾灸療法對兔膝骨性關節炎軟骨細胞凋亡的影響. 大眾商務(投資版), 2009, (6): 246-247.
16.	樊思琴. 超聲波結合艾灸對兔膝骨性關節炎軟骨, 滑膜和滑液 VEGF, MMP-9, TIMP-1 影響的研究. 福州: 福建中醫藥大學, 2018.
17.	李建武, 馬志毅, 熊源胤, 等. 隔物溫和灸對膝骨性關節炎家兔軟骨細胞及滑膜組織病理學的影響. 中西醫結合研究, 2010, 2(2): 64-67.
18.	林瑞珠, 許建峰, 朱寧, 等. 回醫烙灸療法對實驗性兔膝骨性關節炎軟骨細胞凋亡的影響. 甘肅中醫學院學報, 2014, 31(1): 1-3.
19.	林瑞珠, 陳美華, 馬川, 等. 烙灸對兔膝骨性關節炎軟骨細胞外基質Ⅱ型膠原, 蛋白多糖表達的影響. 針灸臨床雜志, 2019, 35(1): 54-57, 89.
20.	章海鳳, 陳樹濤, 冒姣娜, 等. 熱敏灸對膝骨性關節炎兔模型 IL-1β, TNF-α, MMP-13 的影響. 中華中醫藥雜志, 2018, 33(9): 3913-3917.
21.	付勇, 陳樹濤, 冒姣娜, 等. 熱敏灸干預膝骨性關節炎兔模型效應機制的研究. 中國針灸, 2018, 38(3): 291-296.
22.	武永利, 李春, 劉娣, 等. 溫針灸對兔膝骨性關節炎關節軟骨尿激酶型纖溶酶原活物系統的影響. 中華中醫藥雜志, 2017, 32(2): 735-738.
23.	姚暢, 程珂, 趙玲, 等. 艾灸對兔膝骨性關節炎模型血清 IL-1β, COX-2, COMP 表達的影響. 浙江中醫雜志, 2017, 52(8): 579-580.
24.	許家科, 趙璐璐, 廖緒亮, 等. 循證構建動物實驗系統評價制作流程. 中國循證醫學雜志, 2017, 17(11): 1357-1364.
25.	Mankin HJ, Dorfman H, Lippiello L, et al. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am, 1971, 53(3): 523-537.
26.	Goldring MB. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res, 1999, 40(1): 1-11.
27.	管劍龍, 施桂英. 基質金屬蛋白酶與骨關節炎. 中華風濕病學雜志, 2000, (1): 54-56.
28.	Manacu CA, Martel-Pelletier J, Roy-Beaudry M, et al. Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production. Arthritis Res Ther, 2005, 7(2): R324-332.
29.	Takács-Buia L, Iordachel C, Efimov N, et al. Pathogenesis of osteoarthritis: chondrocyte replicative senescence or apoptosis? Cytometry B Clin Cytom, 2008, 74(6): 356-362.
30.	Ling S, Lai A, Borschukova O, et al. Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis Rheum, 2006, 54(11): 3423-3432.

1. Jones G. Osteoarthritis: where are we for pain and therapy in 2013? Aust Fam Physician, 2013, 42(11): 766-769.
2. van Dijk GM, Veenhof C, Schellevis F, et al. Comorbidity, limitations in activities and pain in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord, 2008, 9: 95.
3. Litwic A, Edwards MH, Dennison EM, et al. Epidemiology and burden of osteoarthritis. Br Med Bull, 2013, 105: 185-199.
4. 任燕, 石婭婭, 譚波, 等. 中國人群膝骨關節炎危險因素的 Meta 分析. 現代預防醫學, 2015, 42(12): 2282-2284, 2292.
5. 林雪娟, 陳朝陽. 中藥內治腰椎間盤突出癥研究進展. 中國中藥雜志, 2007, 32(3): 186-191.
6. 于雋, 熊俊. 熱敏灸治療膝骨性關節炎臨床療效的系統評價與 Meta 分析. 廣州中醫藥大學學報, 2015, 32(1): 60-66.
7. Choi TY, Lee MS, Kim JI, et al. Moxibustion for the treatment of osteoarthritis: an updated systematic review and meta-analysis. Maturitas, 2017, 100: 33-48.
8. Song GM, Tian X, Jin YH, et al. Moxibustion is an alternative in treating knee osteoarthritis: the evidence from systematic review and meta-analysis. Medicine (Baltimore), 2016, 95(6): e2790.
9. 陳匡陽, 馬彬, 王亞楠, 等. SYRCLE 動物實驗偏倚風險評估工具簡介. 中國循證醫學雜志, 2014, 14(10): 1281-1285.
10. 廖緒亮, 姜彥彪, 王歡, 等. 如何提高動物實驗系統評價質量—基于動物實驗系統評價與臨床試驗系統評價的比較研究. 中國循證心血管醫學雜志, 2019, 11(5): 526-529, 533.
11. 熊勇, 彭銳, 夏數數. 兔膝骨性關節炎關節液中白細胞介素 1β 和腫瘤壞死因子 α 表達與艾灸的影響. 中國組織工程研究與臨床康復, 2010, 14(41): 7700-7703.
12. 熊勇. 艾灸對膝骨性關節炎的防治作用及其機理的實驗研究. 武漢: 湖北中醫藥大學, 2010.
13. 熊勇, 彭銳, 王華. “雙固一通”溫針灸實驗性膝骨性關節炎模型兔 Bcl-2 及 Bax 蛋白的表達. 中國組織工程研究, 2012, 16(2): 261-264.
14. 肖琳. 艾灸對兔膝骨性關節炎的治療作用及其機理的研究. 武漢: 武漢體育學院, 2006.
15. 肖琳. 艾灸療法對兔膝骨性關節炎軟骨細胞凋亡的影響. 大眾商務(投資版), 2009, (6): 246-247.
16. 樊思琴. 超聲波結合艾灸對兔膝骨性關節炎軟骨, 滑膜和滑液 VEGF, MMP-9, TIMP-1 影響的研究. 福州: 福建中醫藥大學, 2018.
17. 李建武, 馬志毅, 熊源胤, 等. 隔物溫和灸對膝骨性關節炎家兔軟骨細胞及滑膜組織病理學的影響. 中西醫結合研究, 2010, 2(2): 64-67.
18. 林瑞珠, 許建峰, 朱寧, 等. 回醫烙灸療法對實驗性兔膝骨性關節炎軟骨細胞凋亡的影響. 甘肅中醫學院學報, 2014, 31(1): 1-3.
19. 林瑞珠, 陳美華, 馬川, 等. 烙灸對兔膝骨性關節炎軟骨細胞外基質Ⅱ型膠原, 蛋白多糖表達的影響. 針灸臨床雜志, 2019, 35(1): 54-57, 89.
20. 章海鳳, 陳樹濤, 冒姣娜, 等. 熱敏灸對膝骨性關節炎兔模型 IL-1β, TNF-α, MMP-13 的影響. 中華中醫藥雜志, 2018, 33(9): 3913-3917.
21. 付勇, 陳樹濤, 冒姣娜, 等. 熱敏灸干預膝骨性關節炎兔模型效應機制的研究. 中國針灸, 2018, 38(3): 291-296.
22. 武永利, 李春, 劉娣, 等. 溫針灸對兔膝骨性關節炎關節軟骨尿激酶型纖溶酶原活物系統的影響. 中華中醫藥雜志, 2017, 32(2): 735-738.
23. 姚暢, 程珂, 趙玲, 等. 艾灸對兔膝骨性關節炎模型血清 IL-1β, COX-2, COMP 表達的影響. 浙江中醫雜志, 2017, 52(8): 579-580.
24. 許家科, 趙璐璐, 廖緒亮, 等. 循證構建動物實驗系統評價制作流程. 中國循證醫學雜志, 2017, 17(11): 1357-1364.
25. Mankin HJ, Dorfman H, Lippiello L, et al. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am, 1971, 53(3): 523-537.
26. Goldring MB. The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res, 1999, 40(1): 1-11.
27. 管劍龍, 施桂英. 基質金屬蛋白酶與骨關節炎. 中華風濕病學雜志, 2000, (1): 54-56.
28. Manacu CA, Martel-Pelletier J, Roy-Beaudry M, et al. Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production. Arthritis Res Ther, 2005, 7(2): R324-332.
29. Takács-Buia L, Iordachel C, Efimov N, et al. Pathogenesis of osteoarthritis: chondrocyte replicative senescence or apoptosis? Cytometry B Clin Cytom, 2008, 74(6): 356-362.
30. Ling S, Lai A, Borschukova O, et al. Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis Rheum, 2006, 54(11): 3423-3432.

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Efficacy of moxibustion in the treatment of knee osteoarthritis in model rabbit: a systematic review

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